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Influence of agriculture and aquaculture activities on the response of autotrophic picoplankton in Laguna Macapule, Gulf of California (Mexico)

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Ecological Processes 2017年第1期6卷 41-51页

作者： Aída martínez-López Cristian Hakspiel-Segura Diana Cecilia Escobedo-Urías Bárbara González-Acosta Centro Interdisciplinario de Ciencias Marinas-IPn(CICIMAR) Av.IPN s/nCol.Playa Palo de Santa RitaLa PazB.C.S.23096Mexico Centro de Interdisciplinario de Investigación para el Desarrollo Integral Regional (CIIDIR–Unidad Sinaloa)Bulevar Juan de Dios Bátiz Paredes 250Col.San JoachinGuasaveSinaloa 81101Mexico

Introduction:The lagoon is a component of coastal zones,whose populations of autotrophic picoplankton(APP)remain largely *** lagoons display high-nutrient productivity and additionally may also be subjected to anthropogenic *** study selected Laguna Macapule,located on the eastern shore in the mid-region of the Gulf of California,due to the fact that a drainage network servicing the surrounding agricultural region(>230,000 hectares under cultivation)directs irrigation runoff,shrimp farm effluents,and urban wastewater containing large quantities of nutrients to be discharged into this *** propose to identify the APP’s response to various types of environmental and anthropogenic influence in this highly impacted coastal ***:Two sites(separated by 2.7 km)were monitored from December 2007 to December ***,located at the entrance to Laguna Macapule(oceanic influence)and the other a discharge canal(eutrophic conditions)inside the lagoon at El Tortugó***:APP was the numerically dominant phytoplankton fraction(15×106 to 620×106 cells L−1)with coccoidal cyanobacteria as the dominant fraction throughout the *** levels were reached in spring-early autumn and they were the second largest contributor to *** of APP cells corresponds to the lagoon’s eutrophic *** numbers and a higher average of APP were recorded at the El Tortugón channel during the warm season(months with SST higher than 24°C).The general positive relationship of the APP’s annual cycle at both sites as well as a negative relationship with heterotrophic nanoflagellates(HnF)abundance,supports the idea that natural forcing,in particular sea surface temperature(SST)is the predominant influences on APP’s seasonal ***:Distinguishable significant differences in APP abundances and nutrients were recognizable between the two *** interplay of these variables contributed to lower densities of APP in winter and high de

关键词： Aquaculture Autotrophic picoplankton Eutrophic conditions Heterotrophic ciliates Heterotrophic nanoflagellates Urea

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Parental perception of child's weight,their attitudes towards child's dietary habits and the risk of obesity

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World Journal of Pediatrics 2022年第7期18卷 482-489页

作者： Lorena Garcia-Blancol Arantxa Berasaluce Andrea Romanos-nanclares Miguel Angel martinez-Gonzalez Laura Moreno-Galaraga nerea martin-Calvo san Juan Primary Care Health Center.Servicio navarro de Salud-Osasunbidea PamplonaSpain IdisnA.Instituto de Investigacion sanitaria de navrra.Pamplona Spain Department of Preventive Medicine and Public Health School of Medicine.University of NavarraC/Irunlarrea l.31080 Pamplona.Spain Biomedical Research Centre network On Obesity and Nutrition(CIBERobn).Physiopathology of Obesity and NutritionInstituteof Health Carlos Ⅲ.Av.Monforte de Lemos.3-528029 MadridSpain Department of nutrition.Harvard T.H.Chan School of Public Health Boston.MA 02115.USA Department of Pediatrices.Complejo Hospialario de navarra B.Pamplona.Spain

Background The association between parental perception of child's weight and their attitudes towards his/her dietary habits has not been reported *** study aimed to assess the association between parental underestimation of child's weight and parental attitudes towards child's dietary *** We conducted a cross-sectional analysis of SEnDO cohort participants recruited between January 2015 and June *** information was collected through online questionnaires completed by *** calculated crude and multivariable-adjusted odds ratio(OR)and 95%confidence intervals(CI)for unhealthy attitudes towards child's dietary habits associated with parental underestimation of child's *** Sixteen percent of children in the SEnDO project had parents who underestimated their *** who under-estimated their child's weight status were more likely to have unhealthy attitudes toward his/her dietary habits[OR 3.35;95%CI(1.71-6.53)].Conclusions Parental underestimation of child's weight was associated with unhealthy attitudes towards child's dietary *** and public health practitioners should pay attention to the parental perception of child's weight to identify parents who underestimate it as an at-risk group in which to inquire about lifestyle and dietary habits.

关键词： Childhood obesity Dietary atitudes Eating habits Overweight Weight perception

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Management and outcomes of patients with Crohn’s disease with first vs multiple surgeries:results from the PRACTICROHn study

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Gastroenterology Report 2019年第6期7卷 411-418,I0001,I0002页

作者： Marisa Iborra Berta Juliá Maria Dolores martín Arranz Manuel Barreiro-de Acosta Ana Gutiérrez Valle García-Sánchez Carlos Taxonera Javier P.Gisbert Luis Cea-Calvo Eugeni Domènech Gastroenterology Department Hospital La FeValenciaSpain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBERehd) MadridSpain Medical Department Merk Sharp and Dohme(MSD)MadridSpain Gastroenterology Unit Hospital Universitario La PazIdiPAZMadridSpain Gastroenterology Unit Complejo Hospitalario Universitario de SantiagoSantiago de CompostelaSpain Digestive Medicine Department Hospital General de AlicanteAlicanteSpain Unit of Clinical Management of Gastrointestinal Tract Hospital Universitario Reina SofiaMaimonides Institute of Biomedical Research of Cordoba(IMIBIC)Cordoba UniversityCordobaSpain Gastroenterology Department Hospital Clínico San CarlosMadridSpain Instituto de Investigación del Hospital Clínico san Carlos(IdISSC) MadridSpain Gastroenterology Department Hospital Universitario de La PrincesaInstituto de Investigación Sanitaria Princesa(IIS-IP)MadridSpain Gastroenterology Department Hospital Universitari Germans Trias i PujolBadalonaSpain

Background:Surgery in Crohn’s disease(CD)may be associated with poor prognosis and clinical and surgical *** aim of this study was to describe and compare the post-operative management and outcomes of patients with CD who underwent first vs recurrent ***:Observational study that included adult CD patients from 26 Spanish hospitals who underwent ileocolonic resection with ileocolonic anastomosis between January 2007 and December *** were retrospectively collected from the medical ***:Data from 314 patients were analysed,of whom 262(83%)underwent first surgery and 52(17%)referred to previous CD *** characteristics were similar between the two groups except for a higher rate of stricturing behavior at diagnosis among re-operated patients(P=0.03).After surgery,a higher proportion of re-operated patients received prophylactic treatment with immunomodulators compared with patients with first surgery(P=0.04).In re-operated patients,time to clinical recurrence was not associated with the fact of receiving or not prophylaxis,whereas,in patients with first surgery,recurrence-free survival was greater when prophylaxis was received(P=0.03).Conclusions:After surgery,a higher proportion of patients with previous surgeries received prophylactic treatment with immunomodulators compared with patients with first *** prophylactic treatment was beneficial for preventing clinical recurrence in patients operated on for the first time,it did not significantly reduce the risk of further recurrence in patients with previous *** suggests that effective prophylactic therapies are still needed in this subset of patients.

关键词： Crohn’s disease surgery post-operative recurrence

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A tumor-associated heparan sulfate-related glycosaminoglycan promotes the generation of functional regulatory T cells

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Cellular & Molecular Immunology 2023年第12期20卷 1499-1512页

作者： Leticia martín-Cruz Marcos Viñuela Ioanna Kalograiaki Alba Angelina Paola Oquist-Phillips Irene Real-Arévalo Francisco Javier Cañada JoséIgnacio Tudela Luis Moltó Jesús Moreno-Sierra JoséLuis Subiza Oscar Palomares Department of Biochemistry and Molecular Biology School of ChemistryComplutense University of MadridMadridSpain Inmunotek Alcaláde HenaresMadridSpain Fundación Investigación Hospital Clínico san Carlos Martin Lagos s/n28040MadridSpain Centro de Investigaciones Biológicas Margarita Salas CSICRamiro de Maetzu 928040MadridSpain CIBER de Enfermedades Respiratorias(CIBERES)Avda Monforte de Lemos3-528029MadridSpain Servicio de Urología Hospital Clínico San CarlosUniversidad Complutense de MadridMartín Lagos s/n28040MadridSpain

Functional Tregs play a key role in tumor development and progression,representing a major barrier to anticancer *** mechanisms by which Tregs are generated in cancer and the influence of the tumor microenvironment on these processes remain incompletely ***,by using nMR,chemoenzymatic structural assays and a plethora of in vitro and in vivo functional analyses,we demonstrate that the tumoral carbohydrate A10(Ca10),a cell-surface carbohydrate derived from Ehrlich’s tumor(ET)cells,is a heparan sulfate-related proteoglycan that enhances glycolysis and promotes the development of tolerogenic features in human ***10-stimulated human DCs generate highly suppressive Tregs by mechanisms partially dependent on metabolic reprogramming,PD-L1,IL-10,and ***10 also reprograms the differentiation of human monocytes into DCs with tolerogenic *** solid ET-bearing mice,we found positive correlations between Ca10 serum levels,tumor size and splenic Treg *** of isolated Ca10 also increases the proportion of splenic Tregs in tumor-free ***,we provide evidence supporting the presence of a circulating human Ca10 counterpart(Ca10H)and show,for the first time,that serum levels of Ca10H are increased in patients suffering from different cancer types compared to healthy *** note,these levels are higher in prostate cancer patients with bone metastases than in prostate cancer patients without ***,we reveal novel molecular mechanisms by which heparan sulfate-related structures associated with tumor cells promote the generation of functional Tregs in *** discovery of this novel structural-functional relationship may open new avenues of research with important clinical implications in cancer treatment.

关键词： Tumoral carbohydrate A10 Heparan sulfate-related proteoglycan Cancer immunology Dendritic cell Regulatory T cell

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Preandean geological confguration of the eastern north Patagonian Massif, Argentina

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Geoscience Frontiers 2013年第6期4卷 693-708页

作者： Daniel A.Gregori José Kostadinoff Guillermina Alvarez Ariel Raniolo Leonardo Strazzere Juan C.martínez Mercedes Barros InGEOSUR Cátedra de Geología ArgentinaUniversidad Nacional del SurSan Juan 6708000 Bahía BlancaArgentina Departamento de Física Universidad Nacional del SurArgentina Cátedra de Geofísica Universidad Nacional del SurArgentina Cátedra de Cartografía Universidad Nacional del SurArgentina InGEOSUR Cátedra de PetrologíaUniversidad Nacional del SurArgentina

The Preandean geological configuration of the eastern north Patagonian Massif is established through the use of geological and geophysical *** positive gravity anomalies located near the Atlantic coast are due to 535 and 540 Ma old rocks belonging to the Pampean Orogeny （Precambrian-middle Cambrian）,which are widely recognized in central and northern *** Famatinian Cycle （Ordovician-Devonian） is represented by a Silurian-Devonian marine basin equivalent to those of eastern-central Argentina and South Africa,and which was deformed at the end of the Devonian byan～E-W to WnW-ESE compressional event,part of the Famatinian *** strong gravity gradients,the nW-SE belt is coincident with fault zones which were originated during the Gondwanide *** event also produced nW-SE overthrusting of the Silurian-Devonian sequences and strike-slip faults that displaced blocks in the same *** deformation event belongs to the Gondwanide Orogeny that includes movements related to a counterclockwise rotation of blocks in northern *** strong negative anomalies located in the western part of the area stem from the presence of rocks of the Jurassic Ca（n）adón Asfalto basin interbedded in the Marifil *** volcaniclastic sequences show mild deformation of accommodation zones in a pre-Jurassic paleorelief.

关键词： Preandean geological configuration north Patagonia Argentina Tectonics

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Refractory hepatic encephalopathy in a patient with hypothyroidism: Another element in ammonia metabolism

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World Journal of Gastroenterology 2017年第28期23卷 5246-5252页

作者： Fernando Díaz-Fontenla marta Castillo-Pradillo Arantxa Díaz-Gómez Luis Ibanez-Samaniego Pilar Gancedo Juan Adan Guzmán-de-Villoria Pilar Fernández-García Rafael Banares-Canizares Rita García-martínez Unidad de Hepatología Servicio de Aparato DigestivoHospital General Universitario Gregorio Maranón Instituto de Investigación sanitaria Hospital Gregorio Maranón Servicio de Aparato Digestivo Hospital Santa Bárbara Servicio de Radiodiagnóstico Hospital General Universitario Gregorio Maranón Centro de Investigación Biomédica en Red de Salud Mental Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas Facultad de Medicina Universidad San Pablo CEU

Hepatic encephalopathy(HE) remains a diagnosis of exclusion due to the lack of specific signs and symptoms. Refractory HE is an uncommon but serious condition that requires the search of hidden precipitating events(i.e.,portosystemic shunt) and alternative diagnosis. Hypothyroidism shares clinical manifestations with HE and is usually considered within the differential diagnosis of HE. Here,we describe a patient with refractory HE who presented a large portosystemic shunt and post-ablative hypothyroidism. Her cognitive impairment,hyperammonaemia,electroencephalograph alterations,impaired neuropsychological performance,and magnetic resonance imaging and spectroscopy disturbances were highly suggestive of HE,paralleled the course of hypothyroidism and normalized after thyroid hormone replacement. There was no need for intervention over the portosystemic shunt. The case findings support that hypothyroidism may precipitate HE in cirrhotic patients by inducing hyperammonaemia and/or enhancing ammonia brain toxicity. This case led us to consider hypothyroidism not only in the differential diagnosis but also as a precipitating factor of HE.

关键词： Hepatic encephalopathy Hypothyroidism Cognitive impairment Cirrhosis Portosystemic shunt Magnetic resonance spectroscopy

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Two novel mutations in theGAn gene causing giant axonal neuropathy

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World Journal of Pediatrics 2018年第3期14卷 298-304页

作者： Monica Irad normendez-martínez Lucero Monterde-Cruz Roberto martínez Magdalena Marquez-Harper nayelli Esquitin-Garduno Margarita Valdes-Flores Leonora Casas-Avila Valeria Ponce de Leon-Suarez Viktor Javier Romero-Díaz Alberto Hidalgo-Bravo Medical Specialties Hospital Boulevard Milenio 130San Carlos la Roncha37660 LeonGuanajuatoMexico Department of Gene tics National Institute of R ehabilitationAvenue Mexico-Xochimilco 28914389 Me xico CityMexico Department ofHis tology School ofMedicineAutonomous University oft heS tate ofN uevo LeonMonterreyMexico

Background Giant axonal neuropathy (GAn) is a rare neurodegenerative disease transmitted in an autosomal recessive mode. This disorder presents motor and sensitive symptoms with an onset in early childhood. Progressive neurodegeneration makes the patients wheelchair dependent by the end of the second decade of life. Affected individuals do not survive beyond the third decade of life. Molecular analysis has identified mutations in the gene GAn in patients with this disorder. This gene produces a protein called gigaxonin which is presumably involved in protein degradation via the ubiquitin-proteasome system. However, the underlying molecular mechanism is not clearly understood yet. Methods Here we present the fi rst patient from Mexico with clinical data suggesting GAn. Sequencing of the GAn gene was carried out. Changes in the nucleotide sequence were investigated for their possible impact on protein function and structure using the publicly available prediction tools PolyPhen-2 and PAnTHER. Results The patient is a compound heterozygous carrying two novel mutations in the GAn gene. The sequence analy-sis revealed two missense mutations in the Kelch repeats domain. In one allele, a C>T transition was found in exon 9 at the nucleotide position 55393 (g.55393C>T). In the other allele, a transversion G>T in exon 11 at the nucleotide position 67471 (g.67471G>T) was observed. Both of the bioinformatic tools predicted that these amino acid substitutions would have a negative impact on gigaxonin's function. Conclusion This work provides useful information for health professionals and expands the spectrum of disease-causing mutations in the GAn gene and it is the first documented case in Mexican population.

关键词： GAn Genetics Giant axonal neuropathy Incapacity neurodegenerative

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Antifeedant Activity of Caesalpinia coriaria Essential Oil Against Incisitermes marginipennis (Latreille)

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Phyton-International Journal of Experimental Botany 2021年第3期90卷 907-920页

作者： Cesar B.Ramírez-López Rita Beltrán-Sánchez Alistair Hernández-Izquierdo JoséLuis Salvador-Hernández Eduardo Salcedo-Pérez Rosa E.del Río Mauro M.martínez Pacheco Instituto de Investigaciones Químico Biológicas Universidad Michoacana de San Nicolás de HidalgoMorelia58030Mexico Departamento de Botánica y Zoología CUCBA Universidad de GuadalajaraNextipac45200Mexico

This study scrutinized the possibility of finding toxicant or deterrent plant metabolites against the dry wood termite Incisitermes marginipennis(Latreille).Plant deterrent agents act as repellents or antifeedants to prevent wood decay and increase its useful *** potential of the tree Caesalpinia coriaria(Fabaceae)as a biological source of molecules with deterrent effects against the dry wood termite was assessed by a phytochemical fractionation guided by repellence and antifeedant *** gas chromatography-mass spectrometry analysis of the leaf essential oil showed geraniol to be one of the major components and its repellent and antifeedant effects were *** had only an antifeedant effect without affecting the body weight or survival of the dry wood *** the leaf essential oil,geraniol did not exhibit a repellency *** in-silico approach of the activity of acetylcholinesterase in interaction with geraniol resulted in an affinity energy of−7.5 Kcal/*** interacted with the amino acid tyrosine 324 located in the enzyme’s active site while citronellol(negative control)interacted with tryptophan 83 located adjacent to the active *** deterring terpenes have not been implemented for the preservation and restoration of wood products exposed to the attack of the dry wood ***,they are an important natural control alternative.

关键词： Termite geraniol repellent antifeedant deterrent

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Pretreatment inflammatory indices predict Bevacizumab response in recurrent Glioma

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Cancer Drug Resistance 2020年第3期3卷 623-635页

作者： Alicia martínez-González Raquel Cabrera marta Lloret Pedro C.Lara Department de Matemáticas Universidad de Castilla-La ManchaETSI IndustrialesAvdaCiudad Real 13071Spain. Oncología Radioterápica Hospital Universitario de Gran Canaria Dr negrin Barranco de la Ballena s/nLas Palmas de Gran CanariaLas Palmas 35010Spain. Facultad de Ciencias de la Salud Universidad de Las Palmas de Gran CanariaPaseo de Blas Cabrera Felipes/nLas Palmas de Gran CanariaLas Palmas 35016Spain. Fundación Canaria del Instituto Canario de Investigación del Cáncer Avda de la Trinidad 61 Torre Agustín Arevalo 7 planta La LagunaSanta Cruz de Tenerife 38204Spain. san Roque University Hospitals Dolores de la Rocha5Las Palmas de Gran CanariaLas Palmas 35001Spain. Fernando Pessoa Canarias University Dolores dela Rocha 14Las Palmas de Gran CanariaLas Palmas 35016Spain.

Aim:It remains unclear what the best therapeutic option for recurrent glioma patients after Stupp treatment ***(BVZ)is commonly administered in progression,but it appears that only some patients *** would be useful to find biomarkers that determine beforehand who these patients ***:The protocol included 31 high-risk progressing glioma patients after Stupp treatment who received BVZ 5-10 mg/kg every 14 days and temozolomide(3-19 cycles,150-200 mg five days each 28-day cycle)during a mean of eight cycles of BVZ or until tumor progression or unacceptable *** analyzed the clinical outcome values of inflammatory indices measured before BVZ ***:Lymphocyte level before BVZ administration was the best independent predictor of overall survival(HR=0.34;95%CI:0.145-0.81;P=0.015).The area under the receiver operating characteristic(ROC)curve was 0.823,with 1.645 being the optimal cut-off value,and 0.80 and 0.85 the sensitivity and specificity values,*** and non-responder survival curves were also significantly different,considering the first and second tertiles as cut-off *** number of BVZ cycles was not related to *** neutrophil platelet levels,platelet-to-lymphocyte ratio(PLR),and neutrophil-to-lymphocyte ratio(nLR)did not have independent predictive *** variables were not correlated with each ***,patients with high nLR and PLR simultaneously(double positive PLR-nLR)showed a worse clinical outcome than the rest(P=0.043).Conclusion:Pretreatment lymphocyte levels and double positive PLR-nLR could be used as non-invasive hematological prognostic markers for recurrent gliomas treated with bevacizumab.A close relationship emerged between inflammation and angiogenesis.

关键词： Recurrent glioma bevacizumab predictive biomarker inflammatory indices lymphocytes

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Raman spectroscopy for detection of imatinib in plasma: A proof of concept

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Journal of Innovative Optical Health Sciences 2015年第5期8卷 56-66页

作者： sanhita Rath Aditi Sahu Vikram Gota P.G.martínez-Torres J.L.Pichardo-Molina C.Murali Krishna Department of Clinical Pharmacology ACTREC Tata Memorial CenterKharghar Navi Mumbai 410210 India Chilakapati Lab ACTRECTata Memorial Center KhargharNavi Mumbai 410210 India Instituto de Fisica y Matematicas Universidad Michoacana de san nicolas de Hidalgo Edificio C-3 Ciudad Universitaria CP.58040 MoreliaMichoacanMexico Centro de Investigaciones enOptica AC C.P.37#150 Leon Gto.Mexico

Imatinib is the standard first line treatment for chronic myeloid leukemia(CML).Owing to doserelated toxicities of Imatinib such as neutropenia,there is scope for treatment optimization through therapeutic drug monitoring(TDM).Trough concentration of 1g/mL is considered the therapeutic *** methods for the detection of Imatinib in plasma are limited by long read out time and expensive ***,Raman spectroscopy was explored as a rapid and objective tool for monitoring Imatinib *** approaches:conventional Raman spectroscopy(CRS),Drop coating deposition Raman(DCDR)spectroscopy and surface-enhanced Raman spectroscopy(SERS)were employed to detect the required trough concentration of 1g/mL and *** of therapeutically relevant concentrations(1g/mL)using SERS and suitable nanoparticle substrates has been ***,rigorous validation using clinical samples is necessary to confirm the utility of this approach in routine clinical usage.

关键词： Therapeutic drug monitoring Raman spectroscopy Imatinib SERS DCDR chronic myeloid leukemia

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