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Missed colorectal cancers in a fecal immunochemical test-based screening program: Molecular profiling of interval carcinomas

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World Journal of Gastrointestinal Oncology 2022年第11期14卷 2195-2207页

作者： Manon van der Vlugt Beatriz Carvalho Joelle Fliers Nahid Montazeri Christian Rausch esmée J Grobbee Manon van Engeland Manon C W Spaander Gerrit A Meijer Evelien Dekker Department of Gastroenterology and Hepatology Amsterdam University Medical CenterAmsterdam 1105 AZNetherlands Department of Pathology Netherlands Cancer InstituteAmsterdam 1066 CXNetherlands Biostatistics Unit Department of Gastroenterology and HepatologyAmsterdam University Medical CenterAmsterdam 1105 AZNetherlands Department of Gastroenterology and Hepatology Erasmus MC University Medical CenterRotterdam 3015 CNNetherlands Department of Pathology GROW-School for Oncology and Developmental BiologyMaastricht University Medical CenterMaastricht 6202 AZNetherlands

BACKGROUND For optimizing fecal immunochemical test(FIT)-based screening programs,reducing the rate of missed colorectal cancers(CRCs)by FIT(FIT-interval CRCs)is an important *** of the molecular make-up of these missed lesions could facilitate more accurate detection of all(precursor)*** To compare the molecular make-up of FIT-interval CRCs to lesions that are detected by FIT[screen-detected CRCs(SD-CRCs)].METHODS FIT-interval CRCs observed in a Dutch pilot-program of FIT-based screening were compared to a control group of SD-CRCs in a 1:2 ratio,resulting in 27 FIT-interval CRC and 54 *** analyses included microsatellite instability(MSI),CpG island methylator phenotype(CIMP),DNA sequence mutations and copy number alterations(CNAs).RESULTS Although no significant differences were reached,FIT-interval CRCs were more often CIMP positive and MSI positive(33%CIMP in FIT-interval CRCs vs 21%in SD-CRCs(P=0.274);19%MSI in FIT-interval CRCs vs 12%in SD-CRCs(P=0.469)),and showed more often serrated pathway associated features such as BRAF(30%vs 12%,P=0.090)and PTEN(15%vs 2.4%,P=0.063)*** mutations,a classic feature of the adenoma-carcinoma-sequence,were more abundant in SD-CRCs(68%vs 40%in FIT-interval CRCs P=0.035).Regarding CNAs differences between the two groups;FIT-interval CRCs less often showed gains at the regions 8p11.22-q24.3(P=0.009),and more often gains at 20p13-p12.1(P=0.039).CONCLUSION Serrated pathway associated molecular features seem to be more common in FIT-interval CRCs,while classic adenoma carcinoma pathway associated molecular features seem to be more common in *** indicates that proximal serrated lesions may be overrepresented among FITinterval CRCs.

关键词： Fecal immunochemical test-interval colorectal cancer Mutation analysis Colorectal cancer screening Serrated pathway Adenoma-carcinoma pathway

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4G通讯LTE芯片高通领跑联发科猛追

集成电路应用 2014年第10期 22-24页

作者： esm

2013年是联发科的四核3G套片狂缺,2014年高通4G LTE套片狂缺,风水轮流转,真可谓年年岁岁景相似,岁岁年年人不同。唯智能手机市场就这样一年又一年的保持着狂热的热度,终久不衰。因为,没有哪一个电子市场有手机市场的体量和刺激,这是一... 详细信息

2013年是联发科的四核3G套片狂缺,2014年高通4G LTE套片狂缺,风水轮流转,真可谓年年岁岁景相似,岁岁年年人不同。唯智能手机市场就这样一年又一年的保持着狂热的热度,终久不衰。因为,没有哪一个电子市场有手机市场的体量和刺激,这是一个无数人为之疯狂的市场。

关键词： 4G LTE集成电路

Comparison of the systemic action of electroacupuncture and laserpuncture in experimental injuries on the back skin of Wistar rats(Rattus novergicus)

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Journal of Traditional Chinese Medicine 2021年第5期41卷 779-788页

作者： Ivens Takechi Nakagawa Hamilton Ricardo Alonso Fabrício Campos Kuroda JoséRoberto Passarini Junior Juan Guzman Quispe Cabanillas Fernanda Aparecida Sampaio Mendonça Gláucia Maria Tech dos Santos Andrea Aparecida de Aro Edson Rosa Pimentel Maria esméria Corezola do Amaral Marcelo Augusto Marretto Esquisatto Graduate Program in Biomedical Sciences University Center of Herminio Ometto Foundation-FHOAvenida Dr.Maximiliano Baruto500-Jardim UniversitarioArarasSao Paulo 13607-339Brazil Department of Structural and Functional Biology Institute of BiologyState University of Campinas-UNICAMPAvenida Bertrand Russels/n.Caixa Postal 6109CampinasSao Paulo 13083-865Brazil

OBJECTIVE:To evaluate the systemic action of electroacupuncture and laserpuncture in the repair of excisional cutaneous injuries on the back of adult female Wistar ***:Ninety animals were divided into three experimental groups:C-control;E-treated with electroacupuncture[acupoints:Feishu(BL13),Geshu(BL17),Zusanli(ST36)];L-treated with laserpuncture(same acupoints)and euthanized on the 7 th,14 th and 21 st days for tissue removal and preparation for histomorphometric and biochemical(dosages,zymography and Western blotting)***:The number of fibroblasts in the E and L groups presented higher values than the C on the14 th and 21 st *** number of granulocytes was lower than C on the 21 st day in groups E and *** total number of newly formed vessels increased on the 21 st day and was higher in both treatments when compared to *** birefringent collagen fibers detected on the 21 st day was lower in groups E and L than group *** glycosaminoglycans and hydroxyproline amount was similar among groups throughout the experimental *** active isoform of matrixmetallo proteinase(MMP)-2 and the latent isoform of MMP-9 did not show any differences among all groups and experimental *** amount of collagenⅠpresented higher values in the L group on the 14 th day and in the E and L groups on the 21 st *** typeⅢcollagen,groups E and L presented values lower than C in all experimental *** amount of transforming growth factor-β1 in the E and L groups showed higher amounts than C on the 7 th day and lower on the 14 th and 21 st *** vascular endothelial growth factor,E and L groups presented similar and lower values than C on the 7 th and 14 th days,respectively,and similar on the 21 st ***:The therapies evaluated in this article stimulated fibroblast proliferation,neoangiogenesis and altered the reorganization of collagen fibers in the repair of excisional injuries in female adult rats.

关键词： wound healing electroacupuncture inflammation morphological and morphometric findings

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美德乐不再是晡乳妈妈的首选

商业周刊（中文版） 2021年第2期 60-65页

作者： esmÉE.DEPREZ 杨飞(译) 不详

2019年5月15日刚过凌晨四点,在纽约大学朗格尼医学中心的蒂施医院(Tisch Hospital),莎拉·拉德马赫(Sara Rademacher)通过剖宫产手术,生下了一个5磅重(4.5斤)、17英寸长(43厘米)的健康女婴,这个皱巴巴的小肉团名叫诺拉(Nora)。医生把她... 详细信息

2019年5月15日刚过凌晨四点,在纽约大学朗格尼医学中心的蒂施医院(Tisch Hospital),莎拉·拉德马赫(Sara Rademacher)通过剖宫产手术,生下了一个5磅重(4.5斤)、17英寸长(43厘米)的健康女婴,这个皱巴巴的小肉团名叫诺拉(Nora)。医生把她放在拉德马赫的胸口上。女性的身体能够给新生儿提供他们所需要的一切营养,第一次当妈妈的莎拉对这种神奇的力量进行了研究,并为之着迷。所以毫无疑问,她会努力进行母乳喂养。

关键词：纽约大学莎拉母乳喂养拉德神奇的力量剖宫产手术

确定滑动平均剩余重力异常深度的最小二乘极小化法

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物探化探译丛 1995年第4期 19-24页

作者： Abd.,esm 周明海

Focus Group Discussion—Psychodrama in Corporate Environment: Leverage of Investigation of Employees’ Origins of Dissatisfaction within Fludor Benin SA

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Open Journal of Psychiatry 2017年第3期7卷 162-175页

作者： Djidonou Anselme Fiossi-Kpadonou Emilie Hounmènou Jean-Claude Sèdognon Floret Arthur Djidonou Lionelle esméralda Riboux Alain Tognon Tchégnonsi Francis University of Parakou Mental Health Department Parakou Benin University of Abomey-Calavi Mental Health Department Cotonou Benin University of Abomey-Calavi Psychology and Science Education Department Abomey-Calavi Benin Social Change Socio-Anthropologist Montreal University Montreal Canada High Institute of Commerce and Management Cotonou Benin Brussels Free University Faculty of Medicine Brussels Belgium

Background: Employees’ dissatisfaction is as a result of confrontations of two divergent views, compliance with collective labor agreement and the company’s profitability requirements. However, the documentation of internal and external environmental impacts on the employees is poor. Our objective was to study workers’ origin of dissatisfaction from the negative impact of Fludor Benin SA internal and external environment. Population and methods: It was a cross-sectional study, conducted from 11th September 2013 to 08th January 2014, on Fludor Benin SA employees. Data collection was carried out over ten (10) sessions through administration of Focus Group Discussion modules coupled with psychodrama (FGD-psychodrama) and conducted fortnightly. The module was intended for a group of twelve employees per session. It lasted 2 hours and ended with a game comprising a set of sixteen (16) cards. Each participant’s 16-card deck allowed the “player” to identify the likely origin of his dissatisfaction at work. Results: One hundred and twenty (120) employees were expected, but only ninety-nine (99) had participated in the FGD-psychodrama. The rate of participation was 82.5%. The average age of the employees was 35.4 ± 7.4 years, while sex-ratio was 23.75. Average seniority was 9.3 ± 3.2 years. The employees’ robot profile was: 39 (39.39%) passive employees, 18 (18.19%) disappointed employees, 17 (17.17%) unmotivated employees, 14 (14.14%) dedicated to the company but barely recognized and 11 (11.11%) unhappy employees. The reasons for dissatisfaction originated from matrimonial home 25 (25.25%), workplace 23 (23.23%) and use of drugs 11 (11.11%). Seventy-seven 77 (77.78%) employees were satisfied with the FGD-psychodrama modules. Conclusion: FGD-psychodrama may be an effective tool to restore unhealthy corporate atmosphere, help employees to discern the origin of their dissatisfaction and change their perception about stressful situations prevailing in their workplace.

关键词： Dissatisfaction Workplace Focus Group Discussion-Psychodrama Fludor Benin SA

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在得克萨斯州不能流产那就开车到新墨西哥州

商业周刊（中文版） 2015年第3期 32-33页

作者： Laurel Brubaker Calkins esm e E. Deprez Lauren Etter Bobby

2013年年初，美国得克萨斯州共计有41家人流诊所。但之后共和党控制下的得克萨斯州州议会通过了一项法案，要求人流诊所执业医生须取得距其诊所30英里范围内某家医院承认的相关资质（接收病人进入该医院的特权）才能为病人实施人流手术。

关键词：得克萨斯州新墨西哥州流产诊所共和党病人医院法案

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病重特护患者压疮的发生率、预防和治疗

国际护理学杂志 2010年第10期29卷 1598-1598页

作者： Shahin esm Dassen T Halfens RJG 镇艳(摘) 程显山(校)

研究背景压疮普遍发生予急性和慢性患者。然而危重疾病患者通常是压疮发生的高风险因素。目标这个研究的主导是评估重症护理患者的压疮发生率，个体进入到病重护理状态下时，影响压疮发生率的因素和压疮过程。设计纵向设计。环境这个... 详细信息

研究背景压疮普遍发生予急性和慢性患者。然而危重疾病患者通常是压疮发生的高风险因素。目标这个研究的主导是评估重症护理患者的压疮发生率，个体进入到病重护理状态下时，影响压疮发生率的因素和压疮过程。设计纵向设计。环境这个研究对象是普通医院的心脏病外科手术后的重症护理病例和肾病重症护理病例。

关键词：慢性患者发生率压疮病重重症护理特护治疗预防

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Lasertherapy as A Strategy for Treatment Healing under Caloric Restriction – Study in Rats

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Journal of Pharmacy and Pharmacology 2018年第7期6卷 647-658页

作者： Leandro C. Moscardi Talita P. Espíndola Amanda A. Ferreira Naiara Alves Maria esméria C. Amaral Andréa A. Aro Rodrigo A. Dalia Marcelo A. M. Esquisatto Fernanda A. S. Mendonca Gláucia M. T. Santos Thiago A. M. Andrade Graduate Program in Biomedical Sciences of the Hermínio Ometto University Center UNIARARAS Araras So Paulo 13607-339 Brazilc