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Update on the treatment of focal segmental glomerulosclerosis in renal transplantation

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World Journal of Transplantation 2016年第1期6卷 54-68页

作者： Maria Messina ester Gallo Alberto Mella Fabiola Pagani Luigi Biancone Renal Transplantation Center "A. Vercellone" Division of Nephrology Dialysis and Transplantation Department of Medical Sciences Città della Salute e della Scienza Hospital and University of Turin

Focal segmental glomerulosclerosis(FSGS) represents one of the most severe glomerular diseases, with frequent progression to end-stage renal disease and a high rate of recurrence in renal allografts(30%-50%). Recurrent FSGS portends a negative outcome, with the hazard ratio of graft failure being two-fold higher then that of other glomerulonephritis. Two patterns of clinical presentations are observed: Early recurrence, which is characterized by massive proteinuria within hours to days after implantation of the renal graft, and late recurrence, which occurs several months or years after the transplantation. Many clinical conditions have been recognized as risk factors for recurrence, including younger age, rapid progression of the disease to end-stage renal disease on native kidneys, and loss of previous renal allografts due to recurrence. However, much less is known about the incidence and risk factors of the so-called "de novo " type of FSGS, for which sufferers are transplanted patients without disease on native kidneys; but, rapid development of allograft failure is frequently observed. Management of both forms is challenging, and none of the approaches proposed to date have been demonstrated as consistently beneficial or effective. In the present review we report an update on the available therapeutic strategies for FSGS in renal transplantation within the context of a critical overview of the current literature.

关键词： Focal segmental glomerulosclerosis Kidney transplantation Permeability factors Plasma exchange Rituximab

Small intestinal bacterial overgrowth in inactive Crohn's disease:Influence of thiopurine and biological treatment

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World Journal of Gastroenterology 2014年第38期20卷 13999-14003页

作者： Cristina Sánchez-Montes Vicente Ortiz Guillermo Bastida ester Rodríguez María Yago Belén Beltrán Mariam Aguas Marisa Iborra Vicente Garrigues Julio Ponce Pilar Nos Gastroenterology Unit Hospital Universitari i Politécnic La Fe

AIM: To investigate the influence of thiopurines and biological drugs on the presence of small intestinal bacterial overgrowth (SIBO) in patients with inactive Crohn’s disease (CD).

关键词： Crohn’ s disease Bacterial overgrowth Thiopurines Biologics Inflammatory bowel disease

Intracameral 5-fluorouracil and viscous dispersive viscoelastic for diffuse epithelial downgrowth management in aphakia

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International Journal of Ophthalmology(English edition) 2020年第5期13卷 845-847页

作者： Santiago Montolío-Marzo ester Fernández-López Jose Vicente Piá-Ludena Juan María Davó-Cabrera Enrique Antonio Alfonso-Munoz Cristina Peris-Martínez FISABIO Oftalmología Médica Valencia 46015Spain

Dear Editor,I am *** Montolío-Marzo from FISABIO Oftalmología Médica,Valencia,Spain.I write you to present a case report of epithelial downgrowth in an aphakic *** epithelial downgrowth is one of the most feared complications in cases of penetrating ocular trauma or recurrent ocular *** progress can affect all the ocular structures,giving rise to corneal decompensation,retinal detachment,difficult-to-treat glaucoma or phthisis bulbi and many cases end in enucleation[1].Fortunately,the incidence of this condition is very low,there being between 0.08%and 0.12%after cataract surgery and 0.25%after penetrating *** infrequency means that scientific evidence is reduced to case series and the opinions of experts without there being a homogeneous criterion to guide the work of the doctor in *** these reasons,epithelial downgrowth is still a diagnostic and therapeutic challenge.

关键词： viscoelastic viscous camera

清迈宁曼路不止眼前的小清新,还有汤粉、沙律和烤香肠

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美食 2017年第8期 68-75页

作者： ester Yang

宁曼路(Nimmana Haeminda Road)是清迈的小清新代表,从主道延伸出的巷弄,聚集了各种餐厅、酒吧、咖啡厅、酒店和商铺。主干道充斥着专攻游客的店铺,但转进小巷,慢慢走,细细看,喝杯咖啡,吃吃路边摊,才能发现它的好,而不是被所谓的"小清新... 详细信息

宁曼路(Nimmana Haeminda Road)是清迈的小清新代表,从主道延伸出的巷弄,聚集了各种餐厅、酒吧、咖啡厅、酒店和商铺。主干道充斥着专攻游客的店铺,但转进小巷,慢慢走,细细看,喝杯咖啡,吃吃路边摊,才能发现它的好,而不是被所谓的"小清新"蒙蔽。假如在清迈只能喝一杯咖啡,选它!Ristr8to

关键词：烤香肠三文治小清新

Analysis of Global DNA Methylation in Irradiated Fig Selections

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American Journal of Plant Sciences 2015年第14期6卷 2257-2262页

作者： Maria Gabriela Fontanetti Rodrigues Murilo Racy Soares ester Silveira Ramos Silvana Giuliatti Departament do Genetics at the University of Sao Paulo Medical School University of S&atilde o Paulo Ribeir&atilde o Preto Brazil

Fruits from fig tree (Ficus carica L.) are economically important worldwide, and rank among the top 20 fruits exported by Brazil. However, due to particular features in its floral structure, classical plant breeding procedures that involve hybridization are not possible. Thus, genetic improvement of figs by using mutagens is an important line of research. In this study, five fig selections based on their interesting agronomic features were used. Genetic modifications associated with mutations were not detected by molecular markers. Therefore, it was suggested that certain phenotypes could have resulted from epigenetic modifications. The best characterized epigenetic modification is DNA methylation, which can switch genes on or off by acting as a signal. After epigenetic polymorphisms were identified by methylation sensitive amplified polymorphism (MSAP) molecular markers, we quantified the level of DNA methylation in fig selections irradiated with gamma rays and compared it to levels in the commercial cultivar “Roxo-de-Valinhos.” This was achieved by analyzing the global methylation using an Imprint Methylated DNA Quantification kit. The results showed that there were significant differences in global methylation following different treatments, indicating that irradiation was an abiotic factor that could alter the epigenome of plants. Since the material used as a control was also found to be methylated, demethylation of the polymorphic genomic material might account for the phenotypic variations observed among different treatment groups. These results suggest that irradiation is an external factor that is capable of altering epigenetic patterns.

关键词： Epigenetics Methylation Mutagenic Ficus carica

Using a Membrane Reactor for Sucrose Hydrolysis： The Effect of Reactor＇s Design on Invertase Stability

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Journal of Environmental Science and Engineering(A) 2013年第9期2卷 582-592页

作者： Francesco di Addezio ester Junko Yoriyaz Laura Cantarella Maria Cantarella Michele Vitolo Department of lndustrial and lnformation Engineering and Economics University of L 'Aquila L 'Aquila 67100 Italy Department of Biochemical and Pharmaceutical Technology University of Sao Paulo S6o Paulo 05508900 Brazil Department of Civil and Mechanical Engineering University of Cassino and of Lazio Meridionale Cassino 03043 Italy

Invertase hydrolyses sucrose, produces inverted sugar syrup, which is used, mainly, as a food composition in industries. To carry out the hydrolysis properly, the invertase should be stable in the soluble form through a considerable reaction period and recovered afterwards. The chosen reactor was a CSTR-type （continuous stirred tank reactor-type） coupled with an UFM （ultrafiltration-membrane）, the so-called MR （membrane reactor）. The varied parameters were： sucrose concentration （10-300 mM）, temperature （5-65 ℃）, reaction volume （14 mL and 65 mL）, stirring （100-500 rpm）, volumetric feeding rate （2.2-12 mL/h） and UFM MWCO （molecular weight cut off）（10, 20, 30, 50 and 100 kDa）. The invertase kinetic constants （KM = 23.5 mM; Vmax = 2,758 μmolgluJmin-mgprot; Ea = 9.1 kcal/mol） and the temperature deactivation energy （Ead= 20 kcal/mol） were calculated. Moreover, the invertase was unstable as the MR capacity diminished and the agitation increased up to 500 rpm most likely due to the damaging effect of shearing forces （present inside the MR） on the invertase molecule. Finally, both the MWCO and the chemical nature of the UFM affected the invertase stability along the hydrolysis. The enzyme stability increased as the UFM cut-off decreased, the highest value being observed with the 10 kDa-UFM.

关键词： Invertase sucrose membrane reactor.

Chemotherapy-induced neurotoxicity in the treatment of gynecological cancers:State of art and an innovative approach for prevention

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World Journal of Clinical Oncology 2021年第6期12卷 458-467页

作者： ester Oneda Chiara Abeni Laura Zanotti Elisabetta Zaina Sara Bighè Alberto Zaniboni Department of Clinical Oncology Fondazione PoliambulanzaBrescia 25124Italy

Chemotherapy-induced peripheral neuropathy(CIPN)is a common side effect that occurs in 20%of ovarian cancer patients treated with the combination of carboplatin/paclitaxel(CP).This toxicity is directly correlated with the dose of paclitaxel *** studies have investigated whether different formulations of taxane can induce this side effect at a lower rate,but,unfortunately,no significant improvement was *** can be disabling in the daily lives of patients and can cause dose reduction or early termination of the *** can last for months and even years after its ***,patients responsive to CP treatment are candidates for a reintroduction of the same drugs when disease relapse occurs,and residual neuropathy can affect the continuation of *** are no approved drugs that mitigate or prevent the onset of *** this review,we summarize the evidence regarding the incidence of CIPN with different taxane formulations,regimen schedules and prevention *** particular,the Hilotherm®Chemo care device is a regional cooling system that lowers the temperature of the hands and feet to reduce the flow of chemotherapy into the *** used hilotherapy during chemotherapy infusion to prevent the onset of *** data from 44 ovarian cancer patients treated with 6 cycle of CP show that hilotherapy was well tolerated;only two patients(4.5%)stopped hilotherapy because of cold intolerance,and only one patient(2.2%)experienced grade≥2 CIPN.

关键词： Peripheral neuropathy Ovarian cancer Paclitaxel Chemotherapy-induced peripheral neuropathy prevention Hilotherapy

Impact of Feedlot on Soil Phosphorus Concentration

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Journal of Environmental Protection 2011年第3期2卷 280-286页

作者： Nicolás Wyngaard Liliana Picone Cecilia Videla ester Zamuner Néstor Maceira 不详

Raising cattle in feedlots is becoming more common in argentina, but there is little information available about the effects of this practice on soil phosphorus (P) dynamics. In this study, concentrations of water and Bray -1 extractable soil P were quantified in a feedlot (upper and lower slope positions in the feedlot pen), runoff area and pasture during 2006 - 2008. The feedlot showed higher P concentrations in all P forms, soluble reactive P, soluble nonreactive, total soluble P, and Bray-P1 when compared to runoff area and pasture. Most of the total soluble P was soluble reactive P from the soil in the feedlot and the runoff area, while soluble nonreactive P predominated in the pasture. Concentrations of total soluble P were elevated in the feedlot at the soil surface, ranging on average from 158.71 to 245.86 mg?P?kg?1, and had a rapid decrease within the first 20 cm and remained relatively low, about 25.53 - 27.33 mg?P?kg?1. The evidence that total soluble P concentration in the feedlot was significantly (p ar, and correlation coefficient was r2 = 0.95.

关键词： Feedlot Water Soluble P Bray -1 P Cattle Manure Phosphorus Runoff

Alcohol, Caffeine and Nicotine in Adolescents

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Journal of Pharmacy and Pharmacology 2014年第5期2卷 285-294页

作者： Elisabetta Bertol Barbara Gualco Fabio Vaiano Regina Rensi ester Del Bravo Francesco Mari Department of Health Sciences University of Florence Florence 50134 Italy

This project was supported by the Department of Antidrug Policies of the Italian Government＇s Presidency Council and it was undertaken by the Forensic Toxicology Division of the University of Florence, in order to identify the age of onset of abuse of alcohol, caffeine and nicotine, through a scientific approach. The study involved 874 volunteer students aged between 13 and 16 years donating a small lock of their hair. The toxicological researches were performed with gas chromatography-mass spectrometer and liquid chromatography-tandem mass spectrometer instrumentations, on 50 mg of hair （3/4 cm proximal）, detecting： FAEE （fatty acids ethyl esters） and EtG （ethyl glucuronide） as markers of alcohol intake; nicotine and cotinine; caffeine. A self-reported questionnaire was also submitted. The main results showed that 17.6% drinks alcohol （3% is a ＂heavy drinkers＂）, 43.5% ingests more than an espresso/day （21.4% more than 2 espresso/day） and 24.3% is an active smokers （17.0% of ＂heavy smokers＂）. This study depicted a worrisome picture due to the early contact of the adolescents with these substance; moreover it demonstrated that the knowledge about this phenomenon by means of scientific evidences （not only by self-reported questionnaires）, is the only basis for its comprehension and for planning effective prevention strategies.

关键词： Young people alcohol caffeine nicotine scientific evidence.