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RESTful API in Life Science Research Systems and Data Integration Challenges： Linking metabolic Pathway, metabolic Network, Gene and Publication

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通讯和计算机（中英文版） 2013年第9期10卷 1196-1199页

作者： etienne Z. Gnimpieba Brent S. Anderson Abalo Chango Carol m. Lushbough Computer Science Department University of South Dakota Vermillion SD 57069 USA UPSP EGEAL Institute Polytechnique LaSalle Beauvais Beauvais BP 30313-60026 France

Translational science research development requires life sciences researchers to update their concept on systems integration and data integration. The RESTful API has proven to be very useful in integrating the massive amount of data and tools. This work presents an approach for biological systems analysis based on the semantic web and RESTful API. The integration of this approach in the BioExtract Server engine as a WmS (workflow management system) allows us to apply our work to the linking of several biological levels (metabolic pathway, metabolic network model, genes and publications). This work shows how HPC infrastructure and RESTful API can be an opportunity in Systems Biology and life science research challenges. We present a use case in BioExtract server as an integrated workflow management system. The use case shows how we can extract data to build a mathematical model for a specific biological system. The two workflow examples provided in this work enhance the flexibility in the workflow for reusability. Then any other researcher can customize the same workflow for different gene name or biological process.

关键词：数据集成代谢途径 REST 生命科学生物系统科学研究 API 出版物

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阿尔玛奈克住宅群——密度与界限

城市环境设计 2015年第8期 106-113页

作者： michel Delplace Cyril Trétout Fanny Rozé Olivier Calvarese etienne Challet-Hayard matthieu miquel Stéphane Chalmeau Agence Nicolas michelin & Associés-ANmA Nicolas michelin

项目名称:阿尔玛奈克住宅群项目地点:法国波尔多建筑面积:13 629m2竞赛时间:2007.11设计时间:2008.06-2009.12建造时间:2010.01-2012.04建成时间:2012.04位于法国波尔多市的阿尔玛奈克住宅项目开启了城市高密度空间的新形式。形似船头... 详细信息

项目名称:阿尔玛奈克住宅群项目地点:法国波尔多建筑面积:13 629m2竞赛时间:2007.11设计时间:2008.06-2009.12建造时间:2010.01-2012.04建成时间:2012.04位于法国波尔多市的阿尔玛奈克住宅项目开启了城市高密度空间的新形式。形似船头的住宅群引领了贝斯(Belcier)街区的城市发展方向,由现有规模和密度逐步向未来更大的规模和密度迈进。住宅群严谨地沿街道对齐,并朝南边的公共广场开放。项目集住宅、公共设施、健身中心和多媒体中心于一身。它在形态

关键词：住宅群奈克阿尔玛

Nanoscale resetting of the Th/Pb system in an isotopically-closed monazite grain: A combined atom probe and transmission electron microscopy study

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Geoscience Frontiers 2019年第1期10卷 65-76页

作者： A.-m.Seydoux-Guillaume D.Fougerouse A.T.Laurent E.Gardés S.m.Reddy D.W.Saxey Univ Lyon UJM-Saint-Etienne CNRS IRD CNRS Université Clermont Auvergne School of Earth and Planetary Sciences Curtin University Geoscience Atom Probe Advanced Resource Characterisation Facility John de Laeter Centre Curtin University Centre de recherche sur les Ions les Matériaux et la Photonique (CIMAP) Department of Physics and Astronomy Curtin University

Understanding the mechanisms of parent-daughter isotopic mobility at the nanoscale is key to rigorous interpretation of Ue The Pb data and associated dating. Until now, all nanoscale geochronological studies on geological samples have relied on either Transmission Electron microscope(TEm) or Atom Probe microscopy(APm) characterizations alone, thus suffering from the respective weaknesses of each technique. Here we focus on monazite crystals from a ~1 Ga, ultrahigh temperature granulite from Rogaland(Norway). This sample has recorded concordant UeP b dates(measured by LA-ICP-mS) that range over 100 my, with the three domains yielding distinct isotopic Ue Pb ages of 1034 ± 6 ma(D1; Srich core), 1005 ± 7 ma(D2), and 935 ± 7 ma(D3), respectively. Combined APm and TEm characterization of these monazite crystals reveal phase separation that led to the isolation of two different radiogenic Pb(Pb*) reservoirs at the nanoscale. The S-rich core of these monazite crystals contains Cae Srich clusters, 5 -10 nm in size, homogenously distributed within the monazite matrix with a mean interparticle distance of 40 -60 nm. The clusters acted as a sink for radiogenic Pb(Pb*) produced in the monazite matrix, which was reset at the nanoscale via Pb diffusion while the grain remained closed at the micro-scale. Compared to the concordant ages given by conventional micro-scale dating of the grain,the apparent nano-scale age of the monazite matrix in between clusters is about 100 myr younger, which compares remarkably well to the duration of the metamorphic event. This study highlights the capabilities of combined APm-TEm nano-structural and nano-isotopic characterizations in dating and timing of geological events, allowing the detection of processes untraceable with conventional dating methods.

关键词： monazite Nanoscale resetting Nano-clusters APm TEm UHT metamorphism

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欧洲地中海媒体工程研究中心——城市的前哨

城市环境设计 2015年第8期 64-71页

作者： michel Delplace Cyril Trétout Hélène Galifer etienne Challet-Hayard Florent Biais Alessio Loffredo Julien Lanoo Agence Nicolas michelin & Associés-ANmA Nicolas michelin

项目名称:欧洲地中海媒体工程研究中心项目地点:法国土伦总规划面积:10hm2建筑面积:11 160m2竞赛时间:2009.02设计时间:2009.06-2010.08建造时间:2011.08-2014.06建成时间:2014.06土伦媒体工程学院通过延续基地旁边古城墙,形成一个新的... 详细信息

项目名称:欧洲地中海媒体工程研究中心项目地点:法国土伦总规划面积:10hm2建筑面积:11 160m2竞赛时间:2009.02设计时间:2009.06-2010.08建造时间:2011.08-2014.06建成时间:2014.06土伦媒体工程学院通过延续基地旁边古城墙,形成一个新的城市入口。三个体量分别拥有大面玻璃面向城市;同时,其基座相互联系,重塑公共空间。一系列相汇和贯穿的交通空间恰到好处,使学生们在不经意间相遇和交流。新的城市入口这个包含一个欧洲地中海研究中心和媒体工程(Ingemedia)学院的项目,由ANmA事务所在2014年7月完成,是土伦

关键词：工程研究中心土伦项目地点太阳能烟囱地中海古城墙玻璃幕墙媒体自然通风交通空间制作室欧洲

FEm-BEm Coupling for the modelling of Induction Heating Processes Including moving Parts

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Journal of Shanghai Jiaotong university(Science) 2000年第1期5卷 91-99页

作者： J. -m. Bergheau, Ph. Conraux 1. LTDS, UmR5513 CNRS/ECL/ENISE, 58, rue J. Parot, 42023 Saint etienne Cedex 2, France, Email: bergheau@enise.fr 2.SYSTUS International, 84 Bvd Vivier merle, 69485, Lyon Cedex 03, France, Email: ph.conraux@***

Every electrical conductive medium placed in a time varying magnetic field is the seat of eddy currents that dissipate power through Joule effect. The induction hardening process takes advantage of this effect. The power concentrates in the surface of the piece (skin effect), the thickness of which depends on the electromagnetic properties and the frequency of the currents. The numerical simulation of such a process is of major interest to control and estimate the thickness of the treated layer, the superficial hardness, the residual stresses (often compressive in the surface) or the residual distortions. In this paper we focus on the interactions between electromagnetism and heat transfer for the simulation of the heating stage. The method used to couple both phenomena is detailed. A magnetic vector potential formulation is used for the electromagnetic analysis and an approach coupling finite elements with boundary elements is presented. Such a method is especially useful when moving parts are involved as it is generally the case for induction hardening processes. The air is represented by a boundary element that enables to consider independent meshes for all the conductive media within the device (piece and coils). moreover, meshes are now the same for the electromagnetic and thermal analyses. This considerably facilitates the analysis that is performed step by step, each step corresponding to a position of the moving media. At each step, the matrices associated with the boundary element are calculated and the magneto-dynamic and thermal analyses are performed. Finally, an application is presented.

关键词： Induction heating moving parts Finite Element Boundary Element.

Differential diagnosis of gallstones by using hypericin as a fluorescent optical imaging agent

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World Journal of Gastroenterology 2016年第29期22卷 6690-6705页

作者： marlein miranda Cona Ye-Wei Liu Antoine Hubert Ting Yin Yuan-Bo Feng Peter de Witte etienne Waelkens Yan-Sheng Jiang Jian Zhang Stefaan mulier Qian Xia Gang Huang Raymond Oyen Yi-Cheng Ni Department of Imaging and Pathology Faculty of Medicine Biomedical Sciences Group University HospitalsKU Leuven Department of Cellular and molecular medicine Biomedical Sciences GroupKU Leuven molecular Biodiscovery Laboratory Faculty of Pharmaceutical Sciences Biomedical Sciences GroupKU Leuven Laboratory of Translational medicine Jiangsu Province Academy of Traditional Chinese Medicine Department of Nuclear medicine Ren Ji Hospital School of Medicine Shanghai Jiao Tong University

AIm: To explore the feasibility of using hypericin as an optical imaging probe with affinity for cholesterol for differential fluorescent detection of human ***: Cholesterol, mixed and pigment stones from cholecystectomy patients were incubated with hypericin or solvent. After 72 h, the stones were analysed for fluorescence(365 nm) and treated with 2-propanol/dimethyl sulfoxide for high performance liquid chromatography(HPLC) analysis. Rats with virtual gallbladder containing human cholesterol, mixed or pigment gallstones(VGHG) received 5 mg/kg hypericin or solvent and VGHG rats with cholesterol stones were given different hypericin doses(5-15 mg/kg). Twelve hours later, the stones were analysed at 365 nm. Biliary excretion and metabolites of hypericin were assessed in common bile duct(CBD) cannulated rats for 9 h using fluorospectrometry, HPLC and matrixassisted laser desorption/ionization-time-of-flight mass spectrometry(mALDI-TOF mS).RESULTS: Homogeneous high fluorescence was seen on cholesterol stones either pre-incubated with hypericin or extracted from VGHG rats receiving hypericin. mixed stones showed a dotted fluorescent pattern, whereas pigment and solvent-treated ones lacked fluorescence. HPLC showed 7.68, 6.65 and 0.08 × 10^(-3) m of cholesterol in extracts from cholesterol, mixed, and pigment gallstones, respectively. Hypericin accounted for 2.0, 0.5 and 0.2 × 10-6 m in that order. On cholesterol stones from VGHG rats receiving different hypericin doses, a positive correlation was observed between dose and fluorescence. In the bile from CBD-cannulated rats, fluorescence represented 20% of the injected dose with two peaks in 9 h. HPLC analysis revealed that hypericin conjugates reached 60% of the peak area. By mALDI-TOF mS, hypericinglucuronide was detected. CONCLUSION: This study proves the potential use of hypericin for differential fluorescent detection of human gallstones regarding their chemical composition.

关键词： Differential detection Fluorescence Human gallstones Hypericin Rat model of cholelithiasis

圣布里约克家庭补助中心(CAF)办公楼——生态循环与模块化

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城市环境设计 2015年第8期 90-99页

作者： michel Delplace Cyril Trétout Valérie Dubois etienne Challet-Hayard Hélène Dupont Jacqueline Lee Stéphane Chalmeau ANmA Agence Nicolas michelin et Associés Nicolas michelin

项目名称:CAF办公楼项目地点:法国圣布里厄建筑面积:7 212m2竞赛时间:2008.09设计时间:2008.09-2012.05建成时间:2013.05项目基地位于布兰维尔规划区(ZAC de Plaines Villes),在普罗夫拉冈市(Ploufragan)布里欧迟那大区(Agglomé Ration... 详细信息

关键词：办公楼生态花园直立锁边系统布里生态循环 CAF 约克补助模块化

A Numerical model for multiple Phase Transformations in Steels during Thermal Processes

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Journal of Shanghai Jiaotong university(Science) 2000年第1期5卷 213-220页

作者： R. Fortunier, J.B. Leblond, J.m Bergheau 1.ENSm-SE, centre SmS, 158 cours Fauriel, 42023 - St-etienne cedex 02, France 2.Lmm, UmR 7607/CNRS/Université Paris VI, Tour 66, case 162, 4 place Jussieu, 75252 Paris cedex 05, France 3.LTDS, UmIR 5513, CNRS/E

It is now well known that phase changes in steels can be reasonably well modelled by kinetics derived from the concept of extended volume. This has led to a large number of models based on the Koistinen-marburger equation for martensitic type transformations, and on Johnson-mehl-Avraxni-Kolmogorov type equations for transformations involving diffusion. These models are generally based on either isothermal transformation (IT) diagrams or on continuous cooling transformation (CCT) diagrams. Their efficiency is often linked to their ability to represent both CCT and IT diagrams of a given material. After describing classical models used to simulate phase changes in steels along isothermal as well as non-isothermal paths, this paper focuses on (i) the numerical implementation of these models, and (ii) their generalisation to the case where more than two phases are involved. We first show that, in the case of only one possible reaction between two phases, most of the kinetic models can be incorporated into a unique differential formulation. This formulation holds for both martensitic and diffusjonal transformations. For the case where several reactions between two or more phases can take place, an approach assuming that these reactions occur independently is proposed. This approach is illustrated on (i) calculations of CCT diagrams from data obtained on IT diagrams, and (ii) prediction of IT diagrams from parameters fitted on CCT diagrams.

关键词： Phase transformation modelling heat treatment heat transfer steels

Computer simulation of thermochemical treatments: modelling diffusion and precipitation in metals

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Journal of Shanghai Jiaotong university(Science) 2000年第1期5卷 303-309页

作者： R. Fortunier, J.B. Leblond, J.m Bergheau 1.ENSm-SE, centre SmS, 158 yours Fauriel, 42023 - St-etienne cedex 02, France 2.Lmm, UmR 7607/CNRS/Universite Paris VI, Tour 66, case 162, 4 place Jussieu, 75252 Paris cedex 05, France 3.LTDS, UmR 5513, CNRS/ECL

A model for simultaneous diffusion and precipitation in metals has been recently incorporated into a finite element computer code [1][2]. This model allows now for numerical simulations of various thermochemical treatments such as nitriding or carburizing. Subsequent quenching simulations are then made more accurate, by introducing the influence of the carbon content on the thermo-metallurgical and mechanical properties of the materials [3]. After recalling the mathematical equations used to model simultaneous diffusion and precipitation and their implementation into a finite element code, this paper deals with the method used to obtain the local fractions of precipitates as functions of the local content in each chemical element. The law of mass action is employed to calculate the fractions of precipitates obtained at thermodynamic equilibrium. This leads to a nonlinear complementarity problem. The method used to solve this problem is described in detail, and is validated by computing the phase diagram of a micro-alloyed steel. Finally, numerical simulations of combined diffusion and precipitation in steels point out the efficiency of the approach presented, as well as the important role played by precipitation during diffusion in metals.

关键词： Thermochemical treatment diffusion precipitation finite element method