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Clinical profile of gastric cancer in Khuzestan, southwest of Iran

World Journal of Gastroenterology 2006年第30期12卷 4832-4835页

作者： Hajiani eskandar Sarmast Shoshtari Mohammad Hossein Masjedizadeh Rahim Hashemi Jalal Azmi Mehrdad Tahereh Rajabi Division of Gastroenterology and Hepatology Department of Internal Medicine Ahwaz Jundishapur University of Medical Sciences Ahwaz Iran Department of Surgery Ahwaz Jundishapur University of Medical Sciences Ahwaz Iran Department of Pathology Ahwaz Jundishapur University of Medical Sciences Ahwaz Iran

AIM： To analyze the characteristics of epidemiological, clinical and survival patterns among patients with carcinoma of the stomach. METHODS： We retrospectively studied the characteristics of 186 gastric adenocarcinoma patients at Ahwaz Jundishapur University Hospitals （AJSUH） from September 1, 1996 to September 1, 2002. All the patients had histopathologically-confirmed malignancy. Demographic variables, family history of gastric cancer （GC）, clinicopathologic characteristics and treatment-related variables were analyzed. Univariate analysis was performed with the log-rank test and multivariate analysis with Cox regression. P 〈 0.05 was considered statistically significant. RESULTS： Male to female ratio was 2.6：1. The mean age was 60.6 years and 14% of the patients were younger than 40 years. Adenocarcinoma, gastric lymphoma, and gastric metastasis were found in 94.5%, 2.3%, and 3% patients, respectively. There was an average of 6-mo delay between the initial symptoms and the diagnosis. Among adenocarcinoma groups, intestinal type was the commonest （55.9%） and the distal third was the most common localization （88.4%）. One hundred and thirty-four patients （72.1%） were males. Thirty-one patients （17%） had a family history of GC. Surgery was performed in 90% of patients （non-curative）. CONCLUSION： The epidemiological features of GC in south Iran mimic those in high-risk areas. There is a higher frequency of GC in young patients at our institution. Patients are detected and treated after a relatively long delay. Most patients present in advanced stages, which favors a poor overall survival, Family history of GC has a significant problem in our area, Studying the etiology of this cancer in south Iran and earlier diagnosis and subsequent better cares are recommended.

关键词： Gastric cancer Epidemiological features Khuzestan Southwest of Iran

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Celiac disease in South-West of Iran

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World Journal of Gastroenterology 2006年第27期12卷 4416-4419页

作者： Rahim Masjedizadeh eskandar Hajiani Jalal Hashemi Ali Akbar Shayesteh Karim Moula Tahereh Rajabi From the Division of Gastroenterology and Hepatology Department of Internal MedicineAhwaz Jundishapur University of Medical SciencesAhwazIran Department of pathology Ahwaz Jundishapur University of Medical SciencesAhwazIran

AIM： Celiac disease is characterized by life-long gluten intolerance. Clinical features of patients with celiac disease are variable. Studies about the prevalence of celiac disease in our country are scarce and there is no study on the prevalence of celiac disease in southern Iran. In the current study, clinical, laboratory and histological features of 52 patients with celiac disease were evaluated. METHODS： In a cross sectional study we retrospectively studied the characteristics of 52 celiac patients at Ahwaz JundiShapour University Hospitals （AJSUH） from November 1, 1999 to 1st Sep 2004. Intestinal biopsy and serum antigliadin and anti-endomysium antibodies were used for the diagnosis of patients. Mucosal lesions were classified according to the criteria of Marsh. Antigliadin antibodies were measured with a commercial enzyme-linked immunosorbent assay. Anti-endomysium antibodies were analyzed by indirect immunofluorescence with the use of a section of monkey esophagus. Routine hematological and biochemical analyses and measurement of immunoglobulin levels were undertaken.RESULTS： Male： female ratio was 1.08. The mean ＋ SD patient age was 21 ＋ 4.5 years （range 10-70 years） and the most common symptoms were diarrhea and weight loss （78.8%） followed by fatigue （73.1%）, pallor （65.4%）, anorexia （40.4%）, abdominal distention （32.7%）, and failure to thrive （23.1%）. Diarrhea and weight loss and fatigue were the most common findings. Iron deficiency anemia was found in 63.2% of patients and this became normal after adoption of a gluten-free diet in all patients. Immunoglobulin A, IgG antigliadin antibodies and IgA anti-endomysium antibodies were found in 33 and 48 cases, 78.8% and 85.4% of patients, respectively. Biopsy of the small intestine revealed that 90.4% of patients had typical lesions according to the Marsh classification. CONCLUSION： Although classical presentation was seen in most of the patients, atypical clinical manifestations of celiac disease should

关键词： Celiac disease IgG endomysial autoantibodies Southern Iran

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A New Record of Acanthodactylus cantoris(Sauria: Lacertidae) and Its Comparison with Closely Related A. blanfordi in Southeastern Iran

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Asian Herpetological Research 2012年第1期3卷 79-82页

作者： Nastaran HEIDARI Hiva FAIZI Nasrullah RASTEGAR-POUYANI eskandar RASTEGAR-POUYANI Department of Biology Young Researchers ClubZahedan BranchIslamic Azad University Department of Biology Faculty of SciencesRazi University Department of Biology Faculty of ScienceTeacher Training University

A new record of Acanthodactylus cantoris from Sistan and Baluchistan in southeastern Iran is presented in this paper,and this lizard is found occurring in the coastal area of the Persian Gulf from Govater to Chabahar. This species is mainly sympatric with A. blanfordi,and their habits and habitats support their close relationship within the cantoris group. In total,29 specimens of A. cantoris(n = 12) and A. blanfordi(n = 17) were compared morphologically using statistical methods. The occurrence of A. cantoris in Iran has been questioned for a long time by different herpetologists,and the distribution,ecology and taxonomy of this newly recorded species were investigated and provided in this paper. An updated identification key for the species of Acanthodactylus in Iran is given.

关键词： new record Acanthodactylus cantoris Acanthodactylus blanfordi Sistan Baluchistan Iran

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A New Subspecies of Darevskia raddei(Boettger,1892)(Sauria:Lacertidae)from the West Azerbaijan Province,Iran

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Asian Herpetological Research 2011年第4期2卷 216-222页

作者： Rastegar-Pouyani NASRULLAH Karamiani RASOUL Oraei HAMZEH Khosrawani AZAR Rastegar-Pouyani eskandar Department of Biology Faculty of ScienceRazi University Department of Biology Faculty of ScienceTeacher Training University

Based on extensive field work in the northern Zagros Mountains, a new subspecies of Darevskia raddei （Boettger, 1892） from the west Azerbaijan Province, northwestern Iran is described. The new subspecies is distinguishable from all the other three subspecies of D. raddei based on the combination of several distinguishing characters, such as dorsal body with 50-55 oval to round, smooth, or very weakly keeled, scales, 25-31 scales across the gular region, 18-20 femoral pores on each side of body （reaching the knee）, 29-31 tuberculate lamellae under the fourth toe, 11-12 supraciliaries, 9-11 collars and a specific color pattern. The new subspecies meets all the morphological characters described by Eiselt et al. （1993） for an undefined and intermediate form between D. raddei raddei in the east of and D. r vanensis in the west of the distribution range of the species.

关键词： Lacertidae Darevskia raddei chaldoranensis new subspecies Zagros Mountains West Azerbaijan Iran

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Seroepidemiology of hepatitis C and its risk factors in Khuzestan Province, South-West of Iran:A case-control study

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World Journal of Gastroenterology 2006年第30期12卷 4884-4887页

作者： eskandar Hajiani Jalal Hashemi Rahim Masjedizadeh Ali Akbar Shayesteh Esmail Idani Tahereh Rajabi Division of Gastroenterology and Hepatology Department of Internal Medicine Ahwaz Jundishapur University of Medical Sciences Ahwaz Iran Department of Internal Medicine Ahwaz Jundishapur University of Medical Sciences Ahwaz Iran Department of Pathology Ahwaz Jundishapur University of Medical Sciences Ahwaz Iran

AIM：To evaluate possible risk factors for the spread of hepatitis C infection and to analyze the characteristics of the epidemiological and clinical patterns among the patients with hepatitis C infection. METHODS： During a five-year period a cross-sectional study was conducted among HCV positive individuals referred to the Ahwaz JundiShapour University Hospitals （AJSUH） and Hepatitis Clinic from 1 Sept 1999 to 1 Sept 2003. The control group consisted of first time blood donors referred to the Regional Blood Transfusion organization. Enzyme-linked immunosorbent assay and recombinant immunoblot assay anti-hepatitis C virus （HCV） tests were performed for two groups. Positive serum specimens were retested using polymerase chain reaction （PCR） for HCV RNA. Risk factors were evaluated using a questionnaire. Reported risk factors among infected subjects （＂HCV-positive＂） were compared to those of subjects never exposed （＂HCV-negative＂） to HCV. RESULTS： A total of 514 subjects were studied for HCV, of which 254 were HCV-positive and 260 HCV- negative donors comprised the control group. Mean age of the patients was 28.4 （Std 15.22） years. HCV-positive subjects were more likely to be of male gender （63% versus 37%）. Transfusion 132 （52%）, non-intravenous （n-iv） drug abuse and iv drug abuse 37 （14.5%）, haemodialysis 25 （10%）, receiving wounds at war and extramarital sexual activities （2.4%）, tattooing （3.6%） were found to be independent risk factors of being HCV-positive. No apparent risk factors could be demonstrated in 29 （11.2%） of the positive cases. CONCLUSION： Our data indicate that a history of transfusion and iv drug abuse and haemodialysis are important risk factors for HCV infection in our area and that more careful pretransfusion screening of blood for anti- HCV must be introduced in our blood banks. Improvements in certain lifestyle patterns, and customs in this area may be essential to prevent transmission of the infection.

关键词： Epidemiological patterns Hepatitis C virus Risk factors South-West of Iran

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Association of H pylori cagA and vacA genotypes and IL-8 gene polymorphisms with clinical outcome of infection in Iranian patients with gastrointestinal diseases

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World Journal of Gastroenterology 2006年第32期12卷 5205-5210页

作者： eskandar Kamali-Sarvestani Abdulah Bazargani Malihe Masoudian Kamran Lankarani Ali-Reza Taghavi Mehdi Saberifiroozi Department of Immunology and Autoimmune Diseases Research Center Shiraz Medical School Shiraz University of Medical SciencesShirazIran Department of Bacteriology and virology Shiraz Medical School Shiraz University of Medical SciencesShirazIran Department of cellular and molecular sciences Khatam University TehranIran Gastrointestinal and Hepatology Research center Shiraz Medical School Shiraz University of Medical SciencesShirazIran Department of Internal medicine Shiraz Medical School Shiraz University of Medical SciencesShirazIran

AIM： To find out if a functional promoter polymorphism in the IL-8 gene along with cagA status and polymorphisms in vacA gene influence the type of diseases in Iranian patients infected by Hpylori. METHODS： IL-8 -251 A/T polymorphism was genotyped by oligonucleotide allele specific PCR （ASO-PCR） in a sample of 233 patients with Hpylori infection undergoing upper gastrointestinal endoscopy. The presence of cagA gene and polymorphisms in vacA gene was also determined by PCR. Association of these genetic polymorphisms with the development of gastritis, peptic ulcers as well as gastric cancer was tested. RESULTS： When the patients with different clinical manifestations were compared according to the presence of cagA gene or various vacA genotypes, only the vacA genotypes were significantly different among gastritis, peptic ulcer and gastric cancer patients （χ^2= 17.8; P=0.001）. Furthermore, there was a significant difference in the frequency of IL-8 -251 A/T genotypes between patients with gastric cancer and benign diseases （χ^2=10.47;P=0.005） CONCLUSION： The IL-8 -251 A/T polymorphism and the polymorphisms in H pylor/ vacA gene are involved in limiting the infection outcome to gastritis and peptic ulcer or in favoring cancer onset in Iranian patients.

关键词： Interleukin 8 Hpylori Gastric cancer Peptic ulcer Polymorphism

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New Karyological and Morphometric Data on Poorly Known Bufo surdus and Bufo luristanicus in Comparison with Data of Diploid Green Toads of the Bufo viridis Complex from South of Iran

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Asian Herpetological Research 2014年第3期5卷 168-178页

作者： Fatemeh FAKHARZAEH Jamshid DARVISH Haji Gholi KAMI Fereshteh GHASEMZADEH eskandar RASTEGAR-POUYANI Department of Biology Faculty of Sciences Ferdowsi University of Mashhad Department of Biology Faculty of Sciences Shahid Chamran University of Ahvaz Department of Biology Faculty of Sciences Golestan University Department of Biology Faculty of Sciences Hakim Sabzevari university

Previous studies on the Bufo viridis complex, which is distributed broadly across Iran, are incomplete and restricted to a few regions or a few samples. In this paper a new detailed study on the B. viridis complex in southern of Iran （from West to East） is presented. The analysis of 18 morphometric characters with univariate and multivariate methods reveals significant differences between three members of the B. viridis complex namely B. variabilis, B. luristanicus, and B. surdus distributed in southern part of Iran. Our result help to resolve an old taxonomic problem about B. surdus subgroup （taxa closely related to B. surdus） confirming that B. luristanicus and B. surdus are distinct species. Moreover, for the first time we report and describe karyotype details of B. luristanicus and B. surdus which confirmed that they are diploid. Karyological studies demonstrate that all toads from three mentioned species have 2n = 22 chromosomes. These chromosomes are arranged into two groups. First group has six large chromosomes and the second group is composed of five small chromosomes. These chromosomes are metacentric or submetacentric. The number of submetacentric chromosomes is different in three mentioned species of B. viridis complex. Neither sexual heteromorphism, nor secondary constriction was observed in any pairs of chromosomes.

关键词： Bufo viridis complex taxonomy Bufo surdus Bufo luristanicus Bufo variabilis karyotype morphometry,Iran

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H pylori infection and reflux oesophagitis: A case-control study

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World Journal of Gastroenterology 2006年第35期12卷 5658-5662页

作者： Rahim Masjedizadeh eskandar Hajiani Koorosh MoezArdalan Saeed Samie Mohammad-Javad Ehsani-Ardakani Ali Daneshmand Mohammad-Reza Zali Division of Gastroenterology and Hepatology Department of Interna Medicine Ahwaz Jundishapur University of Medical Sciences Ahwaz Iran The National Research Department of Foodborne Diseases(NRDFD) The Research Center of Gastroenterology and LiverDiseases (RCGLD) Shaheed Beheshti University of MedicaSciences Iran

AIM： To examine the relationship between Hpylori and gastro-oesophageal reflux disease （GORD） in Iran. METHODS： In this study 51 GORD patients （referred to endoscopy at Taleghani hospital） were compared with 49 age-sex matched controls. Diagnosis of H pylori was made by gastric mucosal biopsy and rapid urease test （positive if the result of one or both diagnostic methods was positive）. Updated Sydney system was used to report histopathological changes. RESULTS： The frequency of H pylori infection based on rapid urease test and histology was 88.2% （45） in patients and 77.6% （38） in controls, which showed no significant difference. The frequency of H pylori infection was significantly higher in the antrum than in the corpus and cardia. The mean activity, inflammation, and gastritis scores were also higher in the antrum of patients than in the antrum of controls. The mean scores were significantly higher in the corpus of controls than in the corpus of patients. Diffuse active gastritis was observed in a significantly larger number of controls, while the frequency of diffuse chronic gastritis was higher in patients. There in the frequency of other patients and controls. was no significant difference histological findings ***： H pylori infection cannot prevent GORD in this region.

关键词： H pylori Gastro-oesophageal reflux diseases Reflux oesophagitis

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Environmental Suitability and Distribution of the Caucasian Rock Agama,Paralaudakia caucasia (Sauria:Agamidae) in Western and Central Asia

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Asian Herpetological Research 2013年第3期4卷 207-213页

作者： Seyyed Saeed HOSSEINIAN YOUSEFKHANI Gentile Francesco FICETOLA Nasrullah RASTEGAR-POUYANI Natalia B ANANJEVA eskandar RASTEGAR-POUYANI Rafaqat MASROOR Iranian Plateau Herpetology Research Group(IPHRG) Faculty of ScienceRazi University Dipartimento di Scienze dell’Ambiente e del Territorio e di Scienze della Terra Università degli Studi di Milano Bicocca Department of Biology Faculty of ScienceRazi University Department of Herpetology Zoological InstituteRussian Academy of Sciences Department of Biology Faculty of ScienceHakim Sabzevari University Pakistan Museum of Natural History Garden AvenueShakarparian

Predictive potential distribution modeling is crucial in outlining habitat usage and establishing conservation management priorities. In this paper we provide detailed data on the distribution of the Caucasian rock agama Para- laudakia caucasia, and use species distribution models （MAXENT） to evaluate environmental suitability and potential distribution at a broad spatial scale. Locality data on the distribution of P. caucasia have been gathered over nearly its entire range by various authors from field surveys. The distribution model ofP caucasia showed good performance （AUC = 0.887）, and predicted high suitability in regions mainly located in Tajikistan, north Pakistan, Afghanistan, southeast Turkmenistan, northeast Iran along the Elburz mountains, Transcaueasus （Azerbajan, Armenia, Georgia）, northeastern Turkey and northward along the Caspian Sea coast in Daghestan, Russia. The identification of suitable areas for this species will help to assess conservation status of the species, and to set up management programs.

关键词： Western Asia Paralaudakia caucasia distribution Maxent modeling Agamidae

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Updates in the pathophysiological mechanisms of Parkinson's disease: Emerging role of bone marrow mesenchymal stem cells

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World Journal of Stem Cells 2016年第3期8卷 106-117页

作者： Hanaa H Ahmed Ahmed M Salem Hazem M Atta Emad F eskandar Abdel Razik H Farrag Mohamed A Ghazy Neveen A Salem Hadeer A Aglan Department Medical Research Division National Research Centre Biochemistry Department Faculty of Science Ain Shams University Clinical Biochemistry Department Faculty of Medicine King Abdulaziz University Medical Biochemistry and Molecular Biology Department Faculty of Medicine Cairo University Pathology Department Medical Research Division National Research Centre Narcotics Ergogenic aids and Poisons Department Medical Research Division National Research Centre

AIM: To explore the approaches exerted by mesenchymal stem cells (MSCs) to improve Parkinson’s disease (PD) ***: MSCs were harvested from bone marrow of femoral bones of male rats, grown and propagated in culture. Twenty four ovariectomized animals were classified into 3 groups: Group (1) was control, Groups (2) and (3) were subcutaneously administered with rotenone for 14 d after one month of ovariectomy for induction of PD. Then, Group (2) was left untreated, while Group (3) was treated with single intravenous dose of bone marrow derived MSCs (BM-MSCs). SRY gene was assessed by PCR in brain tissue of the female rats. Serum transforming growth factor beta-1 (TGF-β1), monocyte chemoattractant protein-1 (MCP-1) and brain derived neurotrophic factor (BDNF) levels were assayed by ELISA. Brain dopamine DA level was assayed fluorometrically, while brain tyrosine hydroxylase (TH) and nestin gene expression were detected by semi-quantitative real time PCR. Brain survivin expression was determined by immunohistochemical procedure. Histopathological investigation of brain tissues was also ***: BM-MSCs were able to home at the injured brains and elicited significant decrease in serum TGF-β1 (489.7 ± 13.0 vs 691.2 ± 8.0, P 0.05) expression. Finally, the brain sections showed intact histologica

关键词： Parkinson’s disease Pathophysiology Bone marrow derived mesenchymal stem cells Rotenone Anti-inflammatory action Ovariectomy Anti-apoptotic effect Neurogenic potential

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