检索结果-南通市图书馆

Effect of Ultraviolet Radiation on Hsp70 Protein Expression in HaCaT Cells

World Journal of Nuclear Science and Technology 2024年第1期14卷 59-71页

作者： Sergio Hugo Sánchez Rodríguez Jesús Rodríguez Vergil Manuel Venancio Muñoz Juárez Kevin Said Ramírez Dávila Luis Martín garcía Ortiz Germán Flores Cortés Luz Elena Vidales Rodríguez Jesús Adrián López David Alejandro garcía López Laboratorio de Biología Celular y Neurobiología Unidad Académica de Ciencias Biológicas Universidad Autónoma de Zacatecas Zacatecas México Laboatorio de Bacterias y Hongos Filamentosos Unidad Académica de Ciencias Biológicas Universidad Autónoma de Zacatecas Zacatecas México Laboratorio de MicroRNAs Unidad Académica de Ciencias Biológicas Universidad Autónoma de Zacatecas Zacatecas México

Ultraviolet radiation by its wavelength is divided into: UVA, UVB and UVC. Only UVA and UVB manage to penetrate the ozone layer, but due to anthropological activities, all of them are capable of interacting with humans to a greater or lesser extent, and can generate adverse effects such as cellular stress when interacting with intra-and extracellular biomolecules. The skin is the first organ in contact with UV radiation, and the stress it generates can be analyzed by the expression of a bioindicator of cellular damage such as Hsp70. Therefore, the objective of the project was: to determine the effect of UVA, UVB and UVC radiation on HaCaT epithelial cells, by analyzing the expression of Hsp70. Materials and methods: HaCaT cells were cultured in vitro, which were irradiated with UVA, UVB and UVC light at different doses, to subsequently determine the degree of Hsp70 expression by Immunodetection by PAGE-SDS and Western Blot. Results: Basal expression of Hsp70 was observed in no irradiated HaCaT cells. When HaCaT cells were irradiated with UVA, UVB, UVC, an increase in this Hsp70 protein was observed. With UVA, a higher degree of expression was observed at a time of 30 minutes of irradiation. With UVB the highest expression shifted to a time of 20 minutes. With UVC, overexpression was observed after 10 minutes. Conclusion: UV radiation generates cellular stress on HaCaT cells, evaluated by the stress bioindicator Hsp70. According to the wavelength of UV radiation, those that have a shorter wavelength have a greater potential for cellular damage, such as UVC.

关键词： Ultraviolet A Light (UVA) Ultraviolet B Light (UVB) Ultraviolet C Light (UVC) Heat Shock Protein 70 (Hsp70) HaCaT

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optical magnetic field enhancement using ultrafast azimuthally polarized laser beams and tailored metallic nanoantennas

引用

Photonics Research 2024年第5期12卷 1078-1092页

作者： RODRIGO MARTIN-HERNANDEZ LORENZ GRUNEWALD LUIS SANCHEZ-TEJERINA LUIS PLAJA ENRIQUECONEJERO JARQUE CARLOS HERNANDEZ-garcIA SEBASTIAN MAI Grupo de Investigacion en Aplicaciones del Laser y Fotonica Departamento de Fisica AplicadaUniversidad de SalamancaE-37008 SalamancaSpain Unidad de Excelencia en Luz y Materia Estructuradas(LUMES) Universidad de SalamancaE-37008 SalamancaSpain Institute of Theoretical Chemistry Faculty of ChemistryUniversity of Vienna1090 ViennaAustria Vienna Doctoral School in Chemistry(DoSChem) Faculty of ChemistryUniversity of Vienna1090 ViennaAustria Departamento de Electricidad y Electrónica Universidad de Valladolid47011 ValladolidSpain

*** *** thank Valentina Shumakova,Elizaveta Gangrskaia,Alessandra Bellissimo,Audrius Pugzlys,and Andrius Baltu?ka for fruitful discussions and computational support by the Vienna Scientific Cluster(VSC 4).The authors thankfully acknowledge the computer resources at MareNostrum and SCAYLE,and the technical support provided by Barcelona Supercomputing Center(RES-FI-2022-3-0041).R.M.-H.,L.S.-T.,L.P.,E.C.J.,and C.H.-*** funding from the European Research Council(ERC)under the European Union’s Horizon 2020 research and innovation program(Grant Agreement No.851201)and support from Ministerio de Ciencia e Innovación(PID2022-142340NB-I00,PID2019-106910GB-I00).This research was funded in whole or in part by the Austrian Science Fund(FWF)(10.55776/ZK91).For open access purposes,the author has applied a CC BY public copyright license to any author accepted manuscript version arising from this submission.

关键词： metallic polarized discussions

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

How does resveratrol influence the genesis of some neurodegenerative diseases?

引用

Neural Regeneration Research 2016年第1期11卷 86-87页

作者： ester Tellone Antonio Galtieri Annamaria Russo Silvana Ficarra Department of Chemical Biological Pharmaceutical and Environmental Sciences University of Messina

Advancing age and increased lifespan of human populations worldwide in the mid-nineteenth century,have led to a significant increase in the incidence of neurodegenerative diseases one of the major cause of disability and death for most of those *** is one of the biggest public health problems in modern society also because effective pharmacological interventions for prevention and treatment of the disease, are lacking. Based on the premise that oxidative stress underlies a number of neurodegenerative diseases, the identification of novel antioxidants as potential therapeutics is a prolific area of neuroscience research. There is also a close relationship between specific therapies and the induction of oxidative stress in chronic neurodegeneration, such as the case of levodopa in patients with Parkinson＇s disease （Mtiller et al., 2014）.

关键词： resveratrol disability populations genesis superoxide neuronal chromosome prevention incidence monophosphate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

ZigID:Improving visibility in industrial environments by combining WSN and RFID

引用

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第11期12卷 849-859页

作者： Pablo garcíA ANSOLA Andrés garcíA Javier de las MORENAS Javier garcíA ESCRIBANO Francisco Javier OTAMENDI Autolog Labs School of Industrial EngineeringUniversity of Castilla-La Mancha Applied Economic Department University Rey Juan Carlos

The objective of this work is to provide decision-making processes with an updated/real picture of the mobile resources in industrial environments through a constant feedback of *** combination of identification technologies and wireless sensor networks(WSN) is proposed as a key development to guarantee an accurate and timely supply of online information regarding the localization and tracking of the mobile wireless *** approach uses a cooperative and distributed localization system,called ZigID,which is a WSN based on a Zigbee network with radio frequency identification(RFID) active tags as end *** WSN can recover not only the ID information stored at the tags attached to mobile resources,but also any other useful data captured by specific sensors for acceleration,temperature,humidity and fuel *** paper also shows the development of ZigID,including devices and information flows,as well as its implementation in ground handling operations at the Ciudad Real Central Airport,Spain.

关键词： Radio frequency identification(RFID) Tracking Wireless sensor networks(WSNs)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer

引用

Genes & Diseases 2024年第3期11卷 311-323页

作者： David Sanchez-Marin Macrina Beatriz Silva-Cazares Fany Iris Porras-Reyes Rebeca garcia-Roman Alma D.Campos-Parra Posgrado en Ciencias Biologicas Facultad de MedicinaUniversidad Nacional Autonoma de MexicoCiudad de MexicoC.P.04360Mexico Unidad Academica Multidisciplinaria Region Altiplano Universidad Autonoma de San Luis Potost(UASLP)Carretera a Cedral Km 5+600Ejido San Jose de la TrojesMatehualaSan Luis PotosiC.P.78760Mexico Servicio de Anatomia Patologica Instituto Nacional de Cancerologia(INCan)Nino JesuisTlalpanCiudaddeMexicoC.P.14080Mexico Instituto de Salud Publica Universidad Veracruzana(UV)Av.Dr LuisDr.Castelazo Ayala s/nCol.Industrial AnimasXalapaVeracruzC.P.91190Mexico

Long non-coding RNAs(lncRNAs)are non-coding RNAs longer than 200 nucleotides with dynamic regulatory *** interact with a wide range of molecules such as DNA,RNA,and proteins to modulate diverse cellular functions through several mechanisms and,if deregulated,they can lead to cancer development and ***,it has been described that IncRNAs are susceptible to form gene fusions with mRNAs or other IncRNAs,breaking the paradigm of gene fusions consisting mainly of protein-coding ***,their biological significance in the tumor phenotype is still ***,their recent identification opens a new line of research to study their biological role in tumor-igenesis,and their potential as biomarkers with clinical relevance or as therapeutic *** present study aimed to review the IncRNA fusions identified so far and to know which of them have been associated with a potential *** address the current challenges to deepen their study as well as the reasons why they represent a future therapeutic window incancer.

关键词： Cancer Genefusions IncRNAs ncRNAs Therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

University Corporate Governance in the Literature From 2019 to 2024

引用

Journalism and Mass Communication 2024年第3期14卷 179-188页

作者： María del Rosario Molina González María Teresa Gaxiola Sánchez María de Jesús Camargo Pacheco Marco Antonio Velderrain Rodríguez Rafael Campoy Mendoza Cruz garcía Lirios Universidad de Sonora NavojoaMexico

Anti-pandemic policies impacted the governance of Higher Education Institutions(HEIs)through confinement and distancing *** an impact was observed in the identity,reputation,and image of the HEI in the face of the health *** objective of this work was to establish an empirical contrast between the theoretical structure consulted regarding the evaluations of summaries published from 2019 to 2024 by judges.A documentary,cross-sectional,and retrospective study was carried out with a sample of sources indexed in international *** results demonstrate that image and age regulate the impact of identity and income on *** relation to the state of the art,it is recommended to extend the study to sociocultural,demographic,economic,and educational variables in order to anticipate the transition from university governance to corporate governance.

关键词： COVID governance model nodes neural networks

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The translational revolution in atopic dermatitis:the paradigm shift from pathogenesis to treatment

引用

Cellular & Molecular Immunology 2023年第5期20卷 448-474页

作者： Paola Facheris Jane Jeffery ester Del Duca Emma Guttman-Yassky Laboratory of Inflammatory Skin Diseases Department of DermatologyIcahn School of Medicine at Mount SinaiNew YorkNYUSA Humanitas Clinical and Research Center Department of DermatologyRozzanoMilanoItaly Duke University School of Medicine DurhamNCUSA Department of Dermatology Icahn School of Medicine at Mount SinaiNew YorkNYUSA.

Atopic dermatitis(AD)is the most common inflammatory skin disease,and it is considered a complex and heterogeneous *** phenotypes of AD,defined according to the patient age at onset,race,and ethnic background;disease duration;and other disease characteristics,have been recently described,underlying the need for a personalized treatment *** advancements in understanding AD pathogenesis resulted in a real translational revolution and led to the exponential expansion of the therapeutic *** study of biomarkers in clinical studies of emerging treatments is helping clarify the role of each cytokine and immune pathway in AD and will allow addressing the unique immune fingerprints of each AD *** medicine will be the ultimate goal of this targeted translational *** this review,we discuss the changes in the concepts of both the pathogenesis of and treatment approach to AD,highlight the scientific rationale behind each targeted treatment and report the most recent clinical efficacy data.

关键词： Atopic dermatitis translational revolution biomarkers eczema

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

FINITELY GENERATED COMMUTATIVE ARCHIMEDEAN SEMIGROUPS

引用

Acta Mathematica Scientia 2003年第4期23卷 503-511页

作者： J.C.Rosales J.I.garcía-garcía Departamento de Algebra Universidad de Granada E-18071 Granada EspanaDepartamento de Algebra Universidad de Granada E-18071 Granada Espana

In this work commutative Archimedean finitely generated semigroups axe characterized in terms of ideal extensions.

关键词： Commutative semigroups Archimedean

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Engineering of immunoinstructive extracellular matrices for enhanced osteoinductivity

引用

Bioactive Materials 2023年第6期24卷 174-184页

作者： Andrés garcía-garcía Sébastien Pigeot Ivan Martin Department of Biomedicine University Hospital BaselUniversity of Basel4031BaselSwitzerland Department of Biomedical Engineering University of Basel4123AllschwillSwitzerland

The increasing recognition of the contribution of the immune system to activate and prime regeneration implies that tissue engineering strategies and biomaterials design should target regulation of early immunological *** previously proposed the cell-based engineering and devitalization of extracellular matrices(ECMs)as a strategy to generate implant materials delivering custom-defined ***,in the context of bone regeneration,we aimed at enhancing the osteoinductivity of such ECMs by enriching their immunomodulatory factors *** with IL1βa cell line overexpressing BMP-2 enabled engineering of ECMs preserving osteoinductive signals and containing larger amounts of angiogenic(VEGF)and pro-inflammatory molecules(IL6,IL8 and MCP1).Upon implantation,these IL1β-induced materials enhanced processes typical of the inflammatory phase(e.g.,vascular invasion,osteoclast recruitment and differentiation),leading to‘regenerative’events(e.g.,M2 macrophage polarization)and ultimately resulting in faster and more efficient bone *** results bear relevance towards the manufacturing of potent off-the-shelf osteoinductive materials and outline the broader paradigm of engineering immunoinstructive implants to enhance tissue regeneration.

关键词： Immunomodulation Bone tissue engineering Inflammation Hypertrophic cartilage matrices Osteoinduction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Perspective:Chemical Information Encoded in Electron Density

引用

物理化学学报 2018年第6期34卷 567-580页

作者： CONTRERAS-garcíA Julia YANG Weitao UPMC Univ Paris 06 CNRSUMR 7616Laboratoire de Chimie Théorique Department of Chemistry Duke University

In this perspective,we review the chemical information encoded in electron density and other ingredients used in semilocal *** information is usually looked at from the functional point of view:the exchange density or the enhancement factor are discussed in terms of the reduced density ***,what parts of a molecule do these 3D functions represent? We look atthese quantities in real space,aiming to understand the electronic structure information they encode and provide an insight from the quantum chemical topology(QCT).Generalized gradient approximations(GGAs) provide information about the presence of chemical interactions,whereas meta-GGAs can differentiate between the different bonding *** merging these two techniques,we show new insight into the failures of semilocal functionals owing to three main errors:fractional charges,fractional spins,and non-covalent *** build on simple *** also analyze the delocalization error in hydrogen chains,showing the ability of QCT to reveal the delocalization error introduced by semilocal ***,we show how the analysis of localization can help understand the fractional spin error in alkali atoms,and how it can be used to correct ***,we show that the poor description of GGAs of isodesmic reactions in alkanes is due to 1,3-interactions.

关键词： DFT Semi-local functional Electron density Quantum chemical topology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：