检索结果-南通市图书馆

Genomic patterns of homozygosity and inbreeding depression in MurcianoGranadina goats

在线全文

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2022年第3期13卷 721-734页

作者： María Gracia Luigi-Sierra Almudena Fernández Amparo martínez Dailu Guan Juan Vicente Delgado Javier FernándezÁlvarez Vincenzo Landi Francesc Xavier Such Jordi Jordana María Saura Marcel Amills Centre for Research in Agricultural Genomics(CRAG) CSIC-IRTA-UAB-UBUniversitat Autònoma de Barcelona08193 BellaterraSpain Departamento de Mejora Genética Animal INIACarretera de la Coruña km 7528040 MadridSpain Departamento de Genética Universidad de Córdoba14071 CórdobaSpain Department of Veterinary Medicine University of Bari“Aldo Moro”62 per Casamassima km.370010 ValenzanoSPItaly Group of Research in Ruminants(G2R) Department of Animal and Food ScienceUniversitat Autònoma de Barcelona(UAB)BellaterraBarcelonaSpain Departament de Ciència Animal i dels Aliments Facultat de VeterinàriaUniversitat Autònoma de Barcelona08193 BellaterraSpain

Background:Inbreeding depression can adversely affect traits related to fitness,reproduction and productive *** current research suggests that inbreeding levels are generally low in most goat breeds,the impact of inbreeding depression on phenotypes of economic interest has only been investigated in a few studies based on genealogical ***:We genotyped 1040 goats with the Goat SNP50 *** information was used to estimate different molecular inbreeding coefficients and characterise runs of homozygosity and homozygosity *** detected38 genomic regions with increased homozygosity as well as 8 ROH hotspots mapping to chromosomes 1,2,4,6,14,16 and *** hundred seventeen goats with available records for dairy traits were analysed to evaluate the potential consequences of inbreeding depression on milk *** regions on chromosomes 8 and 25were significantly associated with inbreeding depression for the natural logarithm of the somatic cell ***,these regions contain several genes related with immunity,such as SYK,IL27,CCL19 and ***,one region on chromosome 2 was significantly associated with inbreeding depression for milk ***:Although genomic inbreeding levels are low in Murciano-Granadina goats,significant evidence of inbreeding depression for the logarithm of the somatic cell count,a phenotype closely associated with udder health and milk yield,have been detected in this *** inbreeding would be expected to augment economic gain by increasing milk yield and reducing the incidence of mastitis,which is one of the main causes of dairy goat culling.

关键词： Goat Inbreeding Milk yield Murciano-Granadina Somatic cell score

Tracking of iron-labeled human neural stem cells by magnetic resonance imaging in cell replacement therapy for Parkinson＇s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2016年第1期11卷 49-52页

作者： Milagros Ramos-Gómez Alberto martínez-Serrano Centre for Biomedical Technology Polytechnic University of Madrid Madrid Spain Biomedical Research Networking'Center of Bioengineering Biomaterials and Nanomedicine (CIBER-BBN) Madrid Spain Department of Molecular Biology and Center of Molecular Biology"Severo ochoa" Autonomous University of Madrid-C.S.I.C Madrid Spain

Human neural stem cells（h NSCs） derived from the ventral mesencephalon are powerful research tools and candidates for cell therapies in Parkinson＇s disease. However, their clinical translation has not been fully realized due, in part, to the limited ability to track stem cell regional localization and survival over long periods of time after in vivo transplantation. Magnetic resonance imaging provides an excellent non-invasive method to study the fate of transplanted cells in vivo. For magnetic resonance imaging cell tracking, cells need to be labeled with a contrast agent, such as magnetic nanoparticles, at a concentration high enough to be easily detected by magnetic resonance imaging. Grafting of human neural stem cells labeled with magnetic nanoparticles allows cell tracking by magnetic resonance imaging without impairment of cell survival, proliferation, self-renewal, and multipotency. However, the results reviewed here suggest that in long term grafting, activated microglia and macrophages could contribute to magnetic resonance imaging signal by engulfing dead labeled cells or iron nanoparticles dispersed freely in the brain parenchyma over time.

关键词： human neural stem cells Parkinson's disease magnetic resonance imaging magnetic nanoparticles stem cell transplantation

Suppression Effects on Pineapple Soil-Borne Pathogens by Crotalaria juncea,Dolomitic Lime and Plastic Mulch Cover on MD-2 Hybrid Cultivar

在线全文

学校读者我要写书评

暂无评论

Phyton-International Journal of Experimental Botany 2021年第4期90卷 1205-1216页

作者： Luis Alfonso Aguilar Pérez Daniel NietoÁngel Moisés Roberto Vallejo Pérez Daniel Leobardo ochoa martínez David Espinosa Victoria Andrés Rebolledo martinez Abel Rebouças São José Fitopatología Colegio de PostgraduadosMontecillo-Texcoco56230México CONACyT-Universidad Autónoma de San Luis Potosí CIACYTSan Luis Potosí78000México Edafología Colegio de PostgraduadosMontecillo-Texcoco56230México Instituto Nacional de Investigaciones Forestales Agrícolas y PecuariasVeracruz94270México Rebouças São José A.UESB/DFZVitória da Conquista95Brasil

The development and implementation of sustainable and environmentally friendly agricultural practices are indispensable as alternatives to pesticide use and to keep populations of soil-borne plant pathogens at levels that do not affect crop *** present research evaluates the incidence of soil-borne phytopathogens on the pineapple variety MD-2,which was subjected to different treatments:Incorporation of Crotalaria juncea into the soil(organic amendment),application of dolomitic lime to soil(inorganic amendment),and the use of plastic mulch covering the *** the crop cycle(15 months),the following variables were evaluated:plant height(cm),fruit weight(kg·plant^(−1)),crop yield(ton·ha^(−1)),the bud root disease incidence caused by Phytophthora nicotianae,number of soil phytoparasitic nematodes and colony-forming-units(CFUs)of soil fungi and *** results indicate that Crotalaria juncea treatment reduced the pathogen population(nematode and oomycetes)at levels that did not affect crop development,so that yield increased(18–20%).The incorporation of *** into the soil as an organic amendment favors the populations of fungi disease suppressors(Trichoderma-Aspergillus).The phytoparasitic nematodes(Meloidogyne sp.,Pratylenchus sp.,and Mesocriconema sp.)and oomycetes(Phytophthora spp.,and Pythium spp.)showed a reduction of their population levels by effects of organic amendment(***).The plastic mulch was also effective,probably due to the maintenance of optimal condition to crop growth and weed ***,the dolomitic lime application had the poorest effect under the conditions of the study area on the variables *** described observations are characteristics of a system-based approach for the potential management of soil-borne pathogens of pineapple MD-2 in Veracruz,México.

关键词： Suppressive soil integrated pest management Phytophthora nicotiannae Phytoparasitic nematodes

PGE2 as a Morphine-Seeking Behavior Modulator in the Place Preference Model

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Behavioral and Brain Science 2022年第12期12卷 627-639页

作者： Ariadna Jiménez-González Abraham ochoa-Aguilar Katia Mendoza-Negrete Leticia Parra-Gamez Claudia Gómez-Acevedo Department of Pharmacology Behavioral Pharmacology Laboratory Facultad de Medicina Universidad Nacional Autónoma de México (UNAM) México City México Hospital Loma Linda Translational Research Laboratory Naucalpan México Department of Anatomy Facultad de Medicina Universidad Nacional Autónoma de México (UNAM) México City México

The opioid epidemic has become one of the most concerning public health issues in the world, and currently does not have an adequate treatment available. It has been observed that, despite opioids being highly addictive, patients with chronic inflammation are less likely to develop an opioid dependence. This protective effect may be caused by Prostaglandin E2 (PGE2) as it has been found that non-painful carrageenan inflammation reduces morphine induced reward. Taking this into account, the aim of this study was to determine if the direct administration of PGE2 into the central nervous system could modulate the morphine-induced reward. We used the morphine-conditioned place preference (CPP) model with and without PGE2 or PGE2R antagonist in order to test the reward response. We found a significant reduction of morphine-induced reward after administering PGE2. Moreover, we found that this effect could be reversed by PGE2 receptor antagonism. Our data suggest that PGE2 may reduce morphine-induced reward making it an important drug-target research alternative to explore the possibility of modifying or even preventing opioid addiction.

关键词： Morphine Addiction Conditioned Place Preference Rats Prostaglandins Immune System Reward

Effect of phacoemulsification on intraocular pressure in patients with primary open angle glaucoma and pseudoexfoliation glaucoma

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2017年第9期10卷 1374-1378页

作者： Jesus Jimenez-Roman Gabriel Lazcano-Gomez Karina martínez-Baez Mauricio Turati Rosario Gulías-Canizo Luis F.Hernández-Zimbrón Lenin ochoa-De la Paz Rubén Zamora Roberto Gonzalez-Salinas Glaucoma Department Asociation to Prevent Blindness inMexicoMexico City 04030Mexico Research Department Asociation to Prevent Blindness inMexicoMexico City 04030Mexico Cell Biology Department Advanced Research CenterI.P.N.(CINVESTAV)in Mexico CityMexico City 07360Mexico

AIM：To compare the effect of phacoemulsification on intraocular pressure（IOP）in patients with primary open angle glaucoma（POAG）and pseudoexfoliation glaucoma（PXG）.METHODS：A retrospective comparative case series conducted at the Glaucoma Department at the Association to Prevent Blindness in *** study enrolled consecutive patients having phacoemulsification with intraocular lens（IOL）implantation and a diagnosis of POAG or *** about IOP values and number of glaucoma medications used was collected at baseline,1,3,6 and12mo ***：The study enrolled 88 patients（88 eyes）.After phacoemulsification,there was a statistically significant reduction in IOP values and glaucoma medications use compared to baseline in both POAG and PXG patients（P〈0.001）.In the POAG group,a 20%decrease in IOP values was evidenced,and a 56.5%reduction in the number of medications used at the one-year *** PXG group showed a 20.39%,and a 34.46%decrease in IOP and number of medications used,respectively.A significant difference in the meanΔIOP（postoperative changes in IOP）was evidenced between groups（P=0.005）.The reduction of the postsurgical IOP mean values in both groups,the POAG group showed a greater reduction in IOP values compared to the PXG ***：In both types of glaucoma,phacoemulsification cataract surgery can result in a significant IOP reduction（20%）over a 12mo follow-up *** number of medications used is also significantly reduced up to 12mo after surgery,especially in the PXG group.

关键词： cataract surgery pseudoexfoliation glaucoma secondary glaucoma primary open angle glaucoma intraocularpressure

Effect of magnesium on the aluminothermic reduction rate of zinc oxide obtained from spent alkaline battery anodes for the preparation of Al–Zn–Mg alloys

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2016年第4期23卷 458-465页

作者： Rocio ochoa Alfredo Flores Jesus Torres Cinvestav-Saltillo

The aluminothermic reduction of zinc oxide（ZnO） from alkaline battery anodes using molten Al may be a good option for the elaboration of secondary 7000-series alloys. This process is affected by the initial content of Mg within molten Al, which decreases the surface tension of the molten metal and conversely increases the wettability of ZnO particles. The effect of initial Mg concentration on the aluminothermic reduction rate of ZnO was analyzed at the following values： 0.90wt%, 1.20wt%, 4.00t%, 4.25wt%, and 4.40wt%. The ZnO particles were incorporated by mechanical agitation using a graphite paddle inside a bath of molten Al maintained at a constant temperature of 1123 K and at a constant agitation speed of 250 r/min, the treatment time was 240 min and the ZnO particle size was 450？500 mesh. The results show an increase in Zn concentration in the prepared alloys up to 5.43wt% for the highest initial concentration of Mg. The reaction products obtained were characterized by scanning electron microscopy and X-ray diffraction, and the efficiency of the reaction was measured on the basis of the different concentrations of Mg studied.

关键词： aluminothermic reduction alkaline batteries zinc oxide waste utilization aluminum zinc magnesium alloys

Microphysiological systems for solid tumor immunotherapy:opportunities and challenges

在线全文

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2023年第6期9卷 77-106页

作者： Sara Abizanda-Campo María Virumbrales-Muñoz Mouhita Humayun Ines Marmol David J.Beebe Ignacio ochoa Sara Oliván Jose M.Ayuso Department of Dermatology University of Wisconsin-MadisonMadisonWIUSA University of Wisconsin Carbone Cancer Center MadisonWIUSA Department of Biomedical Engineering University of WisconsinMadisonWIUSA Tissue Microenvironment Lab(TME lab) Aragón Institute of Engineering Research(I3A)University of ZaragozaZaragozaSpain Instituto de Investigación Sanitaria Aragón(IISA) ZaragozaSpain Centro Investigación Biomédica en Red.Bioingeniería Biomateriales y Nanomedicina(CIBER-BBN)ZaragozaSpain Department of Obstetrics and Gynecology University of Wisconsin-MadisonMadisonWIUSA Department of Biological Engineering Massachusetts Institute of Technology CambridgeCambridgeMAUSA Department of Pathology&Laboratory Medicine University of WisconsinMadisonWIUSA

Immunotherapy remains more effective for hematologic tumors than for solid *** of the main challenges to immunotherapy of solid tumors is the immunosuppressive microenvironment these tumors generate,which limits the cytotoxic capabilities of immune effector cells(e.g.,cytotoxic T and natural killer cells).This microenvironment is characterized by hypoxia,nutrient starvation,accumulated waste products,and acidic ***-hijacked cells,such as fibroblasts,macrophages,and T regulatory cells,also contribute to this inhospitable microenvironment for immune cells by secreting immunosuppressive cytokines that suppress the antitumor immune response and lead to immune ***,there is a strong interest in developing new drugs and cell formulations that modulate the tumor microenvironment and reduce tumor cell immune *** systems(MPSs)are versatile tools that may accelerate the development and evaluation of these therapies,although specific examples showcasing the potential of MPSs remain *** in microtechnologies have led to the development of sophisticated microfluidic devices used to recapitulate tumor *** resulting models,also known as microphysiological systems(MPSs),are versatile tools with which to decipher the molecular mechanisms driving immune cell antitumor cytotoxicity,immune cell exhaustion,and immune cell exclusion and to evaluate new targeted ***,we review existing microphysiological platforms to study immuno-oncological applications and discuss challenges and opportunities in the field.

关键词： immunotherapy versatile solid

RESEARCH PROGRESS ON THE IMPACT OF NITROGEN DEPOSITION ON GLOBAL GRASSLANDS

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Agricultural Science and Engineering 2022年第3期9卷 425-444页

作者： Carly J.STEVENS Sofía BASTO Michael DBELL Tianxiang HAO Kevin KIRKMAN Raul ochoa-HUESO Lancaster Environment Centre Lancaster UniversityLancasterLA14YQUK Unidad de Ecologia y Sistematica Departamento de BiologiaFacultad de CienciasPontificia Universidad JaverianaCarrera 7 No.43-82 Ed.Jesus Emilio Ramirez(53)BogotaColombia National Park Service Air Resources DivisionLakewoodCO 80235USA Synthesis Research Center of Chinese Ecosystem Research Network Key Laboratory of Ecosystem Network Observation and ModelingInstitute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China College of Resources and Environmental Sciences National Academy of Agriculture Green DevelopmentKey Laboratory of Plant-Soil Interactions of Ministry of EducationBeijing Key Laboratory of Farmland Soil Pollution Prevention and RemediationChina Agricultural UniversityBeijing 100193China School of Life Sciences University of KwaZulu-NatalDurban4041South Africa Departamento de Biologia-IVAGRO Universidad de CadizCampus Rio San Pedro11510 Puerto RealSpain Department of Terrestrial Ecology Netherlands Institute of Ecology(NIOO-KNAW)P.O.Box 506700 ABWageningenthe Netherlands

Grasslands are globally-important ecosystems providing critical ecosystem *** species composition and characteristics of grasslands vary considerably across the planet with a wide variety of different grasslands ***,in many regions grasslands have been impacted by atmospheric nitrogen deposition originating from anthropogenic activities with effects on productivity,species composition and diversity widely *** vary across grassland habitats but many show declines in species richness and increases in biomass production related to soil eutrophication and *** a continental level,there is considerable variation in the research effort that has been put into understanding the impacts of nitrogen *** Europe,North America and parts of Asia,although there are unanswered research questions,there is a good understanding of N deposition impacts in most grassland *** is not the case in other regions with large knowledge gaps in some parts of the *** paper reviews the impacts of N deposition on grasslands around the world,highlighting recent advances and areas where research is still needed.

关键词： acidification biomass production critical load eutrophication species composition species richness

Dendritic nanoarchitecture imparts ZSM-5 zeolite with enhanced adsorption and catalytic performance in energy applications

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2023年第5期80卷 77-88,I0003页

作者： María del Mar Alonso-Doncel Cristina ochoa-Hernández Gema Gómez-Pozuelo Adriana Oliveira JoséGonzález-Aguilar ángel Peral Raúl Sanz David P.Serrano Thermochemical Processes Unit IMDEA Energy InstituteAvda.Ramon de la Sagra3E28935MostolesMadridSpain Department of Heterogeneous Catalysis Max-Planck-Institut für KohlenforschungKaiser-Wilhem-Platz14540Muheim an der RuhGermay Department of Chemical and Environmental Technology Rey Juan Carlos UniversityC/Tulipan s/nE28933MostolesMadridSpain High Temperature Processes Unit IMDEA Energy InstituteAvda.Ramon de la Sagra3E28935MostolesMadridSpain Department of Chemical Energy and Mechanical TechnologyRey Juan Carlos UniversityC/Tulipan s/n28933MostolesMadridSpain

The development of zeolites possessing dendritic features represents a great opportunity for the design of novel materials with applications in a large variety of fields and,in particular,in the energy sector to afford its transition towards a low carbon *** the current work,ZSM-5 zeolite showing a dendritic3D nanoarchitecture has been synthesized by the functionalization of protozeolitic nanounits with an amphiphilic organosilane,which provokes the branched aggregative growth of zeolite *** ZSM-5 exhibits outstanding accessibility arising from a highly interconnected network of radially-oriented mesopores(3-10 nm)and large cavities(20-80 nm),which add to the zeolitic micropores,thus showing a well-defined trimodal pore size *** singular features provide dendritic ZSM-5 with sharply enhanced performance in comparison with nano-and hierarchical reference materials when tested in a number of energy related applications,such as VOCs(toluene)adsorption(improved capacity),plastics(low-density polyethylene)catalytic cracking(boosted activity)and hydrogen production by methane catalytic decomposition(higher activity and deactivation resistance).

关键词： Dendritic ZSM-5 VOCs adsorption Plastics cracking Methane decomposition Hydrogen production