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作者： Nuhad K.Ibrahim Neil Desai Sewa Legha Patrick Soon-Shiong Richard L.Theriault Edgardo Rivera Bita esmaeil Sigrid E.Ring Agop Bedikian Gabriel N.Hortobagyi Julie A Ellerhorst 乳腺肿瘤医学系

目的:ABI-007是一种不用聚氧乙基代蓖麻油(Cremophor E1),且蛋白质稳定的紫杉醇纳米制剂。不使用聚氧乙基代蓖麻油Cremophor EI可使ABI-007给药前不用进行常规预防超敏反应的预处理。此外,这种新制剂可使得紫杉醇在溶液中以更高的浓度存...

目的:ABI-007是一种不用聚氧乙基代蓖麻油(Cremophor E1),且蛋白质稳定的紫杉醇纳米制剂。不使用聚氧乙基代蓖麻油Cremophor EI可使ABI-007给药前不用进行常规预防超敏反应的预处理。此外,这种新制剂可使得紫杉醇在溶液中以更高的浓度存在,这样就可以减少输液的体积和时间,I期临床试验是要研究ABI-007的毒性,最大耐药剂量(MTD)和药物动力学。实验设计:ABI-007在门诊病人中使用,病人不用预先用药,30分钟滴注。ABI-007的剂量范围是从135(0级)到375mg/m2(3级)。16个病人参加了药物动力学的研究。结果:十九个病人在进行输液治疗期间没有观察到急性超敏反应。血药毒性是缓和的且无而非蓄积性。以3级(375mg/m2)治疗的6个病人中的3人发生剂量限制性毒性,口腔粘膜炎有2个病人,2个病人出现轻微的角膜炎。因此最大耐受剂量定为300 mg/m2(2级)。药物动力学分析显示当ABI-007的剂量在135-300mg/m2范围内时紫杉醇的Cmax和曲线下面积线形增加,Cmax和曲线下面积与病人个体毒性呈现出很好的相关性。结论:ABI-007提供了几个临床研究感兴趣的方面,包括快速输液率,不用预先用药处理和较高的紫杉醇最大耐药剂量,我们的研究结果为II期临床试验提供了该药抗肿瘤活性的依据。

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睑板腺囊肿

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英国医学杂志中文版 2010年第6期13卷 379-379页

作者： esmaeil M Arbabi Ross J Kelly Zia I Carrim 张吟眉(译) 不详北京大学第三医院检验科

21岁女性患者，主诉右侧上眼睑无痛肿物。肿物已经出现了几周，且在缓慢增大。她的医师建议她使用抗生素眼膏治疗，但使用了几天症状并无改善。

关键词：睑板腺囊肿抗生素眼膏女性患者上眼睑肿物

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利用组织培养的人羊膜上皮细胞的非外科移植术进行眼表重建

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世界核心医学期刊文摘（眼科学分册） 2006年第5期2卷 12-12页

作者： Parmar D.N. alizadeh H. Awwad S.T. J.P. McCulley 潘佳鸿 Department of Ophthalmology University of Texas Southwestern Medical Center at Dallas 5323 Harry Hines Blvd Dallas TX 75390-9057United States Dr.

PURPOSE: To assess the effect of tissue-cultured human amniotic epithelial cells (AECs) in restoring the ocular surface, transplanted using a collagen shield seeded with AECs supported by a soft contact lens. DESIGN: Prospective interventional single-institutional case series with crossover controls. METHODS: Three eyes in three patients were identified with persistent corneal epithelial defects (PEDs) refractory to medical therapy. Two cases were secondary to neurotrophic keratopathy, while one case was attributable to longstanding alkali injury. AECs were isolated from serologically screened donor human placenta, seeded onto collagen corneal shields, and incubated in tissue culture medium for 7 days. These collagen shields were placed over the PED and supported by an overlying soft contact lens. The collagen shields dissolved by 72 hours, and the contact lenses were removed after this time. This cycle was repeated every week until healing was achieved. As a crossover control, collagen shields without AECs were placed in the same eye 1 week before placing collagen shields containing AECs. The PED was assessed by vital staining and slit-lamp color photography. RESULTS: The PEDs had a mean duration of 4 months and involved 20%to 37%of the corneal surface area, one case secondary to longstanding alkali injury and two cases attributable to neurotrophic keratopathy. No change in PED size was observed in those control eyes receiving collagen shields without AECs. Complete resolution of the PED was seen after two cycles of AEC-seeded collagen shield in one case, and four cycles in two cases, from 7 to 12 weeks following treatment in all patients. No loss of visual acuity was seen and clinical improvement was maintained in all cases, with a mean follow-up of 6.3 months. CONCLUSIONS: Nonsurgical transplantation of tissue-cultured AECs on a collagen shield provides a promising approach to restoring the ocular surface in cases of PED.

关键词：羊膜上皮细胞组织培养液眼表重建移植术软性接触镜角膜胶原外科角膜上皮神经营养性临床研究

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Fungal diversity notes 1387-1511:taxonomic and phylogenetic contributions on genera and species of fungal taxa

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Fungal Diversity 2021年第6期111卷 1-335页

作者： Saranyaphat Boonmee Dhanushka N.Wanasinghe Mark S.Calabon Naruemon Huanraluek Sajini K.U.Chandrasiri Gareth E.B.Jones Walter Rossi Marco Leonardi Sanjay K.Singh Shiwali Rana Paras N.Singh Deepak K.Maurya Ajay C.Lagashetti Deepika Choudhary Yu-Cheng Dai Chang-Lin Zhao Yan-Hong Mu Hai-Sheng Yuan Shuang-Hui He Rungtiwa Phookamsak Hong-Bo Jiang María P.Martín Margarita Dueñas MTeresa Telleria Izabela L.Kałucka Andrzej M.Jagodziński Kare Liimatainen Diana S.Pereira Alan J.L.Phillips Nakarin Suwannarach Jaturong Kumla Surapong Khuna Saisamorn Lumyong Tarynn B.Potter Roger G.Shivas Adam H.Sparks Niloofar Vaghefi Mohamed A.Abdel-Wahab Faten A.Abdel-Aziz Guo-Jie Li Wen-Fei Lin Upendra Singh Rajendra P.Bhatt Hyang Burm Lee Thuong T.T.Nguyen Paul M.Kirk Arun Kumar Dutta Krishnendu Acharya VVenkateswara Sarma M.Niranjan Kunhiraman C.Rajeshkumar Nikhil Ashtekar Sneha Lad Nalin N.Wijayawardene Darbe J.Bhat Rong-Ju Xu Subodini N.Wijesinghe Hong-Wei Shen Zong-Long Luo Jing-Yi Zhang Phongeun Sysouphanthong Naritsada Thongklang Dan-Feng Bao Janith V.S.Aluthmuhandiram Jafar Abdollahzadeh Alireza Javadi Francesco Dovana Muhammad Usman Abdul Nasir Khalid Asha J.Dissanayake Anusha Telagathoti Maraike Probst Ursula Peintner Isaac Garrido-Benavent Lilla Bóna Zsolt Merényi Lajos Boros Bratek Zoltán JBenjamin Stielow Ning Jiang Cheng-Ming Tian esmaeil Shams Farzaneh Dehghanizadeh Adel Pordel Mohammad Javan-Nikkhah Teodor T.Denchev Cvetomir M.Denchev Martin Kemler Dominik Begerow Chun-Ying Deng Emma Harrower Tohir Bozorov Tutigul Kholmuradova Yusufjon Gafforov Aziz Abdurazakov Jian-Chu Xu Peter E.Mortimer Guang-Cong Ren Rajesh Jeewon Sajeewa S.N.Maharachchikumbura Chayanard Phukhamsakda Ausana Mapook Kevin D.Hyde Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand CAS Key Laboratory for Plant Biodiversity and Biogeography of East Asia(KLPB) Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China CIFOR-ICRAF China Program World Agroforestry(ICRAF)Kunming 650201YunnanPeople’s Republic of China Honghe Center for Mountain Futures Kunming Institute of BotanyHonghe CountyKunming 654400YunnanPeople’s Republic of China Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia Section Environmental Sciences Department MeSVAUniversity of L’Aquila67100 CoppitoAQItaly National Fungal Culture Collection of India(NFCCI) Biodiversity and Palaeobiology GroupMACS Agharkar Research InstituteG.G.Agarkar RoadPune 411004India Institute of Microbiology School of Ecology and Nature ConservationBeijing Forestry UniversityBeijing 100083People’s Republic of China College of Biodiversity Conservation Southwest Forestry UniversityKunming 650224People’s Republic of China CAS Key Laboratory of Forest Ecology and Management Institute of Applied EcologyChinese Academy of SciencesShenyang 110164People’s Republic of China University of the Chinese Academy of Sciences Beijing 100049People’s Republic of China Centre for Mountain Futures(CMF) Kunming Institute of BotanyKunming 650201YunnanPeople’s Republic of China Department of Mycology Real Jardín Botánico-CSICPlaza de Murillo 228014 MadridSpain Department of Algology and Mycology Faculty of Biology and Environmental ProtectionUniversity of LodzBanacha 12/1690-237ŁódźPoland Institute of Dendrology Polish Academy of SciencesParkowa 562-035 KórnikPoland Jodrell Laboratory Royal Botanic GardensKewRichmond TW93DSSurreyUK Faculdade de Ciências Biosystems and Integrative Sciences Institute(BioISI)Universidade de LisboaCampo Grande1749-016 LisbonPortugal Dep

This article is the 13th contribution in the Fungal Diversity Notes series,wherein 125 taxa from four phyla,ten classes,31 orders,69 families,92 genera and three genera incertae sedis are treated,demonstrating worldwide and geographic *** taxa described and illustrated in the present study include three new genera,69 new species,one new com-bination,one reference specimen and 51 new records on new hosts and new geographical *** new genera,Cylindrotorula(Torulaceae),Scolecoleotia(Leotiales genus incertae sedis)and Xenovaginatispora(Lindomycetaceae)are introduced based on distinct phylogenetic lineages and unique *** described species are Aspergillus lan-naensis,Cercophora dulciaquae,Cladophialophora aquatica,Coprinellus punjabensis,Cortinarius alutarius,***-latus,***,Coryneum fagi,Cruentomycena uttarakhandina,Cryptocoryneum rosae,Cyathus uniperidiolus,Cylindrotorula indica,Diaporthe chamaeropicola,Didymella azollae,Diplodia alanphillipsii,Dothiora coronicola,Efibula rodriguezarmasiae,Erysiphe salicicola,Fusarium queenslandicum,Geastrum gorgonicum,***,Helicosporium sexualis,Helminthosporium chiangraiensis,Hongkongmyces kokensis,Hydrophilomyces hydraenae,Hygrocybe boertmannii,Hyphoderma australosetigerum,Hyphodontia yunnanensis,Khaleijomyces umikazeana,Laboulbenia divisa,Laboulbenia triarthronis,Laccaria populina,Lactarius pallidozonarius,Lepidosphaeria strobelii,Longipedicellata megafusiformis,Lophiotrema lincangensis,Marasmius benghalensis,***,***,Mariannaea camelliae,Mel-anographium smilaxii,Microbotryum polycnemoides,Mimeomyces digitatus,Minutisphaera thailandensis,Mortierella solitaria,Mucor harpali,Nigrograna jinghongensis,Odontia huanrenensis,***,Paraconiothyrium ajrekarii,Par-afuscosporella niloticus,Phaeocytostroma yomensis,Phaeoisaria synnematicus,Phanerochaete hainanensis,Pleopunctum thailandicum,Pleurotheciella dimorphospora,Pseudochaetosphaeronema

关键词： 72 new taxa One new combination One reference specimen 51 new records Agaricomycetes Ascomycota Bartheletiomycetes Basidiomycota Dothideomycetes Eurotiomycetes Exobasidiomycetes Laboulbeniomycetes Leotiomycetes Mortierellomycetes Mortierellomycota Mucoromycetes Mucoromycota Phylogeny Sordariomycetes Taxonomy

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