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This pain drives me crazy:Psychiatric symptoms in women with interstitial cystitis/bladder pain syndrome

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World Journal of Psychiatry 2024年第6期14卷 954-984页

作者： Marianna Mazza Stella Margoni Giuseppe Mandracchia Guglielmo Donofrio Alessia Fischetti Georgios D Kotzalidis Giuseppe Marano Alessio Simonetti Delfina Janiri Lorenzo Moccia Ilaria Marcelli Greta Sfratta Domenico De Berardis Ottavia Ferrara Evelina Bernardi Antonio Restaino Francesco Maria Lisci Antonio Maria D'Onofrio Caterina Brisi Flavia Grisoni Claudia Calderoni Michele Ciliberto Andrea Brugnami Sara Rossi Maria Chiara Spera Valeria De Masi ester Maria Marzo Francesca Abate Gianluca Boggio Maria Benedetta Anesini Cecilia Falsini Anna Quintano Alberto Torresi Miriam Militenda Giovanni Bartolucci Marco Biscosi Sara Ruggiero Luca Lo Giudice Giulia Mastroeni Elisabetta Benini Luca Di Benedetto Romina Caso Francesco Pesaresi Francesco Traccis Luca Onori Luca Chisari Leonardo Monacelli Mariateresa Acanfora Eleonora Gaetani Monia Marturano Sara Barbonetti Elettra Specogna Francesca Bardi Emanuela De Chiara Gianmarco Stella Andrea Zanzarri Flavio Tavoletta Arianna Crupi Giulia Battisti Laura Monti Giovanni Camardese Daniela Chieffo Antonio Gasbarrini Giovanni Scambia Gabriele Sani Department of Neurosciences Fondazione Policlinico Universitario A Gemelli IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy Department of Psychiatry UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Neurosciences Section of PsychiatryFondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Mental Health NHSASL 4 TeramoTeramo 64100Italy Medical and Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy Division of Gynecologic Oncology UniversitàCattolica del Sacro CuoreRome 00168Italy UOS Psicologia Clinica Governo ClinicoFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy CEMAD Digestive Disease Center Fondazione Policlinico Universitario A.Gemelli-IRCCSRome 00168Italy Department of Woman and Child Health Catholic UniversityRome 00168Italy UOC Psichiatria Clinica e d’Urgenza Dipartimento di Scienze Dell’InvecchiamentoNeurologicheOrtopediche e Della Testa-colloFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy

BACKGROUND Interstitial cystitis/bladder pain syndrome(IC/BPS)is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic,abdominal,and/or pelvic *** the term cystitis suggests an inflammatory or infectious origin,no definite cause has been *** occurs in both sexes,but women are twice as much *** To systematically review evidence of psychiatric/psychological changes in persons with IC/*** Hypothesizing that particular psychological characteristics could underpin IC/BPS,we investigated in three databases the presence of psychiatric symptoms and/or disorders and/or psychological characteristics in patients with IC/BPS using the following strategy:("interstitial cystitis"OR"bladder pain syndrome")AND("mood disorder"OR depressive OR antidepressant OR depression OR depressed OR hyperthymic OR mania OR manic OR rapid cyclasterisk OR dysthymiasterisk OR dysphoriasterisk).RESULTS On September 27,2023,the PubMed search produced 223 articles,CINAHL 62,and the combined PsycLIT/PsycARTICLES/PsycINFO/Psychology and Behavioral Sciences Collection search *** on *** produced 14 studies,of which none had available *** were peer-reviewed articles reporting psychiatric/psychological symptoms in patients with IC/BPS,i.e.63 articles spanning from 2000 to October *** studies identified depression and anxiety problems in the IC/BPS population,along with sleep problems and the tendency to *** Psychotherapies targeting catastrophizing and life stress emotional awareness and expression reduced perceived pain in women with IC/*** concepts should be considered when implementing treatments aimed at reducing IC/BPS-related pain.

关键词： Interstitial cystitis/bladder pain syndrome Psychiatric symptoms Psychological symptoms Catastrophizing Anxiety Depression

A Real-World Perspective on Interfacility Transfers of Acute Ischemic Stroke from a Semi-Rural Center

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Open Journal of Emergency Medicine 2020年第1期8卷 1-12页

作者： Lluís Llauger ester Puyuelo Francisco Sanchez-Mendez Emergency Department Vic University Hospital Vic Spain

Introduction: Interfacility transfers (IFT) of acute ischemic stroke (AIS) may not always lead to a better prognosis. Methods: Retrospective cohort study included AIS patients at an emergency department (ED) with telestroke. Multiple linear regression for departure time from ED (DT), quantile regression for length of in-hospital stay (LOS), and Kaplan-Meier estimator with Cox proportional hazards model for one-year survival (SV) were performed. Results: 192 patients included were categorised according to IFT. Mechanical thrombectomy was performed in 50% who had been transferred. Differences were found in DT, discharge disposition and LOS. An inverse relationship existed between DT and NIHSS. The strongest predictor of LOS was TACS (β = 3.14 [0.03 - 8.49];p = 0.005). SV was related to IFT (HR 4.68 [1.37 - 16.07];p = 0.014), age (HR 1.1 [1.04 - 1.17]), BI Conclusions: Shared decision-making with a stroke unit through telemedicine enabled a standardised clinical management in a non-metropolitan setting. Several improvement opportunities were identified: multimodal computed tomography availability before transfer, as well as optimization of response time and training in neurosonology of emergency physicians.

关键词： Stroke Emergency Room Transportation of Patients Prognosis

In vitro polymerization of the dopamine-borate melanin precursor:A proof-of-concept regarding^(10)boron neutron-capture therapy for melanoma

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BIOCELL 2023年第4期47卷 919-928页

作者： JUAN C.STOCKERT SILVINA A.romero MARCELO N.FELIX-POZZI ALFONSO BLÁZQUEZ-CASTRO Instituto de Oncología“Angel H.Roffo” Área InvestigaciónFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresC1417DTBArgentina Centro Integrativo de Biología y Química Aplicada Universidad Bernardo O’HigginsSantiago8370854Chile Departamento de Micro y Nanotecnología Instituto de Nanociencias y NanotecnologíaCentro Atómico ConstituyentesComisión Nacional de Energía AtómicaBuenos AiresCP 1650Argentina Departamento de Biología Universidad Autónoma de MadridMadrid28049Spain

The^(10)boron neutron-capture therapy(BNCT)is an emerging antitumoral method that shows increasing biomedical *** is based on the selective accumulation of the^(10)boron isotope within the tumor,which is then irradiated with low-energy thermal neutrons,generating nuclear fission that produces 7lithium,4helium,andγ*** catechol-borate esters have been rather overlooked as precursors of melanin biosynthesis,and therefore,a proof-of-concept approach for using dopamine-borate(DABO)as a suitable boron-containing candidate for potential BNCT is presented *** can spontaneously oxidize and autopolymerize in vitro,giving a soluble,eumelaninlike brown-black poly-DABO *** melanoma cell cultures treated with 1 mM DABO for 24 and 48 h were viable and showed no signs of damage or cell *** stability and possible trans-esterification of DABO is shortly *** calculations and quantitative structure-activity relationships(QSAR)analysis of DABO and the BNCT agent BPA indicated that they should be cell permeant and accumulate within lysosomes and *** modeling allows visualization of both the DABO precursor and the structure of a borate derivative of the proposed catechol-porphycene model for eumelanin,showing interesting features from molecular orbital *** main difference between DABO and other agents,such as BPA,is that it is not a boronic acid nor a boron *** simple catechol-borate ester(protected from oxidation and blackening)could be administrated to living cells and organisms,in which biosynthesis of boron-melanin in melanoma melanocytes can lead to improved BNCT.

关键词： ^(10)Boron Borate esters Catechols Dopamine Eumelanin Melanoma

Genetic Screening of Halothane Gene on Selected Philippine Native Pig Herds

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Open Journal of Genetics 2023年第3期13卷 105-113页

作者： Sherwin Dapiawen Matias Maureen Basa Gajeton ester Battad Flores Animal Breeding and Genomics Section Philippine Carabao Center National Headquarters and Genepool Science City of Munoz Nueva Ecija Philippines

The establishment of nucleus herds (NHs) of Native Pigs (NPs) at various R&D stations in the Philippines is currently being undertaken for food security and genetic conservation advocacy. Marker-assisted selection (MAS) is being utilized to identify individuals carrying favorable alleles of genes associated with production traits and screen out genetic defects (GD) for breeding purposes. Porcine Stress Syndrome (PSS) caused by a mutation in Halothane (HAL) gene is a GD frequently found in commercial breeds that when expressed, causes pale, soft, exudative (PSE) meat. PSE is inferior quality meat undesirable in the market causing economic losses to the swine industry. Thus, this study was conducted to screen the HAL gene through mutagenically separated-polymerase chain reaction (MSPCR) in selected NP herds and assessed its repeatability in local breeds. Results showed that out of 577 screened individuals, 543 (94.11%) were normal (NN), 0 (0%) were homozygous mutant (nn) and 34 (5.89%) were heterozygous carriers (Nn). Therefore, the optimized PSS screening protocol using MSPCR is also applicable to local breeds. As such, the availability of genetic tests for PSS could be useful in improving the Philippine NPs breeding selection and inhibiting or eliminating PSS mutant incidence within its nucleus herd.

关键词： Halothane Gene Porcine Stress Syndrome Native Pig

A great disturbance in the crypto:Understanding cryptocurrency returns under attacks

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Blockchain(Research and Applications) 2021年第3期2卷 68-78页

作者： Simona Ramos Fabio Pianese Thomas Leach ester Oliveras Augmented Machine Interaction team AI Research LabNokia Bell LabsParis-SaclayNozay 91620France Department of Computer Science Universitat Pompeu FabraBarcelona 08002Spain Department of Economics Universita di PaviaPavia 27100Italy

A non-traditional type of financial asset,cryptocurrencies based on public blockchains are still little understood in their real-world *** events such as cyber-attacks and their media coverage can strongly affect their supply and demand,adoption and usage,efficiency,and infrastructural development,thus influencing their price stability and market *** the great technical complexity of blockchains,we believe that a pure economic analysis of risks associated with cryptocurrencies is simply not sufficient to convey the relationships between attacks and the disruptive effects that these can bring on the operation of *** these grounds,we survey the most common types of attacks for Proof-of-Work(PoW)cryptocurrencies and evaluate their impact on the returns of a number of real-world cryptocurrencies for which market data are *** to data availability,our event study analysis focuses on instances of 51% attacks,hard forks,and wallet *** main goal of our analysis is to understand the relationship between technical events(cyber-attacks and coordinated user/miner behavior)and the economic impacts surrounding *** aim to develop a deeper understanding of these systems that are objects of great research interest in separate disciplines,supporting policymakers in their regulatory decisions concerning crypto-assets and associated cyber-related financial risks.

关键词： Blockchain Cryptocurrencies Event studies Cyber attacks

The hits and misses of Namibia’s attempt to implement the Ecosystem Approach to Fisheries(EAF)Management

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Ecosystem Health and Sustainability 2021年第1期7卷 135-146页

作者： Johannes A.Iitembu Victoria N.Erasmus Uatjavi Uanivi Dietlinde Nakwaya Richard R.Horaeb ester Nangolo Festus P.Nashima Theopolina K.Iita Osmund Mwandemele Department of Fisheries and Aquatic Sciences University of NamibiaHenties BayNamibia Sam Nujoma Marine and Coastal Resources Research Centre University of Namibia Sam Nujoma CampusHenties BayNamibia National Marine Information and Research Centre(Natmirc) Ministry of Fisheries and Marine ResourcesSwakopmundNamibia Grants Management and Projects Services University of NamibiaWindhoekNamibia

Ecosystem Approach to Fisheries(EAF)management is a concept aimed at the conservation and sustainable use of the entire *** EAF is a noble approach,its implementation has been *** Namibia has committed to the implementation of EAF,only limited assessment has been done of Namibian fisheries management processes and instruments concerning EAF.A qualitative assesment was done to ascertain if the Namibian fisheries management processes and instruments conform to the EAF *** fisheries management processes and instruments largely conform to the EAF principles,although there are notable areas needing *** conformities were pronounced in the total allowable catch setting,rebuilding depleted stocks,minimizing bycatch,and fishing impact *** polluter pays,and user pays principles were also *** that were found lacking in this study included setting the indicators for EAF and ecosystem *** assessment also noted the absence of guidelines for the precautionary approach principle and a transparent policy for quota and right allocation *** strategies for managing transboundary fish species are also not ***,this assessment showed the complexities and challenges that Namibia and other countries need to overcome to implement EAF successfully.

关键词： Fisheries management ecosystem approach to fisheries EAF principles namibia

Practical handling skills during road transport of fattening pigs from farm to slaughterhouse: A brief review

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Agricultural Sciences 2013年第12期4卷 756-761页

作者： Bert Driessen ester Peeters Jos Van Thielen Sanne Van Beirendonck Department of Animal Welfare Federal Government Service Brussels Belgium Department of Bioengineering Technology KU Leuven | Thomas More Geel Belgium

The transport of fattening pigs is characterized by a strong human-animal interaction. Consequent handling is important because of animal welfare, meat quality and matching economic consequences. During road transport, human impact can be divided in different steps: 1) driving pigs from the pens via an alley to the trailer, 2) loading, 3) actual transport, 4) unloading to the lairage, and 5) the final phase driving pigs to the stunning. An inadequate design and a poor condition of the facilities will negatively affect the ease of handling pigs. Because of the consequences, acute stress during transport and slaughter should be minimized by acting on the education of people, on equipment and on preparation of animals for the journey. Education programs have to be repeated regularly so that knowledge can be refreshed.

关键词： Handling Pigs Transport Slaughterhouse Training

Endoscopic Methods in the Diagnosis and Treatment of Pancreatic Cancer

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Journal of Cancer Therapy 2013年第10期4卷 1-6页

作者： Zoltán Berger Maria ester Bufadel Godoy Alex Navarro Reveco University of Chile Clinical Hospital Department of Medicine Gastroenterology Section Santiago Chile

Endoscopic methods are widely used in the diagnosis and palliative treatment of pancreatic cancer. The most sensitive method in early diagnosis is endosonography (EUS) which can also provide histological diagnosis. Diagnostic ERCP became a rather rare procedure as a consequence of wide availability of Magnetic Resonance Cholangiopancreatography (MRCP) but ERCP assisted intraductal methods have gained importance (brush-cytology, intraductal ultrasound, optical coherence tomography) and finally, peroral pancreatoscopy has become technically feasible but available only in some specialized centers. Minimally invasive endoscopic methods play an important role in the palliative treatment of unresectable pancreatic cancer which represents the majority of cases. EUS-guided histological confirmation of adenocarcinoma is crucial in the election of chemotherapy. Celiac plexus blockade and endoscopic biliary and pancreatic stent placement contribute to pain reduction, drainage of obstructed bile duct and assure a better quality of life.

关键词： Endoscopist Early Diagnosis Palliative Treatment

老年人志愿活动对认知功能的纵向影响:基于美国健康与退休研究的二次数据分析

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International Journal of Nursing Sciences 2023年第3期10卷 373-382页

作者： ester Villalonga-Olives Kayleigh R.Majercak Josue Almansa Tasneem Khambaty Sciences and Health Outcomes Research Department University of Maryland School of PharmacyBaltimoreMDUSA Department of Health Sciences Community&Occupational MedicineUniversity Medical CenterUniversity of Groningenthe Netherlands Department of Psychology University of MarylandBaltimore CountyBaltimoreMDUSA

目的研究志愿活动与退休老年人认知活动、社会活动和身体活动的关系,以及与其不同时期认知功能的关系。方法资料来源于美国健康与退休研究小组数据中2008年、2012年和2016年的3波数据(n=2862)。使用自我报告问卷评估老年人的年度志愿服... 详细信息

目的研究志愿活动与退休老年人认知活动、社会活动和身体活动的关系,以及与其不同时期认知功能的关系。方法资料来源于美国健康与退休研究小组数据中2008年、2012年和2016年的3波数据(n=2862)。使用自我报告问卷评估老年人的年度志愿服务频率(无志愿服务,<100 h和≥100 h),并使用认知状态电话访谈(Telephone Interview for Cognitive Status,TICS)修订版评估老年人的记忆、思维、知识、语言和定位等。应用结构方程模型评估退休老年人志愿活动对其认知功能的长期影响。结果与未参加志愿活动者相比,2012年参加志愿活动的老年人在2008—2012年中等体力活动增加(一年志愿活动少于100h者β=0.19,P<0.001;一年志愿活动至少100 h者β=0.21,P<0.001),社交活动增加(前者β=0.10,P=0.052;后者β=0.12,P=0.018),认知活动增加(一年志愿活动至少100h者β=0.13,P<0.001)。2008年和2012年较高的认知活动水平与随后的研究时间段较高认知功能存在关联(β=0.66,β=0.60,P<0.001)。讨论志愿活动是可人为改变的活动,可以通过增加老年人认知活动来改善老年人的认知功能。

关键词：老龄化认知认知功能障碍身体活动退休志愿者