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Free amino acid content in trunk,branches and branchlets of Araucaria angustifolia(Araucariaceae)

Journal of Forestry Research 2018年第6期29卷 1489-1496页

作者： Crizane Hackbarth Patricia Soffiatti Fla′vio Zanette Eny Iochevet segal Floh Amanda Ferreira Macedo Henrique Aparecido Laureano Departamento de Fitotecnia e Fitossanitarismo Federal University of Parana(UFPR)Rua dos Funcionarios1540JuveveCuritibaPR 81531-990Brazil Departamento de Botanica Federal University of Parana(UFPR)Av.Cel.Francisco H.dos Santos100Jardim das AmericasCuritibaPR 81531-980Brazil Instituto de Biociencias University of Sao PauloRua do Matao277Sao PauloSP 05508-090Brazil Departamento de Estatstica Federal University of Parana(UFPR)Av.Cel.Francisco H.dos Santos100Jardim das AmericasCuritibaPR 81531-980Brazil

Araucaria angustifolia(Bertol.) O. Kuntze exhibits dimorphism in its stem structure, where the trunk is orthotropic and branches and branchlets(primary and secondary branches) are plagiotropic. These stems exhibit different behavior when used for vegetative propagation,and only segments of trunk can form a complete plant. The physiological and biochemical mechanisms that characterize these stems are still little known. The aim of this study was to describe the free amino acid profiles in trunks,branches, and branchlets of A. angustifolia. Segments of 5 cm in length were excised from young individuals below the stem apex. The needles were removed and samples were frozen and lyophilized. The determinations were made by high-performance liquid chromatography, and the results were expressed as lg/g fresh weight(FW). The trunks and branches had the highest content of total amino acids, which were 112.23 ± 20.57 lg/g FW and 111.97 ± 27.78 lg/g FW, respectively. The amino acids—glutamine, aspartate and c-aminobutyric acid and tyrosine—were noticeably higher in the three types of *** the trunk, a higher amount of asparagine and tryptophan,was also detected. Glutamic acid and glutamine were found in higher quantities in the branches. The branchlets had very low total amino acid content (30.79 ± 4.19 lg/g FW), wherein asparagine is the only amino acid not detected. Thus, it was observed that the profile of the free amino acid differs among trunks, branches, and branchlets in A. angustifolia, indicating that they perform different functions.

关键词： Brazilian pine Physiological mechanisms Stem’s dimorphism Free amino acids

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COVID-19 as a trigger of irritable bowel syndrome:A review of potential mechanisms

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World Journal of Gastroenterology 2021年第43期27卷 7433-7445页

作者： Carlo Romano Settanni Gianluca Ianiro Francesca Romana Ponziani Stefano Bibbò Jonathan Philip segal Giovanni Cammarota Antonio Gasbarrini UnitàOperativa Complessa Medicina Interna e Gastroenterologia Dipartimento di Scienze Mediche e ChirurgicheFondazione Policlinico Universitario"A.Gemelli"IRCCSRome 00168Italy Istituto di Patologia Speciale Medica UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Gastroenterology and Hepatology Hillingdon HospitalUxbridge HA13UJUnited Kingdom

In December 2019 a novel coronavirus disease 2019(COVID-19),caused by the severe acute respiratory syndrome coronavirus-2(SARS-CoV-2),started spreading from Wuhan city of Chinese Hubei province and rapidly became a global *** symptoms of the disease range from paucisymptomatic disease to a much more severe *** symptoms of the initial phase include fever and cough,with possible progression to acute respiratory distress *** manifestations such as diarrhoea,vomiting and abdominal pain are reported in a considerable number of affected individuals and may be due to the SARS-CoV-2 tropism for the peptidase angiotensin receptor *** intestinal homeostasis and microenvironment appear to play a major role in the pathogenesis of COVID-19 and in the enhancement of the systemic inflammatory ***-term consequences of COVID-19 include respiratory disturbances and other disabling manifestations,such as fatigue and psychological *** date,there is a paucity of data on the gastrointestinal sequelae of SARS-CoV-2 *** COVID-19 can directly or indirectly affect the gut physiology in different ways,it is plausible that functional bowel diseases may occur after the recovery because of potential pathophysiological alterations(dysbiosis,disruption of the intestinal barrier,mucosal microinflammation,post-infectious states,immune dysregulation and psychological stress).In this review we speculate that COVID-19 can trigger irritable bowel syndrome and we discuss the potential mechanisms.

关键词： SARS-CoV-2 COVID-19 Irritable bowel syndrome Microbiota Dysbiosis Gut-brain axis

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Low dose gossypol for male contraception

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Asian Journal of Andrology 2000年第4期2卷 283-287页

作者： Zhi-PingGU Bai-YongMAO Yi-XinWANG Ren-AnZHANG Yong-ZhiTAN Zheng-XingCHEN LinCAO Gen-DiYOU S.J.segal ShanghaiInstituteofMateriaMedica ChineseAcademyofSciencesShanghai200031China RenJiHospital ShanghaiSecondMedicalUniversityShanghai200001China ZhongShahHospital MedicalCentreofFudanUniversityShanghai200032China JingAnDistrictCentralHospital Shanghai200040China PopulationDivision RockefellerFoundationNewYorkUSA

Aim: To ascertain whether the side effects of gossypol, hypokalemia and irreversibility, could be avoided on dose re-duction. Methods: Seventy-seven male volunteers were divided into 3 groups: control (22 cases), 10 mg gossypol(29 cases) and 12.5 mg (26 cases). Serum levels of testosterone, FSH and LH were measured by RIA and potassiumby flame photometry. Spema counts and motility were examined before and regularly after treatment for the evaluationof contraceptive efficacy. Results: The average sperm density and motility started to decrease significantly by theend of month 2 of medication and gradually reached the infertility levels ( < 4 million /mL) in both treated groups. Af-ter that the 10 mg group was asked to take the same dose every other day for up to a total observation period of 16-18months for the maintenance of infertility. Subjects in the 12.5 mg group did not take gossypol any more so as to ob-serve the length of the loading dose required, but in a few, a maintenance dose of 12.5 mg every other day was insti-tuted for a few more months. In both treated groups, none of the spouses was pregnant during the maintenance dose pe-riod. Serum levels of potassium, FSH, LH and testosterone were not significantly changed and not a single volunteercomplained of myoasthenia. After cessation of drug administratioin, the semen data returned to pretreatment ***: A regimen with 10 or 12.5 mg of gossypol as the daily loading dose and 35 or 43.75 mg as the week-ly maintenance dose could induce infertility in male volunteers without developing hypokalemia or irreversibility.(Asian J Androl 2000 Dec; 2: 283-287)

关键词： gossypol male contraceptive agents LH FSH testosterone serum potassium

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爱情的故事

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作者： E.·西格尔(E. segal)

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Diagnosis and management of Barrett’s metaplasia:What’s new?

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World Journal of Gastrointestinal Endoscopy 2012年第9期4卷 379-386页

作者： Fábio segal Helenice Pankowski Breyer Physician and Endoscopist at Hospital Moinhos de Vento Porto Alegre-RS90.035-001Brazil Physician and Endoscopist at Hospital de Clínicas Porto Alegre-RS90.035-003Brazil

Barrett’s esophagus(BE) is a complication of gastroesophageal reflux disease,and a premalignant lesion for esophageal adenocarcinoma(EAC).Observational studies suggest that endoscopic surveillance is associated with the detection of dysplasia and EAC at an early stage along with improved survival,but controversies still *** management of patients with BE involves endoscopic surveillance,preventive and clinical measures for cancer,and endoscopic and surgical approaches to *** upon the most appropriate treatment is a *** study presents the results and the effectiveness of these practices.

关键词： Barrett’s esophagus Intestinal metaplasia Metaplastic columnar mucosa Esophageal premalignancy Esophageal adenocarcinoma

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吞噬细胞的生物化学

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国外医学（输血及血液学分册） 1993年第3期16卷 151-154页

作者： segal AW 贾丽

一、吞噬细胞NADPH氧化酶及其在慢性肉芽肿综合征(CGD)中的缺陷免疫系统的吞噬细胞中有一种重要的能杀伤及消化被吞噬微生物的氧化酶,该氧化酶是一种电子传递链,能把电子从胞浆内的NADPH传递给吞噬细胞中的氧分子,形成超氧阴离子(O_2^-... 详细信息

一、吞噬细胞NADPH氧化酶及其在慢性肉芽肿综合征(CGD)中的缺陷免疫系统的吞噬细胞中有一种重要的能杀伤及消化被吞噬微生物的氧化酶,该氧化酶是一种电子传递链,能把电子从胞浆内的NADPH传递给吞噬细胞中的氧分子,形成超氧阴离子(O_2^-)及过氧化氢(H_2O_2)。这些活性氧物质对杀伤及消化被吞噬的微生物非常重要。

关键词：吞噬细胞生物化学

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Comparison of the extrusion rate of Crawford tubes

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International Journal of Ophthalmology(English edition) 2015年第4期8卷 791-793页

作者： Kira L.segal Sarah H.Van Tassel Charles Kim Nicole Hsu Ashutosh Kacker Gary J.Lelli Jr Department of Ophthalmology Weill Cornell Medical College Department of Otolaryngology Weill Cornell Medical College

· AIM: To compare the outcomes of dacryocystorhinostomy(DCR) using traditional Crawford tubes(TCT) and Crawford tubes with suture(CTS) in the lumen.· METHODS: Retrospective case series consisting of patients who underwent DCR between 2008 and 2013.·RESULTS: A total of 61 DCRs were performed on 50 patients. Patients who underwent DCR using CTS had higher rates of prolapse compared to the TCT group(50% vs 9.4%; P =0.003). Stent removal occurred earlier in patients who received CTS(3.3mo vs 5.1mo; P =0.004). Success rates were equivalent between the two groups(75% vs 81.1%; P =0.684).·CONCLUSION: CTS in the lumen increases the risk of prolapse, prompting earlier tube removal in patients following DCR for nasolacrimal duct obstruction(NLDO).Earlier removal of tubes does not appear to significantly decrease success rates.

关键词： nasolacrimal duct obstruction dacryocystorhinostomy dacryocystitis

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The emergency department length of stay: Is the time running out?

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Chinese Journal of Traumatology 2019年第3期22卷 125-128页

作者： Alexander Becker Gil segal Yuri Berlin Dan Hershko Department of Surgery A Emek Medical CenterAfula 18101Israel

Purpose: To examine the relationships between emergency department length of stay (EDLOS) with hospital length of stay (HLOS) and clinical outcome in hemodynamically stable trauma patients. Methods: Prospective data collected for 2 years from consecutive trauma patients admitted to the trauma resuscitation bay. Only stable blunt trauma patients with appropriate trauma triage criteria requiring trauma teamactivationwere included in the study. EDLOSwas determined short if patient spent less than 2 h in the emergency department (ER) and long for more than 2 h. Results: A total of 248 patients were enrolled in the study. The mean total EDLOS was 125 min (range 78 e180). Injury severity score (ISS) were significantly higher in the long EDLOS group (17 ± 13 versus 11 ± 9, p < 0.001). However, when leveled according to ISS, there were no differences in mean in diagnostic workup, admission rate to intensive care unit (ICU) or HLOS between the short and long EDLOS groups. Conclusion: EDLOS is not a significant parameter for HLOS in stable trauma patients.

关键词： Emergency department length of stay Trauma patients Hospital length of stay

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Genetic analysis of four consanguineous multiplex families with inflammatory bowel disease

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Gastroenterology Report 2021年第6期9卷 521-532页

作者： Noam Ben-Yosef Matthew Frampton Elena RSchiff Saleh Daher Fadi Abu Baker Rifaat Safadi Eran Israeli Anthony W.segal Adam P.Levine Centre for Molecular Medicine Division of MedicineUniversity College LondonLondonUK Institute of Gastroenterology and Liver disease Hadassah Medical CenterJerusalemIsrael Institute of Ophthalmology Moorfields Eye HospitalUniversity College LondonLondonUK Institue of Gastroenterology and Hepatology Hillel Yaffe Medical CenterHaderaIsrael Institute of Gastroenterology and Liver disease E.Wolfson Medical CenterHolonIsrael Department of Pathology University College LondonLondonUK

Background:Family studies support a genetic predisposition to inflammatory bowel diseases(IBD),but known genetic variants only partially explain the disease *** withmultiple affected individuals potentially harbour rare and highimpact causal *** regions of homozygosity due to recent inbreedingmay increase the risk of individuals bearing homozygous loss-of-function *** study aimed to identify rare and homozygous genetic variants contributing to ***:Four families with known consanguinity and multiple cases of IBD were *** a family-specific analysis,we utilised homozygosity mapping complemented by whole-exome ***:We detected a single region of homozygosity shared by Crohn’s disease cases from a family of Druze ancestry,spanning 2.6Mb containing the NOD2 ***-exome sequencing did not identify any potentially damaging variants within the region,suggesting that non-coding variation may be *** addition,affected individuals in the families harboured several rare and potentially damaging homozygous variants in genes with a role in autophagy and innate immunity including LRRK1,WHAMM,DENND3,and ***:This study examined the potential contribution of rare,high-impact homozygous variants in consanguineous families with *** the analysis was not designed to achieve statistical significance,our findings highlight genes or loci that warrant further ***-coding variants affecting NOD2 may be of importance in Druze patients with Crohn’s disease.

关键词： inflammatory bowel disease family study genetics homozygosity

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爱情的故事英语读物

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丛书名：大学英语阶梯阅读系列教程

2001年

作者： Erich segal原李凤华选编

《爱情的故事》是美国畅销小说，书中描写了年轻人的热恋与奋斗，以及美国学生的生活及美国社会家庭、婚姻、父子关系等方面一些矛盾，本书对原文重点有注释，并附有针对性的练习及其参考答案。

ISBN: (数字)7810770322

ISBN: (纸本)7810770322

关键词：长篇小说地点:美国年代:现代英语学科:高等学校

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