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Genetic Disposition: Susceptibility of Human Blood Groups and Abo Analysis to Malaria and Typhoid Infections

Advances in Infectious Diseases 2024年第3期14卷 497-510页

作者： Mbeh Ubana Eteng Ekpe Onot Okon Nyakno Akpan Essien Ugochukwu Iloh Godwin Oju Igile Patrick Ubi Esukwu Richard Undigweundeye Ukpanukpong Ubong Edet Akpan Adaeze Bobchile-Agada etim esin etim John Ojuwu Ojowu Nnennaya Precious Akpa-Onyeabor Ayiku Audu Fanziya Mary Joan Obianuju Ngumah Mcvain Akpam Ugor Department of Biochemistry Faculty of Basic Medical Sciences College of Medical Sciences University of Calabar Calabar Nigeria Department of Biochemistry Faculty of Science Imo State University Owerri Nigeria Department of Biochemistry College of Biological Sciences Federal University of Agriculture Makurdi (JOSTRUM) Benue Nigeria School of Applied Sciences Department of Science Laboratory Technology Federal Polytechnic Wannue Benue State Benue Nigeria School of Applied Sciences and Technology College of Agriculture Science and Technology Lafia Nasarawa Nigeria Department of Biology Alvan Ikoku University of Education Owerri Nigeria

Background: Malaria and typhoid have remained major infectious tropical diseases. Clinically, whenever there is severe malaria, cough is always an associating symptom owing to typhoid infection arising from poor hygiene in respect to drinking water and food. There is a strong association between human blood group and disease. Residual malaria transmission, effect of climate change on malaria vector composition, environmental management targeted at malaria breeding control as an intervention strategy are areas of interest to WHO in malaria control in Sub-saharan Africa. A body of data is been built on susceptibility of human blood groups to malaria, HIV and HBV and presently malaria and typhoid. If climate change warrants a change in composition of vectors and as well resistance to ACT therapy, the susceptibility or vulnerability of the human blood group is also called to question. The link between susceptibility of human blood group to malaria and typhoid has not been previously investigated. Purpose: The present study assesses the genetic disposition (susceptibility of human blood groups and abo analysis) to malaria and typhoid infections. Patients and Methods: One hundred (100) patients were screened for malaria and typhoid infections in a tertiary health facility—His glory hospital Lagos, Nigeria. Blood samples were collected by venu-puncture from 53 females and 47 males adults aged between 15 – 47 years, who were infected either singly or coinfected with malaria and typhoid. Microscopic detection of P. falciparum, widal serological technique for salmonella antibody presence and genotypic determination were all done using standard WHO methods. Human material or data were analyzed or performed in accordance with the declaration of Helsinki (2000). Ethical clearance was obtained from the ethic and research committee of the Ministry of Health via the Faculty of the Basic Medical Sciences, University of Calabar (Ethical Certificate number CRS/MOH/HRP/2023/396). Resul

关键词： Malaria Plasmodium Falciparium Genotype Genetig Disposition

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Comparative Study of the Effects of Nano ZnO and CuO on the Biodegradation,Biocompatibility,and Antibacterial Properties of Micro-arc Oxidation Coating of Magnesium Alloy

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 242-254页

作者： Ying Shen Xianfeng Shan Iniobong P.etim Muhammad Ali Siddiqui Yang Yang Zewen Shi Xuping Su Junxiu Chen Key Laboratory of Materials Surface Science and Technology of Jiangsu Province Changzhou UniversityChangzhou213164China Department of Stomatology The Affiliated Xinhua Hospital of Dalian UniversityDalian116000China Department of Physics University of CalabarCalabar540242Nigeria Metallurgical Engineering Department NED University of Engineering and TechnologyUniversity RoadKarachi75270Pakistan Ningbo No.2 Hospital Ningbo315010China

This research systematically examined the degradation,antibacterial effects,and biocompatibility of micro-arc oxidation(MAO)coatings with nano CuO and ZnO on extruded Mg *** copper(Cu)and Zinc(Zn)possess antibacterial *** findings demonstrated that adding ZnO will appreciably reduce the degradation rate of MAO-coating alloy due to the self-sealing micro ***+MAO coating exhibited excellent antibacterial performance,with an antibacterial rate of over 90%within 6 h co-cultured with Staphylococcus ***,the antibacterial rate of ZnO+MAO coating reached 90%after 12 h *** test using MG63 cell indicated that the incorporation of CuO and ZnO did not notably affect the cell viability rate of the ***,after 14 days of culture,the CuO+MAO and ZnO+MAO coated samples exhibited higher alkaline phosphatase(ALP)activity than the MAO-coated and uncoated samples,suggesting favorable osteogenic properties.

关键词： Copper oxide Zinc oxide Micro-arc oxidation(MAO)coating Corrosion behavior Antibacterial characteristics

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Microstructural Evolution and Biodegradation Response of Mg–2Zn–0.5Nd Alloy During Tensile and Compressive Deformation

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Acta Metallurgica Sinica(English Letters) 2021年第6期34卷 834-844页

作者： Iniobong P.etim Wen Zhang Yi Zhang Lili Tan Ke Yang School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

The effect of deformation behavior on the in vitro corrosion rate of Mg–2Zn–0.5 Nd alloy was investigated experimentally after uniaxial tensile and compressive *** microstructure and texture were characterized using electron backscattered diffraction and X-ray diffraction,while potentiodynamic polarization and immersion tests were used to investigate the corrosion response after *** result reveals that applied compressive stress has more dominant effect on the corrosion rate of Mg–2 Zn–0.5 Nd alloy as compared to tensile *** tensile and compressive strains introduce dislocation slip and deformation twins in the alloy,thereby accelerating the corrosion rate due to the increased stress corrosion related to dislocation slips and deformation ***{10ī2}tension twinning and prismatic slip were the major contributors to tensile deformation while basal slip,and{10ī2}tension twin were obtainable during compressive *** twinning activity after deformation increases with the plastic strain and this correlates with the degradation rate.

关键词： Magnesium EBSD Corrosion Deformation Twinning

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Risk Identification and Assessment of Rural Road Construction Projects in Nigeria

Risk Identification and Assessment of Rural Road Constructio...

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作者： etim Okon Iniekung 山东大学

学位级别：硕士

This study aims primarily to investigate the risk analysis and assessment of rural road construction projects in Nigeria using Analytic Hierarchical Process（AHP）.Primary sources of data collection was used for the *** research among others made the following findings:amongst the identified risks,financial and economic,political and environment,and job-site related risks were highly *** amongst the physical risk sub-criteria,theft,labour injuries and flood/surge risks were ranked *** the financial and economic risk sub-criteria,corruption and financial fraud,delay in supply of funds and financial default of sub-contractors were ranked *** the political and environment risks sub-criteria,pollution and safety rule,requirement for permit and their approval and the government lack of political will were ranked *** the design risk sub-criteria,inadequate specifications,design changes and defective design were ranked *** the job-site related risks sub-criteria,equipment failure,labour dispute and strike,and labour productivity were ranked ***,in the mitigation strategy category,risk reduction,risk transfer,and risk avoidance were ranked *** in the risk reduction sub-criteria,"Government to show adequate commitment to Project","Funds should be released in advance of construction and ensure all tiers of governments are well consulted."Consequently,the study from its findings made the following recommendations:All managers of rural road construction projects should ensure that an integrated framework of risk management is deployed for the effective risk identification,analysis and developing responses and for proper provision of analytical framework in a group decision-making *** construction industry should be ready to adopt best practices in project management methods and *** is need for improved risk management education and training that could influence *** could be attained through adequate tra

关键词： Road Construction Projects Risk Identification Assessment Nigeria

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Effects of microstructure on the torsional properties of biodegradable WE43 Mg alloy

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Journal of Materials Science & Technology 2020年第16期47卷 102-110页

作者： Yi Zhang Lili Tan Qingchuan Wang Ming Gao Iniobong P.etim Ke Yang Institute of Metal Research Chinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China

Torsional properties are important performance parameters for bone screw applications,but they are seldom studied,especially for newly developed biodegradable Mg *** this study,WE43 Mg alloy with different microstructures was achieved by equal channel angular pressing(ECAP)and heat treatment,and their torsional properties were *** addition,tensile properties were also tested as a *** results indicated that grain refinement led to higher torsional strength and ductility,while the second phases improved the torsional strength but reduced the *** texture was strengthened after ECAP,as a result the tensile strength increased,but the torsional strength did not increase and even decreased,especially for 2-pass ECAP sample with a typical basal fiber *** basal plane orientation deviation from the extrusion direction after 4-pass ECAP resulted in higher torsional strength and lower torsional ductility,but lower tensile strength and higher tensile ductility were *** implied that a strong fiber texture would reduce the torsional strength but improve the torsional ductility,which was different from its effect on tensile properties.

关键词： Torsional properties Texture ECAP WE43 Mg alloy

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Influence of stamping on the biodegradation behavior of Mg–2Zn-0.5Nd (ZN20) sheet

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Bioactive Materials 2020年第1期5卷 133-141页

作者： Iniobong P.etim Wen Zhang Lili Tan Ke Yang Institute of Metal Research Chinese Academy of SciencesShenyang110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang110016China

Stamping processing is commonly used to form medical devices and ***,for biodegradable Mg alloy,the stamping will influence the degradation behavior because of the change in microstructure after *** in this study,the As-rolled Mg–2Zn-0.5Nd alloy(ZN20)was processed by *** microstructure,crystallographic orientation and corrosion performance of this processing method was investigated to reveal the influence of the stamping process on the degradation rate of Rolled Mg–2Zn–Nd(ZN20).The degradation rate was measured by immersion of the Mg–2Zn-0.5Nd alloy in simulated body fluid using Electrochemical Impedance Spectroscopy,Potentiodynamic polarization and mass *** in vitro degradation result shows that the degradation rate of the Rolled Mg–2Zn-0.5Nd increased from 0.2 mm/year to 0.5 mm/year after stamping *** result reveals that the activation of the{101‾2}tension twin during stamping can remarkably weaken the{0001}basal texture and have a significant influence on the corrosion rate of Stamped Mg–2Zn-0.5Nd *** removing the deformation by annealing,the degradation rate was reduced to 0.15 mm/*** work is expected to prompt better microstructural design of biomedical Mg in order to control its degradation behavior for biomedical application.

关键词： Texture Degradation rate Crystallographic orientation Stamping Annealing Twin Deformation

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Effect of residual dissolved oxygen on the corrosion behavior of low carbon steel in 0.1 M NaHCO3 solution

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Journal of Materials Science & Technology 2018年第8期34卷 1349-1358页

作者： Fang Xue Xin Wei Junhua Dong Ini-Ibehe Nabuk etim Changgang Wang Wei Ke Institute of Metal Research Chinese Academy of SciencesShenyang 110016China University of Science and Technology of China Hefei 230026China

The effect of residual dissolved oxygen （DO） on the corrosion behavior of carbon steel in 0.1 M NaHCO3 solution was investigated by electrochemical measurements, corrosion mass loss test, scanning electron microscopy （SEM） and X-ray diffraction （XRD）. In the initial immersion stage, the increase of the dissolved oxygen concentration led to the change of from a reductive state of active dissolution to an oxidizing state of pseudo passivation in low carbon steel. While in the final stage, all the steels transformed into the steady state of pseudo passivation. In the anaerobic solution, the formation of c^-FeOOH was attributed to the chemical oxidization of the ferrous corrosion products and the final cathodic process only included the reduction of c^-FeOOH, while in the aerobic solution, it included the reduction of oxygen and （x-FeOOH simultaneously. As the main corrosion products, the content of （x-FeOOH was increased while that of Fe6（OH）12CO3 was decreased with increasing concentration of dissolved oxygen. The total corrosion mass loss of the steel was promoted with the increase of dissolved oxygen concentration.

关键词： Low carbon steel Residual dissolved oxygen Electrochemical characterization Anodic dissolution state Pseudo passivation

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基于氧传感器信号的用于研究空气/燃料比率变化的统计方法

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内燃机学报 2008年第1期26卷 11-23页

作者： etim U Ubong Boyan Dimitrov Department of Mechanical Engineering Kettering University Flint Michigan 48504 USA

给出了火花点火式发动机排气氧传感器(EGO)输出信号的实验结果。实验中采用V6、3.8 L、BUICK发动机且每个气缸中安装有一个氧传感器,以研究影响发动机消耗燃料的因素。应用LabView数据采集装置记录单个气缸废气以及主流尾气氧传感器的... 详细信息

给出了火花点火式发动机排气氧传感器(EGO)输出信号的实验结果。实验中采用V6、3.8 L、BUICK发动机且每个气缸中安装有一个氧传感器,以研究影响发动机消耗燃料的因素。应用LabView数据采集装置记录单个气缸废气以及主流尾气氧传感器的输出电压信号。对来自6个气缸变量的平均值采用统计的方法进行处理后,并与主流的EGO电压进行比较,确定了产生系统误差的因素。对左右两侧气缸信号平均值的差别进行比较发现,采用此种排气管结构的气缸中空气—燃料混合气平均值存在一些明显差别。根据数据和图表解释了统计的结果。研究表明,V字形排列的发动机两侧的气缸的空气和燃料混合气是不同的;在低速、高负荷和高辛烷燃料的情况下,右侧气缸具有比较稀的混合气;而在某些情况下两侧气缸具有相同的混合气。基于统计估计的方法,提出了一个可以用于估计V字形排列发动机左右两侧气缸中空气—燃料混合气的简单模型。此方法还可以应用于分析进气管和排气管的缺陷。

关键词：排气氧传感器气缸间空气/氧气比率变动统计分析

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Corrosion Behaviour of Carbon Steel Fasteners in Neutral Chloride Solution

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Acta Metallurgica Sinica(English Letters) 2022年第4期35卷 563-576页

作者： Enobong Felix Daniel Junhua Dong Xiaofang Li Ini-Ibehe Nabuk etim Inime Ime Udoh Rongyao Ma Lei Chen Changgang Wang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China School of Materials Science and Engineering Northeastern UniversityShenyang 110819China School of Environmental and Chemical Engineering Shenyang Ligong UniversityShenyang 110159China Department of Marine Biology Akwa Ibom State UniversityP.M.B 1167UyoNigeria

An experimental model for simulating the corrosion of carbon steel fasteners(bolt and nut) composed of a contact carbon steel electrode(CCSE) and an exposed bare carbon steel plate electrode(BCSE) was designed. The effect of coupling on the corrosion process of the galvanically coupled carbon steel electrode was evaluated and compared with the self-corrosion process observed independently at the exposed and contact regions. Results obtained indicated that at an equal area ratio and uncoupled conditions, the corrosion rate is accelerated in the surface directly exposed to bulk solution compared to the bolt surface in contact with the nut. A coupling current was recorded when the exposed surface(BCSE) was electrically connected with the contact surface(CCSE);with the CCSE acting as the anode thereby suppressing the corrosion process in the exposed surface. By implication, the galvanic coupling between CCSE and BCSE increased the corrosion rate of CCSE. The diff erence in oxygen supply was responsible for the coupling effect observed in the system as there was no decrease in the solution pH. Moreover, varying the cathode-to-anode area( S c/S a) ratio significantly influenced the corrosion current density as increased S c/S a ratio resulted in an accelerated galvanic corrosion process. The corroded surfaces and interfaces were analysed using stereomicroscopy and scanning electron microscopy. X-ray diff ractometry was adopted for corrosion product characterization. The results obtained showed supportive evidence of the corrosion behaviour in carbon steel fasteners.

关键词： Bolt and nut Galvanic current density Zero resistance ammetry(ZRA) Coupling potential Differential aeration cell Carbon steel fasteners

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Electrochemical noise analysis on the pit corrosion susceptibility of biodegradable AZ31 magnesium alloy in four types of simulated body solutions

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Journal of Materials Science & Technology 2018年第10期34卷 1876-1884页

作者： changgang wang liping wu fang xue rongyao ma ini-ibehe nabuk etim xuehui hao junhua dong wei ke Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

Magnesium alloys have been investigated as biodegradable implant materials since the last century. Non-uniform degradation caused by local corrosion limits their application, and no appropriate technology has been used in the research. In this study, electrochemical noise has been used to study the pit corrosion on magnesium alloy AZ31 in four types of simulated body solutions, and the data have been analyzed using wavelet analysis and stochastic theory. Combining these with the conventional polarization curves, mass loss tests and scanning electron microscopy, the electrochemical noise results implied that AZ31 alloy in normal saline has the fastest corrosion rate, a high pit initiation rate, and maximum pit growth probability. In Hanks＇ balanced salt solution and phosphate-buffered saline, AZ31 alloy has a high pit initiation rate and larger pit growth probability, while in simulated body fluid, AZ31 alloy has the slowest corrosion rate, lowest pit initiation rate and smallest pit growth probability.

关键词： Biodegradable magnesium alloy Electrochemical noise (EN) Pit corrosion susceptibilities Wavelet analysis Stochastic model

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