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世界核心医学期刊文摘（胃肠病学分册） 2005年第3期1卷 25-25页

作者： Lake J.P. essani r. Petr.ne P. r.W. Bear. Jr. 李康 Depar.ment of Color.ctal Sur.er. Keck School of Medicine University of Southern California 1441 Eastlake Avenue Los Angeles CA 90033 United States Dr.

PUr.OSE: This study was designed to r.view exper.ence at our.hospital with r.tained color.ctal for.ign bodies. METHODS: We r.viewed the consultation r.cor.s at Los Angeles County +Univer.ity of Souther. Califor.ia Gener.l Hospital fr.m October.1993 thr.ugh October.2002. Ninety thr.e cases of tr.nsanally intr.duced, r.tained for.ign bodies wer. identified in 87 patients. Data collected included patient demogr.phics, extr.ction method, location, size and type of for.ign body, and postextr.ction cour.e. r.SULTS: Of 93 cases r.viewed, ther. wer. 87 individuals who pr.sented with fir.t time episodes of having a r.tained color.ctal for.ign body. For.these patients, bedside extr.ction was successful in 74 per.ent. Ultimately, 23 patients wer. taken to the oper.ting r.om for.r.moval of their.for.ign body. In total, 17 examinations under.anesthesia and 8 lapar.tomies wer. per.or.ed (2 patients initially under.ent an anesthetized examination befor. lapar.tomy). In the eight patients who under.ent explor.tor. lapar.tomy, only one had successful deliver. of the for.ign object into the r.ctum for.tr.nsanal extr.ction. The r.mainder.r.quir.d r.pair.of per.or.ted bowel or.r.tr.eval of the for.ign body via a colotomy. In our.r.view, a major.ty of cases had objects r.tained within the r.ctum; the r.st wer. located in the sigmoid colon. Fifty five per.ent of patients (6/11) pr.senting with a for.ign body in the sigmoid colon r.quir.d oper.tive inter.ention vs. 24 per.ent of patients (17/70) with objects in their.r.ctum (P = 0.04). CONCLUSIONS: This is the lar.est single institution ser.es of r.tained color.ctal for.ign bodies. Although for.ign objects located in the sigmoid colon can be r.tr.eved at the bedside, these cases ar. mor. likely to r.quir. oper.tive inter.ention.

关键词：手术干预开腹手术回顾研究穿孔修补病例记录开腹探查综合医院人口统计学第一时间南加

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Oncoselectivity in Oncolytic Vir.ses against Color.ctal Cancer

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Jour.al of Cancer.Ther.py 2014年第13期5卷 1153-1174页

作者： Steven J. Conr.d Kar.m essani Labor.tor. of Vir.logy Depar.ment of Biological Sciences Western Michigan University Kalamazoo USA

In humans color.ctal cancer.(Cr.) is a significant cause of mor.idity and mor.ality. New tr.atment options ar. ur.ently needed to supplement existing ther.pies. r.plication-competent oncolytic vir.ses (r.OVs) for.the tr.atment of cancer.us tumor.?in vivo?is a r.latively new ther.peutic modality with gr.at but lar.ely unr.alized potential against Cr.. In the context of oncolytic vir.s safety, oncoselectivity is an impor.ant cr.ter.on. It is at the conceptual inter.ection of vir.l r.plication str.tegy and tumor.cell biology that r.OVs acquir. their.oncoselectivity, and thus their.safety. Ever. aspect of tumor.molecular.biology which distinguishes it fr.m nor.al, non-neoplastic cells is a potential tar.et for.exploitation. In the fir.t section of this r.view we will pr.vide an explanation of some of the successful and widely used str.tegies for.impr.ving oncoselectivity in wild-type vir.ses to make them mor. suitable as r.OVs. In the second section we will descr.be some of the char.cter.stics of Cr. biology which can be exploited to pr.vide oncoselectivity against Cr.. Thr.ughout the r.view examples of successfully-engineer.d r.OVs which embody the appr.ach or.str.tegy under.discussion ar. noted. By showing what has been done, we hope to highlight what is possible and what r.mains to be done to gener.te oncoselective r.OVs for.use against Cr. in humans.

关键词： Color.ctal Cancer r.plication-Competent Oncolytic Vir.s Oncoselectivity Vir.ther.py

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