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Prognostic and predictive biomarkers for metastatic renal cell carcinoma

journal of Cancer Metastasis and Treatment 2021年第1期7卷 659-671页

作者： Logan G.Briggs eugene B.Cone Richard j.Lee Michael L.Blute Harvard Medical School BostonMA 02114USA Department of Urology Massachusetts General HospitalBostonMA 02114USA Department of Medicine Division of Hematology/OncologyMassachusetts General HospitalBostonMA 02114USA.

Several prognostic models incorporating serum biomarkers to estimate patient survival have been established for metastatic renal cell *** advancements in biomarker research have highlighted much additional serum,gene mutation,genetic expression signatures,and histologic biomarkers that predict clinical outcomes and response to ***,therefore,reviewed biomarkers associated with overall,cancer-specific,progression-free,and disease-free survival,overall response,and time to treatment failure rate in adult populations with metastatic renal cell *** reviewed human studies reporting associations between biomarkers and clinical *** were abstracted via standardized form,then reported with hazard ratios and confidence intervals where appropriate,subdivided by biomarker type(serum,gene mutation,genetic expression,and histologic).We identified a range of newer biomarkers that have clinical associations with prognostic and predictive *** biomarkers used in modern risk models,those consistently associated with prognosis included serum levels of CAIX,COP-NLR,CRP,s-TATI,and VEGF,gene mutations in BAP1,CDKN2A,CIMP/FH,and TERT,gene expression of ERV and NQO1,and histologic macrophage infiltration and expression of CAIX and *** consistently associated with the response to targeted antiangiogenic therapy included serum CRP,mutations in MET,PBRM-1,BAP1,and the mTOR pathway,TERT promoter mutations,and expression of PTEN and angiogenic gene *** expression of hERV,T-effector,and immunogenic signatures have been associated with improved response to immune checkpoint *** models should incorporate well-studied biomarkers to help clinicians predict outcomes and treatment responses for patients with metastatic renal cell carcinoma.

关键词： Carcinoma renal cell biomarkers precision medicine patient-specific modeling neoplasms

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Three-dimensional reconstructed magnetic resonance scans:Accuracy in identifying and defining knee meniscal tears

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World journal of Orthopedics 2016年第11期7卷 731-737页

作者： Neil Kruger eugene Mc Nally Sami Al-Ali Raj Rout jonathan L Rees Andrew j Price Orthopaedic Research Unit University of Cape Town Nuffield Orthopaedic Centre University of Oxford the Whittington Hospital

AIM To determine whether three-dimensional(3D) reconstruction from conventional magnetic resonance imaging(MRI) is able to accurately detect a meniscal tear, and define the *** Thirty-three patients' 3T MRI scan data were collected and sagittal uni-planar 3D reconstructions performed from the preoperative MRI. There were 24 meniscal tears in 24 patients, and nine controls. All patients had arthroscopic corroboration of MRI findings. Two independent observers prospectively reported on all 33 reconstructions. Meniscal tear presence or absence was noted, and tear configuration subsequently categorised as either radial, bucket-handle, parrot beak, horizontal or *** Identification of control menisci or meniscal tear presence was excellent(Accuracy: observer 1 = 90.9%; observer 2 = 81.8%). Of the tear configurations, bucket handle tears were accurately identified(Accuracy observer 1 and 2 = 80%). The remaining tear configurations were notaccurately *** Uni-planar 3D reconstruction from 3T MRI knee scan sequences are useful in identifying normal menisci and menisci with bucket-handle tears. Advances in MRI sequencing and reconstruction software are awaited for accurate identification of the remaining meniscal tear configurations.

关键词： Knee Meniscus Arthroscopy Magnetic resonance imaging Three-dimensional reconstruction Materialise Interactive Medical Control System Tear

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Heat transfer characteristics of nanofluid through circular tube

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journal of Central South University 2013年第1期20卷 142-148页

作者： WUSIMAN Ku-er-ban-jiang CHUNG Han-shik MD.j.Nine HANDRY Afrianto EOM yoon-sub KIM jun-hyo jEONG Hyo-min Department of Mechanical and Precision Engineering GyeongSang National University445 Inpyeong-dongTongYoungGyeongNam 650-160Korea Department of Energy and Mechanical Engineering The Institute of Marine IndustryGyeongSang National University445 Inpyeong-dongTongYoungGyeongNam 650-160Korea Division of Marine Engineering Mokpo National Maritime UniversityHaeyangdaehang-Ro 91Mokpo-siJeollanam-do530-729Korea

Nano fluid is considered to be a class of high efficient heat transfer fluid created by dispersing some special solid nanoparticles (normally less than 100 nm) in traditional heat transfer fluid. The present experiment was conducted aiming at investigating the forced heat transfer characteristics of aqueous copper (Cu) nanofluid at varying concentration of Cu nano-particles in different flow regimes (300

关键词： nanofluid heat transfer characteristic circular tube metallic particles

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MORTl/FADD is involved in liver regeneration

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World journal of Gastroenterology 2005年第46期11卷 7248-7253页

作者： Marcus Schuchmann Felix Rückert jose F Garcia-Lazaro Andrea Karg jürgen Burg Natalia Knorr jürgen Siebler eugene E Varfolomeev David Wallach Wolfgang Schreiber Ansgar W Lohse Peter R Galle Department of Medicine University of Mainz Langenbeckstr.1Mainz 55101 Germany Institute of RadiologyUniversity of Mainz Langenbeckstr.1Mainz 55101Germany Institute of PathologyUniversity of Mainz Langenbeckstr. 1 Mainz 55101 Germany Department of MedicineUniversity of Mainz Langenbeckstr.1Mainz 55101Germany GenentechSouth San Francisco CAUnited States The Weizmann Institute of ScienceRehovot Israel Institute of RadiologyUniversity of Mainz Langenbeckstr.1Mainz 55101 Germany Department of Medicine University of Mainz Langenbeckstr.1Mainz 55101 Germany

AIM: To explore the role of the adaptor molecule in liver regeneration after partial hepatectomy (PH). METHODS: We used transgenic mice expressing an N-terminal truncated form of MORT1/FADD under the control of the albumin promoter. As previously shown, this transgenic protein abrogated CD95- and CD120a-mediated apoptosis in the liver. Cyclin A expression was detected using Western blotting. ELISA and RT-PCR were used to detect IL-6 and IL-6 mRNA, respectively. DNA synthesis in liver tissue was measured by BrdU staining. RESULTS: Resection of 70% of the liver was followed by a reduced early regenerative response in the transgenic group at 36 h. Accordingly, 36 h after hepatectomy, cyclin A expression was only detectable in wild-type animals. Consequently, the onset of liver mass restoration was retarded as measured by MRI volumetry and mortality was significantly higher in the transgenic group. CONCLUSION: Our data demonstrate for the first time an involvement of the death receptor molecule MORT1/ FADD in liver regeneration, beyond its well described role as part of the intracellular death signaling pathway.

关键词： MORT1/FADD CD95 TNF Apoptosis Liver regeneration

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Highly Flexible Fabrics/Epoxy Composites with Hybrid Carbon Nanofillers for Absorption-Dominated Electromagnetic Interference Shielding

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Nano-Micro Letters 2022年第11期14卷 307-323页

作者： jong-Hoon Lee yoon-Sub Kim Hea-jin Ru Seul-Yi Lee Soo-jin Park Department of Chemistry Inha University100 InharoIncheon 22212Korea Korea Architecture Safety Testing and Research Institute(KASTI) 88 Gasan Digital 1-roSeoul 08590Korea

Epoxy-based nano-composites can be ideal electromagnetic interference(EMI)-shielding materials owing to their lightness,chemical inertness,and mechanical ***,poor conductivity and brittleness of the epoxy resin are challenges for fast-growing portable and flexible EMI-shielding applications,such as smart wristband,medical cloth,aerospace,and military *** this study,we explored hybrid nanofillers of single-walled carbon nanotubes(SWCNT)/reduced graphene oxide(rGO)as conductive inks and polyester fabrics(PFs)as a substrate for flexible EMI-shielding *** highest electrical conductivity and fracture toughness of the SWCNT/rGO/PF/epoxy composites were 30.2 S m^(−1)and 38.5 MPa m^(1/2),which are~270 and 65%enhancement over those of the composites without SWCNTs,*** mechanical durability was demonstrated by stable electrical conductivity retention during 1000 cycles of bending *** EMI-shielding effectiveness of~41 dB in the X-band frequency of 8.2-12.4 GHz with a thickness of 0.6 mm was obtained with an EM absorption-dominant behavior over a 0.7 absorption *** results are attributed to the hierarchical architecture of the macroscale PF skeleton and nanoscale SWCNT/rGO networks,leading to superior EMI-shielding *** believe that this approach provides highly flexible and robust EMI-shielding composites for next-generation wearable electronic devices.

关键词： Conductive polymer composites Fracture toughness Flexible composites Absorption-dominated electromagnetic interference shielding

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Evaluation of high yielding soybean germplasm under water limitation

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journal of Integrative Plant Biology 2016年第5期58卷 475-491页

作者： Silvas j.Prince Mackensie Murphy Raymond N.Mutava Zhengzhi Zhang Na Nguyen yoon Ha Kim Safiullah M.Pathan Grover j.Shannon Babu Valliyodan Henry T.Nguyen National Center for Soybean Biotechnology and Division of Plant Sciences University of Missouri

Limited information is available for soybean root traits and their plasticity under drought stress. To date, no studies have focused on examining diverse soybean germ- plasm for regulation of shoot and root response under water limited conditions across varying soil types. In this study, 17 genetically diverse soybean germplasm lines were selected to study root response to water limited conditions in clay （trial 1） and sandy soil （trial 2） in two target environments. Physiological data on shoot traits was measured at multiple crop stages ranging from early vegetative to pod filling. The phenotypic root traits, and biomass accumulation data are collected at pod filling stage. In trial 1, the number of lateral roots and forks were positively correlated with plot yield under water limitation and in trial 2, lateral root thickness was positively correlated with the hill plot yield. Plant Introduction （PI） 578477A and 088444 were found to have higher later root number and forks in clay soil with higher yield under water limitation, in sandy soil, P1458o2o was found to have a thicker lateral root system and higher yield under water limitation. The genotypes identified in this study could be used to enhance drought tolerance of elite soybean cultivars through improved root traits specific to target environments.

关键词： Fibrous root root angle root plasticity root systemarchitecture (RSA) root thickness spectral indices soybean spectralindices total root length water limitation

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Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma

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World journal of Gastroenterology 2020年第32期26卷 4833-4845页

作者： jae H yoon Young j Goo Chae-jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H jun Department of Gastroenterology Chonnam National University Hospital and Medical SchoolGwangju 61469South Korea Department of Gastroenterology Hwasun Chonnam National University Hospital and Medical SchoolHwasun 58128South Korea Department of Radiology Chonnam National University Hospital and Medical SchoolGwangju 61469South Korea Department of Internal Medicine Mokpo Hankook HospitalMokpo 58643South Korea

BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor ***,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain *** To elucidate the characteristics and risk factors of EHM after RFA for *** From january 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary *** inclusion criteria were age≥18 years,a diagnosis of HCC,and *** computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 *** analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as *** EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 *** 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,*** recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first *** was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level *** multivariate analysis,recurrence-free survival400 IU/mL were associated with a high EHM *** EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for *** especially with high-risk factors require close follow-up for

关键词： Hepatocellular carcinoma Metastasis Radiofrequency ablation Surveillance Risk factor

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Novel diamond shuttle to deliver flexible neural probe with reduced tissue compression

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Microsystems & Nanoengineering 2020年第1期6卷 903-915页

作者： Kyounghwan Na Zachariah j.Sperry jiaao Lu Mihaly Voroslakos Saman S.Parizi Tim M.Bruns Euisik yoon john P.Seymour Electrical Engineering&Computer Science Department University of MichiganAnn ArborMI 48105USA Biomedical Engineering Department University of MichiganAnn ArborMI 48105USA Biointerfaces Institute University of MichiganAnn ArborMI 48105USA The Neuroscience Institute New York UniversityNew YorkNY 10016USA Center for Nanomedicine Institute for Basic Science(IBS)Seoul 03722Korea Graduate Program of Nano Biomedical Engineering(Nano BME) Yonsei-IBS InstituteYonsei UniversitySeoul 03722Korea Vivian L Smith Department of Neurosurgery University of Texas Health Science CenterHoustonTX 77030USA Department of Electrical and Computer Engineering Rice UniversityHoustonTX 77005USA

The ability to deliver flexible biosensors through the toughest membranes of the central and peripheral nervous system is an important challenge in neuroscience and neural *** devices implanted through dura mater and thick epineurium would ideally create minimal compression and acute damage as they reach the neurons of *** demonstrate that a three-dimensional diamond shuttle can be easily made with a vertical support to deliver ultra-compliant polymer microelectrodes(4.5-µm thick)through dura mater and thick *** diamond shuttle has 54%less cross-sectional area than an equivalently stiff silicon shuttle,which we simulated will result in a 37%reduction in blood vessel *** also discovered that higher frequency oscillation of the shuttle(200Hz)significantly reduced tissue compression regardless of the insertion speed,while slow speeds also independently reduced tissue *** and recording performance are demonstrated in rat and feline models,but the large design space of these tools are suitable for research in a variety of animal models and nervous system targets.

关键词： sectional neural thick

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Protein-protein complexation in bioluminescence

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Protein & Cell 2011年第12期2卷 957-972页

作者： Maxim S.Titushin Yingang Feng john Lee eugene S.Vysotski Zhi-jie Liu National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of SciencesQingdao 266101China Department of Biochemistry and Molecular Biology University of GeorgiaAthensGA 30602USA Laboratory of Photobiology Institute of Biophysics Russian Academy of SciencesSiberian BranchKrasnoyarsk 660036Russia

In this review we summarize the progress made towards understanding the role of protein-protein interactions in the function of various bioluminescence systems of marine organisms,including bacteria,jellyfish and soft corals,with particular focus on methodology used to detect and characterize these *** some bioluminescence systems,protein-protein interactions involve an“accessory protein”whereby a stored substrate is efficiently delivered to the bioluminescent enzyme *** types of complexation mediate energy transfer to an“antenna protein”altering the color and quantum yield of a bioluminescence *** structures of the complexes reveal an important role of electrostatic forces in governing the corresponding weak interactions and define the nature of the interaction *** most reliable structural model is available for the protein-protein complex of the Ca2+-regulated photoprotein clytin and green-fluorescent protein(GFP)from the jellyfish Clytia gregaria,solved by means of Xray crystallography,NMR mapping and molecular *** provides an example of the potential strategies in studying the transient complexes involved in *** is emphasized that structural studies such as these can provide valuable insight into the detailed mechanism of bioluminescence.

关键词： green-fluorescent protein(GFP) photoprotein luciferase lumazine protein Förster resonance energy transfer(FRET) docking

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Modeling and Design of H-Infinity Controller for Piezoelectric Actuator LIPCA

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journal of Bionic Engineering 2010年第2期7卷 168-174页

作者： Gigun Lee Kwanwoo You Taesam Kang Kwang joon yoon jeong Oog Lee jung Keun Park Department of Aerospace Information Engineering Konkuk University

We proposed a dynamic model identification and design of an H-Infinity （i.e.H） controller using a LightweightPiezo-Composite Actuator （LIPCA）.A second-order dynamic model was obtained by using input and output data, and applyingan identification *** identified model coincides well with the real *** reduce the resonating mode that istypical of piezoelectric actuators, a notch filter was used.A feedback controller using the Hcontrol scheme was designed basedon the identified dynamic model; thus, the LIPCA can be easily used as an actuator for biomemetic applications such as artificialmuscles or macro/micro positioning in *** control algorithm was implemented using a microprocessor, analogfilters, and power amplifying *** simulation and experimental results demonstrate that the proposed control algorithmworks well in real environment, providing robust performance and stability with uncertain disturbances.

关键词： piezoelectric actuator model identification H-infinity controller biomimetic artificial muscle LIPCA

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