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Evaluation of Biomarkers in Egyptian Patients with Different Grades of Nonalcoholic Fatty Liver Disease

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Journal of Clinical and Translational Hepatology 2017年第2期5卷 109-118页

作者： Ibrahim H.Borai Yehia Shaker Maha Moustafa Kamal Wafaa M.Ezzat esmat ashour Mie Afify Weaam Gouda Maha M.Elbrashy Biochemistry Department Faculty of Science Ain Shams University Cairo Egypt Biochemistry Department National Research Centre Giza Egypt Department of Internal Medicine National Research Center Giza Egypt

Background and Aims:Nonalcoholic fatty liver disease (NAFLD) is a silent disease;its spectrum includes simple steatosis,nonalcoholic steatohepatitis and ***-and anti-inflammatory cytokines play roles in the pathogenesis of NAFLD and insulin resistance (IR).Moreover,plasma cell antigen-1 (PC-1) is related to IR and associated with NAFLD ***,we aimed to detect biomarkers,ultrasonographic and anthropometric findings capable of differentiating NAFLD grades,since most previous investigators were concerned more with NAFLD patients without classifying them into ***:A total of 87 NAFLD patients (31 with grade 1 (mild NAFLD),26 with grade 2 (moderate NAFLD) and 30 with grade 3 (severe NAFLD) were included in the study,in addition to 47 controls (grade 0).All subjects underwent ultrasonographic examination for NAFLD *** interleukin-10 (IL-10),plasma interleukin-18 (IL-18) and plasma PC-1 levels were determined using enzyme-linked immunosorbent ***:Homoeostasis model assessment (HOMA)-IR was higher in different NAFLD grades than in *** and anthropometric findings and lipid profile indices (except for high-density lipoprotein cholesterol,which was decreased) were increased with NAFLD *** 3 patients showed significant increase in levels of IL-18 and significant decrease in IL-10 and PC-1 levels when compared to grade 1 ***:Anthropometric and ultrasonographic findings were valuable in differentiating NAFLD *** is very important in NAFLD ***-18,HOMA-index and PC-1 levels could be used to differentiate between NAFLD grades,together with other measurements.

关键词： NAFLD Interleukin-18(IL-18) Interleukin-10(IL-10) Plasma cell antigen-1(PC-1)

Hepatobiliary Schistosomiasis

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Journal of Clinical and Translational Hepatology 2014年第3期2卷 212-216页

作者： Yehia Shaker Nervana Samy esmat ashour Biochemistry Department National Research CenterCairoEgypt

Schistosomiasis is an ancient parasitic disease that has afflicted Egyptians since the time of the *** disease is caused by lodged schistosome eggs in the host liver,evoking an immune response and leading in some patients to the development of hepatic granuloma and ***,we review the epidemiology,immunopathogenesis,and clinical profile of *** information may aid in the development of more efficacious treatments and improved disease prognosis.

关键词： Schistosomiasis Immunopathogenesis Hepatosplenic schistosomiasis Co-infection and complications Anti-schistosomal vaccine

An all-optical 1*2 de-multiplexer based on two-dimensional nonlinear photonic crystal ring resonators

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Optoelectronics Letters 2024年第1期20卷 23-27页

作者： esmat Rafiee Fatemeh Abolghasemi Department of Electrical Engineering Faculty of EngineeringAlzahra UniversityTehranIran

In this work,a new configuration of an all-optical nonlinear de-multiplexer gate based on two-dimensional(2D)photonic crystals(Ph C)is *** gate is considered in the double-ring resonator shaped structure of silicon *** order to have a more functional structure,some defect rods made of nonlinear materials were positioned in the *** the functionality of the structure,photonic band gap(PBG),field distribution and transmitted power spectra are *** wave expansion and finite difference time domain(FDTD)methods are utilized for extracting the PBG and field distribution *** remarkable dimension,bit rate,maximum intensity and contrast ratio of 116.64μm2,3.125 Tbit/s,97%and 40.2 dB are obtained,respectively,which make the gate an appropriate candidate for utilization in optical integrated circuits.

关键词： optical resonator nonlinear

Deciphering resistancemechanisms and novel strategies to overcome drug resistance in ovarian cancer:a comprehensive review

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Oncology Research 2024年第5期32卷 831-847页

作者： EFFAT ALEMZADEH LEILA ALLAHQOLI AFROOZ MAZIDIMORADI esmat ALEMZADEH FAHIMEH GHASEMI HAMID SALEHINIYA IBRAHIM ALKATOUT Infectious Diseases Research Center Birjand University of Medical SciencesBirjandIran Department of Midwifery Ministry of Health and Medical EducationTehranIran Student Research Committee Shiraz University of Medical SciencesShirazIran Department of Biotechnology Faculty of MedicineBirjand University of Medical SciencesBirjandIran Cellular and Molecular Research Center Birjand University of Medical SciencesBirjandIran Social Determinants of Health Research Center Birjand University of Medical SciencesBirjandIran Kiel School of Gynaecological Endoscopy Campus KielUniversity Hospitals Schleswig-HolsteinKielGermany

Ovarian cancer is among the most lethal gynecological cancers,primarily due to the lack of specific symptoms leading to an advanced-stage diagnosis and resistance to *** resistance(DR)poses the most significant challenge in treating patients with existing *** Food and Drug Administration(FDA)has recently approved three new therapeutic drugs,including two poly(ADP-ribose)polymerase(PARP)inhibitors(olaparib and niraparib)and one vascular endothelial growth factor(VEGF)inhibitor(bevacizumab)for maintenance ***,resistance to these new drugs has ***,understanding the mechanisms of DR and exploring new approaches to overcome them is crucial for effective *** this review,we summarize the major molecular mechanisms of DR and discuss novel strategies to combat DR.

关键词： Chemotherapy Drug resistance mechanisms Ovarian cancer PARP inhibitors VEGF inhibitor

Dehydration of natural gas and biogas streams using solid desiccants:a review

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Frontiers of Chemical Science and Engineering 2021年第5期15卷 1050-1074页

作者： Soheil Bahraminia Mansoor Anbia esmat Koohsaryan Research Laboratory of Nanoporous Materials Faculty of ChemistryIran University of Science and Technology16846-13114TehranIran

Natural gas and biogas are two mixtures that consist of methane as their main *** two gas mixtures are usually saturated with water vapor,which cause many problems,such as damaging the gas processing equipment by increasing the gas’s corrosion potential or clogging the pipelines due to gas hydrate ***,removing water vapor from these gas streams is *** this review paper,the main dehydration methods have been overviewed,and scrutiny of the adsorption dehydration has been carried ***,the most important solid desiccants and their improvements have been reviewed.

关键词： natural gas biogas dehydration adsorption solid desiccant

Analysis of Fractional-order Linear Systems with Saturation Using Lyapunov's Second Method and Convex Optimization

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International Journal of Automation and computing 2015年第4期12卷 440-447页

作者： esmat Sadat Alaviyan Shahri Saeed Balochian Department of Electrical Engineering Islamic Azad University

In this paper,local stability and performance analysis of fractional-order linear systems with saturating elements are shown,which lead to less conservative information and data on the region of stability and the disturbance ***,a standard performance analysis and global stability by using Lyapunov’s second method are addressed,and the introduction of Lyapunov’s function candidate whose sub-level set provide stability region and performance with a restricted state space origin is also *** results include both single and multiple saturation elements and can be extended to fractional-order linear systems with any nonlinear elements and nonlinear noise that satisfy Lipschitz condition.A noticeable application of these techniques is analysis of control fractional-order linear systems with saturation control inputs.

关键词： Fractional nonlinear systems saturation systems region of attraction disturbance rejection optimization problem.

Buffalo stirred yoghurt fortified with grape seed extract:New insights into its functional properties

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Food Bioscience 2022年第3期47卷 1330-1336页

作者： Suzan H.Tami esmat Aly Aliaa A.Darwish esmat S.Mohamed Department of Clinical Nutrition College of Applied Medical SciencesKing Faisal UniversitySaudi Arabia Dairy Research Department Food Technology Research InstituteAgricultural Research Center12613GizaEgypt Biotechnology Department Higher Institute for Agriculture Co-Operation13766ShobraCairoEgypt

Grape seed extract(GSE)is considered one of the major byproducts,which are rich in phenolic content and possess several health-promoting activities including antibacterial,anticancer,and *** current research was devoted to improve the bioactive properties of stirred yoghurt through supplementation with GSE at three concentrations(0.1,0.25,and 0.5 g/100 g yoghurt).The obtained stirred yoghurts were analyzed for determining their composition,pH,syneresis,viscosity,and sensory ***,some functional properties including antioxidant,antibacterial,anticancer activities were *** increments(p≤0.05)were observed in total solids,ash contents,pH,water holding capacity,and viscosity values,especially when 0.5%GSE was ***,adding 0.5%GSE showed higher(p≤0.05)in vitro antioxidant,antibacterial,and anticancer ***,the improved bioactive properties resulting from adding GSE,even at the higher concentration,were not accompanied by any change in sensory *** particular,the color descriptor was mostly preferred by panelists when 0.5%GSE was *** assessors did not observe any off-flavors in any of the tested stirred yoghurt ***,the functional properties of stirred yoghurt could be improved by adding GSE preparation without affecting its organoleptic properties.

关键词： Stirred yoghurt Grape seed extract Bioactive properties Antibacterial and anticancer activities Antioxidant

Broadband absorption enhancement in hole-transport-layer-free perovskite solar cell by grating structure

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Optoelectronics Letters 2023年第10期19卷 587-592页

作者： Hamideh Talebi Farzin Emami esmat Rafiee Nano-Optoelectronic Research Center Electronic DepartmentShiraz University of TechnologyShirazIran Department of Electrical Engineering Faculty of EngineeringAlzahra UniversityTehranIran

Recently,the hole transport layer-free planar perovskite solar cells(HTL-free PSCs)have attracted intense ***,the poor absorption of light in the wavelengths longer than 800 nm is an important challenge in all configurations of *** this study,the HTL-free PSC with a gold rectangular grating at back contact is *** order to improve the performance of the solar cell,effects of grating dimensions and periodicity on the absorption of the active layer are numerically *** the improved condition,an absorption enhancement of 25%in the range of 300–1400 nm is obtained compared with the flat electrode-based *** improvements are attributed to the coupling of light to surface plasmon polariton(SPP)***,the electrical simulation results of the improved solar cell demonstrated short-circuit current density and power conversion efficiency of 27.72 mA/cm2 and 18%,respectively.

关键词： absorption layer free

Status of intestinal parasitic infections among rural and urban populations, southwestern Iran

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Asian Pacific Journal of Tropical Medicine 2019年第3期12卷 130-136页

作者： Molouk Beiromv esmat Panabad Abdollah Rafiei Infectious and Tropical Diseases Research Center Health Research Institute Ahvaz Jundishapur University of Medical Sciences Department of Parasitology School of Medicine Ahvaz Jundishapur University of Medical Sciences

Objective: To evaluate the prevalence and risk factors of intestinal parasitic infections in the urban and rural areas of Shushtar County,southwest ***: A total of 1 008 fecal samples were analyzed by direct smear examination,formalinether concentration,and Ziehl-Neelsen and trichrome staining; furthermore,PCR was used to distinguish Trichostrongylus and hookworm species based on 28 S rRNA ***: Totally,16.0% cases tested positive,either with a pathogenic or a non-pathogenic parasite. Protozoa were detected in 14.0%,helminths in 1.0%,protozoa and helminth coinfections were detected in 0.3%,and co-infections of two protozoa were detected in 0.7% of cases. The most common protozoa and helminths were Giardia duodenalis(7.7%) and Trichostrongylus spp.(0.5%),respectively. Among five microscopy Trichostrongylus positive cases,Trichostrongylus culbriformis was successfully identified in three isolates by sequencing. In the rural areas,the prevalence of parasitic infection was higher(9.8%) than that in the urban areas(6.2%). A significant association was found between educational level,type of drinking water,animals contact,hand-washing,and clinical symptoms. Conclusions: This study indicates that intestinal parasitic infections remain as a public health priority in Shushtar County. It seems that drinking water and environmental sanitation are the main risk factors of parasitic infections in rural areas.

关键词： Intestinal parasitic infections Risk factors Iran