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World Journal of Gastroenterology 2018年第23期24卷 2427-2440页

作者： esteban juan fiore Luciana María Domínguez juan Bayo Mariana Gabriela García Guillermo Daniel Mazzolini Laboratory of Gene Therapy Instituto de Investigaciones en Medicina TraslacionalCONICET-Universidad Austral

Cell-based therapies for acute and chronic liver diseases are under continuous progress. Mesenchymal stem/stromal cells(MSCs) are multipotent cells able to migrate selectively to damaged tissue and contribute to its healing and regeneration. The MSC pro-regenerative effect occurs due to their immunomodulatory capacity and their ability to produce factors that promote cell protection and survival. Likewise,it has been observed that part of their paracrine effect is mediated by MSC-derived extracellular vesicles(EVs). EVs contain proteins,lipids and nucleic acids(DNA,m RNA,mi RNA,lnc RNA) from the cell of origin,allowing for intercellular communication. Recently,different studies have demonstrated that MSC-derived EVs could reproduce,at least in part,the biological effects obtained by MSCbased therapies. Moreover,due to EVs' stability for long periods of time and easy isolation methods they have become a therapeutic option to MSCs treatments. This review summarizes the latest results achieved in clinical trials using MSCs as cell therapy for liver regeneration,the role of EVs in liver physiopathology and the potential of MSC-derived EVs as intercellular mediators and therapeutic tools in liver diseases.

关键词： Mesenchymal stem cells Extracellular vesicles Cirrhosis Liver Acute damage Regeneration

Understanding the Link:Emotional Attention in Italian Families and Children’s Social Development

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International Journal of Mental Health Promotion 2024年第9期26卷 709-718页

作者： Catalda Corvasce juan Pedro Martínez-Ramón Francisco Manuel Morales-Rodríguez Lidia Pellicer-García Inmaculada Méndez Cecilia Ruiz-esteban Liceo Statale“Carlo Cafiero” Barletta(BT)76121Italy Department of Developmental Psychology and Education University of MurciaMurcia30100Spain Department of Developmental Psychology and Education University of GranadaCampus of La CartujaGranadaCP 18071Spain Department of Spanish Language and General Linguistics University of MurciaCampus of La MercedMurciaCP 30001Spain

Background:Emotional attention refers to the capacity to recognize and properly respond to one’s and others’emotional *** another note,family is a primary source of socialization that influences the development of various social *** another line,adolescence is a complex stage that has been associated with emotional difficulties that could be related to competences such as prosociability and *** is inferred that through the family context and the attention that is processed,a series of competencies are transmitted to the youngsters,but this relationship is still *** this reason,the study’s purpose was to examine the relationship between the emotional attention of mothers and fathers and the social and prosocial competencies of their ***:To accomplish this,a cross-sectional study and ex post facto design were *** Trait-Meta Mood Scale(TMMS-24)-to assess emotional attention-,the Strengths and Difficulties Questionnaire(SDQ)-to determine the prosociality dimension-,and the Test on Passing Developmental Tasks in Adolescence(TCS-A)-to measure social inclusionwere *** participants were N=228 families composed of n=114 mothers/fathers(67.5%females)and n=114 daughters/sons(38.5%females)selected through non-probabilistic sampling using a convenience sample in the Bari region of Italy.A descriptive and inferential analysis-Student’s test and Pearson’s correlation-was performed with the statistic package SPSS version 28(significance level p<0.05).Results:The findings showed that the families possessed an adequate background in emotional attention and that their daughters and sons were also generally well-adjusted in social inclusion and *** also found certain signs that the prosocial competence of the children could be related to the behavior of their mothers and ***:In conclusion,social inclusion is related to prosocial behavior,and maybe primarily cultivated within families where paren

关键词： Educational style coping strategies stress social inclusion emotional attention prosociality

Secondary Metabolites of Entomopathogenic Fungi, Biological Alternative for the Control of Agricultural Pests and Disease: Present and Perspectives

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Advances in Enzyme Research 2024年第1期12卷 1-15页

作者： Nallely San juan-Maldonado Silvia Rodríguez-Navarro Alejandro Angel-Cuapio José Norberto Vásquez Bonilla juan esteban Barranco-Florido Departamento de Producció n Agr&#237cola y Animal Universidad Aut&#243noma Metropolitana Unidad Xochimilco Ciudad de M&#233xico M&#233xico Divisió n de Ingenier&#237a Qu&#237mica y Bioqu&#237mica Tecnol&#243gico Nacional de M&#233xico/TES de Ecatepec Ecatepec de Morelos M&#233xico Departamento de Sistemas Bioló gicos Universidad Aut&#243noma Metropolitana Unidad Xochimilco Ciudad de M&#233xico M&#233xico

The use of entomopathogenic fungi (EF) in recent years has been highly effective against the different orders of insects considered pests of agricultural importance and their conidia have been commonly applied, but it has been reported that these are sensitive to the environmental conditions. For this reason, biopesticides products have been formulated based on secondary metabolites, recently. These biomolecules participate as biological control agent, such as: cyclic depsipeptides, amino acids, polyketides, polyphenols and terpenoids, affecting their morphology, life cycle and insect behavior. The use of secondary metabolites of entomopathogenic fungi opens the possibility of application in a more efficient way for the control of agricultural pests in a compatible with the environment and human health;therefore, it is important to know, analyzing the type of molecules, their effects, and their different methods of application.

关键词： Secondary Metabolites Entomopathogenic Fungi Biological Control Agent

Clinical profile and outcomes in very elderly patients with atrial fibrillation anticoagulated with rivaroxaban: data from the EMIR study

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Journal of Geriatric Cardiology 2024年第7期21卷 723-732页

作者： Francisco Marín Manuel Anguita Sánchez Iñaki Lekuona Marcelo Sanmartín Fernán-dez Vivencio Barrios Carlos Perez Muñoz juan Cosín-Sales Alejandro IPérez Cabeza Vanesa Roldán Schilling Carles Rafols Priu esteban Orenes-Piñero María Asunción Es-teve-Pastor Department of Cardiology Hospital Clínico Universitario Virgen de la ArrixacaIMIB-ArrixacaUniversity of MurciaCIBERCVMurciaSpain Department of Cardiology Hospital Reina Sofía CórdobaIMIBICUniversity of CordobaCIBERCVCórdobaSpain Hospital Galdakao-Usansolo BizkaiaSpain Department of Cardiology Hospital Uni-versitario Ramony CajalCIBERCVMadridSpain Department of Cardiology University Hospital Ramóny CajalAl-caláUniversityMadridSpain Medical Center La Capillita Sanlúcar de Barrameda.Private cardiology clinicJerez de la FronteraSpain Department of Cardiology Hospital Arnau de VilanovaValenciaSpain Department of Car-diology Virgen de la Victoria University HospitalCIBERCV.MalagaSpain Department of Haematology Hospital Clínico Universitario Virgen de la ArrixacaUniversity of MurciaMurciaSpain Department of Medical Affairs Bayer HispaniaBarcelonaSpain Department of Biochemistry and Molecular Biology-A University of MurciaMurciaSpain

Objectives To analyze the clinical profile,adequacy of treatment with rivaroxaban and outcomes in octogenarians with atrial fibrillation(AF),taking rivaroxaban in clinical *** Observational and non-interventional study that included AF adults recruited from 79 Spanish centers,anticoagulated with rivaroxaban ≥ 6 months before being *** were analyzed according to age(≥ 80 vs.< 80 years) at *** Out of 1433 patients,453(31.6%) were octogenarians at *** to younger patients,octogenarians had more comorbidities,higher CHA2DS2-VASc(4.5 ± 1.3 vs.3.0 ± 1.4;P < 0.001) and HAS-BLED scores(2.0 ± 1.0 vs.1.4 ± 1.0;P < 0.001).Overall,the dose of rivaroxaban was adequately prescribed in 83.4% of patients,but more frequently in the younger population(71.1% vs.89.1%;P = 0.039).After a mean follow-up of 2.2 ± 0.6 years,annual rates of stroke + systemic embolism + transient ischemic attack,MACE,cardiovascular death and major bleeding were 1.03%,1.24%,1.03% and 1.75%,respectively,in octogenarian *** for progressive heart failure death and major bleeding,rates of outcomes in octogenarians were similar compared to younger *** octogenarians,the concomitant use of antiplatelet agents and non-severe dementia were independently associated with the development of ischemic stroke,whereas previous coronary revascularization and heart failure with MACE,and higher HAS-BLED score with major *** In clinical practice,around one third of patients taking rivaroxaban are *** patients have many comorbidities and a high thromboembolic *** that,rates of adverse events remain *** is adequately prescribed in the majority of octogenarians.

关键词： patients atrial bleeding

Digestive and breast cancer patients managed during the first wave of COVID-19 pandemic:Short and middle term outcomes

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World Journal of Methodology 2024年第2期14卷 107-126页

作者： Jacobo Trébol Ana Carabias-Orgaz María Carmen esteban-Velasco Asunción García-Plaza juan Ignacio González-Munoz Ana Belén Sánchez-Casado Felipe Carlos Parreno-Manchado Marta Eguía-Larrea José Antonio Alcázar-Montero Cirugía General y del Aparato Digestivo Complejo Asistencial Universitario de SalamancaSalamanca 37007SalamancaSpain Cirugía Universidad de SalamancaSalamanca 37007SalamancaSpain Oftalmología Complejo Asistencial Universitario de SalamancaSalamanca 37007SalamancaSpain

BACKGROUND The first wave of coronavirus disease 2019(COVID-19)pandemic in Spain lasted from middle March to the end of June *** population was subjected to lockdown periods and scheduled surgeries were discontinued or reduced during variable *** our centre,we managed patients previously and newly diagnosed with *** established a strategy based on limiting perioperative social contacts,preoperative screening(symptoms and reverse transcriptionpolymerase chain reaction)and creating separated in-hospital COVID-19-free pathways for non-infected *** also adopted some practice modifications(surgery in different facilities,changes in staff and guidelines,using continuously changing personal protective equipment…),that supposed new *** To analyse cancer patients with a decision for surgery managed during the first wave,focalizing on outcomes and pandemic-related *** We prospectively included adults with a confirmed diagnosis of colorectal,oesophago-gastric,liver-pancreatic or breast cancer with a decision for surgery,regardless of whether they ultimately underwent *** analysed short-term outcomes[30-d postoperative morbimortality and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection]and outcomes after 3 years(adjuvant therapies,oncological events,death,SARS-CoV-2 infection and vaccination).We also investigated modifications to usual *** From 96 included patients,seven didn’t receive treatment that period and four never(3 due to COVID-19).Operated patients:28 colon and 21 rectal cancers;laparoscopy 53.6%/90.0%,mortality 3.57%/0%,major complications 7.04%/25.00%,anastomotic leaks 0%/5.00%,3-years disease-free survival(DFS)82.14%/52.4%and overall survival(OS)78.57%/76.2%.Six liver metastases and six pancreatic cancers:no mortality,one major complication,three grade A/B liver failures,one bile leak;3-year DFS 0%/33.3%and OS 50.0%/33.3%(liver metastases/pancreatic carcinoma).5 g

关键词： COVID-19 SARS-CoV-2 Colon cancer Rectal cancer Breast cancer Liver cancer Pancreatic cancer Gastric cancer Oesophageal cancer Surgery

Persistent Abdominal Pain Associated with Splenic Lymphangioma in An Adult Patient: A Case Presentation

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Journal of Biosciences and Medicines 2024年第9期12卷 82-88页

作者： David Fernando Ortiz Pérez Janne Jorgeth Fabregas Ramirez Mario Enrique Montoya Jaramillo juan José Iles Bravo John Sebastián Osorio Muñoz Manuel Fernando Chavarro Muñoz Daniel de Jesús González Villarreal Manuel esteban Ortiz Pérez Department of Internal Medicine Cartagena del Mar Clinical Center Cartagena Colombia

Splenic lymphangioma is a rare benign lesion, predominantly seen in the pediatric population and exceptionally in adults. It is usually associated with lymphatic system malformations caused by secondary lymphangiectasia due to abnormal communication between lymphatic ducts. It often coexists with complex clinical syndromes, such as Klippel-Trenaunay syndrome, congenital epithelial cysts, or, in less frequent conditions, infectious or post-traumatic triggering events. It typically presents in the neck or axillae, with intra-abdominal cases accounting for less than 5% of all cases. We present the clinical case of a 44-year-old male patient who presented with a clinical course of approximately one month, characterized by progressive abdominal pain associated with nausea, multiple episodes of emesis, anorexia, and involuntary weight loss. A diagnostic laparoscopy was performed, revealing a poorly differentiated lesion in the splenic topography, for which a biopsy was performed, leading to the definitive diagnosis. In this scenario, splenic lymphangioma should be considered among the differential diagnoses of persistent abdominal pain, and definitive interventions should be determined based on clinical characteristics.

关键词： Lymphangioma Neoplasms Splenic Neoplasms Laparoscopy Adulthood

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应用机器学习对外卖含糖饮料消费的研究

农业经济问题 2024年第7期 20-33页

作者：翟倩倩蒋玉张家铭胡安·埃斯特班·格瓦拉王红浙江大学中国农村发展研究院杭州310058 西南财经大学中国西部经济研究院成都611130 普渡大学农业经济系西拉法叶47907 普渡大学统计系西拉法叶47907

含糖饮料因其高热量而导致慢性疾病,引起的健康问题得到全球的关注。在外卖平台迅速发展的大背景下,本文基于中国六个城市的外卖平台的销售数据,运用机器学习方法识别外卖含糖饮料消费动态,并对价格折扣、糖税等模拟情景进行了销售变动... 详细信息

含糖饮料因其高热量而导致慢性疾病,引起的健康问题得到全球的关注。在外卖平台迅速发展的大背景下,本文基于中国六个城市的外卖平台的销售数据,运用机器学习方法识别外卖含糖饮料消费动态,并对价格折扣、糖税等模拟情景进行了销售变动分析。研究发现,第一,有监督机器学习模型中的神经网络相较于传统计量回归模型更加适用于消费趋势预测分析。第二,模型预测结果表明,当价格降低10%时,总销售额将比原始销售增加0.49%,说明含糖饮料消费富有价格弹性;此外,当价格上升10%时,总销量额将比原始销售下降0.17%,表明通过税收手段来减少含糖饮料的消费是可行策略。第三,外卖含糖饮料的销售情况存在时空差异,长三角地区外卖含糖饮料的销售量高于其他地区,周中的销售量高于周末时段,下午的销售量是一天的高峰。本文研究对于建立降低含糖饮料的过度消费的路径与机制,引导消费者健康饮食选择,推动外卖服务行业的可持续发展具有重要意义。

关键词：含糖饮料外卖机器学习神经网络

Mechanical and natural ventilation systems in a greenhouse designed using computational fluid dynamics

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International Journal of Agricultural and Biological Engineering 2014年第1期7卷 1-16页

作者： Jorge Flores-Velazquez juan I.Montero esteban J.Baeza juan C.Lopez Mexican Institute of Water Technology.Paseo Cuauhnáhuac 8532 Col.ProgresoC.P.62550JiutepecMor.Mexico Institut de Recerca i Tecnologia Agroalimentàries 08348Cabrils(Barcelona)Spain IFAPA Centro La Mojonera(Junta de Andalucía) Camino San Nicolás 104745 La MojoneraAlmeríaSpain Fundación Cajamar.Estación Experimental“Las Palmerillas”Autovía del Mediterráneo Km 416 704710El EjidoAlmeríaSpain

The aim of this study was to analyse air exchange and temperature distribution in a greenhouse with combined mechanical and natural ventilation and to design more efficient mechanical ventilation *** this purpose,a computational fluid dynamics(CFD)model of the greenhouse was *** configurations were considered:Configuration 1(mechanical ventilation and closed roof ventilators),Configurations 2 and 3(mechanical ventilation and roof ventilators open 30%and 100%,respectively).After validation,the CFD model was used to improve the design of the greenhouse mechanical ventilation system in each of the three configurations *** greenhouse lengths,28 m,50 m,75 m and 100 m,were used in the *** to fan ventilation only,roof ventilation improved the climate of fan-ventilated greenhouses in terms of the air exchange rate(22%)and climate uniformity because the internal air was mixed better than with mechanical ventilation *** the greenhouse length increased,more advantages were achieved with natural ventilation compared to mechanical *** most configurations,there was a strong linear correlation between temperature gradient and greenhouse *** greenhouse whose regression line had the steepest slope was the one with closed roof *** the fan capacity produced a general reduction in temperature,but the effect was less intense for the greenhouses with open roof *** to box inlet ventilators,an enlarged continuous inlet in the wall opposite the fans increased overall system performance because it eliminated backflow recirculation zones,which are prone to produce high temperatures.

关键词： greenhouse cooling fan ventilation roof ventilators combined ventilation

Effect of snow on mountain river regimes： an example from the Pyrenees

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Frontiers of Earth Science 2017年第3期11卷 515-530页

作者： Alba SANMIGUEL-VALLELADO Enrique MORAN-TEJEDA esteban ALONSO-GONZALEZ juan Ignacio LOPEZ-MORENO Pyrenean Institute of Ecology CSIC (Spanish Research Council) Zaragoza Spain Department of Geography University of the Balearic Islands Palma de Mallorca Spain

The purpose of this study was to characterize mountain river regimes in the Spanish Pyrenees and to assess the importance of snow accumulation and snowmelt on the timing of river flows. Daily streamflow data from 9 gauging stations in the Pyrenees were used to characterize river regimes. These data were analyzed by hydrological indices, with a focus on periods when snow accumulation and snowmelt occurred. These results were combined with data on Snow Water Equivalent （SWE）（from measure- ments of depth and density of snow in the main river basins and also simulated by a process-based hydrological model）, snowmelting （simulated by a process-based hydrological model）, precipitation （from observations）, and temperature （from observations）. Longitude. and elevation gradients in the Pyrenees explain the transition of river regimes from those that mostly had low nival signals （in the west and at low elevations） to those that mostly had high nival signals （low winter runoff and late spring peakflow, in the east and at high elevations）. Although trend analyses indicated no statistically signifi- cant changes, there was a trend of decreased nival signal over time in most of the analyzed rivers. Our results also demonstrated that snow processes cannot explain all of the interannual variability of river regimes, because the temporal distribution of liquid precipitation and tempera- ture play key roles in hydrography.

关键词： river regime precipitation snow indices,Spanish Pyrenees streamflow

Differential responses to artificial selection on oviposition site preferences in Drosophila melanogaster and D. simulans

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Insect Science 2015年第6期22卷 821-828页

作者： Eduardo M. Soto Maria I. L. Betti juan Hurtado esteban Hasson Departamento de Ecologia Genetica y Evolucion IEGEBA (CONICET-UBA) Facultad de Ciencias Exactas y Naturales Universidad deBuenos Aires Buenos Aires Argentina

The preference-performance relationship in plant-insect interactions is a cen- tral theme in evolutionary ecology. Among many insects, eggs are vulnerable and larvae have limited mobility, making the choice of an appropriate oviposition site one of the most important decisions for a female. We investigated the evolution of oviposition preferences in Drosophila melanogaster Meigen and Drosophila simulans Sturtevant by artificially selecting for the preference for 2 natural resources, grape and quince. The main finding of our study is the differential responses of D. melanogaster and D. simulans. Although preferences evolved in the experimental populations of D. melanogaster, responses were not consistent with the selection regimes applied. In contrast, responses in D. simulans were consistent with expectations, demonstrating that this species has selectable genetic variation for the trait. Furthermore, crosses between D. simulans divergent lines showed that the genetic factors involved in grape preference appear to be largely recessive. In summary, our artificial selection study suggests that D. melanogaster and D. simulans possess different genetic architectures for this trait.

关键词： artificial selection behavior Drosophila genetic variation naturalresources oviposition preference