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A RETRoSPECTIVE oN THE DEVASTATING IMPACTS oF TRoPICAL SToRM WASHI

Tropical Cyclone Research and Review 2012年第2期1卷 163-176页

作者： SUSAN R.ESPINUEVA Esperanza O.Cayanan NIVAGINE C.NIEVARES Philippine Atmospheric Geophysical and Astronomical Services (PAGASA)

The December 2011 disaster in the Philippines which was induced by TS Washi was investigated. This disastrous event which claimed 1,268 human lives and Ph P1.455 Billion(US$63.26M) damages to infrastructure and agriculture was analyzed in terms of meteorological, hydrological, environmental and social aspects. Government’s response to the disaster was also included. Meteorological analysis was carried out using surface observations, satellite data and simulation of numerical weather prediction model. Intense short duration rainfall upstream the river basin and the damming effect along the river triggered the flashfloods downstream in Cagayan de oro and Iligan Cities. The strong storm winds coupled with orographic lifting enhanced the rainfall activity over the mountain. The encroachment in the sandbars and the river banks due to urbanization and unabated development impeded the flow of water resulting to greater damage. In addition, the timing of the high tide constrained the flow of the flood waters that resulted to widespread flooding in the downstream areas. This flood event on 16 December 2011 reached a maximum height of 7 meters and the extent of inundation covered about 7 to 10 meters high from the river banks in Cagayan de oro City.The conclusion was that the disaster was the result of the interplay of climatic, environmental and social factors. As a result of the flood disaster and based on the findings of the different agencies, the Philippine government came up with various recommendations which include regulation of the development in the floodplain areas, hazard mapping and installation of early warning system.

关键词： tropical storm Washi forecast rainfall satellite based information flashflood disaster river basin management

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Science and prediction of monsoon heavy rainfall

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Science Bulletin 2019年第21期64卷 1557-1561页

作者： Yali Luo Liye Li Richard HJohnson Chih-Pei Chang Lianshou Chen Wai-Kin Wong Jing Chen Kalli Furtado John LMcBride Ajit Tyagi Nanette Lomarda Thierry Lefort Esperanza O.Cayanan State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China HIWeather International Coordination office Chinese Academy of Meteorological SciencesBeijing 100081China Colorado State University Fort CollinsCO 80523USA Naval Postgraduate School MontereyCA 93943USA Hong Kong observatory.Hong Kong 999077 China Numerical Prediction Center China Meteorological AdministrationBeijing 100081China Met office ExeterDevon EXI 3PBUK Bureau of Meteorology MelbourneVictoria 3001Australia India Meteorological Department Noida 201303India World Weather Research Division World Meteorological OrganizationGeneva 1211Switzerland Meteo-France Toulouse 31000France Philippine Atmospheric Geophysical and Astronomical Services Administration Quezon City 1100Philippines

With the increasing incidence of heavy rainfall events,particularly over the monsoon regions,the highly dense populations are more vulnerable[1].Research initiatives on observation,modeling,and prediction of monsoon heavy rainfall have been promoted actively by World Weather Research Programme's(WWRP)Working Group on Tropical Meteorology Research(WGTMR)of the World Meteorological organization(WMo)since 2010.Series of monsoon-heavy-rainfall workshops were held in Beijing(2011),Petaling Jaya(2012),and New Delhi(2015)to benefit scientists worldwide and forecasters from the National Meteorological and Hydrological Services.An international Research and Development Project,namely,the Southern China Monsoon Rainfall Experiment(SCMREX)[2]was established in 2013 to coordinate field campaign experiments and to conduct scientific research on presummer(April-June)heavy rainfall processes in southern China.

关键词： China. rainfall monsoon

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A DISCUSSIoN oF THE MoST INTENSE TRoPICAL CYCLoNES IN THE WESTERN NoRTH PACIFIC FRoM 1978 To 2013

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Tropical Cyclone Research and Review 2015年第1期4卷 1-11页

作者： CHUN-WING CHoY SZE-NING CHoNG DEXIN KoNG Esperanza O.Cayanan Hong Kong observatory School of Energy and Environment City University of Hong Kong Philippine Atmospheric Geophysical and Astronomical Services Administration

This study examines a number of very intense tropical cyclones(TCs) in the western North Pacific(WNP) since 1978 as depicted by the best track data from the four main weather agencies in the WNP, namely the Hong Kong observatory, China Meteorological Administration, Regional Specialized Meteorological Centre Tokyo and Joint Typhoon Warning Centre, and the Advanced Dvorak Technique–Hurricane Satellite dataset prepared by the University of Wisconsin/NoAA National Climatic Data Center to identify the most intense TCs in the western North Pacific. Comparison analysis reveals that there are very large differences in the ranking of maximum sustained wind speed(MSW) among these datasets, probably due to data inhomogeneity issues and the discrepancies in TC intensity assessment among these centres. Re-assessment of the MSW of potential candidates suggests that, within uncertainty range of the analysis, Tip(1979) and Haiyan(2013) are the most intense TCs in the WNP during the period. Among the potential candidates, eight of them made landfall during their lifetime. Satellite pattern comparison and the best track dataset analysis of these typhoons show that Haiyan(2013) has the highest estimated MSW right before landfalling, making it the most intense TC making landfall in the WNP during the period 1978-2013.

关键词： tropical cyclone analysis Dvorak analysis Tip Haiyan

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RECENT ADVANCES IN RESEARCH AND FoRECASTING oF TRoPICAL CYCLoNE TRACK, INTENSITY, AND STRUCTURE AT LANDFALL

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Tropical Cyclone Research and Review 2018年第2期7卷 85-105页

作者： MARIE-DoMINIQUE LERoUX KIMBERLY WooD RUSSELL L.ELSBERRY Esperanza O.Cayanan ERIC HENDRICKS MATTHEW KUCAS PETER oTTo RoBERT RoGERS BUCK SAMPSoN ZIFENG YU Météo-France DIRoI/EC Mississippi State University University of Colorado-Colorado Springs Philippine Atmospheric Geophysical and Astronomical Services Administration Naval Postgraduate School Joint Typhoon Warning Center Bureau of Meteorology NoAA/AoML/Hurricane Research Division Naval Research Laboratory Shanghai Typhoon Institute and Laboratory of Typhoon Forecast Technique China Meteorological Administration

This review prepared for the fourth International Workshop on Tropical Cyclone Landfall Processes(IWTCLP-4) summarizes the most recent(2015-2017) theoretical and practical knowledge in the field of tropical cyclone(TC) track, intensity, and structure rapid changes at or near landfall. Although the focus of IWTCLPIV was on landfall, this summary necessarily embraces the characteristics of storms during their course over the ocean prior to and leading up to landfall. In the past few years, extremely valuable observational datasets have been collected for TC forecasting guidance and research studies using both aircraft reconnaissance and new geostationary or low-earth orbiting satellites at high temporal and spatial resolution. Track deflections for systems near complex topography such as that of Taiwan and La Réunion have been further investigated, and advanced numerical models with high spatial resolution necessary to predict the interaction of the TC circulation with steep island topography have been developed. An analog technique has been designed to meet the need for longer range landfall intensity forecast guidance that will provide more time for emergency preparedness. Probabilistic track and intensity forecasts have also been developed to better communicate on forecast uncertainty. operational practices of several TC forecast centers are described herein and some challenges regarding forecasts and warnings for TCs making landfall are identified. This review concludes with insights from both researchers and forecasters regarding future directions to improve predictions of TC track, intensity, and structure at landfall.

关键词： tropical cyclone track intensity structure landfall rapid intensification rapid changes

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Effect of Fe_(3)o_(4) nanoparticles on magnetic xerogel composites for enhanced removal of fluoride and arsenic from aqueous solution

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Water Science and Engineering 2022年第4期15卷 305-317页

作者： Sasirot Khamkure Victoria Bustos-Terrones Nancy Jakelin Benitez-Avila María Fernanda Cabello-Lugo Prócoro Gamero-Melo Sofía esperanza Garrido-Hoyos Juan Marcos Esparza-Schulz Postgraduate Department National Council for Science and Technology(CONACyT)-Mexican Institute of Water TechnologyMorelos 62574Mexico Department of Environmental Technology Engineering Polytechnic University of the State of MorelosMorelos 62550Mexico Department of Sustainability of Natural Resources and Energy Center for Research and Advanced Studies of the National Polytechnic InstituteCoahuila 25900Mexico Department of Chemistry Metropolitan Autonomous University Campus IztapalapaMexico City 09340Mexico

Fe_(3)o_(4)magnetic xerogel composites were prepared by polycondensation of resorcinol(R)-formaldehyde reaction via a sol-gel process in an aqueous solution through varying the molar ratio of Fe_(3)o_(4)nanoparticles(MNPs),catalyst(C),and water(W)content.MNPs were obtained by co-precipitation(MC),oxidation of iron salts(Mo),or solvothermal synthesis(MS).Both MNPs and magnetic xerogels were examined regarding the performance of arsenic and fluoride removal in a batch system.The MC-based MNPs had higher adsorption capacities for both fluoride(202.9 mg/g)and arsenic(3.2 mg/g)than other MNPs in optimum conditions.The X-ray diffraction,Fourier transform infrared spectroscopy,and energy-dispersive X-ray spectroscopy confirmed that Fe was composed into the polymeric matrix of magnetic xerogels that contained 0.59%-4.42%of Fe with a molar ratio of MNPs(M)to R between 0.01 and 0.10.With low R/C and optimum M/R ratios,an increase in the surface area of magnetic xerogels affected the fluoride and arsenic adsorption capacities.The magnetic xerogel composites with the MC-based MNPs prepared at a fixed R/C ratio(100)and at different R/W(0.05-0.06)and M/R(0.07-0.10)ratios had a high arsenic removal efficiency of 100%at an As(V)concentration of 0.1 mg/L and pH of 3.0.The maximum adsorption capacities of magnetic xerogels were approximately five times higher than those of the xerogels without MNP composites.Therefore,Fe_(3)o_(4)nanoparticles enhanced the adsorption of arsenate and fluoride.The variations of alkaline catalyst and water content significantly affected the resulting properties of textural and surface chemistry of magnetic xerogel composites.

关键词： Adsorption Arsenic Fluoride Composite Magnetite nanoparticles Xerogel

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神经干/祖细胞移植对脑损伤导致的胶质细胞活化有调节作用并有助于移植细胞与宿主胶质细胞间缝隙连接的建立

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神经损伤与功能重建 2014年第2期9卷 F0003-F0003页

作者： Rocío Talaverón esperanza R.Matarredona Rosa R.de la Cruz David Macías Victoria Gálvez and Angel M. Pastor Departamento de Fisiología Facultad de Biología Universidad de Sevilla Avenida Reina Mercedes

移植神经干/祖细胞有助于受损脑组织形态和功能的恢复。移植部位的微环境及移植细胞与宿主细胞间的通讯在神经干/祖细胞移植的神经保护机制中有重要意义。笔者既往研究显示,对中枢轴索损伤动物进行神经干/祖细胞移植有助于恢复损伤神经... 详细信息

移植神经干/祖细胞有助于受损脑组织形态和功能的恢复。移植部位的微环境及移植细胞与宿主细胞间的通讯在神经干/祖细胞移植的神经保护机制中有重要意义。笔者既往研究显示,对中枢轴索损伤动物进行神经干/祖细胞移植有助于恢复损伤神经元的电活动及突触联系,并可增加神经营养因子的释放。本研究拟观察移植的神经干/祖细胞与宿主胶质细胞间的解剖关系,以探讨神经干/祖细胞移植的神经保护作用的可能机制。从新生大鼠的脑室下区提取神经干/祖细胞移植到内侧纵束横断伤模型大鼠脑内。移植后8周取脑进行相关检测。免疫组化检测结果显示,与未移植神经干/祖细胞的大鼠相比,移植了神经干/祖细胞的大鼠脑内更多的小胶质细胞被激活。移植的神经干/祖细胞聚集在激活的小胶质细胞和星形胶质细胞附近。缝隙连接蛋白CX-43表达在损伤部位的神经干/祖细胞和胶质细胞上,且较多的存在于移植细胞和胶质细胞相连接的部位。移植的神经干/祖细胞和宿主胶质细胞及宿主小胶质细胞间均形成了缝隙连接,但移植的神经干/祖细胞和宿主胶质细胞间的缝隙连接较多。本研究结果显示,神经干/祖细胞移植对脑损伤导致的胶质细胞活化有调节作用,并可能通过在移植细胞和宿主细胞间建立缝隙连接来调节细胞间的通讯,这可能是细胞移植的神经保护作用的机制之一。

关键词：星形胶质细胞轴索断裂缝隙连接蛋白-43 小胶质细胞脑室下区

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Studying Some Brain and ovarian Morphological Traits in Diaglena spatulata Female Frogs Thriving in Conserved and Perturbed Habitats:A Preliminary Report and Its Implications for Amphibian Survival and Continuity

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Advances in Bioscience and Biotechnology 2014年第9期5卷 740-747页

作者： esperanza Melendez-Herrera Bryan Victor Phillips-Farfan Fany Edith Bucio-Pina Noemi Ramirez-Arres Gabriel Gutierrez-ospina Ireri Suazo-ortuno Javier Alvarado-Diaz Alma Lilia Fuentes-Farias Laboratorio de Ecofisiologia Animal Departamento de ZoologiaInstituto de Investigaciones sobre los Recursos NaturalesUniversidad Michoacana de San Nicolas de HidalgoMoreliaMéxico Laboratorio de Nutricion Experimental Instituto Nacional de PediatriaSecretaria de SaludMexico Distrito FederalMexico Laboratorio de Biologia de Sistemas Departamento de Biologia Celular y FisiologiaInstituto de Investigaciones BiomedicasCoordinacion de Psicobiologia y NeurocienciasFacultad de PsicologiaUniversidad Nacional Autonoma de MexicoMexico Distrito FederalMexico Laboratorio de Ecologia Departamento de ZoologiaInstituto de Investigaciones sobre los Recursos NaturalesUniversidad Michoacana de San Nicolas de HidalgoMoreliaMexico Laboratorio de Herpetologia Departamento de ZoologiaInstituto de Investigaciones sobre los Recursos NaturalesUniversidad Michoacana de San Nicolas de HidalgoMoreliaMexico

Amphibians are thought to be highly susceptible to perturbed environments. However, recent studies show that many of them are successful inhabitants of disturbed, fragmented habitats. The source of this resilience is yet unclear, but it may be the byproduct of having a robust phenotype and/or the result of phenotypic plasticity. We then assessed the contribution of each by evaluating cytological features of two brain nuclei that modulate reproductive behavior and of the ovary, using female specimens of the frog Diaglena spatulata prospering in conserved and disturbed areas of a tropical dry forest. our results in the brain show that the medial amygdala, but not the preoptic area, had a reduced size in frogs collected in disturbed forests compared to specimens collected in conserved forests. Both brain nuclei displayed, however, neurons with a reduced size in frogs captured in disturbed forest patches. In contrast, ovarian cytological features were similar between groups. our preliminary results lead us to propose that Diaglena spatulata female specimens might combine robust ovary and plastic brain’s phenotypic traits to confront disturbed environments. This, however, is still a working hypothetical framework that needs to be experimentally confirmed.

关键词： Amphibians Reproductive Traits Amygdala Medial Preoptic Area ovary

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Combined U-Pb SHRIMP and Hf isotope study of the Late Paleozoic Yaminue Complex,Rio Negro Province,Argentina:Implications for the origin and evolution of the Patagonia composite terrane

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Geoscience Frontiers 2013年第1期4卷 37-56页

作者： Carlos J.Chernicoff Eduardo o.Zappettini Joao o.S.Santos Neal J.McNaughton Elena Belousova National Scientific and Technical Research Council(CoNICET) Argentina Argentine Geological-Mining Survey(SEGEMAR) Argentina Argentine Geological-Mining Survey(SEGEMAR).Argentina University of Western Australia PerthWA 6009Australia Redstone Resources.Perth.WA 6849.Australia John de Laeter Centre Curtin UniversityPerthWA 6102Australia ARC National Key Centre for Geochemical Evolution and Metallogeny of Continents(GEMoC) Macquarie UniversitySydneyNSW 2109Australia

We have carried out zircon U-Pb SHRIMP dating and Hf isotope determinations on a biotite paraschist and on a tonalitic orthogneiss of the Yaminué Complex, and re-evaluate this complex in the broader context of the tectonic evolution of the Patagonia composite terrane. In the metasedimentary unit （msuYC）, the youngest detrital zircon dated at 318 ± 5 Ma （Mississippian/Pennsylvanian boundary） indicates a Pennsylvanian （or younger） depositional age. The three main age populations peak at 474, 454 and 374 Ma. Preliminary Hf isotope data for two detrital zircons （447 and 655 Ma） yielded ε（Hf） values of -0.32 and 0.48, indicating that their primary sources contained small amounts of recycled crustal components （of Calymmian age; TDM 1.56 Ga）. Zircons from the orthogneiss （miuYC; intrusive into msuYC） show a crystallization age of 261.3 - 2.7 Ma （Capitanian; late middle Permian） which is broadly coeval with deformation, and Neoarchean-Paleoproterozoic inheritance. Meaningful core-rim relationship between Neoarchean zircon cores and late Permian rims is well defined, indicating the occurrence of Archean crust in this sector of Patagonia. Hf TDM of Permian zircons is mainly Meso-Paleoarchean （2.97-3.35 Ga）, with highly negative e（Hf） values （ca, -33）. Hf TDM of inherited Neoarchean zircon cores is also Meso-Paleoarchean （3.14-3.45 Ga） but more juvenile （ε（Hf） = -0.3）. Hf isotopes reinforce the presence of unexposed ancient crust in this area. Combining geological and isotope data, as well as geophysical models, we identify the Yaminué Complex within the La esperanza-Yaminué crustal block flanked by two other, distinct crustal blocks： the Eastern block which forms part of the Patagonia terrane sensu stricto, located in the eastern Patagonian region, and the Western block forming part of the Southern Patagonia terrane. Their origins and timing of amalgamation to form the Patagonia composite terrane are also discussed.

关键词： Yaminue Complex U-Pb SHRIMP geochronology Hf isotopes Tectonics North Patagonian Massif Argentina

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Cortical columns(barrels)display normal size in the brain’s primary somatosensory cortex of mice carrying null mutations of the insulin receptor substrate 1 gene:A preliminary report

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Advances in Bioscience and Biotechnology 2013年第10期4卷 945-948页

作者： Marta Lopez-Santibanez Guevara Eileen Uribe-Querol Alma Lilia Fuentes Farias esperanza Melendez-Herrera Agustine Joseph D’Ercole Gabriel Gutierrez-ospina Departamento de Biologia Celular y Fisiologia Instituto de Investigaciones BiomedicasUniversidad Nacional Autonoma de MexicoMexico D.F.Mexico Division de Estudios de Posgrado e Investigacion Facultad de OdontologiaUniversidad Nacional Autonoma de MexicoMexico D.F.Mexico Departamento de Zoologia Instituto de Investigaciones sobre los Recursos NaturalesUniversidad Michoacana de San Nicolas de HidalgoMoreliaMexico Department of Pediatrics The University of North Carolina at Chapel HillChapel HillUSA Coordinacion de Psicofisiologia Facultad de PsicologiaUniversidad Nacional Autonoma de MexicoMexico D.F.Mexico

Circuits in barrels of the rodent brain’s primary somatosensory (S1) cortex build up following constructivist rules. Previous evidence in mice supports that the precise addition of barrel neuropil is promoted by insulin-like growth factor-1 (IGF-1). The signaling cascades mediating this response remain undetermined. To address whether the effects of IGF-1 upon the growth of S1 circuits are mediated by insulin receptor substrate-1 (IRS-1), we studied barrel size in adult mice having the IRS-1 gene knocked out (IRS-1 ko). our results reveal that barrel size is similar between wild type and IRS-1 ko mice suggesting that IRS-1 is not essential for barrel circuitry growth. Hence, investigations aimed at exploring other substrates activated by IGF-1, namely IRS-2 and IRS-4, are needed to reveal signaling pathways that mediate the precise addition of S1 neuronal circuitry.

关键词： Barrel Cortex Neuronal Circuit Assemblage Trophic Interactions Constructivism

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Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

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Cellular & Molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco ortega María Paniagua-García Amelia Peña-Rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of Medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive Care Unit Virgen del Rocío University HospitalSevilleSpain Department of Medicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal Medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and Clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In CoVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute CoVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDo)levels were observed.These findings contribute to a better understanding of the immunological sequelae of CoVID-19.

关键词： SARS-CoV-2 CoVID-19 Dendritic cell Long-CoVID

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