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Hallux rigidus: How do I approach it?

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World Journal of Orthopedics 2017年第5期8卷 364-371页

作者： Aaron Lam Jimmy J Chan Michele F Surace ettore vulcano Albert Einstein College of Medicine Leni and Peter W. May De-partment of Orthopaedic Surgery Icahn School of Medicine at Mount Sinai Department of Orthopedics University of Insubria

Hallux rigidus is a degenerative disease of the first metatarsalphalangeal(MTP) joint and affects 2.5% of people over age 50. Dorsal osteophytes and narrowed joint space leads to debilitating pain and limited range of motion. Altered gait mechanics often ensued as 119% of the body force transmit through the 1^(st) MTP joint during gait cycle. Precise etiology remains under debate with trauma being often cited in the literature. Hallux valgus interphalangeus, female gender, inflammatory and metabolic conditions have all been identified as associative factors. Clinical symptoms, physical exam and radiographic evidence are important in assessing and grading the disease. Non-operative managements including nonsteroidal antiinflammatory drugs, intraarticular injections, shoe modification, activity modification and physical therapy, should always be attempted for all hallux rigidus patients. The goal of surgery is to relieve pain, maintain stability of the first MTP joint, and improve function and quality of life. Operative treatments can be divided into joint-sparing vs joint-sacrificing. Cheilectomy and moberg osteotomy are examples of joint-sparing techniques that have demonstrated great success in early stages of hallux rigidus. Arthrodesis is a joint-sacrificing procedure that has been the gold standard for advanced hallux rigidus. Other newer procedures such as implant arthroplasty, interpositional arthroplasty and arthroscopy, have demonstrated promising early patient outcomes. However, future studies are still needed to validate its long-term efficacy and safety. The choice of procedure should be based on the condition of the joint, patient's goal and expectations, and surgeon's experience with the technique.

关键词： Hallux rigidus Cheilectomy Arthrodiastasis Moberg osteotomy Arthodesis Interpositional arthroplasty Arthroplasty

On the Proper Homotopy Invariance of the Tucker Property

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Acta Mathematica Sinica,English Series 2007年第3期23卷 571-576页

作者： Daniele ettore OTERA Universitádi Palermo Dipartimento di Matematica ed Applicazionivia Archirafi 3490123-PalermoItaly and Université Paris-SudMathématiquesBt 42591405 Orsay Cedex-France

A non-compact polyhedron P is Tucker if, for any compact subset K begong to P, the fundamental group π1 （P - K） is finitely generated. The main result of this note is that a manifold which is proper homotopy equivalent to a Tucker polyhedron is Tucker. We use Poenaru＇s theory of the equivalence relations forced by the singularities of a non-degenerate simplicial map.

关键词： proper homotopy Φ/ψ-theory tucker property

Recent developments in Boolean networks control

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Journal of Control and Decision 2016年第1期3卷 1-18页

作者： ettore Fornasini Maria Elena Valcher Dipartimento di Ingegneria dell’Informazione Universitàdi PadovaPadovaItaly

The aim of this survey paper is to provide the state of the art of the research on control and optimal control of Boolean control networks,under the assumption that all the state variables are accessible and hence available for *** and sufficient conditions for stabilisability to a limit cycle or to an equilibrium point are ***,it is shown that when such conditions are satisfied,stabilisation can always be achieved by means of state *** results are obtained for the safe control problem that is investigated for the first time in this *** and infinite horizon optimal control are subsequently considered,and solution algorithms are provided,based on suitable adaptations of theRiccati difference and algebraic ***,an appropriate definition of the cost function allows to restate and to solve both stabilisation and safe control as infinite horizon optimal control problems.

关键词： Boolean control networks algebraic representation controllability stabilisation optimal control safe control

Impacts of COVID-19 Pandemic on Italian Electricity Demand and Markets

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CSEE Journal of Power and Energy Systems 2023年第2期9卷 824-827页

作者： Mahmood Hosseini Imani ettore Bompard Pietro Colella Tao Huang Politecnico di Torino Dipartimento EnergiaTurin10129Italy

In this paper,the short-,medium-,and long-term effects of the COVID-19 pandemic on the Italian power system,particularly electricity consumption behavior and electricity market prices,are investigated by defining various *** investigation reveals that COVID-19 lockdown caused a drop in load consumption and,consequently,a decrement in day-ahead market prices and an increase in ancillary service prices.

关键词： Ancillary service market price COVID-19 day-ahead market price Italian electricity markets load consumption

Kinetics of defect formation in chemically vapor deposited （CVD） graphene during laser irradiation： The case of Raman investigation

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Nano Research 2015年第12期8卷 3972-3981页

作者： Giampiero Amato Gianluca Milano Umberto Vignolo ettore Vittone Quantum Research Laboratory INRIM Strada delle Cacce 91 Torino Italy Department of Physics NIS Research Center University of Torino via Pietro Giuria 1 10125 Torino Italy

The effect of laser irradiation on chemically vapor deposited （CVD） graphene was studied by analyzing the temporal evolution of Raman spectra acquired under various illumination conditions. The spectra showed that the normalized intensity of the defect-related peak increases with the square root of the exposure time and varies almost linearly with the laser power density. Furthermore, the hardness of graphene to radiation damage depends on its intrinsic structural quality. The results suggest that, contrary to the common belief, micro-Raman spectroscopy cannot be considered a noninvasive tool for the characterization of graphene. The experimental observations are compatible with a model that we derived from the interpretative approach of the Staebler-Wronski effect in hydrogenated amorphous silicon; this approach assumes that the recombination of photoexcited carriers induces the breaking of weak C-C bonds.

关键词： chemically vapor deposited (CVD) graphene Raman spectroscopy defect kinetics laser irradiation

Does kinship affect spatial organization in a small and isolated population of a solitary felid: The Eurasian lynx?

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Integrative Zoology 2016年第5期11卷 334-349页

作者： Krzysztof SCHMIDT Francesca DAVOLI Rafał KOWALCZYK ettore RANDI Mammal Research Institute Polish Academy of SciencesBiałowieżaPoland Laboratory of Genetics Institute for Environmental Protection and ResearchOzzano EmiliaItaly Aalborg University Department of BiotechnologyChemistry and Environmental EngineeringAalborgDenmark

Social organization in wild carnivores is mostly determined by patterns of family bonds,which may shape the degree of relatedness among individuals in the *** studied kinship in a small and isolated population of a solitary carnivore,the Eurasian lynx(Lynx lynx)to evaluate its effect on spatial distribution of *** investigated the relationship between spatial location and pair-wise kinship among 28 lynx individuals identified in 2004-2011 by telemetry,non-invasive sampling and genotyping with the use of 12 autosomal microsatellites in the Białowieża Primeval Forest,*** average relatedness of the lynx population was relatively low(Lynch and Ritland’s R=0.03).Females were significantly more related to each other than males with other *** inferred pedigree showed that the population was dominated by only 2 familial *** did not find significant correlations between the relatedness and the extent of home range overlap or the straight-line distances between the home ranges’central *** results suggest that the dynamics of kinship in this solitary felid may not differ from the random mating processes described in social *** the chances of random mating could be limited to a few resident males and females,the presence of unrelated floaters may provide a“breeding buffer”that may prevent an increase of relatedness and likely inbreeding in the pop*** system is likely to fail in preserving genetic diversity in small,highly isolated populations;therefore,restoring habitat connectivity is crucial to ensure sufficient immigration from neighboring populations.

关键词： genetic variability inbreeding mating system relatedness social organization

Viability of thermal imaging in detecting nests of the invasive hornet Vespa velutina

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Insect Science 2021年第1期28卷 271-277页

作者： Simone Lioy ettore Bianchi Alessandro Biglia Mattia Bessone Daniela Laurino Marco Porporato Department of Agriculture Forest and Food SciencesUniversity of TurinGrugliasco(Turin)Italy School of Biological and Environmental Science Liverpool John Moores UniversityLiverpoolUK

Vespa velutina is an invasive hornet species that is colonising Europe,generating considerable impacts on honeybees,beekeeping and *** and early warning strategies for this species are mainly based on monitoring plans and procedures of nest detection and *** tools(harmonic radar,radio-telemetry)have been developed to increase the probabilities of nest detection in new *** hornets are able to regulate nest temperature,thermography may represent an additional technique that may be used,both alone or in support to other *** this study,the viability of thermal imaging in detecting nests of *** was evaluated in controlled *** influence of different environmental and operative variables(time of the day,presence/absence of leaves covering the nest,distance between the nest and the operator)were tested on three nests detected during August 2018 in *** the nests were detectable by thermal imaging,but environmental and operative variables affect their *** temperature difference between the nests and the surrounding reaches its maximum before sunrise and without a tree canopy covering the *** nests were visible in some cases from 30 m,the detectability was higher at shorter distances,even if this variable may also depend on infrared camera *** increase in the environmental temperature also generates a decrease of nest *** some limitations could occur,these results show the applicability of thermography in detecting V velutina nests before the beginning of the reproductive phase,and consequently its potentiality in control strategies.

关键词： alien species Asian yellow-legged hornet monitoring nest detection remote sensing thermography

Physical exercise and synaptic protection in human and pre-clinical models of multiple sclerosis

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Neural Regeneration Research 2024年第8期19卷 1768-1771页

作者： Federica Azzolini ettore Dolcetti Antonio Bruno Valentina Rovella Diego Centonze Fabio Buttari Unit of Neurology IRCCS NeuromedPozzilliItaly Department of System Medicine University of Tor VergataRomeItaly Synaptic Immunopathology Lab Department of Systems MedicineTor Vergata UniversityRomeItaly

In multiple sclerosis,only immunomodulato ry and immunosuppressive drugs are recognized as disease-modifying *** r,in recent years,several data from pre-clinical and clinical studies suggested a possible role of physical exe rcise as disease-modifying therapy in multiple *** evidence is sparse and often conflicting,and the mechanisms underlying the neuroprotective and antinflammatory role of exercise in multiple sclerosis have not been fully ***,mainly derived from pre-clinical studies,suggest that exe rcise could enhance longterm potentiation and thus neuroplasticity,could reduce neuroinflammation and synaptopathy,and dampen astrogliosis and *** humans,most trials focused on direct clinical and MRI outcomes,as investigating synaptic,neuroinflammato ry,and pathological changes is not straightfo rward compared to animal *** present review analyzed current evidence and limitations in research concerning the potential disease-modifying therapy effects of exercise in multiple sclerosis in animal models and human studies.

关键词： disease-modifying behaviour endocannabinoid system long-term potentiation multiple sclerosis neuroplasticity neuroprotection physical exercise synaptopathy

Molecular signaling involving intrinsically disordered proteins in prostate cancer

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Asian Journal of Andrology 2016年第5期18卷 673-681页

作者： Anna Russo Sara La Manna ettore Novellino Anna Maria Malfitano Daniela Marasco Department of Pharmacy Centro Interuniversitario di Ricerca sui Peptidi Bioattivi University of Naples 'Federico II' 80134 Naples Italy

Investigations on cellular protein interaction networks （PINs） reveal that proteins that constitute hubs in a PIN are notably enriched in Intrinsically Disordered Proteins （IDPs） compared to proteins that constitute edges, highlighting the role of IDPs in signaling pathways. Most IDPs rapidly undergo disorder-to-order transitions upon binding to their biological targets to perform their function. Conformational dynamics enables IDPs to be versatile and to interact with a broad range of interactors under normal physiological conditions where their expression is tightly modulated. IDPs are involved in many cellular processes such as cellular signaling, transcriptional regulation, and splicing; thus, their high-specificity/low-affinity interactions play crucial roles in many human diseases including cancer. Prostate cancer （PCa） is one of the leading causes of cancer-related mortality in men worldwide. Therefore, identifying molecular mechanisms of the oncogenic signaling pathways that are involved in prostate carcinogenesis is crucial. In this review, we focus on the aspects of cellular pathways leading to PCa in which IDPs exert a Iorimary role.

关键词： inflammation intrinsically disordered proteins prostate cancer