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Effects of L-arginine supplementation on glycemic profile: Evidence from a systematic review and meta-analysis of clinical trials

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Journal of Integrative Medicine 2020年第4期18卷 284-291页

作者： esmaeil yousefi rad Behzad Nazarian Somayeh Saboori Ebrahim Falahi Azita Hekmatdoost Nutritional Health Research Center Lorestan University of Medical SciencesKhorramabad ***Iran Student Research Committee Lorestan University of Medical SciencesKhorramabad ***Iran Department of Clinical Nutrition and Dietetics Faculty of Nutrition and Food TechnologyNational Nutrition and Food TechnologyResearch InstituteShahid Beheshti University of Medical SciencesTehran ***Iran Division of Gastroenterology Hepatology and NutritionBritish Columbia’s Children’s Hospital and Child and Family Research Institutethe University of British ColumbiaBritish Columbia ***Canada

Background:The effects of l-arginine supplementation on indices of glycemic control and the role of many factors influencing this intervention have been controversial in clinical ***:This meta-analysis was performed to assess the effects of l-arginine supplementation on indices of glycemic control,including fasting blood glucose(FBG),hemoglobin A1c(HbA1c),serum insulin and homeostatic model assessment of insulin resistance(HOMA-IR)levels in randomized controlled trials(RCTs).Search strategy:This study conducted a systematic review of RCTs published in PubMed,Scopus,Web of Science,Cochrane Library and Embase,up to 5 May,*** criteria:Studies were included in this meta-analysis if they were RCTs with parallel design and reported sufficient data on participants before and after intervention,and outcomes of glycemic profile parameters in both the arginine supplementation and control *** extraction and analysis:The screening of titles and abstracts was performed independently by two *** articles were considered if they met the study’s inclusion *** quality of included studies was assessed by using the Cochrane Collaboration modified *** 710 articles retrieved in the initial search,only 10 trials were suitable for pooling the effects of arginine supplementation on serum glucose,insulin,HOMA-IR and HbA1c levels,with effect sizes of nine,eight,five and five,***:Pooled random-effect analysis revealed that l-arginine supplementation could significantly decrease FBG level(weighted mean difference[WMD]:3.35 mg/dL;95%confidence interval[CI]=[−6.55,−0.16];P=0.04)and serum insulin level(WMD:−2.19μIU/mL;95%CI=[−3.70,−0.67];P=0.005).However,the effects of l-arginine supplementation on HOMA-IR and HbA1c were not *** of subgroup analysis showed that supplementation with l-arginine could significantly decrease serum insulin levels when the dosage of l-arginine is>6.5 g/d(WMD:−3.49μIU/mL;95%CI=

关键词： l-arginine Fasting blood glucose Insulin resistance Hemoglobin A1c Glycemic profile Meta-analysis

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Microbiostratigraphy of the Sediments of Talezang Formation in Ghalebi Section (Southwest Lorestan, Iran)

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Open Journal of Geology 2015年第6期5卷 399-404页

作者： Mostafa yousefi rad Hamideh Noroozpour Faculty of Science Department of Geology Payame Noor University Tehran Iran

In the present paper, Talezang Formation, located in southwest of Khoramabad, is studied. Ghalebi section (200 m thickness) contains gray limestones with cherty nodules and sandy limestone isoclinally overlies Amiran Formation (gray shale and limestone). It is underlain concordantly and discontinuously by Kashkan Formation. 160 samples are surveyed (examined) from the section;28 genera and 4 species of benthonic foraminifera and 6 genera and 2 species of algae are identified. Due to similarity between identified benthonic foraminifera and Miscellanea-Kathina Assemblage Zone, the age of Talezang Formation can be assumed late Paleocene (Thanetian).

关键词： Biozone Microbiostratigraphy Paleocene Talezang Thanetian

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Modeling relationships between the network distance and travel time dynamics for assessing equity of accessibility to urban parks

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Geo-Spatial Information Science 2021年第3期24卷 509-526页

作者： Tahereh Ghaemi rad Abbas Alimohammadi GIS Department Faculty of Geomatics EngineeringCenter of Excellence in Geospatial Information TechnologyK.N.Toosi University of TechnologyTehranIran

Static models of accessibility are usually based on the fixed distance or Average Travel Time(ATT)*** of ignoring the traffic as a dynamic process affecting the accessibility through the change of Travel Time(TT),these models lead to unperceived temporal *** contrast to the consideration of the temporal Variation of TT(VTT)in the previous studies,the variation of traffic-related TT and its relations with network distance has not been *** this study,relations between VTT and network distance to access urban parks in Tehran megacity has been *** maps at five times of day are used to produce TT maps of Traffic Analysis Zones(TAZs)to their 3-closest *** of the Gini coefficients of accessibility show significant inequities of accessibility at different times of *** between the distance,ATT,and TT_(max) are modeled by statistical *** show both TT and TTmax have significant positive relations with distance and traffic and reach their maximum at 6 *** of significant relations between distance,ATT,TT_(max),and VTT provides interesting knowledge for the conversion of temporal measures of equity(TT)to a physical measure of equity(distance).A simple application of these findings for effective management of the spatiotemporal inequities is the definition of critical distances from public *** an example,to decrease the TT_(max) of TAZs to less than 12 min,their maximum distance to the closest parks should be less than 4 *** developed approach can be adopted for the accessibility evaluation of the other public services,particularly the health and education centers.

关键词： Spatiotemporal equity accessibility travel time variability Gini coefficient Lorenz curve urban parks Tehran megacity

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A Review on Fossil Findings of Central Iran’s Permo-Triassic Deposits

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Open Journal of Geology 2015年第6期5卷 383-386页

作者： Hamideh Noroozpour Mostafa yousefi rad Faculty of Sciences Department of Geology Payame Noor University Tehran Iran

In this research, a review was done on Permo-Triassic deposits in Central Iran including Abadeh, Hambast, and Elika formations. Following an overview about the circumstances of Central Iran Basin during Permotriassic time interval, the respective formations are introduced, and then, history of paleontology studies on these deposits will be depicted. Through analysis and comparison of previous studies, the following ages were estimated for the aforementioned formations: Early Dzhulfian for Abadeh Formation, Late Dzhulfian-Dorashamian for Hambast Formation, and Early Triassic (Scythian) for Elika Formation. Also, Permotriassic boundary in Central Iran is continuous, bearing the proposed sedimentation and fossil content. It is noteworthy that due to volcanic events at the boundary of these deposits in Central Iran, one might infer that occurrence of the aforementioned activities has been among the major causes of the respective extinction.

关键词： Abadeh Central Iran Hambast Permotriassic

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Hygroelasticity analysis of an elastically restrained functionally graded porous metamaterial circular plate resting on an auxetic material circular plate

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Applied Mathematics and Mechanics(English Edition) 2020年第9期41卷 1359-1380页

作者： A.BEHRAVAN-rad M.JAFARI Faculty of Mechanical and Mechatronics Engineering Shahrood University of TechnologyShahrood ***Iran

The main objective of this research is to investigate the hygroelastic behavior of a non-homogeneous circular plate made up of porous metamaterial resting on an auxetic material *** mechanical properties of the main plate,as well as moisture concentration,vary as an exponential function in the transverse ***’s ratio is *** elastic supporting medium is developed by considering the structurestructure *** on the linear hygroelasticity theory,the governing state equations in terms of displacements and moisture concentration are *** first,the Fickian equation is solved to compute the nonlinear distribution of moisture through the plate thickness,and then the state equations are semi-analytically solved using the statespace(SS)method and the differential quadrature(DQ)rule to predict the elastic field quantities.A comprehensive parametric analysis is accomplished to elucidate the effects of key parameters on the steady-state response of the plate under the mechanical and hygral loads.

关键词： metamaterial hygroelasticity auxeticity hygral interaction

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Semi-Analytical Solution for Functionally Graded Solid Circular and Annular Plates Resting on Elastic Foundations Subjected to Axisymmetric Transverse Loading

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Advances in Applied Mathematics and Mechanics 2012年第2期4卷 205-222页

作者： A.Behravan rad Department of Mechanical Engineering Karaj BranchIslamic Azad UniversityKarajIran

In this paper,the static analysis of functionally graded(FG)circular plates resting on linear elastic foundation with various edge conditions is carried out by using a semi-analytical *** governing differential equations are derived based on the three dimensional theory of elasticity and assuming that the mechanical properties of the material vary exponentially along the thickness direction and Poisson’s ratio remains *** solution is obtained by employing the state space method(SSM)to express exactly the plate behavior along the graded direction and the one dimensional differential quadrature method(DQM)to approximate the radial variations of the *** effects of different parameters(e.g.,material property gradient index,elastic foundation coefficients,the surfaces conditions(hard or soft surface of the plate on foundation),plate geometric parameters and edges condition)on the deformation and stress distributions of the FG circular plates are investigated.

关键词： Functionally graded circular plate elastic foundation differential quadrature method state-space method

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A THREE-DIMENSIONAL ELASTICITY SOLUTION FOR TWO-DIRECTIONAL FGM ANNULAR PLATES WITH NON-UNIFORM ELASTIC FOUNDATIONS SUBJECTED TO NORMAL AND SHEAR TRACTIONS

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Acta Mechanica Solida Sinica 2013年第6期26卷 671-690页

作者： A.Behravan rad M.Shariyat Department of Mechanical Engineering Islamic Azad UniversityKaraj Branch Faculty of Mechanical Engineering K.N.Toosi University of TechnologyPardis StreetMolasadra AvenueVanak SquareTehranIran

In the present paper, bending and stress analyses of two-directional functionally graded （FG） annular plates resting on non-uniform two-parameter Winkler-Pasternak founda- tions and subjected to normal and in-plane-shear tractions is investigated using the exact three- dimensional theory of elasticity. Neither the in-plane shear loading nor the influence of the two- directional material heterogeneity has been investigated by the researchers before. The solution is obtained by employing the state space and differential quadrature methods. The material proper- ties are assumed to vary in both transverse and radial directions. Three different types of variations of the stiffness of the foundation are considered in the radial direction： linear, parabolic, and sinu- soidal. The convergence analysis and the comparative studies demonstrate the high accuracy and high convergence rate of the present approach. A parametric study consisting of evaluating effects of different parameters （e.g., exponents of the material properties laws, the thickness to radius ratio, trends of variations of the foundation stiffness, and different edge conditions） is carried out. The results are reported for the first time and are discussed in detail.

关键词： three-dimensional theory of elasticity two-directionM functionally graded materi- als annular and circular plates elastic foundation differential quadrature in-plane shear

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Reduced graphene oxide (RGO) reinforced Mg biocomposites for use as orthopedic applications: Mechanical properties, cytocompatibility and antibacterial activity

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Journal of Magnesium and Alloys 2022年第12期10卷 3612-3627页

作者： Somayeh Abazari Ali Shamsipur HamidRezaBakhsheshi-rad Department of Materials and Metallurgical Engineering Amirkabir University of TechnologyTehranIran Advanced Materials Research Center Department of Materials EngineeringNajafabad BranchIslamic Azad UniversityNajafabadIran

Magnesium(Mg) has attracted wide interest in orthopedic applications as they exhibit great biodegradability and strong biocompatibility,while corrosion is the main concern for Mg that should be addressed prior to biomedical applications. In this work, ZM31(Mg-3Zn-1Mn)/x RGO(x = 0, 0.5, 1 and 1.5 wt%) biocomposites were synthesized by semi-powder metallurgy method. The results showed that the RGO acting as an effective reinforcing filler to prevent deformation and showed better compressive strength(282.3 ± 9 MPa) and revealed enhancement in failure Strain(7.8 ± 2.1%) at 1 wt% RGO concentration compared to Mg alloy(244.5 ± 9 MPa and 7.1 ± 1.5%respectively). Moreover, fracture analysis indicated a more ductile fracture of the nanocomposites after the incorporation of RGO. Crack bridging, crack deflection and crack branching are dominant mechanisms for reinforcement of Mg-based containing RGO. Mg composites containing 0.5 wt% RGO showed a low corrosion rate(2.75 mm/year), while more incorporation of RGO resulted in an increased corrosion rate(4.38 mm/year). In addition, the degradation rate of ZM31 alloy(2.57 mg·cm-2·d-1) obviously decreased with the addition of 0.5 wt%RGO(1.84 mg·cm-2·d-1) in the SBF. Besides, continuous apatite layers were created on the composites in the SBF solution. Also, the cell culture examinations showed good cell viability and adhesion on composites with 0.5 and 1 wt% RGO, which was demonstrated by the SEM and MTT assay The alkaline phosphatase(ALP) activity of the ZM3–0.5RGO composite was considerably higher than that of ZM31matrix alloy in 24 h and 48 h, implying higher osteoblastic differentiation. The antibacterial behavior toward both bacteria(E. coli and ***) exhibited that escalating RGO concentration in Mg-matrix composites leads to further inhibition of bacteria growth. These findings suggested that ZM31–0.5RGO biocomposite could be a more promising candidate for orthopedic implants.

关键词： Mg alloys Reduced graphene oxide Mechanical properties Corrosion resistance Antibacterial activity Biocompatibility

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An expeditious and one-pot synthesis of unsymmetrical 2,5-disubstituted-1,3,4-oxadiazoles under microwave irradiation and solvent-free conditions

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Chinese Chemical Letters 2008年第10期19卷 1143-1146页

作者： Nasser Montazeri Kurosh rad-Moghadam Chemistry Department Azad University of TonekabonTonekabon 46841-61167Iran Chemistry Department University of GuilanRashtP.O.Box 41335-1914Iran

A one-pot synthesis of some unsymmetrical 2,5-disubstituted-1,3,4-oxadiazoles via cyclocondensation of benzoylhydrazines with orthoesters under solvent-free and microwave conditions are described here. The reaction is efficiently catalyzed by silica- supported sulfuric acid as it provided the title compounds in high yields and relatively short times. The catalyst is reusable and can be applied several times without considerable decrease in the yields and rates of the reactions.

关键词： 2,5-Disubstituted-1,3,4-oxadiazoles Silica-supported sulfuric acid Solvent-free Microwave Orthoester

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Optimization of passive control performance for different hard disk drives subjected to shock excitation

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Journal of Central South University 2017年第4期24卷 891-899页

作者： Seyed Rashid Alavi Mehdi Rahmati Saeed Ziaei-rad Department of Mechanical Engineering Isfahan University of Technology Isfahan 84156-83111 Iran Isfahan Mathematics House Isfahan 81698-51177 Iran

Laptop personal computers(LPCs) and their components are vulnerable devices in harsh mechanical environments. One of the most sensitive components of LPCs is hard disk drive(HDD) which needs to be protected against damages attributable to shock and vibration in order to have better magnetic read/write performance. In the present work, a LPC and its HDD are modeled as two degrees of freedom system and the nonlinear optimization method is employed to perform a passive control through minimizing peak of HDD absolute acceleration caused by a base shock excitation. The presented shock excitation is considered as half-sine pulse of acceleration. In addition, eleven inequality constraints are defined based on geometrical limitations and allowable intervals of lumped modal parameters. The target of the optimization is to reach optimum modal parameters of rubber mounts and rubber feet as design variables and subsequently propose new characteristics of rubber mounts and rubber feet to be manufactured for the HDD protection against shock excitation. The genetic algorithm and the modified constrained steepest descent algorithm are employed in order to solve the nonlinear optimization problem for three widely-used commercial cases of HDD. Finally, the results of both optimization methods are compared to make sure about their accuracy.

关键词： hard disk drive passive control shock excitation sequential quadratic programming genetic algorithm rubber

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