检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

追逐日光

英语学习 2016年第5期 62-65页

作者： eugene O’kelly 蒋素华

《追逐日光》记述了作者尤金·奥凯利本人在人生最后四个月的心路旅程。尤金·奥凯利生前是毕马威会计师事务所（KPMG）的董事长和首席执行官，在53岁时他被诊断为脑癌晚期，医生给他的预言是还有三到六个月的时间。这个消息对于正处于... 详细信息

《追逐日光》记述了作者尤金·奥凯利本人在人生最后四个月的心路旅程。尤金·奥凯利生前是毕马威会计师事务所（KPMG）的董事长和首席执行官，在53岁时他被诊断为脑癌晚期，医生给他的预言是还有三到六个月的时间。这个消息对于正处于人生与事业巅峰上的尤金仿佛当头一棒，原本充满光明的未来顿时阴影笼罩。然而他没有被击垮也没有？消沉，而是着手修改原来的人生计划，并充当自己生命最后旅程的首席执行官，拿出在高：尔夫球场上为多打一杆球而追逐日光的精神，追逐自己生命中最后的时光，活得精彩，死得无憾。

关键词：首席执行官《追逐日光》会计师事务所人生计划董事长毕马威凯利生命

Water and lysozyme： Some results from the bending and stretching vibrational modes

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

frontiers of physics 2015年第5期10卷 27-34页

作者： francescoMallamace Carmelo Corsaro Domenico Mallamace Cirino Vasi Nicola Cicero H. eugene Stanley Dipartimento di fisica e Scienze della Terra Universita di Messina 1-98166 Messina Italy Department of Nuclear Science and Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA Center for Polymer Studies and Department of Physics Boston University Boston MA 02215 USA Consiglio Nazionale delle Ricerche-IPCf Messina 1-98166 Messina Italy Dipartimento di Scienze dell'Ambiente della Sicurezza del Territorio degli Alimenti e della Salute Universita di Messina Viale F. Stagno d'Alcontres 31 98166 Messina Italy

The dynamic or glass transition in biomolecules is important to their functioning. Also essential is the transition between the protein native state and the unfolding process. To better understand these transitions, we use fourier transform infrared spectroscopy to study the vibrational bending and stretching modes of hydrated lysozymes across a wide temperature range. We find that these transitions are triggered by the strong hydrogen bond coupling between the protein and hydration water. More precisely, we demonstrate that in both cases the water properties dominate the evolution of the system. We find that two characteristic temperatures are relevant： in the supercooled regime of confined water, the fragile-to-strong dynamic transition occurs at TL, and in the stable liquid phase, T＊ 315 ± 5 K characterizes the behavior of both isothermal compressibility KT（T, P） and the coefficient of thermal expansion ap（T, P）.

关键词： protein unfolding hydration water infrared spectroscopy

Intermediate financial management 7th ed.

在线全文

学校读者我要写书评

暂无评论

Eff-3DPSeg:3D Organ-Level Plant Shoot Segmentation Using Annotation-Efficient Deep Learning

2002年

作者： Brigham eugene f.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Plant Phenomics 2023年第3期5卷 626-641页

作者： Liyi Luo Xintong Jiang Yu Yang eugene Roy Antony Samy Mark Lefsrud Valerio Hoyos-Villegas Shangpeng Sun Bioresource Engineering Department McGill UniversityMontrealQCCanada Key Laboratory of Advanced Process Control for Light Industry(Ministry of Education) Jiangnan UniversityWuxiJiangsuChina Plant Science Department McGill UniversityMontrealQCCanada

Reliable and automated 3-dimensional(3D)plant shoot segmentation is a core prerequisite for the extraction of plant phenotypic traits at the organ *** deep learning and point clouds can provide effective ways to address the ***,fully supervised deep learning methods require datasets to be point-wise annotated,which is extremely expensive and *** our work,we proposed a novel weakly supervised framework,Eff-3DPSeg,for 3D plant shoot ***,high-resolution point clouds of soybean were reconstructed using a low-cost photogrammetry system,and the Meshlab-based Plant Annotator was developed for plant point cloud ***,a weakly supervised deep learning method was proposed for plant organ *** method contained(a)pretraining a self-supervised network using Viewpoint Bottleneck loss to learn meaningful intrinsic structure representation from the raw point clouds and(b)fine-tuning the pretrained model with about only 0.5%points being annotated to implement plant organ ***,3 phenotypic traits(stem diameter,leaf width,and leaf length)were *** test the generality of the proposed method,the public dataset Pheno4D was included in this *** results showed that the weakly supervised network obtained similar segmentation performance compared with the fully supervised *** method achieved 95.1%,96.6%,95.8%,and 92.2%in the precision,recall,f1 score,and mIoU for stem–leaf segmentation for the soybean dataset and 53%,62.8%,and 70.3%in the AP,AP@25,and AP@50 for leaf instance segmentation for the Pheno4D *** study provides an effective way for characterizing 3D plant architecture,which will become useful for plant breeders to enhance selection *** trained networks are available at https://***/jieyi-one/Eff-3DPSEG.

关键词： Deep Plant weakly

DAZL is a master translational regulator of murine spermatogenesis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2019年第3期6卷 455-468页

作者： Haixin Li Zhuqing Liang Jian Yang Dan Wang Hanben Wang Mengyi Zhu Baobao Geng eugene Yujun Xu State Key Laboratory of Reproductive Medicine Nanjing Medical University

Expression of DAZ-like(DAZL) is a hallmark of vertebrate germ cells, and is essential for embryonic germ cell development and differentiation, yet the gametogenic function of DAZL has not been fully characterized and most of its in vivo direct targets remain unknown. We showed that postnatal stage-specific deletion of Dazl in mouse germ cells did not affect female fertility, but caused complete male sterility with gradual loss of spermatogonial stem cells, meiotic arrest and spermatid arrest. Using the genome-wide high-throughput sequencing of RNAs isolated by cross-linking immunoprecipitation and mass spectrometry approach, we found that DAZL bound to a large number of testicular m RNA transcripts(at least 3008) at the 3-untranslated region and interacted with translation proteins including poly(A) binding protein. In the absence of DAZL, polysome-associated target transcripts, but not their total transcripts, were significantly decreased, resulting in a drastic reduction of an array of spermatogenic proteins and thus developmental arrest. Thus, DAZL is a master translational regulator essential for spermatogenesis.

关键词： RNA binding proteins CLIPs infertility translational regulation DAZ

ReSSIM:a mixed-level simulator for dynamic coarse-grained reconfigurable processor

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2013年第6期56卷 137-152页

作者： LIU LeiBo JIA Wen YIN ShouYi WANG Dong SUN GuanYi TANG eugene WEI ShaoJun Institute of Microelectronics and National Laboratory for Information Science and Technology Tsinghua University Intel China Research Center

This paper proposes a mixed-level simulator for dynamic coarse-grained reconfigurable processor(CGRP),called ReSSIM(reconfigurable system simulation implementation mechanism),and the corresponding simulation tool-chain,including task compiler,profiler and debugger.A generic modeling methodology supporting convenient extension of on-chip modules is also *** order to explore the details of the interested modules while maintaining reasonable simulation speed,RCA(reconfigurable computing array),the key reconfigurable device in ReSSIM,is modeled on cycle-accurate level,while the other modules are modeled on transaction *** typical parameters of RCA are scalable and adjustable,which helps the architects to explore the massive details of the reconfigurable *** shows that simulation speedup achieved ranges from 9.26× to 18.39× compared with VCS(Synopsys verilog compiler simulator) when running three computingintensive kernel tasks of H.264 decoding algorithm-IDCT(inverse discrete cosine transform),deblocking and MC-chroma(motion compensation).Simulation speed for a set of real applications,such as MPEG4,G.729 and EfR,is 35× slower than the corresponding native executions(*** from the real chip).And the relative simulation errors are 11% less than the measured IPC(instructions per cycle) of the real chip.

关键词： CGRP RCA ReSSIM modeling simulator

Bacterial direct-fed microbials fail to reduce methane emissions in primiparous lactating dairy cows

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2019年第3期10卷 802-810页

作者： Jeyamalar Jeyanathan Cecile Martin Maguy eugene Anne ferlay Milka Popova Diego P.Morgavi Universite Clermont Auvergne INRAVetAgro SupUMR 1213 HerbivoresF-63122 Saint-Genes-ChampanelleFrance Laboratory for Animal Nutrition and Animal Product Quality Faculty of Bioscience EngineeringGhent UniversityCoupure Links 6539000 GhentBelgium

Direct-fed microbials(DfM) are considered as a promising technique to improve animal productivity without affecting animal health or harming the *** potential of three bacterial DfM to reduce methane(CH4)emissions,modulate ruminal fermentation,milk production and composition of primiparous dairy cows was examined in this *** previous reports have shown that DfM respond differently to different diets,two contrasting diets were used in this *** lactating primiparous cows were randomly divided into two groups that were fed a corn silage-based,high-starch diet(HSD) or a grass silage-based,high-fiber diet(HfD).Cows in each dietary group were randomly assigned to four treatments in a 4 × 4 Latin square *** bacterial DfM used were selected for their proven CH4-reducing effect in *** included control(without DfM) and 3 DfM treatments: Propionibacterium freudenreichii 53-W(2.9 × 10^10 colony forming units(CfU)/cow per day),Lactobacillus pentosus D31(3.6 × 10^11 CfU/cow per day) and Lactobacillus bulgaricus D1(4.6 × 10^10 CfU/cow per day).Each experimental period included 4 weeks of treatment and 1 week of wash-out,with measures performed in the fourth week of the treatment *** CH4 emissions were measured during 3 consecutive days using respiration *** samples were collected for ruminal fermentation parameters and quantitative microbial *** samples were collected for composition *** weight of cows were recorded at the end of each treatment *** of diet,no mitigating effect of DfM was observed on CH4 emissions in dairy *** contrast,Propionibacterium increased CH4 intensity by 27%(g CH4/kg milk) in cows fed *** was no effect of DfM on other fermentation parameters and on bacterial,archaeal and protozoal ***,the effect of DfM on milk fatty acid composition was *** and *** DfM tended to increase body weight gain with ***

关键词： Bacterial direct-fed microbial Dairy cow Methane Milk fatty acid

Highly selective/enantioselective Pt-ReOx/C catalyst for hydrogenation of L-malic acid at mild conditions

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2018年第3期27卷 903-912页

作者： Bair S.Bal'zhinimaev eugene A.Paukshtis Alexey P.Suknev Nikita V.Makolkin Boreskov Institute of Catalysis SB RA5 Prospect Akademika Lavrentieva5Novosibirsk 630090Russia

The catalyst preparation strategy was based on a strict introduction sequence of rhenium and platinum precursors and their strong interaction with carbon support resulted in the formation of 0.5 nm Pt-Re Ox species of atomic dispersion, where platinum is metallic, while monolayer rhenium is partially oxidized（Re2＋）. The reaction kinetics was studied taking into account the process of L-malic acid association leading to the formation of inactive cyclic oligomeric species. High TOfs（ca. 50 h-1）, selectivities（ca. 99%）and stability of Pt-Re Ox/C catalysts in aqueous-phase hydrogenation of L-malic acid, which are close to those of the homogeneous pincer type complexes, were revealed at mild conditions（T = 90–130 ℃）. Taking into account that（i） hydrogenation reaction occurred 2–3 orders of magnitude faster than its racemization and（ii） association of L-malic acid dominates at low temperatures and in a concentrated solution,special reaction conditions that allow obtaining chemically and optically（ee 〉 99%） pure（S）-3-hydroxy-γ-butyrolactone and（S）-1,2,4-butanetriol were found. Basing on HAADf-STEM, EDX, XPS, and kinetic studies, the structure of active species and basic reaction pathways are proposed.

关键词： L-malic acid Hydrogenation Enantioselectivity Platinum Rhenium Atomic dispersion

Kruppel-like factors and vascular wall homeostasis

在线全文

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2017年第5期9卷 352-363页

作者： Yanbo fan Haocheng Lu Wenying Liang Wenting Hu Jifeng Zhang Y. eugene Chen Cardiovascular Center Department of Internal Medicine University of Michigan Medical Center Ann Arbor MI 48109 USA

Cardiovascular diseases （CVDs） are major causes of death worldwide. Identification of promising targets for prevention and treatment of CVDs is paramount in the cardiovascular field. Numerous transcription factors regulate cellular function through modulation of spe- cific genes and thereby are involved in the physiological and pathophysiologicai processes of CVDs. Although Kriippel-like factors （KLfs） have a similar protein structure with a conserved zinc finger domain, they possess distinct tissue and cell distribution patterns as well as biological functions. In the vascular system, KLf activities are regulated at both transcriptional and posttranscriptional levels. Growing in vitro, in vivo, and genetic epidemiology studies suggest that specific KLfs play important roles in vascular walt biology, which further affect vascular diseases. KLfs regulate various functional aspects such as cell growth, differentiation, activa- tion, and development through controlling a whole cluster of functionally related genes and modulating various signaling pathways in response to pathological conditions. Therapeutic targeting of selective KLf family members may be desirable to achieve distinct treatment effects in the context of various vascular diseases. further elucidation of the association of KLfs with human CVDs, their underlying molecular mechanisms, and precise protein structure studies will be essential to define KLfs as promising targets for therapeutic interventions in CVDs.

关键词： endothelial cells vascular smooth muscle cells inflammation shear stress atherosclerosis vascular injury drugdevelopment