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Modulation of the in vitro Oxidative Stress and Erythrocyte Cell Membrane Integrity Using Aqueous, Hydroethanolic and Ethanolic Stem-Barks Extracts of Greenwayodendron suaveolens (Engl. & Diels) Verdc

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Pharmacology & Pharmacy 2024年第3期15卷 39-61页

作者： Patrick Hervé Diboue Betote Moustapha Gambo Abdoulaye Francis Ngolsou esther del florence ndedi moni Adeline Sabine Fanta Yadang Fidel Castro Lah Weyepe Gabriel A. Agbor Nga Nnanga Maximilienne Ascension Nyegue Laboratory of Pharmacology and Drugs Discovery Centre for Research on Medicinal Plants and Traditional Medicine Institute of Medical Research and Medicinal Plants Studies Yaoundé Cameroon Laboratory of Microbiology Department of Microbiology Faculty of Science University of Yaoundé I Yaoundé Cameroon Multidisciplinary Laboratory Department of Galenical Pharmacy and Pharmaceutical Law Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Department of Physicochemical and Pharmaceutical Sciences Faculty of Health Sciences Abdou Moumouni University Niamey Niger Department of Pharmaceutical and Biological Sciences Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Laboratory of Pharmaceutical Technology Centre for Research on Medicinal Plants and Traditional Medicine Institute of Medical Research and Medicinal Plants Studies Yaoundé Cameroon

Pneumonia, a respiratory infection induces acute or chronic inflammation, characterized by increased activity of lymphocytes and neutrophils, thus generating oxygen-free radicals that decrease the endogenous antioxidants defence system. The aim of this experimental study focused on the capacity of nontoxic aqueous, hydroethanolic and ethanolic extracts of Greenwayodendron suaveolens (Engl. & Diels) Verdc. subsp. suaveolens to regulate free reactive species and protein inflammation generated by infectious disease. The phytochemical screenings of G. suaveolens extracts were carried out according to precipitation and colorimetric methods. The total antioxidant and flavonoid contents were determined by the Folin-Ciocalteu and Aluminium Chloride ethanolic methods. The efficiency of G. suaveolens extracts on free radicals was evaluated using DPPH•, ABTS+•, and FRAP methods. The anti-inflammatory properties of extracts were evaluated according to in vitro protein (BSA) denaturation, Proteinase Inhibitory Action, and Red Blood Cell Membrane stabilization assays. The G. suaveolens aqueous, hydroethanolic and ethanolic extracts were used for the acute toxicity assessment according to the OECD protocol. The obtained results showed the presence of flavonoids, phenols, polyphenols, tannins, anthocyanins, alkaloids, terpenoids, and sterols as secondary metabolites families in G. suaveolens extracts. The highest contents of total antioxidants and flavonoids were highlighted in the hydroethanolic extract. However, it’s the G. suaveolens aqueous extract that showed the best free radical DPPH• and ABTS+• scavenging activities (SC50) of 11.06 μg/mL and 15.16 μg/mL respectively. The highest ferric-reducing activity was found in G. suaveolens ethanolic extract with 866.23 μg EGA/mg of dry weight. The hydroethanolic extract has shown a high anti-inflammatory activity through BSA denaturation and erythrocyte membrane haemolysis with i

关键词： Greenwayodendron suaveolens Secondary Metabolites Oxidative Stress Antioxidant Activity Anti-Inflammatory Properties and Oral Acute Toxicity

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INF-γ and IL-2 Profile as Therapeutic Markers in Tuberculosis Patients at the Jamot Hospital of Yaounde-Cameroon

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Journal of Tuberculosis Research 2024年第2期12卷 119-128页

作者： Alexandra Emmanuelle Membangbi Jacky Njiki-Bikoï esther del-florence moni ndedi Donatien Serge Mbaga Elsa Nguiffo Makue André Chris Mikangue Mbongue Koko-Ta Ladiff Sharonne Martha Mesembe Justin Olivier Essindi Aïcha Ngoutane Arnaud Franck Elang Sabine Aimée Touangnou-Chamda George Ikomey Mondinde Eric Walter Perfura-Yone Marie Joseph Nkodo Mindimi Sara Honorine Riwom Essama Department of Microbiology The University of Yaound 1 Yaound Cameroon Center for the Study and Control of Communicable Diseases (CSCCD) Yaound Cameroon The Institute for Medical Research and Medicinal Plants Studies Yaound Cameroon Faculty of Medicine and Biomedical Sciences The University of Yaound I Yaound Cameroon The Pneumology Department Jamot Hospital of Yaound Yaound Cameroon

Background: Tuberculosis (TB) is one of the top lethal infectious diseases worldwide. In recent years, interferon-γ (INF-γ) release assays (IGRAs) have been established as routine tests for diagnosing TB infection. However, produced INF-γ assessment cannot permit to distinguish active ATB from latent TB infection (LTBI), especially in TB epidemic areas. In addition to IFN-γ, interleukin-2 (IL-2), secreted by activated T cells, is involved in immune response against Mycobacterium tuberculosis. This could be involved in the follow up of treatment response. The aim of our study was to determine IFN-γ and IL2 cytokines profiles of patients under antituberculosis treatment. Materials and Methods: A six months’ cross-sectional study was conducted at the Jamot Hospital of Yaoundé, from May to August 2021. Sociodemographic and clinical data as well as 5 mL of blood were collected from each participant. INF-γ and IL-2 were determined using indirect Enzyme linked Immuno-Sorbent Assay (ELISA) according to the manufacturer’s recommendations and spectrum exam in combination with radiography and GeneXpert were used as standard. P-values Results: The results showed that men were more infected 14/61 (31.8%) with a high presence in active and resistant TB groups. The mean age was 41.3 ± 13.1 years with a 95% CI = [38.2 - 44.7], the age group with the highest infection rate was ranged between 31 and 40 years. The IL-2 and INF-γ means were respectively 327.6 ± 160.6 pg/mL and 26.6 ± 13.0 pg/mL in ATB patients, 251.1 ± 30.9 pg/mL and 21.4 ± 9.2 pg/mL in patients with resistant tuberculosis, while it was 149.3 ± 93.3 pg/mL and 17.9 ± 9.4 pg/mL in cured patients, 15.1 ± 8.4 pg/mL and 5.3 ± 2.6 pg/mL in participants presumed healthy (p γ and IL-2rates were observed between the different groups. Conclusion: monitoring the serum levels of INF-γ and IL-2 would be useful for the follow-up of anti-tuberculosis patients, particularly in the both cytokines association case.

关键词： Tuberculosis Antituberculosis Treatment INF-γ IL-2 ELISA

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Effect of E × B electron drift and plasma discharge in dc magnetron sputtering plasma

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Chinese Physics B 2011年第1期20卷 435-443页

作者： Sankar moni Borah Arup Ratan Pal Heremba Bailung Joyanti Chutia Plasma Physics Laboratory Material Sciences DivisionInstitute of Advanced Study in Science and TechnologyPaschim BoragaonGuwahati - 781035AssamIndia

Study of electron drift velocity caused by E ×B motion is done with the help of a Mach probe in a dc cylindrical magnetron sputtering system at different plasma discharge parameters like discharge voltage, gas pressure and applied magnetic field strength. The interplay of the electron drift with the different discharge parameters has been investi- gated. Strong radial variation of the electron drift velocity is observed and is found to be maximum near the cathode and it decreases slowly with the increase of radial distance from the cathode. The sheath electric field, E measured experimentally from potential profile curve using an emissive probe is contributed to the observed radial variation of the electron drift velocity. The measured values of the drift velocities are also compared with the values from the con- ventionM theory using the experimental values of electric and magnetic fields. This study of the drift velocity variation is helpful in providing a useful insight for determining the discharge conditions and parameters for sputter deposition of thin film.

关键词： electron drift velocity Mach probe cylindrical magnetron sputtering

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Diversity-oriented synthesis of blue emissive nitrogen heterocycles and their conjugation with carbon nano-onions

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Frontiers of Chemical Science and Engineering 2020年第1期14卷 76-89页

作者： Viviana Maffeis Lisa moni Daniele Di Stefano Silvia Giordani Renata Riva Nano Carbon Materials Istituto Italiano di Tecnologia(IIT)10144 TorinoItaly Department of Chemistry and Industrial Chemistry University of Genova16146 GenovaItaly School of Chemical Sciences Dublin City UniversityDublin 9Ireland Department of Pharmacy University of Genova16147 GenovaItaly

The search for new fluorescent molecules for possible applications as functional p-electron systems and their conjugation with different nanomaterials is nowadays of paramount importance to broaden the availability of materials with different *** we present a diversity-oriented approach to heterocyclic luminophores based on a multicomponent Ugi reaction followed by a Pd-mediated cascade *** new molecules are coupled to carbon nano-onions,and hybrid systems represent the first example of blue emitters conjugated with these carbon nanoparticles.

关键词： carbon nano-onions multicomponent reactions blue emitters fluorescence isoquinolines

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Media optimization for extracellular amylase production by Pseudomonas balearica vitps19 using response surface methodology

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Frontiers in Biology 2018年第2期13卷 123-129页

作者： moni Philip Jacob Kizhakedathil Subathra Devi Chandrasekaran Department of Biotechnology School of Biosciences and Technology VIT University Vellore -632014 Tamil Nadu India

BACKGROUND： In this study, we optimized the process for enhancing amylase production from Pseudomonas balearica VITPS 19 isolated from agricultural lands in Kolathur, India. METHODS： Process optimization for enhancing amylase production from the isolate was carried out by Response Surface Methodology （RSM） with optimized chemical and physical sources using Design expert v.7.0. A central composite design was used to evaluate the interaction between parameters. Interaction between four factors - maltose （C-source）, malt extract （N- source）, pH, and CaCl2 was studied. RESULTS： The factors pH and CaCl2 concentration were found to affect amylase production. Validation of the experiment showed a nearly twofold increase in alpha amylase production. CONCLUSION： Amylase production was thus optimized and increased yield was achieved.

关键词： Pseudomonas balearica VITPS19 alpha amylase optimization response surface methodology central composite design pH

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A Research about Human Security for Sustainable Development of Garments Industries in Bangladesh

A Research about Human Security for Sustainable Development ...

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作者： Disha moni 四川大学

学位级别：硕士

The purpose of this research is to identify the human security concerns in Bangladesh's garment *** project incorporated both quantitative as well as qualitative data were *** samples used in the study come from people who work in the garments *** simple random sampling method of 300 samples was divided into 3 groups by 3 districts Dhaka,Narayonganj,and *** tool used in the study is questionnaires for collecting data from those people who voluntarily responded to the questionnaire,reliability was tested via the Cronbach alpha method and the validity has checked the accuracy of content from qualified *** statistics,percentages,means,standard deviations,and inferential statistics are all utilized in data *** are independent variables,namely health security,economic security,and environmental security and sustainable development as dependent *** research can be classified into three *** first set of elements in this research that health security includes two observed variable namely HI&CI that influence sustainable development,and the second group of factors is economic security includes observed variable namely JS&SS,and the third group of factors about environmental security includes WP&MP,that can affect sustainable development of garments ***,WP,MP,CI,HI independent variables are statistically significant relationship with healthcare issues（HI）(t=6.964,p<0.000,Beta=0.392),workplace safety（CI）(t=3.545,p<0.000,Beta=0.180),ability to solve the environmental problem（WP）(t=3.236,p<0.001,Beta=0.152),prevention of accidents and related impact（MP）(t=2.048,p<0.041,Beta=0.100),protection against unemployment（JS）(t=2.256,p<0.025,Beta=0.089)for sustainable development（DM）.In combination,HI,CI,MP,WP,JS,and SS accounted for 58.9%of the variability in sustainable development（DM）,R2=0.589,adjusted R2=0.580,F（6,293）=69.889,p<.0001).The KMO index was *** Alpha coefficient test results

关键词： Health Security Economic Security Environmental Security Sustainable Development Garments Industry

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Arsenic Stress Responses and Tolerance in Rice: Physiological, Cellular and Molecular Approaches

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Rice science 2018年第5期25卷 235-249页

作者： Jyotirmay KALITA Amit Kumar PRADHAN Zina moni SHANDILYA Bhaben TANTI Department of Botany Gauhati University

Arsenic （As）, a potentially toxic metalloid released in the soil environment as a result of natural as well as anthropogenic processes, is subsequently taken up by crop plants. In rice grains, As has been reported in Asia, North America and Europe, suggesting a future threat to food security and crop production. As3＋ by dint of its availability, mobility and phytotoxicity, is the most harmful species of As for the rice crop. Specific transporters mediate the transport of different species of As from roots to the aboveground parts of the plant body. Accumulation of As leads to toxic reactions in plants, affecting its growth and productivity. Increase in As uptake leads to oxidative stress and production of antioxidants to counteract this stress. Cultivars tolerant to As stress are efficient in antioxidant metabolism compared to sensitive ones. Iron and selenium are found to have ameliorating effect on the oxidative stress caused by As. Microbes, even many indigenous ones, in the plant rhizosphere are also capable of utilizing As in their metabolism, both independently and in association. Some of these microbes impart tolerance to As-stress in plants grown in As contaminated sites.

关键词： arsenic rice phytotoxicity hyperaccumulator phytochelatin antioxidant mitigation

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Unravelling lncRNA mediated gene expression as potential mechanism for regulating secondary metabolism in Citrus limon

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Food Bioscience 2022年第2期46卷 703-718页

作者： Kuntala Sarma Bordoloi Pooja moni Baruah Mami Das Niraj Agarwala Department of Botany Gauhati UniversityGopinath Bordoloi NagarGuwahatiAssam781014India

Plant long non-coding RNAs(lncRNAs)are emerging as important regulators of gene expression through various mechanisms *** to double-stranded DNA(dsDNA),physically targeting mRNAs and also act as microRNA(miRNA)*** secondary metabolites and their content determine the market value of Citrus plant products for culinary and industrial *** lncRNAs are emerging as important molecular players that regulate secondary metabolites in plants but the roles of lncRNAs are yet unknown for the regulation of secondary metabolites in Citrus *** this study,a total of 11814 lncRNAs were identified from four RNA-seq datasets comprising of data from four different tissues of *** ***,bud,fruit and ***-expression analysis of whole set of genes with identified lncRNAs revealed a total of 632 lncRNAs correlating with 5810 *** annotation of genes correlating with lncRNAs unveiled the association of 379 genes with the biosynthesis of secondary metabolite pathways and among them,36 and 12 genes are from terpenoids and flavonoids metabolism/biosynthesis pathways *** correlation analysis unfolded the possible role of 113 lncRNAs in terpenoids metabolism and 29 lncRNAs in the flavonoids metabolic *** nine lncRNAs were predicted to take part in miRNA-mediated gene regulation,out of which 10 lncRNAs were predicted to act as endogenous target mimics(eTMs)for miRNAs and 74 lncRNAs were found to act as miRNA *** of six predicted lncRNAs and seven correlated genes involved in terpenoids and flavonoids metabolism were validated using semi-quantitative RT-PCR.

关键词： Citrus limon Long non-coding RNA Terpenoids Flavonoids Co-expression

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Water-soluble-template-derived nanoscale silicon nano- flake and nano-rod morphologies： Stable architectures for lithium-ion battery anodes

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Nano Research 2017年第12期10卷 4284-4297页

作者： Bharat Gattu Prashanth Hanumantha Jampani moni Kanchan Datta Ramalinga Kuruba Prashant N. Kumta Department of Chemical and Petroleum Engineering University of Pittsburgh Pittsburgh PA 1526 I USA Department of Mechanical Engineering and Materials Science University of Pittsburgh Pittsburgh PA 15261 USA Department of Bioengineering University of Pittsburgh Pittsburgh PA 1526 I USA Center for Complex Engineered Multifunctional Materials (CCEMM) University of Pittsburgh PA 15261 USA

Earth abundant and economical rock salt （NaC1） particles of different sizes （〈3 μm and 5-20 μm） prepared by high energy mechanical milling were used as water-soluble templates for generation of Si with novel nanoscale architectures via low pressure chemical vapor deposition （LPCVD）. Si nanoflakes （SiNF） comprising largely amorphous Si （a-Si） with a small volume fraction of nanocrystalline Si （nc-Si）, and Si nanorods （SiNR） composed of a larger volume fraction of crystalline Si （c-Si） and a small volume fraction of a-Si resulted from modification of the NaCI crystals. SiNF yielded first-cycle discharge and charge capacities of -2,830 and 2,175 mAh.g-1, respective134 at a current rate of 50 mA.g-1 with a first-cycle irreversible loss （FIR loss） of -15%-20%. SiNR displayed first-cycle discharge and charge capacities of -2,980 and -2,500 mAh-g-1, respectively, at a current rate of 50 mA-g-1 with an FIR loss of -12%-15%. However, at a current rate of 1 A.g-1, SiNF exhibited a stable discharge capacity of -810 mAh-g-1 at the end of 250 cycles with a fade rate of -0.11% loss per cycle, while SiNR showed a stable specific discharge capacity of -740 mAh.g-1 with a fade rate of -0.23% loss per cycle. The morphology of the nanostructures and compositions of the different phases/phase of Si influence the performance of SiNF and SINK, making them attractive anodes for lithium-ion batteries.

关键词： silicon nanoflakes nanorods water-soluble template NaC1

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Polyorogenic evolution of the Paleoproterozoic Trans-North China Belt--New insights from the Luliangshan-Hengshan-Wutaishan and Fuping massifs

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Episodes 2007年第2期30卷 96-107页

作者： Michel Faure Pierre Trap Wei Line Patrick monié Olivier Bruguier Institut des Sciences de la Terre d＇Orléans UMR-CNRS 6113 Bǎtiment Géosciences Université d＇Orléans F-45067 Orléans Cedex 2 France. State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 10029 China. 3 Géociences Montpellier cc 56 Université Montpellier 2 P1. E.-Bataillon F-34095 Montpellier Cedex France.

The Trans-North China Belt （TNCB） is a Paleoproterozoic collisional orogen （ca. 1.9-1.8 Ga） responsible for the amalgamation of the North China Craton. Detailed field works in Liiliangshan, Hengshan, Wutaishan and Fuping massifs where the belt is well exposed, allow us to draw a new tectonic map and crustal-scale cross sections. The available petrologic, radiometric, geochronologic data are integrated in a geodynamic evolution scheme for this orogen. The Low Grade Mafic Unit （LGMU） is interpreted as an ophiolitic nappe rooted in a suture zone located in the western part of the Lüliangshan. This ophiolitic nappe overthrusts to the SE upon the Orthogneiss-Volcanites Unit （OVU） that consists of a bimodal volcanic-sedimentary series metamorphosed under amphibolite facies conditions intruded by calcalkaline orthogneiss. The OVU is a composite Neoarchean-Paleoproterozoic magmatic arc developed during two stages （ca. 2500 and 2100 Ma） upon a continental basement corresponding to the western extension of the Neoarchean Fuping massif The OVU overthrusts to the SE the Fuping massif along the Longquanguan shear zone. This stack of nappes, coeval with an amphibolite facies metamorphism, is dated at ca. 1880 Ma. Subsequently, the metamorphic series experienced a widespread migmatization at 1850 Ma and was intruded by post-orogenic plutons dated at 1800 Ma. The weakly to unmetamorphosed Hutuo Supergroup unconformably overlies the metamorphosed and ductilely deformed units （OVU and LGMU）, but it is also involved in a second tectonic phase developed in subsurface conditions. These structural features lead us to question the ca. 2090 Ma age attributed to the Hutuo supergroup. Moreover, in the Fuping massif several structural and magmatic lines of evidence argue for an earlier orogenic event at ca. 2100 Ma that we relate to an older west-directed subduction below the Fuping Block. The Taihangshan Fault might be the location of a possible suture zone between the Fuping Block and an ea

关键词：进化方式中国山丘地块

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