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Factors Affecting Treatment Interruption among TB Patients in Lagos Nigeria: Is There Any Need for Treatment Supporters?

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International Journal of Clinical Medicine 2016年第6期7卷 389-398页

作者： Olusola Adedeji adejumo Olusoji James Daniel Andrew Folarin Otesanya Temitope Ashipa esther ngozi adejumo Husseine A. Abdur-Razzaq Department of Community Health and Primary Health Care Lagos State University Teaching Hospital Ikeja Lagos Nigeria Department of Community Medicine and Primary Care Olabisi Onabanjo University Teaching Hospital Sagamu Ogun State Nigeria Medical Services Department Central Bank of Nigeria Lagos Nigeria Department of Community Medicine Babcock University Teaching Hospital Ilishan-Remo Ogun State Nigeria Department of Medical Laboratory Science Babcock University Ilisan-Remo Ogun State Nigeria Lagos State TB and Leprosy Control Programme Lagos State Ministry of Health Alausa Ikeja Lagos Nigeria

Background: This study assessed treatment interruption of tuberculosis (TB) patients managed by treatment supporters and health care workers and other predictors of treatment interruption. Methods: A descriptive cross-sectional study was conducted. Four hundred and seventy new smear positive TB patients above 14 years of age were consecutively recruited between October 1 and December 31 2012 from 34 (23 public and 11 private) directly observed treatment short course (DOTS) facilities that offered TB treatment and microscopy services. They were followed up till treatment was completed. Logistic regression was used to assess the predictors of treatment interruption. Results: A significantly higher proportion of smokers (58.6% vs 38.3%, p = 0.030), patients supervised by treatment supporters (44.4% vs 34.7%, p = 0.032), patients not counselled before initiation of treatment (55.6% vs 38.2%, p = 0.041), patients managed at private DOTS facilities (50% vs 36.3%, p = 0.010) and TB/HIV co-infected patients (54.2% vs 38.6%, p = 0.038) had treatment interruption. Predictors of treatment interruption were supervision by treatment supporters, smoking, lack of pre-treatment counselling and TB/HIV co-infection. Conclusion: A higher proportion of patients supervised by treatment supporters had treatment interruption than those supervised by health care workers. There may be a need to review the concept of treatment supervision by treatment supporters in Lagos state Nigeria.

关键词： Treatment Supporter Treatment Interruption Tuberculosis DOTS Nigeria

Are Tuberculosis Patients Managed According to the National Guidelines in Lagos State Nigeria?

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International Journal of Clinical Medicine 2016年第1期7卷 16-24页

作者： Olusola Adedeji adejumo Olusoji James Daniel Mustapha Gidado Andrew Folarin Otesanya esther ngozi adejumo Ebunoluwa O. Jaiyesimi Oluwatoyin esther Idowu Olumuyiwa O. Odusanya Department of Community Health and Primary Health Care Lagos State University Teaching Hospital Ikeja Lagos Nigeria Department of Community Medicine and Primary Care Olabisi Onabanjo University Teaching Hospital Sagamu Nigeria KNCV Tuberculosis Foundation/TB CARE I Project Abuja Nigeria Medical Services Department Central Bank of Nigeria Lagos Nigeria Department of Medical Laboratory Science Babcock University Ilisan-Remo Nigeria Department of Community Health and Primary Health Care College of Medicine Lagos Lagos State University Lagos Nigeria

Setting: Private and public tuberculosis (TB) treatment centers in Lagos State, Nigeria. Objective: To compare adherence of private and public providers of directly observed treatment short course (DOTS) in the Lagos State TB control program, Nigeria (LSTBLCP) with the national TB guidelines. Design: A retrospective review of treatment cards of TB patients managed within the first and second quarter of 2012 in 34 DOTS facilities {23 public, 7 private for profit (PFP), and 4 private not for profit (PNFP)} involved in the private public mix of the LSTBLCP. Results: Of the 1896 treatment cards reviewed, 1524 (80.4%), 132 (7.0%) and 240 (12.6%) were from public, PFP and PNFP DOTS facilities, respectively. About 19%, 25% and none of the patients managed at the public, PNFP, and PFP DOTS facilities were treated in full adherence with the national guidelines respectively. A significantly higher proportion of adults and sputum smear positive TB patients were treated in full adherence with the national guidelines (p < 0.05). Treatment success was associated with full adherence with the national guidelines. Conclusion: There is a need to reorient health care providers in public and private health facilities in Lagos State Nigeria to ensure full adherence with the national TB guidelines.

关键词： Adherence National Guidelines Health Workers DOTS Facilities

Empowering women to combat osteoporosis:unveiling the causes,consequences,and control strategies

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Aging Communications 2023年第3期5卷 8-17页

作者： Seyi Samson Enitan Babatunde Ishola Gabriel adejumo esther ngozi adejumo Temitope Oyewole Olusanya Eguagie Osareniro Osakue Oluwakemi Anike Ladipo Comfort Bosede Enitan Department of Medical Laboratory Science Babcock UniversityIlishan-Remo 121103Nigeria Department of Medical Laboratory Science University of BeninBenin City 300213Nigeria Department of Chemical Pathology Babcock University Teaching HospitalIlishan-Remo 121103Nigeria

Osteoporosis is a common bone disease in women worldwide, leading to decreased bone density and an accelerated risk of fractures. The causes of osteoporosis in women include age (senile osteoporosis), menopause-associated hormonal changes, deficiencies in calcium and vitamin D, genetics, lifestyle factors, medical conditions, and some type of medications. The consequences of osteoporosis are colossal, consisting of fractures, decreased quality of life, psychological impacts, and economic burden. To effectively control the menace of osteoporosis in women, numerous strategies are advocated. Adequate calcium and vitamin D consumption through diet or supplements is vital. Regular weight-bearing activities and strength training that promote bone density. Maintaining a healthy life-style through avoiding smoking, limiting alcohol in-take and maintaining a wholesome body weight is essential. Hormone replacement therapy and some medications may be recommended in certain cases. Early detection through regular bone density and blood tests is crucial to lowering its impact. Creating a supportive network through educational programs and resources fosters awareness and empowerment. By engaging these strategies, women can be empowered to combat osteoporosis, reduce fracture risk, and build stronger bones for their overall well-being.

关键词： women aging osteoporosis causes consequences control strategies

Personalized medicine approach to osteoporosis management in women: integrating genetics, pharmacogenomics, and precision treatments

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Clinical Research Communications 2023年第3期6卷 22-29页

作者： Seyi Samson Enitan esther ngozi adejumo John Osaigbovoh Imaralu Ayodele Ademola Adelakun Oluwakemi Anike Ladipo Comfort Bosede Enitan Department of Medical Laboratory Science Babcock UniversityIlishan-Remo 121103Nigeria Department of Gynaecology and Obstetrics Babcock University Teaching HospitalIlishan-Remo 121103Nigeria Department of Chemical Pathology Babcock University Teaching HospitalIlishan-Remo 121103Nigeria

Osteoporosis has emerged as a significant health issue among postmenopausal *** this concern necessitates a multifaceted approach encompassing genetics,pharmacogenomics,bone turnover markers,lifestyle factors,concurrent medical conditions,biomarkers,and advanced imaging ***,challenges in terms of cost-effectiveness and ethical considerations do ***,the convergence of technological progress and research endeavors offers a promising *** integration of genetic testing and pharmacogenomics into clinical practice holds substantial *** integration empowers healthcare professionals to forecast treatment responses and pinpoint individuals with elevated susceptibility,thereby enabling the implementation of tailored and efficacious interventions that optimize outcomes–personalized *** the intricate nature of osteoporosis,personalized strategies stand to greatly benefit women grappling with this *** research and collaborative efforts are imperative to propel advancements within this domain,paving the way for further breakthroughs.

关键词： osteoporosis management personalized medicine pharmacogenomics women

A review of complementary and alternative medicine used in cancer care:challenges and prospects

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TMR Integrative Medicine 2023年第21期7卷 1-7页

作者： Samson Seyi Enitan Godwin Avwioro esther ngozi adejumo Oluwakemi Anike Ladipo Chinenye Alaezi Okorochi Gideon Taiwo Oluwaloye Damilola Christianah Ademola-Kemiki Department of Medical Laboratory Science Babcock UniversityIlishan-Remo 121103Nigeria Faculty of Science Delta State UniversityAbraka 330106Nigeria Department of Chemical Pathology Babcock University Teaching HospitalIlishan-Remo 121103Nigeria

Cancer is a leading cause of death globally,and most patients with cancers frequently seek for complementary and alternative medicine(CAM)to ameliorate their *** of the available CAM care include:acupuncture,aromatherapy,Ayurvedic medicinal drug,cannabis,chelation remedy,homeopathy,hypnotherapy,massage therapy,naturopathic medication,and conventional Chinese remedy amongst *** the growing use of CAM,the evidence-base for its efficacy and safety is *** challenges confronting the efficient deployment of CAM is lack of standardization and regulation;as well as the demand for more extensive studies to validate their safety and *** oncology which is the combination of CAM and conventional cancer care is likewise complicated through the potential adverse interactions between CAM options and most cancers *** article serves as a guide for healthcare providers and patients to determine how CAM can be safely integrated into the cancer care *** into account safety concerns,however,more studies need to be conducted to properly evaluate its ***,CAM can help cancer patients in achieving greater health and well-being.

关键词： alternative medicine cancer care challenges prospects

Occupational exposure to flour dust among bakery workers:prevalence,potential hazards and promising interventions

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Toxicology Advances 2023年第4期5卷 33-44页

作者： Seyi-Samson Enitan Osareniro-Eguagie Osakue esther-ngozi adejumo Temitope-Oyewole Olusanya Emmanuel-Olusegun Ileoma Comfort-Bosede Enitan Nwachi-Idume Ogbonna Department of Medical Laboratory Science Babcock University Ilishan-RemoOgun state 121103Nigeria Department of Chemical Pathology Babcock University Teaching HospitalIlishan-RemoOgun state 121103Nigeria Department of Education Medical Laboratory Science Council of NigeriaFCT-Abuja 900110Nigeria

Occupational exposure to flour dust within bakery environments presents significant health hazards to bakery *** dust,generated as a byproduct during baking,becomes airborne during the baking process,thus constituting a respiratory *** health consequences include respiratory diseases,skin irritation,allergic reactions,and potential long-term health *** indicates that a broad segment of bakery workers encounters exposure to flour dust,with specific subgroups,such as bakers and dough mixers,being particularly *** factors to this exposure encompass insufficient ventilation and a lack of *** is vital to assess exposure levels through air quality monitoring and health *** interventions encompass engineering solutions(e.g.,ventilation systems,dust extraction),administrative measures(including training and the use of personal protective equipment),and the implementation of occupational health and safety *** efforts with healthcare professionals and regulatory authorities are paramount for achieving *** studies underscore the effectiveness of such interventions,resulting in improved worker health,thus underscoring the advantages of protective *** in this endeavor include industry resistance to change,financial considerations,and issues related to *** recommendations entail further research,policy enhancements,and the involvement of industry stakeholders and labor unions in advocating for worker safety.

关键词： flour dust bakery workers occupational exposure interventions health hazards

Knowledge and Practice of Handwashing among Health Care Workers as a Measure of Covid-19 Infection Prevention in Federal Medical Centre, Asaba

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Journal of Biosciences and Medicines 2022年第9期10卷 48-59页

作者： Ezunu ngozi esther Ezunu Emmanuel Okechukwu Aigbokhaode Adesuwa Queen Agbele Theresa Okwudishu Marian ngozi Ogwuazor Phillipa Iwebelua Rosemary ngozi Ofilli Antoinette ngozi Appiah Stella Osiatuma Victor Azubuike Federal Medical Centre Asaba Nigeria Department of Public Health & Community Medicine University of Benin Teaching Hospital Benin City Nigeria Valley View University Accra Ghana

Background: COVID-19 is a respiratory tract infection which is responsible for the recent Pandemic with its socioeconomic and Health consequences. One way to control the spread of the disease is through hand hygiene. This study was done to examine the knowledge and practice of hand washing to limit COVID-19. Method: An institutional-based, cross-sectional study carried out among 247 Health care workers using systemic sampling. A standardized questionnaire used in a previous study was used to collect data. SPSS version 25 was used for data analysis. Statistical significance was set at 0.05. Results: Health care workers had good knowledge (92.0%) and practice (99.0%) of hand washing, respondent’s profession (chi-square value = 618, p value = 0.001), and Gender (chi-square = 5234, p-value = 0.022) were statistically significant. Conclusion: Knowledge and practice of hand-washing were generally good in Federal Medical Centre Asaba. However, conscious and targeted efforts should be maintained by hospital organizations in organizing regular training on Infection, Prevention. They should also make available running water and consumables for hand-washing exercises.

关键词： Asaba Hand-Washing Healthcare-Workers Knowledge Practice

Sociodemographic Factors for Vitamin D Levels in Children with Acute Respiratory Infection

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Open Journal of Pediatrics 2021年第4期11卷 759-769页

作者： esther ngozi Umeadi Sylvia Tochukwu Echendu Chinyelu Uchenna Ufoaroh Ernest Ndukaife Anyabolu Ezinne Ifeyinwa Nwaneli Wilson Chukwuneke Igwe Chijioke E. Ezeudu Ekene Agatha Emeka Joy Chinelo Ebenebe Ifeoma Egbuonu Department of Pediatrics Nnamdi Azikiwe University Nnewi Nigeria Department of Medicine Nnamdi Azikiwe University Nnewi Nigeria Department of Medicine Chukwuemeka Odumegwu Ojukwu University Awka Nigeria

Background and Objectives: Childhood acute respiratory infection is a public health problem with significant morbidity and mortality in developing countries. The present study was to assess the sociodemographic determinants of vitamin D levels in patient with acute respiratory infections (ARIs) receiving care in Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Southeast Nigeria. Methodology: This was a cross-sectional study, conducted in Nnewi, Nigeria, on 250 children with ARI. Sociodemographic data were collected and serum vitamin D levels of the subjects were assayed. The association between sociodemographic variables and vitamin D was evaluated using multivariate logistic regression analysis. Results: A total of 250 children with ARI aged 1 - 59 months were enrolled in this study, with slight male preponderance (57.2%). About 60% of the population was less than 2 years. The majority (85.6%) of the subjects had adequate vitamin D levels (≥20 ng/dL). The mean serum vitamin D level in the subjects was (52.2 ± 25.6 ng/mL). Multivariate logistic regression showed that only gender was significantly related to vitamin D levels with males found to have a lower risk of vitamin D deficiency. {OR = 0.05

关键词： Vitamin D Deficiency Under-Five Children Acute Respiratory Infection Gender

Outcome of Symptom-Based RT-PCR Testing for SARS-CoV-2: Experience from a Large Public Testing Centre in Nigeria

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Advances in Infectious Diseases 2022年第4期12卷 799-812页

作者： Aigbe Gregory Ohihoin Kazeem Adewale Osuolale Patrick Azuka Okwuraiwe Adesola Zaidat Musa Ayorinde Babatunde James Chika Kingsley Onwuamah Olufemi Samuel Amoo Joseph Ojonugwa Shaibu Fehintola Ige esther ngozi Ohihoin Emelda Chukwu ngozi Mirabel Otuonye Tajudeen Bamidele Adeola Olukosi Olusola Ajibaye Yekeen Raheem David Oladele Agatha Nkiru David Babatunde Adewale Rosemary Audu Oliver Ezechi Nkiruka Nnonyelum Odunukwe Richard Adegbola Babatunde Lawal Salako Clinical Sciences Department Nigerian Institute of Medical Research Yaba Lagos Grants and M/E Unit (Biostatistics) Nigerian Institute of Medical Research Yaba Lagos Centre for Human Virology and Genomics Microbiology Department Nigerian Institute of Medical Research Yaba Lagos Department of Biochemistry and Nutrition Nigerian Institute of Medical Research Yaba Lagos Centre of Infectious Disease Research Microbiology Department Nigerian Institute of Medical Research Yaba Lagos Central Research Laboratory Nigerian Institute of Medical Research Yaba Lagos Department of Molecular Biology and Biotechnology Nigerian Institute of Medical Research Yaba Lagos Clinical Diagnostic Laboratory Nigerian Institute of Medical Research Yaba Lagos Department of Public Health Nigerian Institute of Medical Research Yaba Lagos

Background: Access to testing for SARS-CoV-2 in Nigeria is still highly restricted. Only patients who are symptomatic for SARS-CoV-2 are selected for testing. This pattern of testing will miss a large proportion of individuals with the infection who are asymptomatic and presymptomatic. This study reports the experience of a symptom-based study from a large testing centre in Nigeria. Methods: A cross-sectional study, reviewing data collected from respondents presenting at the Nigerian Institute of Medical Research (NIMR) modified drive-through center for COVID-19 test between the period March 31st and August 31st, 2020 were included in the analysis. Results: A total of 9891 participants were recruited into the study and 2465 participants (24.9%) had a positive PCR result for SARS-CoV-2. The majority of the respondents were above 18 years old, n = 9163 (93.4%). The average age of the respondents was 36.7 years (sd 13.8 years). The age of the participants has a significant effect on SARS-CoV-2 status (AOR = 1.009, CI, 1.005 to 1.012, p = 0.0001). There was a male preponderance, n = 5652 (57.6%). The odds of having a positive status for SARS-CoV-2 were 0.9 times lower for female participants. The majority of the respondents had a history of travel, n = 6788 (68.6%). Cough was the commonest symptom, n = 1062 (10.7%) followed by fever, n = 979 (9.9%). The mortality rate was 0.1%. Among the participants with comorbidity, 31 (51.7%) had positive results for SARS-CoV-2 while 29 (48.3%) had negative results. Conclusion: Symptom-based approach to testing for SARS-CoV-2 in Nigeria revealed a high positivity rate, while mortality from those tested in the study is low. Age and gender appear to play a significant role in the dynamics of the disease.

关键词： SARS-CoV-2 COVID-19 Symptoms RT-PCR Nigeria