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World Journal of Methodology 2015年第3期5卷 127-135页

作者： Jesús Espinel eugenia Pinedo Vanesa Ojeda Maria Guerra del Rio Department of Digestive Diseases Hospital Universitario de León Department of Radiodiagnosis Hospital Universitario de León Department of Digestive Diseases Hospital Universitario Dr. Negrín Consultant Gastroenterologist Burton Hospitals NHS foundation trust

Lesions of the ampulla of Vater represent an uncommon group of gastrointestinal malignancies. The majority of lesions of the ampulla of Vater are either adenomas or adenocarcinomas. Ampullary lesions are often incidental findings. Accurate preoperative diagnosis and staging of ampullary tumors is imperative for predicting prognosis and determining the most appropriate therapeutic approach. Endoscopic ampullectomy is a safe and efficacious therapeutic procedure that can obviate the need for potentially major surgical intervention. This review will provide the framework for the diagnosis and management of ampullary lesions from the perspective of the practicing gastroenterologist. Strategies for safe and successful endoscopic ampullectomy with a focus on accurate preoperative diagnosis and staging, resection technique, and management of complications are presented.

关键词： Papillary tumors Endoscopic ampullectomy Endoscopic ultrasound Ampullary adenoma Pancreatitis

Malignant transformation of hepatocellular adenoma in a young female patient after ovulation induction fertility treatment:A case report

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World Journal of Gastrointestinal Surgery 2019年第4期11卷 229-236页

作者： Juan Glinka Rodrigo Sanchez Clariá eugenia Fratanoni Juan Spina Eduardo Mullen Victoria Ardiles Oscar Mazza Juan Pekolj Martín de Santiba?es Eduardo de Santiba?es Department of General Surgery Hepatobilio-pancreatic Unit Hospital Italiano de Buenos Aires Department of Radiology Hospital Italiano de Buenos Aires Department of Surgical Pathology Hospital Italiano de Buenos Aires

BACKGROUND Hepatocellular adenoma(HCA) is a rare benign liver tumor usually affecting young women with a history of prolonged use of hormonal *** the majority is asymptomatic, a low proportion may have significant complications such as bleeding or malignancy. Despite responding to the hormonal stimulus, the desire for pregnancy in patients with small HCA is not contraindicated. However, through this work we demonstrate that intensive hormonal therapies such as those used in the treatment of infertility can trigger serious complications CASE SUMMARY A 33-year-old female with a 10-year history of oral contraceptive use was diagnosed with a hepatic tumor as an incidental finding in an abdominal ultrasound. The patient showed no symptoms and physical examination was unremarkable. Laboratory functional tests were within normal limits and tests for serum tumor markers were negative. An abdominal magnetic resonance imaging(MRI) was performed, showing a 30 mm × 29 mm focal lesion in segment VI of the liver compatible with HCA or Focal Nodular Hyperplasia with atypical behavior. After a total of six years of follow-up, the patient underwent ovulation induction treatment for infertility. On a following MRI, a suspected malignancy was warned and hence, surgery was decided. The surgical specimen revealed malignant transformation of HCA towards trabecular hepatocarcinoma with dedifferentiated areas. There was non-evidence of tumor recurrence after three years of clinical and imaging follow-up.,CONCLUSION HCAs can be malignant regardless its size and low-risk appearance on MRI when an ovultation induction therapy is indicated.

关键词： Hepatocellular adenoma Malignant transformation Focal liver lesion Adenoma Ovulation induction Case report

Synthesis and Determination of Antitumor Activity of Jacaranone and Synthetic Analogs

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International Journal of Organic Chemistry 2018年第1期8卷 115-124页

作者： María L. Arias eugenia Corrales Rebeca Poveda Jorge A. Cabezas ResearchCenter for Tropical Disease (CIET) and Faculty of Microbiology University of Costa Rica San José Costa Rica School of Chemistry University of Costa Rica San José Costa Rica

Natural product jacaranone, 1, and three analog derivatives were synthesized and their apoptotic and necrotic activity against four cancer cell lines was tested. One of these derivatives 7, was more active than the natural product, and exhibited an important necrotic effect against three of the cell lines tested (ovarian carcinoma, liver cancer and breast cancer cells). Derivative 6 was more active than the natural product, and showed a significant apoptotic activity against breast cancer and ovarian carcinoma cells. Some derivatives analyzed in this study showed promising anti-tumor results, nevertheless, further studies have to be done in order to determine their in vivo activity, their mechanism as well as their safety and stability.

关键词： Jacaranone Jacaranone Synthetic Analogs Antitumor Activity

Treatment modalities for early gastric cancer

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World Journal of Gastrointestinal Endoscopy 2015年第12期7卷 1062-1069页

作者： Jesús Espinel eugenia Pinedo Vanesa Ojeda Maria Guerra del Rio Department of Digestive Diseases Hospital Universitario de León Department of Radiodiagnosis Hospital Universitario de León Department of Digestive Diseases Hospital Universitario Dr.Negrín Las Palmas de Gran Canaria Burton Hospitals NHS Foundation Trust Burton on TrentStaffordshire DE13 0RB United Kingdom

Different treatment modalities have been proposed in the treatment of early gastric cancer(EGC). Endoscopic resection(ER) is an established treatment that allows curative treatment, in selected cases. In addition, ER allows for an accurate histological staging, which is crucial when deciding on the best treatment option for EGC. Recently, endoscopic mucosal resection(EMR) and endoscopic submucosal dissection(ESD) have become alternatives to surgery in early gastric cancer, mainly in Asian countries. Patients with "standard" criteria can be successfully treated by EMR techniques. Those who meet "expanded" criteria may benefit from treatment by ESD, reducing the need for surgery. Standardized ESD training system is imperative to promulgate effective and safe ESD technique to practices with limited expertise. Although endoscopic resection is an option in patients with EGC, surgical treatment continues to be a widespread therapeutic option worldwide. In this review we tried to point out the treatment modalities for early gastric cancer.

关键词： Early gastric cancer Endoscopic submucosal dissect

The Role of Sentinel Lymph Node Biopsy in Thin Melanoma (Breslow Thickness ≤ 0.75 mm and 0.76 mm - 1.0 mm Respectively): Our Results and Review of the Literature

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Journal of Cancer Therapy 2016年第3期7卷 163-168页

作者： Georgios Kechagias Aristea Marra Athanasios Karonidis eugenia Kyriopoulos Helen Gogas Dimosthenis Tsoutsos Department of Plastic Surgery Microsurgery and Burns Unit General Hospital of Athens “G. Gennimatas” Athens Greece 1st Department of Medicine University of Athens Medical School “Laikon” General Hospital Athens Greece

Introduction: The Sentinel Lymph Node Biopsy (SLNB) in melanoma is an important tool of staging. The impact on overall survival still remains unclear. The guidelines in regard to depth, taking in mind where SLNB staging benefits do not outweigh the risks of the procedure, are constantly reviewed and modified. Patients and Methods: From 2010 to 2015, 104 patients with thin melanoma Stage IA with presence of adverse or high risk features and from IB only TIb, N0, M0 (American Joint Committee on Cancer, AJCC Melanoma Staging and Classification 7th Edition 2009) were included and divided into 2 groups: Group A: 68 patients with Breslow ≤ 0.75 mm and Group B: 36 patients with Breslow 0.76 - 1.0 mm. Initially all patients underwent excision of the primary site and subsequently wide local excision and SLNB. We analyzed the histopathology reports of SLNB procedures in both groups. Results: There was no positive SLN in group A (0%). 4 patients from group B had positive SLN (11.1%) and underwent Completion Lymph Node Dissection (CLND). The total percentage of positive SLNs from both groups was 3.8%. Conclusions: Our findings justify the SLNB procedure in thin melanomas of 0.76 - 1.0 mm. In melanomas ≤ 0.75 mm, SLNB should be considered on an individual basis when “high-risk features” are present. More comparable studies should be evaluated in order to accurately define the threshold value of Breslow thickness where SLNB is safely deemed unnecessary.

关键词： Thin Melanoma SLN SLNB

ELISA测定中TMB显色体系的优化及其稳定性研究

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生物技术通报 2010年第2期26卷 126-130页

作者：李红梅陈佳徐斐曹慧 Maria eugenia 上海理工大学医疗器械与食品学院上海200093

通过对间接酶联免疫测定中显色体系的各影响因素的研究,确定了酶联免疫测定的最优显色体系为二甲基亚砜(DMSO)配制四甲基联苯胺(TMB)浓度为0.3 mg/mL的溶液为A液,pH5.5,0.2 mol/L磷酸氢二钠与0.1 mol/L柠檬酸缓冲液配制过氧化脲素浓度为... 详细信息

通过对间接酶联免疫测定中显色体系的各影响因素的研究,确定了酶联免疫测定的最优显色体系为二甲基亚砜(DMSO)配制四甲基联苯胺(TMB)浓度为0.3 mg/mL的溶液为A液,pH5.5,0.2 mol/L磷酸氢二钠与0.1 mol/L柠檬酸缓冲液配制过氧化脲素浓度为0.74 mg/mL的溶液为B液,两者按一定比例混合后使用。试验结果表明,此显色体系在25-40℃内进行都可得到较为准确的结果,且A、B液混合后在室温下放置4 h仍可使用。A液及B液分别在4℃放置60 d后混合使用仍不影响测定结果。

关键词：酶联免疫测定显色辣根过氧化物酶 TMB

Vulnerability to Stress and Depression Risk Related to Occupational Exposure to Aluminum

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Occupational Diseases and Environmental Medicine 2022年第4期10卷 262-270页

作者： Isabel Ghita Claudia-Mariana Handra eugenia Naghi Irina-Luciana Gurzu Marinela Chirila Pharmacology Department “Carol Davila” University of Medicine and Pharmacy Bucharest Bucharest Romania Occupational Medicine Department “Carol Davila” University of Medicine and Pharmacy Bucharest Bucharest Romania Occupational Medicine Department “Gr. T. Popa” University of Medicine and Pharmacy Iasi Iasi Romania Faculty of Pharmacy “Titu Maiorescu” University Bucharest Romania

Occupational exposure to aluminum was reported to be associated with various neurotoxic effects including cognitive impairment, depression, anxiety, and also Alzheimer’s disease. The purpose of the present study was to evaluate the level of vulnerability to stress in workers exposed to aluminum. The correlation between vulnerability to stress and depression was also investigated. This was a retrospective study that included 135 participants, 99 were exposed to aluminum, and 36 were not exposed to aluminum. Vulnerability to stress and depression was assessed using a self-rating scale developed in-house. Vulnerability to stress was reported in various degrees in a total of 84 participants, 69 (69.70%) participants from the exposed group and 15 (41.67%) participants from the control group. Out of the 84 participants with vulnerability to stress, 51 had depression also. Excellent resistance to stress was reported in 51 out of 135 participants, 30 (30.30%) in the exposed group and 21 (58.33%) in the control group. Out of the 51 participants with excellent resistance to stress, only 2 participants had depression. The results of the present study suggested that exposure to aluminum is correlated with vulnerability to stress. The level of vulnerability to stress is increasing with the level of exposure to aluminum. Furthermore, since vulnerability to stress is correlated with depression, higher exposure to aluminum might be a risk factor for depression.

关键词： Aluminum Vulnerability to Stress Depression

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欢迎光临米兰路76号

中华手工 2014年第11期 38-39页

作者： eugenia

修复档案修复机构:罗马书籍病理学院,成立于1938年,是世件界上最古老,也是最先进的纸质文物修复中心。修复技艺:古籍、手稿、绘画等纸质修复离意大利罗马市中心的民族街不远,有一条叫米兰路的小巷。76号,是一栋掩映在葱郁树木中的粉墙... 详细信息

修复档案修复机构:罗马书籍病理学院,成立于1938年,是世件界上最古老,也是最先进的纸质文物修复中心。修复技艺:古籍、手稿、绘画等纸质修复离意大利罗马市中心的民族街不远,有一条叫米兰路的小巷。76号,是一栋掩映在葱郁树木中的粉墙二层小楼,不久前,这里接待了世界上仅存的一幅达.芬奇自画像。因为它长了霉斑,需要到这里接受专业"治疗"。这里,是成立于1938年的中央档案保存修复图书馆(ICPAL),亦称罗马书籍病理学院,是世界上最古老,也是最先进的纸质文物修复中心。

关键词：文物修复档案修复保存修复死海古卷一封信玛利亚维亚方政托斯卡纳环境原因

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把雾霾戴在手上

中华手工 2016年第4期 26-27页

作者： eugenia Studio Roosegaarde

近几年,中国的绝大部分城市都吃过雾霾天的苦头,看不见天,看不见路,甚至看不清1米开外的人和物。所以当荷兰设计师Daan Roosegaarde发明出雾霾净化塔(The Smog Free Tower)时,人们沸腾了。这座高6.5米的塔,由轻型材料和LED装置制成,每... 详细信息

近几年,中国的绝大部分城市都吃过雾霾天的苦头,看不见天,看不见路,甚至看不清1米开外的人和物。所以当荷兰设计师Daan Roosegaarde发明出雾霾净化塔(The Smog Free Tower)时,人们沸腾了。这座高6.5米的塔,由轻型材料和LED装置制成,每小时可以净化3万立方米空气,用以捕捉空气中的PM2.5。"

关键词：轻型材料上呼吸道疾病宝石戒指灵感源安装时间太阳能板纳米技术制作成本维护费用