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Enhanced apoptosis in post-liver transplant hepatitis C:Effects of virus and immunosuppressants

World Journal of Gastroenterology 2012年第18期18卷 2172-2179页

作者： eu jin lim Ruth Chin Peter W Angus Joseph Torresi Liver Transplant Unit Austin HospitalHeidelbergVictoria 3084Australia Department of Medicine University of MelbourneAustin HealthHeidelbergVictoria 3084Australia Department of Infectious Diseases Austin HospitalHeidelbergVictoria 3084Australia

Hepatitis C(HCV)-infected patients have a poorer survival post-liver transplantation compared to patients transplanted for other indications,since HCV recurrence post-transplant is universal and commonly follows an aggressive *** is increasing evidence that in the non-transplant setting,induction of hepatocyte apoptosis is one of the main mechanisms by which HCV drives liver inflammation and fibrosis,and that HCV proteins directly promote *** studies have shown that post-liver transplant,there is a link between high levels of HCV replication,enhanced hepatocyte apoptosis and the subsequent development of rapidly progressive liver *** the responsible mechanisms remain unclear,it is likely that immunosuppressive drugs play an important *** is well known that immunosuppressants impair immune control of HCV,thereby allowing increased viral *** there is also evidence that immunosuppressants may directly induce apoptosis and this may be facilitated by the presence of high levels of HCV *** HCV and immunosuppressants may synergistically interact to further enhance apoptosis and drive more rapid *** findings suggest that modulation of apoptosis within the liver either by changing immunosuppressive therapy or the use of apoptosis inhibitors may help prevent fibrosis progression in patients with post-transplant HCV disease.

关键词：丙型肝炎病毒免疫抑制剂细胞凋亡肝移植肝纤维化病毒复制直接诱导病毒蛋白

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Tbit/s line-rate satellite feeder links enabled by coherent modulation and full-adaptive optics

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Light(Science & Applications) 2023年第9期12卷 1727-1738页

作者： Yannik Horst Bertold Ian Bitachon Laurenz Kulmer Jannik Brun Tobias Blatter Jean-Marc Conan Aurélie Montmerle-Bonnefois Joseph Montri Béatrice Sorrente Caroline B.lim Nicolas Védrenne Daniel Matter Loann Pommarel Benedikt Baeuerle Juerg Leuthold ETH Zurich Institute of Electromagnetic Fields(IEF)Gloriastrasse 358092 ZürichSwitzerland ONERA DOTAParis Saclay UniversityF-92322 ChâtillonFrance Thales Alenia Space in Switzerland Schaffhauserstrasse 5808052 ZürichSwitzerland Polariton Technologies AG 8803 RüschlikonSwitzerland Present address:Currently with LNE-SYRTE Observatoire de ParisParisFrance

Free-space optical(FSO)communication technologies constitute a solution to cope with the bandwidth demand of future satellite-ground *** may overcome the RF bottleneck and attain data rates in the order of Tbit/s with only a handful of ground ***,we demonstrate single-carrier Tbit/s line-rate transmission over a free-space channel of 53.42 km between the Jungfraujoch mountain top(3700 m)in the Swiss Alps and the Zimmerwald Observatory(895 m)near the city of Bern,achieving net-rates of up to 0.94 Tbit/*** this scenario a satellite-ground feeder link is mimicked under turbulent *** adverse conditions high throughput was achieved by employing a full adaptive optics system to correct the distorted wavefront of the channel and by using polarization-multiplexed high-order complex modulation *** was found that adaptive optics does not distort the reception of coherent modulation ***,we introduce constellation modulation–a new four-dimensional BPSK(4D-BPSK)modulation format as a technique to transmit high data rates under lowest *** way we show 53 km FSO transmission of 13.3 Gbit/s and 210 Gbit/s with as little as 4.3 and 7.8 photons per bit,respectively,at a bit-error ratio of 1∙10−*** experiments show that advanced coherent modulation coding in combination with full adaptive optical filtering are proper means to make next-generation Tbit/s satellite communications practical.

关键词： Tbit/s Gbit/s polarization

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Effects of dietary levels of potassium diformate on growth,feed utilization and resistance to Streptococcus iniae of Nile tilapia,Oreochromis niloticus

Effects of dietary levels of potassium diformate on growth,f...

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The 14th International Symposium on Fish Nutrition & Feeding

作者： Chhorn lim Phillip H.Klesius Christian Luckstadt Aquatic Animal Health Research Unit USDA-ARS990 Wire RoadAuburnAlabama 36832

The use of antibiotics as growth promoters in animal production,including aquaculture,is increasingly under public scrutiny and *** the eu countries,the use of antibiotics as growth promoters in livestock production has been banned since January ***-chain organic acids or their salts have received much attention as *** these,potassium diformate(KDF) has been shown to be an effective growth stimulator in diets of pigs,but its effects on aquaculture species are ***,this study was conducted to evaluate the effects of dietary levels of KDF on growth,feed utilization,hematology,immune response and resistance of Nile tilapia(Oreochromis niloticus) to Streptococcus iniae challenge.

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亚洲临床试验纳入的HCV感染患者中,基线NS5A和NS5B NI耐药相关变异的流行率

亚洲临床试验纳入的HCV感染患者中,基线NS5A和NS5B NI耐药相关变...

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第九届全国疑难及重症肝病大会

作者： Wei Lai Masao Omata Young-Suk lim Wan-Long Chuang Dao Long Xie Qing Hou jin Lin Jia Jidong Evguenia Svarovskaia Ross Martin Brian Doehle Jenny Yang Shampa De-Oertel Benedetta Massetto Kathryn Kersey Diana M.Brainard Hongmei Mo Nguyen Kinh Jia-Horng Kao Kwang-Hyub Han Masashi Mizokami Duan Zhongping YamanashiPrefecturalHospitalOrganization KaohsiungMedicalUniversityHospital KaohsiungMedicalUniversity YonseiUniversityCollegeofMedicineSeoul ShanghaiJiaotonhUniversityRuijinHospital NationalHospitalOrganizationNagasakiMedicalCenter AsanMedicalCenter UniversityofUlsanCollegeofMedicine PekingUniversityPeople’sHospital NationalTaiwanUniversityCollegeofMedicineandHospital NationalHospitalofTropicalDiseases GileadScience Inc BeijingFriendshipHospitalAffiliatedtoCapitalMedicalUniversity BeijingYouanHospitalAffiliatedtoCapitalMedicalUniversity BachMaiHospital HanoiMedicalUniversityHospital NanfangHospitalofSouthernMedicalUniversity

背景:耐药相关变异(RAS)可以降低一些HCV的直接抗病毒(DAA)药物的疗效。尽管已经有关于欧洲和北美洲的NS5A和NS5B RAS的流行率的详尽描述,但是有关其在亚洲的流行率的资料相对较少。此研究在适用的情况下,对比美国和欧洲(eu),评估了NS5A...

背景:耐药相关变异(RAS)可以降低一些HCV的直接抗病毒(DAA)药物的疗效。尽管已经有关于欧洲和北美洲的NS5A和NS5B RAS的流行率的详尽描述,但是有关其在亚洲的流行率的资料相对较少。此研究在适用的情况下,对比美国和欧洲(eu),评估了NS5A和NS5B核苷类抑制剂(NI)RAS在中国大陆、中国台湾、日本、韩国和越南的基因1b、2、3和6型HCV感染患者中的流行率。

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