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Prevalence and risk factors of acute-on-chronic liver failure in a single center from Argentina

World Journal of Hepatology 2016年第34期8卷 1529-1534页

作者： Cristian Dominguez eugenia Romero Jorgelina Graciano Jose Luis Fernandez Luis Viola Division of Gastroenterology Sanatorio Guemes Centro Integral de Gastroenterología

AIMTo study the prevalence, characteristics, risk factors and mortality at 28 d of acute-on-chronic liver failure (ACLF). METHODSA total of 100 cirrhotic patients admitted to our hospital for more than one day were included during the period between June 2013 and December 2015. We used the European Association for the Study of the Liver-Chronic Liver Failure-Consortium diagnostic criteria for ACLF, considering it as the acute decompensation of cirrhosis associated with the presence of one or more organ failure. For the diagnosis of organic failure the Chronic Liver Failure-Sequential Organ Failure Assessment score was used. Our population was divided into patients with and without ACLF. Clinical characteristics, presence of precipitating events, potential risk factors for developing ACLF and causes of mortality were analyzed. Mortality at 28 d was evaluated. RESULTSTwenty-nine patients (29%) developed ACLF criteria. Alcoholism, detected in 58 patients (58%), was the major etiological agent of cirrhosis. Bacterial infections were recognized as a precipitating event in 41.3% of cases and gastrointestinal bleeding in 27.5%. No precipitating event was identifiable in 27.5% of patients with ACLF. Comparing patients with and without ACLF, statistically significant risk factors were: Child Pugh score 10.2 ± 2.1 vs 8.4 ± 1.6 (P ˂ 0.0001), MELD score 20.7 ± 8.5 vs 12.3 ± 4 (P ˂ 0.0001), presence of ascites 27 (93%) vs 43 (60.5%) (P = 0.001), leukocytosis 15300 ± 8033 per cubic millimeter vs 10770 ± 5601 per cubic millimeter (P ˂ 0.0001), and high plasma levels of C reactive protein values 50.9 ± 46.4 mg/L vs 28.6 ± 23.4 mg/L (P ˂ 0.0019). Mortality rate was 62% (18 patients) vs 5.6% (4 patients), respectively (P CONCLUSIONWe observed that the ACLF is a frequent entity in this group of patients and has a significantly higher mortality rate.

关键词： Acute-on-chronic liver failure Acute liver decompensation Cirrhosis Ascites Mortality

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The Cretaceous Turn of Geological Evolution: Key Evidence from East Asia

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Acta Geologica Sinica(English Edition) 2018年第5期92卷 1991-2003页

作者： Victor P.NECHAEV DAI Shifeng F.Lin SUTHERLAND Ian T.GRAHAM eugenia V.NECHAEVA Far East Geological Institute Far Eastern Branch Russian Academy of Sciences Engineering School Far Eastern Federal University State Key Laboratory of Coal Resources and Safe Mining China University of Mining and Technology School of Resources and Geosciences China University of Mining and Technology Geoscience Australian Museum PANGEA Research Centre School of Biological Earth and Environmental Sciences University of New South Wales

this work focuses on one of the critical points of Earth＇s history when the Solar System passed through the most distant point of its galactic orbit. During this event, Earth may have suffered from maximum extension, associated with its relative proximity to the Sun at that time, followed by long-term contraction related to its later distancing. This paper is based on generalized data on the Cretaceous evolution of the Earth as a whole and of East Asia in particular. The evidence suggests that major geological processes at this time may be interpreted as transitional changes in the state of Earth. A liquid nature of its core may have reacted to the gravitational and electromagnetic transformations. When the cosmic changes took place at 135-120 Ma, more turbulent flows in the outer core would have favoured the rise of voluminous magmatic plumes and associated fluid flows. These would substantially transform the mantle, crust, hydrosphere, biosphere and atmosphere. In particular, plume-related melting of overlying subducting slabs and lower continental crust could have initiated numerous adakitic melts that formed the East Asian Adakitic Province. These and associated juvenile events produced numerous metallic ore, coal, gas and oil deposits. The Cretaceous is one of the most significant resource-producing periods.

关键词： Cretaceous geological evolution galactic orbit super plume adakitic rocks coal ore and petroleum resources

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eugenia Loli作品欣赏

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美与时代(上) 2015年第7期 2-2页

作者： eugenia Loli

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Culp,Robert,Eddy U,and Wen-hsin Yeh,*** Acts in Modern China:Ideas,Institutions,and Identities

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2018年第4期12卷 715-719页

作者： eugenia Lean Columbia University

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SWEET POTATO PIE

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英语学习 1995年第11期 3-14页

作者： eugenia COLLIER 乐安

From up here on the 14th floor,my brother Charley looks likean insect scurrying among other insects.A deep feeling oflove surges through *** the distance,he seems to feel it,for he turns and scans the upper windows,but failing to find me,continues on his way.I watch him moving quickly-gingerly,itseems to me-down Fifth Avenue and around the corner to his

关键词： down than

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Artificial Neural Networks for COVID-19 Time Series Forecasting

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Open Journal of Statistics 2022年第2期12卷 277-290页

作者： Lorena Saliaj eugenia Nissi Department of Economics “Gabriele d’Annunzio” University Pescara Italy

Today, COVID-19 pandemic has become the greatest worldwide threat, as it spreads rapidly among individuals in most countries around the world. This study concerns the problem of daily prediction of new COVID-19 cases in Italy, aiming to find the best predictive model for daily infection number in countries with a large number of confirmed cases. Finding the most accurate forecasting model would help allocate medical resources, handle the spread of the pandemic and get more prepared in terms of health care systems. We compare the forecasting performance of linear and nonlinear forecasting models using daily COVID-19 data for the period between 22 February 2020 and 10 January 2022. We discuss various forecasting approaches, including an Autoregressive Integrated Moving Average (ARIMA) model, a Nonlinear Autoregressive Neural Network (NARNN) model, a TBATS model and Exponential Smoothing on the data collected from 22 February 2020 to 10 January 2022 and compared their accuracy using the data collected from 26 March 2020 to 04 April 2020, choosing the model with the lowest Mean Absolute Percentage Error (MAPE) value. Since the linear models seem not to easily follow the nonlinear patterns of daily confirmed COVID-19 cases, Artificial Neural Network (ANN) has been successfully applied to solve problems of forecasting nonlinear models. The model has been used for daily prediction of COVID-19 cases for the next 20 days without any additional intervention. The prediction model can be applied to other countries struggling with the COVID-19 pandemic and to any possible future pandemics.

关键词： COVID-19 Time Series Forecasting ANN ARIMA

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Notch signaling in female cancers: a multifaceted node to overcome drug resistance

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Cancer Drug Resistance 2021年第4期4卷 805-836页

作者： Maria V.Giuli Angelica Mancusi eugenia Giuliani Isabella Screpanti Saula Checquolo Laboratory of Molecular Pathology Department of Molecular MedicineSapienza UniversityRome 00161Italy Scientific Direction San Gallicano Dermatological Institute IRCCSRome 00144Italy Department of Medico-Surgical Sciences and Biotechnology Sapienza UniversityLatina 04100Italy Center for Life Nano Science@Sapienza Istituto Italiano di TecnologiaRome 00161Italy

Drug resistance is one of the main challenges in cancer therapy,including in the treatment of female-specific malignancies,which account for more than 60%of cancer cases among ***,elucidating the underlying molecular mechanisms is an urgent need in gynecological cancers to foster novel therapeutic ***,Notch signaling,including either receptors or ligands,has emerged as a promising candidate given its multifaceted role in almost all of the hallmarks of *** the connection between Notch pathway and drug resistance in the afore-mentioned tumor contexts,several studies focused on the Notch-dependent regulation of the cancer stem cell(CSC)subpopulation or the induction of the epithelial-to-mesenchymal transition(EMT),both features implicated in either intrinsic or acquired ***,the present review provides an up-to-date overview of the published results on Notch signaling and EMT-or CSC-driven drug ***,other drug resistance-related mechanisms are examined such as the involvement of the Notch pathway in drug efflux and tumor ***,there is a long way to go before every facet will be fully understood;nevertheless,some small pieces are falling neatly into ***,the main aim of this review is to provide strong evidence in support of Notch signaling inhibition as an effective strategy to evade or reverse resistance in female-specific cancers.

关键词： Notch signaling drug resistance female-specific cancers cancer stem cells epithelial-to-mesenchymal transition drug efflux tumor microenvironment

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Passive seismic investigation of intraplate earthquakes epicentral zones in the North of Russia as one of the ways to understand their source mechanics

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Journal of Earth Science 2024年

作者： Konstantin Danilov Galina Antonovskaya Irina Basakina eugenia Shakhova Natalia Kapustian N.Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences

Studying the inner structure of intraplate earthquakes originating in aseismic areas， which are poorly covered by seismic networks or as historical earthquakes is usually the only way to get knowledge about their source mechanisms that is partially important to deeper understand intraplate geodynamics. The epicentral zones of earthquakes are situated in hard-to-reach areas， so， using active seismic methods for such purposes is unreasonable or even impossible because of high cost and logistical difficulties. We are presenting a way to join using different passive seismic methods， which allows us to get sufficient information about geological environment structure for such task solutions. As an example， we investigated the inner structure of platform earthquake epicentral zone originated up north of Russia. We used four passive seismic methods: microseismic sounding method， passive seismic interferometry， HVSR method， and microseismic activity method. We show that passive seismic data， recoded in the same installation and processed by these different methods， can provide sufficient information about structure of studied environment， needed to explain source mechanism. In sum， the hypocenter zone is presented by intersection of vertical faults and a lateral fractured zone in the middle crust. Results were confirmed by comparison with results by active seismic methods.

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Entrapment neuropathies in diabetes mellitus

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World Journal of Diabetes 2016年第17期7卷 342-353页

作者： eugenia Rota Nicola Morelli Department of Neurology Ospedale G. da Saliceto

Neuropathy is a common complication of diabetes mellitus(DM) with a wide clinical spectrum that encompasses generalized to focal and multifocal forms. Entrapment neuropathies(EN), which are focal forms, are so frequent at any stage of the diabetic disease, that they may be considered a neurophysiological hallmarkof peripheral nerve involvement in DM. Indeed, EN may be the earliest neurophysiological abnormalities in DM,particularly in the upper limbs, even in the absence of a generalized polyneuropathy, or it may be superimposed on a generalized diabetic neuropathy. This remarkable frequency of EN in diabetes is underlain by a peculiar pathophysiological background. Due to the metabolic alterations consequent to abnormal glucose metabolism,the peripheral nerves show both functional impairment and structural changes, even in the preclinical stage,making them more prone to entrapment in anatomically constrained channels. This review discusses the most common and relevant EN encountered in diabetic patient in their epidemiological, pathophysiological and diagnostic features.

关键词： Diabetes mellitus Neuropathy Diabetic neuropathy Median entrapment neuropathy at the wrist Ulnar entrapment neuropathy at the elbow Ulnar entrapment neuropathy at the wrist Carpal tunnel syndrome Electrodiagnosis Tarsal tunnel syndrome

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Discrete-Time Sliding-Mode Control of Four Driving-Steering Wheels Autonomous Vehicle

Discrete-Time Sliding-Mode Control of Four Driving-Steering ...

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第三十届中国控制会议

作者： DUMITRASCU Bogdan FILIPESCU Adrian MINZU Viorel VODA Alina MINCA eugenia Department of Automation and Electrical Engineering University“Dunarea de Jos”of Galati Department of Control Systems GIPSA-labGrenoble University Joseph Fourier38000 GrenobleFrance

ISBN: (纸本)9781457706776

＜正＞A discrete-time sliding-mode control for the trajectory tracking problem of four driving-steering wheels（4DW/SW） autonomous vehicle SEEKUR is presented in this *** is a holonomic,all-wether,outdoor robot platform for outdor security,inspection and ***’s unique shape and omni-directional steering allow truly holonomic movement.A discrete-time nonholonomic model of SEEKUR is used for the design of the controller,instead of the usual continuous-time model,thus avoiding problems caused by the discretization of the continuous-time *** effectiveness of the proposed controller is proven by simulation results.

关键词： Discrete-time sliding-mode control Trajectory tracking Nonholonomic

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