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Alternative RNA splicing in stem cells and cancer stem cells:Importance of transcript-based expression analysis

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World Journal of Stem Cells 2021年第10期13卷 1394-1416页

作者： esmaeil Ebrahimie Samira Rahimirad Mohammadreza Tahsili Manijeh Mohammadi-Dehcheshmeh School of Animal and Veterinary Sciences The University of AdelaideAdelaide 5005South AustraliaAustralia La Trobe Genomics Research Platform School of Life SciencesCollege of ScienceHealth and EngineeringLa Trobe UniversityMelbourne 3086Australia School of Biosciences The University of MelbourneMelbourne 3010Australia Department of Medical Genetics National Institute of Genetic Engineering and BiotechnologyTehran ***Iran Division of Urology Department of SurgeryMcGill University and the Research Institute of the McGill University Health CentreMontreal H4A 3J1QuebecCanada Department of Biology University of QomQom ***Iran

Alternative ribonucleic acid(RNA)splicing can lead to the assembly of different protein isoforms with distinctive *** outcome of alternative splicing(AS)can result in a complete loss of function or the acquisition of new *** is a gap in knowledge of abnormal RNA splice variants promoting cancer stem cells(CSCs),and their prospective contribution in cancer *** directly regulates the self-renewal features of stem cells(SCs)and stem-like cancer ***,octamer-binding transcription factor 4A spliced variant of octamerbinding transcription factor 4 contributes to maintaining stemness properties in both SCs and *** epithelial to mesenchymal transition pathway regulates the AS events in CSCs to maintain *** alternative spliced variants of CSCs markers,including cluster of differentiation 44,aldehyde dehydrogenase,and doublecortin-like kinase,α6β1 integrin,have pivotal roles in increasing selfrenewal properties and maintaining the pluripotency of *** splicing analysis tools are considered in this *** software can be considered as the best tool for differential splicing analysis and identification of the type of splicing ***,LeafCutter can be used for efficient mapping splicing quantitative trait ***,the accumulating evidence re-enforces the fact that gene and protein expression need to be investigated in parallel with alternative splice variants.

关键词： Alternative splicing Stem cell Cancer stem cell Transcriptome Expression analysis

A survey on Hibiscus rosa-sinensis,Alcea rosea *** Malva neglecta Wallr as antibacterial agents

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Asian Pacific Journal of Tropical Medicine 2010年第5期3卷 351-355页

作者： Seyyed Mansour Seyyednejad Haniyeh Koochak esmaeil Darabpour Hossein Motamedi Department of Biology Faculty of ScienceShahid Chamran University

Objective:To guide for selection of plants with antibacterial activity for further phytochemical works on the isolation and identification of the active ***:Ethanolic extracts of 3 species from Malvaceae family were evaluated by agar disc diffusion method for antibacterial activity against some gram-positive and gram-negative bacteria(Pseudomonas aeruginosa,Listeria monocytogenes,Staphylococcus *** aureus, Klebsiella *** typhi,Bacillus *** anthracis,Escherichia coli and Streptococcus pyogenes).The extracts were obtained from aerial parts of Hibiscus rosa(H. rosa)-sinensis(leaf and flower),Alcea rosea(***) L.(leaf and flower) and Malva neglecta(M. neglecta) Wallr(flower).Results:These extracts had inhibitory effects at different concentrations (0.05,0.10,0.20 and 0.40 g/mL) against above mentioned *** coli was the most resistant *** highest inhibitory zone was showed by ethanolic extract of *** against Staphylococcus epidermidis(22 mm) and followed by ethanolic extract from flower of *** against Staphylococcus epidermidis and Staphylococcus aureus(20 mm).The Minimum Inhibitory Concentration(MIC) and Minimum Bactericidal Concentration(MBC) values against Staphylococcus epidermidis were equal(M1C=MBC=5 mg/mL for *** extract and for H. rosa extract MIC=MBC=20 mg/mL).Conclusions:These findings suggest that these native plants have good antibacterial properties that can be used for infection control and treatment and could also be as new source for antibiotics discovery and infection treatment.

关键词： Alcea rosea Antibacterial activity Ethanolic extract Hibiscus rosa-sinensis Malva neglecta

Gravitational search algorithm for coordinated design of PSS and TCSC as damping controller

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Journal of Central South University 2012年第4期19卷 923-932页

作者： M.eslami H.Shareef A.Mohamed M.Khajehzadeh Department of Electrical Electronic and Systems EngineeringUniversity Kebangsaan MalaysiaBangi 43600SelangorMalaysia

A newly developed heuristic global optimization algorithm,called gravitational search algorithm(GSA),was introduced and applied for simultaneously coordinated designing of power system stabilizer(PSS) and thyristor controlled series capacitor(TCSC) as a damping controller in the multi-machine power *** coordinated design problem of PSS and TCSC controllers over a wide range of loading conditions is formulated as a multi-objective optimization problem which is the aggregation of two objectives related to damping ratio and damping *** minimizing the objective function with oscillation,the characteristics between areas are contained and hence the interactions among the PSS and TCSC controller under transient conditions are *** evaluation of effectiveness and robustness of proposed controllers,the performance was tested on a weakly connected power system subjected to different disturbances,loading conditions and system parameter *** eigenvalues analysis and nonlinear simulation results demonstrate the high performance of proposed controllers which is able to provide efficient damping of low frequency oscillations.

关键词：阻尼控制器全局优化算法 TCSC PSS 协调设计引力电力系统稳定器多目标优化问题

Disability and post-trauma stress in the population over 15 years old in Kashan,Iran:A population-based study

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Chinese Journal of Traumatology 2020年第6期23卷 351-355页

作者： Zahra Sehata esmaeil Fakharian Mojtaba Sehata Abdollah Omidi Trauma Research Center Kashan University of Medical SciencesKashanIran Department of Neurosurgery Trauma Research CenterKashan University of Medical SciencesIran Department of Clinical Psychology Faculty of MedicineKashan University of Medical SciencesKashanIran

Purpose One of the consequences of trauma-related injuries is *** are more than one billion people with disabilities *** in people reduces their quality of *** goal of this study was to determine the rate of post-trauma stress and disability related to trauma in the population over 15 years old in Kashan during a solar year of 2018–*** This is a cross-sectional population-based study.A cluster sampling method was used in the city of Kashan,and 3880 persons were interviewed with individuals randomly selected in each *** a person had trauma during one year ago,the World Health Organization Disability Assessment Schedule 2.0 and Post Trauma Stress Disorder(PTSD)Checklist were applied for further *** were analyzed using Chi-square test or *** Among the 3880 participants residing in Kashan,274(7.1%)reported a history of traumatic injury during one year ago in 2018–*** of all injuries was estimated to be 70.61(62.60–78.70)per 1000 *** the trauma population,213(77.7%)were male and 75.1%were *** half of them(50.3%,138/274)aged 21–39 *** most common cause of injuries was related to traffic accidents:140(51.1%).Of the 274 trauma participants,47(17.2%)reported PTSD;244(89.1%)had a mild disability,and 30(10.9%)reported moderate *** One of the main causes of disability in the human community is the traumatic *** to the results of this study,89.1%of trauma participants have sustained at last mild disability following *** people require follow-up and post-treatment *** should be noted that psychological complications such as PTSD are as significant as physical symptoms.

关键词： Disability Epidemiology Population-based study Post-traumatic stress disorder Trauma

Analysis of Spatial Autocorrelation Patterns of Heavy and Super-Heavy Rainfall in Iran

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Advances in Atmospheric Sciences 2017年第9期34卷 1069-1081页

作者： Iman ROUSTA Mehdi DOOSTKAMIAN esmaeil HAGHIGHI Hamid Reza GHAFARIAN MALAMIRI Parvane YARAHMADI Department of Geography Yazd University Department of Geography Zanjan University Department of Geography Tabriz University Department of Geography Khwarizmi University

Rainfall is a highly variable climatic element, and rainfall-related changes occur in spatial and temporal dimensions within a regional climate. The purpose of this study is to investigate the spatial autocorrelation changes of Iran＇s heavy and super-heavy rainfall over the past 40 years. For this purpose, the daily rainfall data of 664 meteorological stations between 1971 and 2011 are used. To analyze the changes in rainfall within a decade, geostatistical techniques like spatial autocorrelation analysis of hot spots, based on the Getis-Ord Gi statistic, are employed. Furthermore, programming features in MATLAB, Surfer, and GIS are used. The results indicate that the Caspian coast, the northwest and west of the western foothills of the Zagros Mountains of Iran, the inner regions of Iran, and southern parts of Southeast and Northeast Iran, have the highest likelihood of heavy and super-heavy rainfall. The spatial pattern of heavy rainfall shows that, despite its oscillation in different periods, the maximum positive spatial autocorrelation pattern of heavy rainfall includes areas of the west, northwest and west coast of the Caspian Sea. On the other hand, a negative spatial autocorrelation pattern of heavy rainfall is observed in central Iran and parts of the east, particularly in Zabul. Finally, it is found that patterns of super-heavy rainfall are similar to those of heavy rainfall.

关键词： Iran heavy rainfall super-heavy rainfall spatial autocorrelation Gi index

Mechanical Properties of V-,Nb-,and Ti-bearing As-cast Microalloyed Steels

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Journal of Materials Science & Technology 2007年第6期23卷 779-784页

作者： J.Rassizadehghani H.Najafi M.Emamy G.eslami-Saeen School of Metallurgy and Materials Engineering University College of EngineeringUniversity of TehranP.O.Box 14395-731TehranIran

The influence of microalloying additions on the mechanical properties of a low-carbon cast steel containing combinations of V, Nb, and Ti in the as-cast condition was evaluated. Tensile and hardness test results indicated that good combinations of strength and ductility could be achieved by V and Nb additions. While the yield strength and UTS （ultimate tensile strength） increased up to the range of 378-435 MPa and 579- 590 MPa, respectively in the microalloyed heats, their total elongation ranged from 18% to 23%. The presence of Ti, however, led to some reduction in the strength. Microstructural studies including scanning electron microscopy （SEM） and optical microscopy revealed that coarse TiN particles were responsible for this behavior. The Charpy impact values of all compositions indicated that microalloying additions significantly decreased the impact energy and led to the dominance of cleavage facets on the fracture surfaces. It seems that the increase in the hardness of coarse ferrite grains due to the precipitation hardening is the main reason for brittle fracture.

关键词： Cast steel Microalloyed steel Titanium Niobium Vanadium

Numerical investigation of hydraulic characteristics and prediction of cavitation number in Shahid Madani Dam’s Spillway

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Journal of Groundwater Science and Engineering 2019年第4期7卷 323-332页

作者： Babak Ghazi Rasoul Daneshfaraz esmaeil Jeihouni Department of Civil Engineering Sofian BranchIslamic Azad UniversitySofianIran Department of Civil Engineering Faculty of EngineeringUniversity of MaraghehMaraghehIran

The prediction of the probability of cavitation occurrence to prevent serious damages in the spillways is the major concern for hydraulic engineers. In this research, the three-dimensional model of Shahid Madani Dam's spillway was simulated with the Flow 3D software and by the comparison of numerical model results with the experi- mental data, the probability of occurrence of the cavitation phenomenon has been investigated. The flow parameters including pressure, velocity, and water depth were calculated for three different flow rates of 495 m3/s, 705 m3/s and 2 205 m3/s respectively. The Renormalization Group (RNG) turbulence model was used to simulate current turbu- lence. Comparison of simulation results for pressure, velocity and water depth with the results of the experimental model with two statistical indices Root Mean Square Error (RMSE) and Coefficient of Determination (R2) showed that the numerical simulation results are in good consistency with experimental model. However, simulation results indicated that at any flow rates with a return period of 1 000 years, probable maximum flood and designed flow rates, the cavitation number is not lower than the critical cavitation number. Therefore, it is predicted that the cavitation phenomenon in Shahid Madani Dam's spillway will not happen.

关键词： Spillway Cavitation index Velocity Water depth Pressure distribution

Exergetic sustainability evaluation and optimization of an irreversible Brayton cycle performance

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Frontiers in Energy 2019年第2期13卷 399-410页

作者： Mohammad H. AHMADI Mohammad-Ali AHMADI esmaeil ABOUKAZEMPOUR Lavinia GROSU Fathollah POURFAYAZ Mokhtar BIDI Renewable Energies Faculty of New Sciences and Technologies University of Tehran Tehran *** Iran Department of Petroleum Engineering Ahwaz Faculty of Petroleum Engineering Petroleum University of Technology (PUT) Ahwaz 61963165 Iran Graduate School of the Environment and Energy Science and Research Branch Islamic Azad University Tehran *** Iran University of Paris Ouest Nanterre La Defense 50 rue Sevres 92 410 Ville dAvray France Faculty of Mechanical & Energy Engineering Shahid Beheshti University A.C.Tehran ***Iran

Owing to the energy demands and global warming issue, employing more effective power cycles has become a responsibility. This paper presents a thermo-dynamical study of an irreversible Brayton cycle with the aim of optimizing the performance of the Brayton cycle. Moreover, four different schemes in the process of multi-objective optimization were suggested, and the outcomes of each scheme are assessed separately. The power output, the concepts of entropy generation, the energy, the exergy output, and the exergy efficiencies for the irreversible Brayton cycle are considered in the analysis. In the first scheme, in order to maximize the exergy output, the ecological function and the ecological coefficient of performance, a multi-objective optimization algorithm (MOEA) is used. In the second scheme, three objective functions including the exergetic performance criteria, the ecological coefficient of performance, and the ecological function are maximized at the same time by employing MOEA. In the third scenario, in order to maximize the exergy output, the exergetic performance criteria and the ecological coefficient of performance, a MOEA is performed. In the last scheme, three objective functions containing the exergetic performance criteria, the ecologi-cal coefficient of performance, and the exergy-based ecological function are maximized at the same time by employing multi-objective optimization algorithms. All the strategies are implemented via multi-objective evolu-tionary algorithms based on the NSGAII method. Finally, to govern the final outcome in each scheme, three well- known decision makers were employed.

关键词： entropy generation exergy Brayton cycle ecological function irreversibility

Expeditious solvent-free synthesis of 1,3-thiazolanes via multicomponent reactions

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Chinese Chemical Letters 2014年第5期25卷 794-796页

作者： Zinatossadat Hossaini Faramarz Rostami-Charati Mahboube eslami Moghadam Fatemeh Moghaddasi-Kochaksaraee Department of Chemistry Qaemshahr BranchIslamic Azad University Department of Chemistry Faculty of ScienceGonbad Kavous University Chemistry & Chemical Engineering Research Center of Iran

A series of 1 3-thiazolane derivatives have been synthesized via multicomponent reactions of activated acetylenes,primary amines and isothiocyanates in the presence of a catalytic amount of Nmethylimidazole under solv... 详细信息

关键词： 1 3-Thiazolane Activated acetylenes Primary amines Solvent-free Arylisothiocyanate