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Food Bioscience 2022年第3期47卷 197-210页

作者： Rock-Seth Agoua Laurent Bazinet Jacinthe Thibodeau eugène vorobiev Nabil Grimi Sergey Mikhaylin Institute of Nutrition and Functional Foods (INAF) Dairy Research Center (STELA)Food Science DepartmentUniversité LavalQuébecQCCanada Laboratory of Food Sustainability (EcoFoodLab) Food Science DepartmentUniversité LavalQuébecQCCanada Laboratoire de Transformation Alimentaire et Procédés Électro-Membranaires (LTAPEM) Food Science DepartmentUniversité LavalQuébecQCCanada University of Technology of Compiègne Laboratory of Agro-industrial technologiesCompiègneFrance

Chymotryptic hydrolysis of β-lactoglobulin (β-lg) leads to the release of a wide range of biofunctional ***,the proteolysis of native β-lg is limited due to its compact globular structure,thus ending with low yields of *** our previous study showed that eco-efficient High Voltage Electric Treatments (HVET),namely Pulsed Electric Fields (PEF) and Electric Arc (ARC),of β-lg substantially improved its enzymatic hydrolysis,no information regarding the nature of released peptides is available up to ***,the time-dependent release of peptides and the dynamics of this release were discussed in the current *** analysis of the final hydrolysates showed that chymotrypsinolysis of HVET samples released 19% more peptides with higher concentration than the native and preheated ***,1-min HVET were found to be more efficient than 10-min ones as they led to the release of bioactive peptides (even without chymotrypsin) with higher eco-efficiency scores.

关键词： β-lactoglobulin Peptides High-voltage electrical treatments Eco-efficiency Chymotrypsin Hydrolysis.

An Environment Friendly, Low-Cost Extraction Process of Phenolic Compounds from Grape Byproducts. Optimization by Multi-Response Surface Methodology

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Food and Nutrition Sciences 2013年第6期4卷 650-659页

作者： Hiba N. Rajha Nada El Darra eugène vorobiev Nicolas Louka Richard G. Maroun Département des Sciences de la Vie et de la Terre Centre d’Analyse et de Recherche Faculté des Sciences Université Saint-Joseph de Beyrouth Beirut Lebanon Département des Sciences de la Vie et de la Terre Centre d’Analyse et de Recherche Faculté des Sciences Université Saint-Joseph de Beyrouth Beirut Lebanon UTC/ESCOM EA 4297 TIMR Département de Génie des Procédés Industriels Laboratoire Trans- formations Intégrées de la Matière Renouvelable Université de Technologie de Compiègne Centre de Recherche de Royallieu Compiègne France. UTC/ESCOM EA 4297 TIMR Département de Génie des Procédés Industriels Laboratoire Trans- formations Intégrées de la Matière Renouvelable Université de Technologie de Compiègne Centre de Recherche de Royallieu Compiègne France.

Due to their beneficial effects on human health, phenolic compounds are increasingly attracting the attention of scientists and researchers all over the world. The main interest is in the extraction process of those natural plant-originated compounds from fruits, vegetables and plant wastes, namely grape wastes, in which phenolic compounds are the most abundant secondary metabolites. This waste exploitation not only re-assimilates those byproducts into the food cycle, but also avoids major environmental problems. Herein, the optimization of the phenolic compounds concentration and free radical scavenging activity from Cabernet Sauvignon grape byproducts was conducted, using multi-response surface methodology. A conventional solid-liquid extraction process was performed with pure water as a solvent to study the effects of both time and temperature on the procedure. The maximal phenolic compounds concentration (878.9 mg/L) was reached at 47℃ after 30 hours while the optimal free radical scavenging activity (41.15%) was obtained at 30℃ after 20 hours. A multi-response surface methodology compromised between the quantity and the quality of the extracted phenolics, and the parameters maximizing both responses were obtained at 37℃ and 28 hours. This low-cost and energy saving process provides an excellent tool for further industrial applications.

关键词： Phenolic Compounds Grape Byproducts Extraction Optimization Free Radical Scavenging Activity

Multiple Response Optimization of High Temperature, Low Time Aqueous Extraction Process of Phenolic Compounds from Grape Byproducts

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Food and Nutrition Sciences 2014年第4期5卷 351-360页

作者： Hiba N. Rajha Nicolas Louka Nada El Darra Zeina Hobaika Nadia Boussetta eugène vorobiev Richard G. Maroun Centre d’Analyses et de Recherche UR TVA Faculté des Sciences Université Saint-Joseph de Beyrouth Lebanon Centre d’Analyses et de Recherche UR TVA Faculté des Sciences Université Saint-Joseph de Beyrouth Lebanon UTC/ESCOM EA 4297 TIMR Département de Génie des Procédés Industriels Laboratoire Transformations Intégrées de la Matière Renouvelable Université de Technologie de Compiègne Centre de Recherche de Royallieu Compiègne France. UTC/ESCOM EA 4297 TIMR Département de Génie des Procédés Industriels Laboratoire Transformations Intégrées de la Matière Renouvelable Université de Technologie de Compiègne Centre de Recherche de Royallieu Compiègne France

In this study phenolic compounds extraction from grape byproducts was conducted using pure water as a solvent. High temperatures and low time incubation periods were used in the aim of reducing the cost of the process and heightening the phenolic compounds yield. Response surface methodology (RSM) was realized to study the effect of time and temperature on crushed and uncrushed grape pomace. The phenolic content was evaluated considering the quantity (total phenolics (TPC), flavonoids (FC), total monomeric anthocyanins (TMA) and tannins (TC)), and quality (antiradical activity (AA) and antioxidant capacity (AC)) of the extracts. High temperature low time extraction design used in this study was compared to the extraction process at moderate temperatures with relatively long periods of time. This was proved to ameliorate the quantitative extraction of phenolic compounds from grape pomace without affecting their bioactivity. Moreover, multiple response optimization showed the optimal extraction parameters to be 81?C and 140 minutes for the unmilled pomace samples, and 88?C and 5 minutes for the milled. TPC, FC, TMA, TC, AA and AC are almost the same for both optimums. Thus the possibility of replacing the milling process by the extraction time prolongation (for the unmilled pomace) of 135 minutes seems to be very plausible. HPLC analysis showed different quantity and diversity of extracted phenolics for the optimums. However this difference did not significantly affect the overall activity, showing that PC in the different extracts act in complete synergy all together leading to important biological properties. The obtained results using the extraction strategy adopted in this work could lead to several industrial applications.

关键词： Phenolic Compounds Grape Byproducts Optimization Aqueous Extraction Response Surface Methodology

A Comparative Study on Antiradical and Antimicrobial Properties of Red Grapes Extracts Obtained from Different <i>Vitis vinifera</i>Varieties

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Food and Nutrition Sciences 2012年第10期3卷 1420-1432页

作者： Nada El Darra Joanna Tannous Paulette Bou Mouncef James Palge Joseph Yaghi eugène vorobiev Nicolas Louka Richard G. Maroun Chateau KSARA S.A.L Ksara Békaa Valley Lebanon. Unité de Biochimie and Centre d’Analyse et de Recherche Faculté des Sciences Université Saint-Joseph de Beyrouth 1107 2050 Beirut Lebanon Université de Technologie de Compiègne Département de Génie chimique Unité Transformations Intégrées de la Matière Renouvelable Centre de Recherche de Royallieu B.P. 20529-60205 Compiègne Cedex France

The present work is devoted to the study of antiradical and antimicrobial activities of phenolic compounds extracted from different grapevine varieties grown in the Bekaa plane-Lebanon. The amount of phenolic compounds in selected grape extracts was determined by the Folin-Ciocalteau method. Phenolic composition was specified by high performance liquid chromatography. Free radical scavenging activity was examined by using the (2,2’-diphenyl-1-picrylhy-drazyl) DPPH assay. The potential antimicrobial activity was studied using a new quantitative method developed during this work. This activity was tested against several microbial pathogens, including a Gram-positive strain (Listeria monocytogenes), two Gram-negative strains (Escherichia coli and Salmonella arizonae) and a fungal strain (Candida albicans). According to the results of the present screening study, a great variability in the composition of phenolic com-pounds in red grape extracts was detected. All phenolic compounds extracts, demonstrated important scavenging properties and antimicrobial effect against bacterial and fungal strains. Yet, a different response degree was noticed depending on the tested microorganism and the phenolic composition of grape extracts. Antimicrobial activity was more effective against Gram-positive than Gram-negative and yeast strains. Furthermore, our results highlighted a significant role of synergistic effect between various phenolic compounds in the free radical scavenging and antimicrobial activities.

关键词： Phenolic Compounds DPPH HPLC-DAD Antimicrobial Antiradical Grapevines and Synergistic Effect

Basal cisternostomy for traumatic brain injury: A case report of unexpected good recovery

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Chinese Journal of Traumatology 2022年第5期25卷 302-305页

作者： Manuel De Jesus Encarnacion Ramirez Rossi Evelyn Barrientos Castilo Anton vorobiev Nikita Kiselev Amaya Alvarez Aquino Ibrahim E.Efe Department of neurosurgery Russian People's Friendship University MoscowRussia Department of neurosurgery Municipal HospitalPodolskRusia Department of neurosurgery International Center for neurological Restoration HavanaCuba Charite-Universitatsmedizin Berlin Corporate Member of Freie Universitat BerlinHumbold-Universitat zu BerlinAnd Berlin Institute of HealthBerlinGermany

In subarachnoid hemorrhage following traumatic brain injury (TBI), the high intracisternal pressure drives the cerebrospinal fluid into the brain parenchyma, causing cerebral edema. Basal cisternostomy involves opening the basal cisterns to atmospheric pressure and draining cerebrospinal fluid in an attempt to reverse the edema. We describe a case of basal cisternostomy combined with decompressive craniectomy. A 35-year-old man with severe TBI following a road vehicle accident presented with acute subdural hematoma, Glasgow coma scale score of 6, fixed pupils and no corneal response. Opening of the basal cisterns and placement of a temporary cisternal drain led to immediate relaxation of the brain. The patient had a Glasgow coma scale score of 15 on postoperative day 6 and was discharged on day 10. We think basal cisternostomy is a feasible and effective procedure that should be considered in the management of TBI.

关键词： Basal cisternostomy Cerebral edema Decompressive craniectomy neurotrauma Traumatic brain injury

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Energy spectrum of an electron confined in the hexagon-shaped quantum well

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Science China(Technological Sciences) 2009年第1期52卷 15-18页

作者： Yu.V.vorobiev V.R.VIEIRA P.P.HORLEY P.N.GORLEY J.GONZALEZ-HERNANDEZ CINVESTAV Unidad Querétaro Libramiento Norponiente#2000 Centro de Física das Interaccoes Fundamentais Av.Rovisco Pais Yuri Fedkovych Chernivtsi National University 2 Kotsyubynsky str. CIMAV 120 Miguel de Cervantes

Considering the hexagonal-shaped quantum-scale formations on the surface of thin semiconductor films, a methodology was developed to obtain the analytical solution of the Schrdinger equation when impenetrable walls of a quantum well are treated as mirrors. The results obtained allowed the calculation of the space probability distributions and the energy spectrum of the particle confined in a hex-agonal-shaped well.

关键词： quantum well Schrodinger equation wave function hexagon reflection boundary conditions impenetrable walls

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冲击矿渣堆的人工冻结技术研究及合理采矿技术的进展(英文)

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冰川冻土 2004年第S1期26卷 175-178页

作者： A. vorobiev S. Cheburashkin Russian University of People s Friendship (RUDN) Moscow Russia Norilsk Industrial Institute (NII) Norilsk Russia

The tailing dump of concentrating mills isspecific ground massifs in permafrost areas, whichimpactson geological environmentheavily. The deposits are important, namely, the sources of the rare metals in the Norilsk industrial *** engineering process of the permafrost tailing dump mining is discussed in this paper based on the study of the artificial cryogenesis.

关键词： cryonival zone tailing dump cryogenesis dredger mining

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Synthesis of Ag/Ag<sub>2</sub>S Nanoclusters Resistive Switches for Memory Cells

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Advances in Nanoparticles 2014年第1期3卷 1-4页

作者： Aleksey Nikolaevich Belov Olga Veniaminovna Pyatilova Maksim Igorevich vorobiev National Research University of Electronic Technology Zelenograd Russia

Resistive switching Ag/Ag2S nanoclusters were formed by sulphidation of melting-dispersed thin and continuous Ag films. The morphology, structure and electrical properties of the prepared clusters were characterized by scanning (SEM), transmitting electron (TEM), scanning resistance microscopes (SRM) and Raman scattering. Hysteretic resistive switching behavior was observed in the samples that were studied with ON/OFF switching voltage equal to 8 - 10 V respectively. Simple empirical numerical simulation model, based on Deal-Grove model assumptions and mechanisms, for silver nanoclusters sulphidation process, was proposed.

关键词： Silver Sulphide Clusters Memory Cells Sulphidation Deal-Grove Model

Direct nanoscopic observation of plasma waves in the channel of a graphene field-effect transistor

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Light(Science & Applications) 2020年第1期9卷 1079-1085页

作者： Amin Soltani Frederik Kuschewski Marlene Bonmann Andrey Generalov Andrei vorobiev Florian Ludwig Matthias M.Wiecha Dovile Cibiraite Frederik Walla Stephan Winnerl Susanne C.Kehr Lukas M.Eng Jan Stake Hartmut G.Roskos Physikalisches Institut Johann Wolfgang Goethe-UniversitatMax-von-Laue-Str.1D-60438 Frankfurt am MainGermany Institut für Angewandte Physik Technische Universitat DresdenNöthnitzer Str.61D-01187 DresdenGermany Department of Microtechnology and Nanoscience Chalmers University of TechnologySE-41296 GothenburgSweden Institute of Ion Beam Physics and Materials Research Helmholtz-Zentrum Dresden-RossendorfBautzner Landstraße 400D-01328 DresdenGermany Complexity and Topology in Quantum Matter(CT.QMAT) Cluster of Excellence EXC 2147Dresden/WurzburgGermany Department of Electronics and Nanoengineering Aalto UniversityTietotie 302150EspooFinland

Plasma waves play an important role in many solid-state phenomena and *** also become significant in electronic device structures as the operation frequencies of these devices increase.A prominent example is field-effect transistors(FETs),that witness increased attention for application as rectifying detectors and mixers of electromagnetic waves at gigahertz and terahertz frequencies,where they exhibit very good sensitivity even high above the cut-off frequency defined by the carrier transit *** theory predicts that the coupling of radiation at THz frequencies into the channel of an antenna-coupled FET leads to the development of a gated plasma wave,collectively involving the charge carriers of both the two-dimensional electron gas and the gate *** this paper,we present the first direct visualization of these *** graphene FETs containing a buried gate electrode,we utilize near-field THz nanoscopy at room temperature to directly probe the envelope function of the electric field amplitude on the exposed graphene sheet and the neighboring antenna *** of the field distribution documents that wave injection is unidirectional from the source side since the oscillating electrical potentials on the gate and drain are equalized by capacitive *** plasma waves,excited at 2 THz,are overdamped,and their decay time lies in the range of 25-70 *** this short decay time,the decay length is rather long,i.e.,0.3-0.5μm,because of the rather large propagation speed of the plasma waves,which is found to lie in the range of 3.5-7×10^(6)m/s,in good agreement with *** propagation speed depends only weakly on the gate voltage swing and is consistent with the theoretically predicted 1/4 power law.

关键词： antenna channel transistor

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关于当代作曲家对民乐传统的适应问题

名家名作 2021年第8期 78-79页

作者： vorobiev Igor Stanislavovich 圣彼得堡国立音乐学院

欧洲音乐文化的历史证明了专业传统与民间艺术之间沟通的可能性。通过美学和音乐创作技术的角度来思考这种沟通的类型及原理,这些原理在欧洲文化发展的各个阶段中占据着主导地位。在"新民族主义"作曲家之后的时代,作曲家与民间音乐之间... 详细信息

欧洲音乐文化的历史证明了专业传统与民间艺术之间沟通的可能性。通过美学和音乐创作技术的角度来思考这种沟通的类型及原理,这些原理在欧洲文化发展的各个阶段中占据着主导地位。在"新民族主义"作曲家之后的时代,作曲家与民间音乐之间的关联依然存在。在现实的背景下,提出了解决该问题的方法:国际间文化的融合,民间音乐素材与现代作曲技术的融合,通过合成真实和艺术的声音来扩展音乐及音色特性。

关键词：民间音乐作曲家种族国籍新民族主义新民间音乐浪潮