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Report on Childhood Obesity in China (5) Body Weight, Body Dissatisfaction, and Depression Symptoms of Chinese Children Aged 9-10 Years

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Biomedical and Environmental Sciences 2007年第1期20卷 11-18页

作者： YAN-PING LI GUAN-SHENG MA EVERT G. SCHOUTEN XIAO-QI HU ZHAO-HUI CUI DONG WANG FRANS j. kok National Institute for Nutrition and Food Safety Chinese Center for Disease Control and Prevention 29 Nanwei Road Beijing 100050 China Division of Human Nutrition Wageningen University The Netherlands

Objective To investigate the relationship between body weight, body dissatisfaction and depression symptoms among Chinese children. Methods The fasting body weight and height of the third and fourth grade students （n=3886, aged 9 or 10 years） from 20 schools in Beijing, China, were measured, and the students were asked to choose the figures of body image and to complete the self-reported children＇s depression inventory （CDI） questionnaire. Results The CDI Cronbach＇s alpha was 0.81. The total CDI score was 9.60±7.50, 13.2% of children （boys 16.7% vs girls 9.5%） were at risk of developing depression symptoms. Overweight girls, but not boys, had significantly higher total CDI score than their normal weight counteparts. Both obese girls and boys showed a higher negative self-esteem score. More than one fifth underweight girls still wanted to be thinner while more than one third obese boys still wanted to be heavier. Children who wanted to be thinner showed slightly higher scores of ineffectiveness and negative self-esteem. After introducing the body dissatisfaction into the model, overweight was still associated with total CDI score among girls and obesity was still associated with negative self-esteem among both boys and girls. Conclusion Overweight girls show a significantly higher depression symptom score than their normal weight counterparts, which maybe partially explained by body dissatisfaction. Obese boys and girls are both more likely to suffer from low self-esteem, which is partially explained by body dissatisfaction.

关键词： Depression symptoms Body dissatisfaction Overweight Children

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In situ compression and X-ray computed tomography of flow battery electrodes

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journal of Energy Chemistry 2018年第5期27卷 1353-1361页

作者： Rhodri jervis Matt D.R.kok Tobias P.Neville Quentin Meyer Leon D.Brown Francesco Iacoviello jeff T.Gostick Dan j.L.Brett Paul R.Shearing Electrochemical Innovation Lab Department of Chemical Engineering University College London Department of Chemical Engineering McGill University Porous Media Engineering and Analysis Lab Department of Chemical Engineering University of Waterloo

Redox flow batteries offer a potential solution to an increase in renewable energy generation on the grid by offering long-term, large-scale storage and regulation of power. However, they are currently un- derutilised due to cost and performance issues, many of which are linked to the microstructure of the porous carbon electrodes used. Here, for the first time, we offer a detailed study of the in situ effects of compression on a commercially available carbon felt electrode. Visualisation of electrode structure us- ing X-ray computed tomography shows the non-linear way that these materials compress and various metrics are used to elucidate the changes in porosity, pore size distribution and tortuosity factor under compressions from 0%-90%.

关键词： Redox flow battery X-ray computed tomography Compression Carbon felt RFB

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中国新发肺结核患者中2型糖尿病的患病率:一项基于社区的队列研究

中国新发肺结核患者中2型糖尿病的患病率:一项基于社区的队列研究

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作者：汪求真马爱国韩秀霞赵善良蔡静马云波赵杰王玉文董怀峰赵振蕾魏来于涛陈沛学 EvertG.Schouten Frans j.kok Anil Kapur 青岛大学公共卫生学院/营养与健康研究院临沂市胸科医院沂水县结核病防治所郯城县结核病防治所沂南县结核病防治所兰山区结核病防治所费县结核病防治所平邑县结核病防治所苍山县结核病防治所瓦赫宁根大学人类营养学系

2型糖尿病(DM)患者患肺结核(PTB)的风险较高;此外,合并DM与PTB治疗效果差有关。以社区为基础的结核病患者中,DM和DM前期患病率数据缺乏,发展中国家尤为突出。因此,我们进行了一项前瞻性研究,以调查中国农村地区新发现PTB患者中DM和DM前... 详细信息

2型糖尿病(DM)患者患肺结核(PTB)的风险较高;此外,合并DM与PTB治疗效果差有关。以社区为基础的结核病患者中,DM和DM前期患病率数据缺乏,发展中国家尤为突出。因此,我们进行了一项前瞻性研究,以调查中国农村地区新发现PTB患者中DM和DM前期的患病率,并评估存在DM的危险因素。在2010年至2012年进行的一项基于社区的前瞻性研究中,对临沂市7个结核病防治所新发现的6382名PTB患者的代表性样本进行了DM测试。来自同一社区的6674名非结核病对照人群也进行了测试。结核病患者的糖尿病患病率(6.3%)高于对照组的患病率(4.7%,p<0.05)。与对照组相比,PTB患者有更高的DM风险(aOR:3.17,95%CI:1.14-8.84)。DM的患病率随年龄增加而增加,在30岁以上的结核病患者中DM的患病率更高(p<0.05)。在结核病患者中,体重正常者(BMI:18.5-23.9)的糖尿病患病率最低(5.8%)。年龄增长、DM家族史、痰涂片阳性、胸腔X线检查和较高的年收入(≥10000元)呈与DM正相关,而频繁的户外活动与DM呈负相关。PTB患者中DM的患病率高于非TB对照组,其患有DM的调整后比值比高出3倍。鉴于中国的DM患病率不断上升且结核病负担仍然很高,DM与PTB之间的这种关联可能代表着预防和治疗这两种疾病的新的公共卫生挑战。

关键词：糖尿病肺结核队列研究发病率

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Comparison between type-2 and type-1 myocardial infarction：clinical features, treatment strategies and outcomes

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journal of Geriatric Cardiology 2016年第1期13卷 15-22页

作者： Angel Lopez-Cuenca Miriam Gomez-Molina Pedro j Flores-Blanco Marianela Sanchez-Martinez Andrea Garcia-Narbon Ignacio De Las Heras-Gomez Maria j Sainchez-Galian esther Guerrero-Perez Mariano Valdes Sergio Manzano-Femandez Department of Internal Medicine Hospital de la Vega Lorenzo Guirao Cieza Spain Division of Cardiology University Hospital Virgen de la Arrixaca School of Medicine IMIB Murcia Spain Department of Biochemistry University Hospital Virgen de la Arrixaca School of Medicine IMIB Murcia Spain Department of lnternal Medicine University of Murcia Murcia Spain

ObjectiveTo 与尖锐心肌的梗塞(AMI ).MethodsWe 包括了的 type-2 对 type-1 在病人在发生，临床的特征，当前的治疗策略和结果估计差别有 type-1 或 type-2 AMI 的诊断的 824 个连续病人。在索引住院期间，临床的特征和治疗策略详细被... 详细信息

ObjectiveTo 与尖锐心肌的梗塞(AMI ).MethodsWe 包括了的 type-2 对 type-1 在病人在发生，临床的特征，当前的治疗策略和结果估计差别有 type-1 或 type-2 AMI 的诊断的 824 个连续病人。在索引住院期间，临床的特征和治疗策略详细被收集。在 1 年的后续，死亡，击，流血的非致命的心肌的梗塞和专业是 ***-1 AMI 在 707 是在场的(86%) 盒子当(14%) 117 作为 type-2 被分类时。有 type-2 AMI 的病人更经常是象糖尿病那样的女、有的更高的合作病态，以前的非圣片断举起急性冠的症候群，损害肾的功能，贫血症， atrial 纤维性颤动和恶意。然而，保存了左室的喷射部分，正常冠的动脉是经常看见的更多，侵略治疗是不太普通的，并且反血小板药， statins 和 beta-blockers 是在有 type-2 AMI 的病人规定的更少。在 1 年的后续， type-2 AMI 与更高粗略的死亡风险被联系(HR：1.75， 95% CI：1.14-2.68；P = 0.001 ) ，但是这个协会没在 multivariable 调整以后仍然保持重要(P = 0.785 ) 。而且，我们没发现 type-2 AMI 与另外的临床的 *** 被联系这张真实人口与 type-1 相比， type-2 AMI 是主要女人们并且有更多的合作病态。侵略治疗策略和 cardioprotective 药是在 type-2 使用的更少，当 1 年的临床的结果是类似的时。

关键词：冠的容器后续学习心肌的梗塞

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Neurocognitive and mental health outcomes in children with tungiasis:a cross-sectional study in rural Kenya and Uganda

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Infectious Diseases of Poverty 2023年第6期12卷 98-98页

作者： Berrick Otieno Lynne Elson Abneel K.Matharu Naomi Riithi esther Chongwo Khamis Katana Carophine Nasambu Francis Mutebi Herman Feldmeier jürgen Krücken Ulrike Fillinger Amina Abubakar Kenya Medical Research Institute (KEMRI)-Wellcome Trust Programme Hospital Road Kilifi Kenya Centre for Tropical Medicine and Global Health Nuffield Department of Medicine University of Oxford Oxford UK International Centre of Insect Physiology and Ecology (ICIE) Human Health Theme Nairobi Kenya Institute for Parasitology and Tropical Veterinary Medicine Freie Universität Berlin Berlin Germany Institute for Human Development Aga Khan University Nairobi Kenya School of Veterinary Medicine and Animal Resources College of Veterinary Medicine Animal Resources and Biosecurity Makerere University Kampala Uganda Charité University Medicine Berlin Germany

Background Tungiasis,a neglected tropical parasitosis,disproportionately afects *** empirical studies have reported neurocognitive and mental health outcomes of children with ectoparasitic skin diseases like *** of tungiasis suggests it could detrimentally afect cognition and *** study pioneered the investigation of neurocognitive and mental health outcomes in children with *** This was a multi-site cross-sectional study including 454 quasi-randomly sampled school-children aged 8-14 from 48 randomly selected schools in two counties in Kenya and a district in *** participants were stratifed into infected and uninfected based on the presence of *** infected were further classifed into mild and severe infection groups based on the intensity of the ***,validated,and standardized measures of cognition and mental health such as Raven Matrices and Child Behaviour Checklist were used to collect *** tests including a multilevel,generalized mixed-efects linear models with family link set to identity were used to compare the scores of uninfected and infected children and to identify other potential risk factors for neurocognitive and behavioural *** When adjusted for covariates,mild infection was associated with lower scores in literacy[adjustedβ(aβ)=−8.9;95%confdence interval(CI)−17.2,−0.6],language(aβ=−1.7;95%CI−3.2,−0.3),cognitive fexibility(aβ=−6.1;95%CI−10.4,−1.7)and working memory(aβ=−0.3;95%CI−0.6,−0.1).Severe infection was associated with lower scores in literacy(aβ=−11.0;95%CI−19.3,−2.8),response inhibition,(aβ=−2.2;95%CI−4.2,−0.2),fne motor control(aβ=−0.7;95%CI−1.1,−0.4)and numeracy(aβ=−3;95%CI−5.5,−0.4).Conclusions This study provides frst evidence that tungiasis is associated with poor neurocognitive functioning in *** tungiasis is a chronic disease with frequent reinfections,such negative efects may potentially impair their development and l

关键词： Tungiasis Tunga penetrans Neglected tropical disease Neurocognition Mental health School-aged children Africa

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Crowdfunding Effort Identifies the Causative Mutation in a Patient with Nystagmus,Microcephaly,Dystonia and Hypomyelination

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journal of Genetics and Genomics 2015年第2期42卷 79-81页

作者： Ofer Isakov Dorit Lev Lubov Blumkin Gershon Celniker esther Leshinsky-Silver Noam Shomron Sackler School of Medicine Tel Aviv University Metabolic-Neurogenetic Clinic Wolfson Medical Center Institute of Medical Genetics Wolfson Medical Center Pediatric Neurology Unit Wolfson Medical Center Molecular Genetic Laboratory Wolfson Medical Center

Crowdfunding refers to the online gathering of finance via numerous small donations from individual supporters （the ＂crowd＂） in order to fund a service, project or cause from various fields including business, arts, medicine and science （Sisler, 2012; Cameron et al., 2013; Weigmann, 2013; Wheat et al., 2013）. Crowdfunding platforms facilitate the interaction between organizations soliciting funding for their projects and the people who wish to support them. As prices of molecular testing plummet, utilizing crowdfunding in order to support genetic research becomes increasingly feasible （Cameron et al., 2013）. Whole Exome Sequencing （WES） has been used extensively for the purpose of identifying the genetic cause of rare mendelian diseases, uncovering novel mutations in previously implicated genes or identifying new disease- causing genes （Ng et al., 2009; Bamshad et al., 2011; Gilissen et al., 2011）.

关键词： PHENOTYPE EXPANSION SPECTRUM

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High prevalence of viable Mycobacterium avium subspecies paratuberculosis in Crohn's disease

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World journal of Gastroenterology 2010年第36期16卷 4558-4563页

作者： juan L Mendoza Amparo San-Pedro esther Culebras Raquel Cíes Carlos Taxonera Raquel Lana Elena Urcelay Fernando de la Torre juan j Picazo Manuel Díaz-Rubio Department of Gastroenterology Hospital Clinico San Carlos28040 MadridSpain Department of Clinical Microbiology Hospital Clinico San Carlos28040 MadridSpain Department of Internal Medicine Hospital Clinico San Carlos28040 MadridSpain Department of Immunology Hospital Clinico San Carlos28040 MadridSpain

AIM:To examine the detection rate of viable Mycobacterium avium subspecies paratuberculosis(MAP) in patients with inflammatory bowel disease [Crohn's disease(CD) and ulcerative colitis(UC)].METHODS:Thirty patients with CD(15 with at least one NOD2/CARD15 mutation),29 with UC,and 10 with no inflammatory bowel disease(IBD).were tested for MAP by polymerase chain reaction(specific IS900 fragment) and blood ***:MAP DNA was detected in all original blood samples and 8-wk blood cultures(CD,UC and non-IBD).Positive MAP DNA status was confirmed by dot blot *** 69 cultures were negative by acid-fast Ziehl-Neelsen *** MAP,in spheroplast form,was isolated from the 18-mo blood cultures of all 30 CD patients,one UC patient,and none of the non-IBD *** association was found between positive MAP cultures and use of immunosuppressive drugs or CDassociated single nucleotide ***:MAP is widely present in our area and MAP DNA can be recovered from the blood of CD,UC and non-IBD ***,MAP spheroplasts were only found in CD patients.

关键词： Mycobacterium avium subspecies paratuberculosis Crohn’s disease Ulcerative colitis Inflammatory bowel disease Polymerase chain reaction Genetic susceptibility

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Electrospinning as a route to advanced carbon fibre materials for selected low-temperature electrochemical devices:A review

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journal of Energy Chemistry 2021年第8期30卷 492-529,I0011页

作者： Yue Wen Matt D.R.kok jorge Pavel Victoria Tafoya Ana Bjorge Sobrido Ellsworth Bell jeff T.Gostick Servann Herou Philipp Schlee Maria-Magdalena Titirici Dan j.L.Brett Paul R.Shearing Rhodri jervis The Electrochemical Innovation Lab Dept.of Chemical EngineeringUniversity College LondonTorrington PlaceWC1E 7JE LondonUK Queen Mary University of London School of Engineering and Materials ScienceMile End RoadE14NS LondonUK Department of Chemical Engineering University of WaterlooWaterlooCanada Department of Chemical Engineering Imperial College LondonSouth Kensington CampusSW72AZ LondonUK

Electrospinning has been proven as a highly versatile fabrication method for producing nano-structured fibres with controllable morphology,of both the fibres themselves and the void structure of the ***,it is possible to use heteroatom doped polymers or to include catalytic precursors in the electrospinning solution to control the surface properties of the *** factors make it an ideal method for the production of electrodes and flow media for a variety of electrochemical devices,enabling reduction in mass transport and activation overpotentials and therefore increasing ***,the use of biomass as a polymer source has recently gained attention for the ability to embed sustainable principles in the materials of electrochemical devices,complementing their ability to allow an increase in the use of renewable electricity via their *** this review,the historical and recent developments of electrospun materials for application in redox flow batteries,fuel cells,metal air batteries and supercapacitors are thoroughly reviewed,including an overview of the electrospinning process and a guide to best ***,we provide an outlook for the emerging use of this process in the field of electrochemical energy devices with the hope that the combination of tailored microstructure,surface functionality and computer modelling will herald a new era of bespoke functional materials that can significantly improve the performance of the devices in which they are used.

关键词： Electrospinning Redox flow batteries Fuel cells Metal-air batteries Supercapacitors

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Skin tissue engineering advances in severe burns:review and therapeutic applications

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Burns & Trauma 2016年第1期4卷 13-26页

作者： Alvin Wen Choong Chua Yik Cheong Khoo Bien Keem Tan kok Chai Tan Chee Liam Foo Si jack Chong Singapore General Hospital Department of PlasticReconstructive andAesthetic Surgery20 College RoadAcademia Level 4Singapore 169845Singapore. Singapore General Hospital Skin Bank UnitBlock 4 Level 3Room 15Outram RoadSingapore 169608Singapore. Transplant TissueCentre c/o Skin Bank UnitSingapore General HospitalBlock 4 Level 3 RoomA7Outram RoadSingapore 169608Singapore. Singapore General Hospital Skin Bank UnitBlock 4 Level 3Room 15Outram RoadSingapore 169608Singapore. Transplant TissueCentre c/o Skin Bank UnitSingapore General HospitalBlock 4 Level 3 RoomA7Outram RoadSingapore 169608Singapore. Singapore General Hospital Department of PlasticReconstructive andAesthetic Surgery20 College RoadAcademia Level 4Singapore 169845Singapore. Singapore General Hospital Skin Bank UnitBlock 4 Level 3Room 15Outram RoadSingapore 169608Singapore.

Current advances in basic stem cell research and tissue engineering augur well for the development of improved cultured skin tissue substitutes:a class of products that is still fraught with limitations for clinical *** the ability to grow autologous keratinocytes in-vitro from a small skin biopsy into sheets of stratified epithelium(within 3 to 4 weeks)helped alleviate the problem of insufficient donor site for extensive burn,many burn units still have to grapple with insufficient skin allografts which are used as intermediate wound coverage after burn *** offered by tissue-engineered skin dermal replacements to meet emergency demand have been used fairly *** the availability of these commercial products,they all suffer from the same problems of extremely high cost,sub-normal skin microstructure and inconsistent engraftment,especially in full thickness *** practice for severe burn treatment has since evolved to incorporate these tissue-engineered skin substitutes,usually as an adjunct to speed up epithelization for wound closure and/or to improve quality of life by improving the functional and cosmetic results *** review seeks to bring the reader through the beginnings of skin tissue engineering,the utilization of some of the key products developed for the treatment of severe burns and the hope of harnessing stem cells to improve on current practice.

关键词： Burns Skin tissue engineering Stem cells Cultured epithelial autografts Dermal substitutes Microskin grafting

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Immunoexpression of cyclooxygenase-2 in primary gastric carcinomas and lymph node metastases

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World journal of Gastroenterology 2012年第8期18卷 778-784页

作者： Paulo RC Almeida Francisco VA Ferreira Cássio C Santos Francisco D Rocha-Filho Raul RP Feitosa esther AA Falco Belise K Cavada Roberto CP Lima-júnior Ronaldo A Ribeiro Faculty of Medicine Federal University of Ceará Hospital of Cancer Cancer Institute of Ceará

AIM: To evaluate immunoexpression of cyclooxygenase-2 (COX-2) in primary gastric carcinomas and respective lymph node metastases. METHODS: Immunohistochemistry to analyze COX-2 expression was performed on tissue microarray slices obtained from 36 specimens of gastrectomy and satellite lymph nodes from patients with gastric carcinoma. RESULTS: Immunostaining was seen in most cases, and COX-2 expression was higher in lymph node me-tastases than in corresponding primary gastric tumors of intestinal, diffuse and mixed carcinomas, with a statistically signif icant difference in the diffuse histotype (P = 0.0108). CONCLUSION: COX-2 immunoexpression occurs frequently in primary gastric carcinomas, but higher expression of this enzyme is observed in lymph node metastases of the diffuse histotype.

关键词：环氧合酶-2 淋巴结原发性胃癌 COX-2 组织学芯片技术免疫组化

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