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Propolis reduces bacterial translocation and intestinal villus atrophy in experimental obstructive jaundice

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World Journal of Gastroenterology 2007年第39期13卷 5226-5231页

作者： Mehmet Zafer Sabuncuoglu Kemal Kismet Sibel Serin Kilicoglu Bulent Kilicoglu Serap Erel Sabahattin Muratoglu Asli Elif Sunay esra erdemli Mehmet Ali Akkus 4th General Surgery Department Ankara Training and Research Hospital Ulucanlar Ankara 06340 Turkey Department of Histology and EmbriologyUfuk University School of Medicine Ankara 06520 Turkey Microbiology Department Ankara Training and Research Hospital Ulucanlar Ankara 06340 Turkey Food Engineer Balparmak Pazarlama Cekmekoy 34760 Istanbul Turkey Department of Histology and Embriology Ankara University School of Medicine 06100 Ankara Turkey

AIM： To investigate the effects of propolis on bacterial translocation and ultrastructure of intestinal morphology in experimental obstructive jaundice. METHODS： Thirty Wistar-Albino male rats were randomly divided into three groups, each including 10 animals： group Ⅰ, sham-operated; group Ⅱ, ligation and division of the common bile duct （BDL）; group Ⅲ, BDL followed by oral supplementation of propolis 100 mg/kg per day. Liver, blood, spleen, mesenteric lymph nodes, and ileal samples were taken for microbiological, light and transmission electron microscopic examination on postoperative 7^th d after sacrification. RESULTS： The mean number of villi per centimeter and mean mucosal height of the propolis group were significantly different in the BDL group （P = 0.001 and 0.012, respectively）. The electron microscopic changes were also different between these groups. Sham and BDL＋propolis groups had similar incidence of bacterial translocation （BT）. The BDL group had significantly higher rates of BT as compared with sham and BDL ＋ propolis groups. BT was predominantly detected in MLNs and the most commonly isolated bacteria was Escherichia coil CONCLUSION： Propolis showed a significant protective effect on ileal mucosa and reduced bacterial translocation in the experimental obstructive jaundice model. Further studies should be carried out to explain the mechanisms of these effects,

关键词： Obstructive jaundice Bacterial translocation Ileal morphology

Effect of honey on bacterial translocation and intestinal morphology in obstructive jaundice

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World Journal of Gastroenterology 2008年第21期14卷 3410-3415页

作者： Cem Gencay Kemal Kismet Bulent Kilicoglu Serap Erel Mehmet Ali Akkus Sibel Serin Kilicoglu Sabahattin Muratoglu Asli Elif Sunay esra erdemli Ankara Training and Research Hospital4th General Surgery Department Ankara 06340Turkey Ufuk University School of Medicine Department of Histology and EmbryologyAnkara 06800Turkey Ankara Training and Research Hospital Microbiology Department Ankara 06340Turkey Food Engineer Balparmak Pazarlama34760CekmekoyIstanbul Turkey Ankara University School of Medicine Department of Histology and Embryology4Ankara 06370Turkey

AIM:To evaluate the effects of honey on bacterial translocation and intestinal villus histopathology in experimental obstructive ***:Thirty Wistar-Albino rats were randomly divided into three groups each including 10 animals:group Ⅰ,sham-operated;group Ⅱ,ligation and section of the common bile duct(BDL);group Ⅲ,bile duct ligation followed by oral supplementation of honey(BDL+honey) 10 g/kg per ***,blood,spleen,mesenteric lymph nodes,and ileal samples were taken for microbiological,light and transmission electrone microscopic ***:Although the number of villi per centimeter and the height of the mucosa were higher in sham group,there was no statistically significant difference between sham and BDL + honey groups(P>0.05).On the other hand,there was a statistically significant difference between BDL group and other groups(P0.05).BDL group had significantly higher rates of bacterial translocation as compared with sham and honey *** translocation was predominantly detected in mesenteric lymph ***:Supplementation of honey in presence of obstructive jaundice ameliorates bacterial translocation and improves ileal morphology.

关键词： Honey Obstructive jaundice Intestinalvillus atrophy Bacterial translocation

Effects of honey as a scolicidal agent on the hepatobiliary system

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World Journal of Gastroenterology 2008年第13期14卷 2085-2088页

作者： Bulent Kilicoglu Kemal Kismet Sibel Serin Kilicoglu Serap Erel Omur Gencay Kadriye Sorkun esra erdemli Okan Akhan Mehmet Ali Akkus Iskender Sayek Department of General Surgery Ankara Training and Research Hospital Ankara 06340 Turkey Department of Histology-Embryology Ufuk University Ankara 06340 Turkey Department of Biology Faculty of Science Hacettepe University Ankara 06340 Turkey Department of Histology-Embryology Ankara University Ankara 06340 Turkey Department of Radiology Hacettepe University Ankara 06340 Turkey Department of General Surgery Hacettepe University Ankara 06340 Turkey

AIM： To examine the effects of 10% diluted honey, which has been shown to be scolicidal, on the liver and biliary system and determine whether it could be used as a scolicidal agent in the presence of biliary-cystic communication. METHODS： Thirty Wistar-Albino rats were divided into two groups. Honey with 10% dilution in the study group and 0.9% saline （NaCI） in the control group were injected into the common bile ducts of rats through a 3-mm duodenotomy. The animals were sacrificed 6 mo alter the procedure. Histopathological, biochemical, and radiological examinations were performed for evaluation of side effects. RESULTS： At the end of the sixth month, liver function tests were found to be normal in both groups. The tissue samples of liver and ductus choledochus of the honey group showed no histomorphologic difference from the control group. No stricture on the biliary tree was detected on the retrograde cholangiograms. CONCLUSION： According to these results, we concluded that 10% diluted honey could be used as scolicidal agent safely in the presence of biliary-cystic communication.

关键词： Scolocidal agent Honey Hepatobiliary system

Investigation of stem cells in adult and prepubertal mouse ovaries

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Advances in Bioscience and Biotechnology 2012年第7期3卷 936-944页

作者： Yashar Esmaeilian Bala Gur Dedeoglu Arzu Atalay esra erdemli Central Lab of Biotechnology Institute University of Ankara Ankara Turkey Department of Histology and Embryology School of Medicine University of Ankara Ankara Turkey

The possible presence of oocyte and granulosa cells originated from stem cells in the adult mammalian ovaries was claimed by some studies which will lead to major changes in reproductive biology and infertility treatments. Purpose of this research is to investigate the possible existence and the location of the potential stem cells in mouse ovaries. In this study, the ovaries from 2-week (pre-puberty) and 8-week (adult) old BALB-C mice were used. For the investigation of the presence of possible stem cells, the expression profiles of three well known stem cell markers, Oct-4, Nanog and Sox2 were determined in the ovaries of two different age groups by real time quantitative RT-PCR (qRT-PCR). Protein expression levels and their localization in the ovary cells were immunohistochemically evaluated on fresh-frozen ovary tissue sections by using monoclonal antibodies specific to Sox2, Nanog and Oct-4. The gene expression levels of Oct-4 and Nanog were found to be significantly differentiated between 2-week old and 8-week old mice whereas no significant difference was observed in the expression level of Sox2 between two age groups. Immunohistochemistry results showed the presence of both Sox2 and Oct-4 protein in the cytoplasm of ovarian epithelial cells, granulosa cells, oocytes and theca cells. Nanog protein was observed only in the nucleus of the oocytes and furthermore the expression of Nanog was higher in eight weeks old samples compared to two weeks old ones according to qRT-PCR results. These results suggest for the first time that Nanog protein is expressed both in adult and pre-puberty mouse ovaries and locate at the nucleus of the oocytes and to the best of our knowledge this is the first study that shows the differential expression of Oct-4, Nanog and Sox2 in pre-puberty and adult mouse ovaries by qRT-PCR. Collectively, our results may suggest that both pre-puberty and adult mice ovaries accommodate cells carrying stem cell features.

关键词： Ovarian Stem Cell (OSC) Oct-4 Nanog Sox2 Real Time-PCR Immunohistochemical Staining

Projectively Ricci-flat General(α,β)-metrics

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Acta Mathematica Sinica,English Series 2024年第6期40卷 1409-1419页

作者： esra Sengelen SEVIM Department of Mathematics Istanbul Bilgi University34060Eski Silahtaraga Elektrik SantraliKazim Karabekir Cad.No:2/13 EyupsultanIstanbulTurkey

In this paper,we study the projectively Ricci-flat general(α,β)-metrics within to a spray framework and also bring out the rich variety of behaviour displayed by an important projective *** Ricci curvature is one of the essential projective invariant in Finsler geometry which has been introduced by *** projective Ricci curvature is defined as Ricci curvature of a projective spray associated with a given spray G on M^(n) with a volume form dV on M^(n).

关键词： Finsler metrics general(α β)-metrics projective Ricci curvature

Effects of precommercial thinning on growth parameters in Pinus nigra ***(Lamb.)Holmboe stand

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Journal of Forestry Research 2020年第5期31卷 1803-1811页

作者： esra Bayar Ayse Deligoz Department of Forestry Engineering Faculty of ForestryIsparta University of Applied SciencesIsparta 32260Turkey

We investigated the effects of precommercial thinning(PCT)applied at different levels on the growth parameters of natural Anatolian black pine *** experimental site was located in the province of Isparta in southern *** was set up using a randomized complete block design with three replicates and three treatments(control,2–2.5 m×–2.5 m and 3–3.5 m×–3.5 m spacing).The experimental plots were established in March *** the end of the growing seasons for three years(2014–2016),growth parameters such as diameter,height and crown radius were *** was found to be significantly effective on diameter,height,individual tree basal area,and crown radius increment at the end of the third year(p<0.05).While diameter,individual tree basal area and crown radius increment increased with increasing PCT intensity,height increment was higher in control than *** the PCT treatments applied with 3–3.5 m spacing affected individual tree development positively,we need long-term results on wood quality and *** to the short-term results,it is thought that it is better to lower the stand closeness gradually,so,it may be advisable to apply PCT by 2–2.5 m×–2.5 m spacing.

关键词： Precommercial thinning Anatolian black pine Diameter increment Height increment

Binding energy of the donor impurities in GaAs-Ga_(1-x)Al_xAs quantum well wires with Morse potential in the presence of electric and magnetic fields

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Chinese Physics B 2016年第10期25卷 39-44页

作者： esra Aciksoz Orhan Bayrak Asim Soylu Department of Physics Akdeniz University Department of Physics Nigde University

The behavior of a donor in the GaAs–GaAlAs quantum well wire represented by the Morse potential is examined within the framework of the effective-mass approximation. The donor binding energies are numerically calculated for with and without the electric and magnetic fields in order to show their influence on the binding energies. Moreover, how the donor binding energies change for the constant potential parameters(De, re, and a) as well as with the different values of the electric and magnetic field strengths is determined. It is found that the donor binding energy is highly dependent on the external electric and magnetic fields as well as parameters of the Morse potential.

关键词： Morse potential electric field magnetic field the donor atom quantum well wire

Synthesis and Structural Studies of 6-(2,5-Dimethyl-1H-pyrrol-1-yl)pyridin-2-amine

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Chinese Journal of Structural Chemistry 2010年第5期29卷 720-725页

作者： SAHN Zarife Sibel KARABCEK Serdar SENSES esra KARABCEK esra ISIK Samil Department of Physics Faculty of Arts and SciencesOndokuz Mayιs University Department of Chemistry Faculty of Arts and SciencesKaradeniz Technical University

6-（2,5-Dimethyl-1H-pyrrol-1-yl）pyridin-2-amine （1） was synthesized and characte-rized by elemental analyses,1H-NMR and 13C-NMR,FTIR,Uv-Vis,mass spectral studies and single-crystal X-ray *** data obtained from spectral studies support the structural properties of *** N-H…N hydrogen bonds produce an R22（8） *** extensive three-dimensional network formed by C-H…π and N-H…π-facial hydrogen bonds is responsible for the crystal *** combination of C-H…π interactions produces R33（12）,R43（19） and R44（20） rings.

关键词： 2,6-diaminopyridine Schiff bases methylpyridine pyrrol

Speech Separation Methodology for Hearing Aid

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Computer Systems Science & Engineering 2023年第2期44卷 1659-1678页

作者： Joseph Sathiadhas esra Y.Sukhi Meenakshi Sundararajan Engineering College ChennaiTamil naduIndia R.M.K.Engineering College KavaraipettaiTamil naduIndia

In the design of hearing aids(HA),the real-time speech-enhancement is *** digital hearing aids should provide high signal-to-noise ratio,gain improvement and should eliminate *** generic hearing aids the perfor-mance towards different frequencies varies and non *** noise can-cellation and speech separation methods drops the voice magnitude under the noise *** performance of the HA for frequency response is non *** noise suppression methods reduce the required signal strength ***,the performance of uniform sub band analysis is poor when hearing aid is *** this paper,a speech separation method using Non-negative Matrix Fac-torization(NMF)algorithm is proposed for wavelet *** Proposed non-uniformﬁlter-bank was validated by parameters like band power,Signal-to-noise ratio(SNR),Mean Square Error(MSE),Signal to Noise and Dis-tortion Ratio(SINAD),Spurious-free dynamic range(SFDR),error and *** speech recordings before and after separation was evaluated for quality using objective speech quality measures International Telecommunication Union-Telecommunication standard ITU-T P.862.

关键词： Speech separation waveletﬁlter independent component analysis(ICA) non-negative matrix factorization(NMF) fejer-korovkin(FK) signal-to-noise ratio(SNR)