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Concise review of radiosurgery for contemporary management of pilocytic astrocytomas in children and adults

World Journal of Experimental Medicine 2022年第3期12卷 36-43页

作者： Omer Sager Ferrat Dincoglan Selcuk Demiral Bora Uysal Hakan Gamsiz Esra Gumustepe Fatih Ozcan Onurhan Colak Ahmet Tarik Gursoy Cemal Ugur Dursun Ahmet Oguz Tugcu Galip Dogukan Dogru Rukiyye Arslan Yelda Elcim esin gundem Bahar Dirican Murat Beyzadeoglu Department of Radiation Oncology Gulhane Medical FacultyUniversity of Health SciencesAnkara 0090Turkey

Pilocytic astrocytoma(PA)may be seen in both adults and children as a distinct histologic and biologic subset of low-grade *** is the principal treatment for the management of PAs;however,selected patients may benefit from irradiation particularly in the setting of inoperability,incomplete resection,or recurrent *** conventionally fractionated radiation therapy has been traditionally utilized for radiotherapeutic management,stereotactic irradiation strategies have been introduced more recently to improve the toxicity profile of radiation delivery without compromising tumor *** may be suitable for radiosurgical management due to their typical appearance as well circumscribed *** and precise targeting of these well-defined lesions under stereotactic immobilization and image guidance may offer great potential for achieving an improved therapeutic ratio by virtue of radiosurgical *** the high conformality along with steep dose gradients around the target volume allowing for reduced normal tissue exposure,radiosurgery may be considered a viable modality of radiotherapeutic *** advantage of radiosurgery may be the completion of therapy in a usually shorter overall treatment time,which may be particularly well suited for children with requirement of anesthesia during *** studies have addressed the utility of radiosurgery particularly as an adjuvant or salvage treatment modality for ***,despite the growing body of evidence supporting the use of radiosurgery,there is need for a high level of evidence to dictate treatment decisions and establish its optimal role in the management of ***,we provide a concise review of radiosurgery for PA in light of the literature.

关键词： Pilocytic astrocytoma Radiosurgery Stereotactic irradiation Low-grade glioma Radiation oncology Children

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Concise review of stereotactic irradiation for pediatric glial neoplasms:Current concepts and future directions

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World Journal of Methodology 2021年第3期11卷 61-74页

作者： Omer Sager Ferrat Dincoglan Selcuk Demiral Bora Uysal Hakan Gamsiz Onurhan Colak Fatih Ozcan esin gundem Yelda Elcim Bahar Dirican Murat Beyzadeoglu Department of Radiation Oncology Gulhane Medical FacultyUniversity of Health SciencesAnkara 06018Turkey

Brain tumors,which are among the most common solid tumors in childhood,remain a leading cause of cancer-related mortality in pediatric ***,which may be broadly categorized as low grade glioma and high grade glioma,account for the majority of brain tumors in *** management,surgery,radiation therapy(RT),chemotherapy,targeted therapy or combinations of these modalities may be used for management of pediatric *** patient,tumor and treatment-related characteristics including age,lesion size,grade,location,phenotypic and genotypic features,symptomatology,predicted outcomes and toxicity profile of available therapeutic options should be considered in decision making for optimal *** of pediatric gliomas poses a formidable challenge to the physicians due to concerns about treatment induced *** effects of therapy may include neurological deficits,hemiparesis,dysphagia,ataxia,spasticity,endocrine sequelae,neurocognitive and communication impairment,deterioration in quality of life,adverse socioeconomic consequences,and secondary ***,improved understanding of molecular pathology and technological advancements may pave the way for progress in management of pediatric glial *** management with close collaboration of disciplines including pediatric oncology,surgery,and radiation oncology is warranted to achieve optimal therapeutic *** the context of RT,stereotactic irradiation is a viable treatment modality for several central nervous system disorders and brain *** the importance of minimizing adverse effects of irradiation,radiosurgery has attracted great attention for clinical applications in both adults and *** applications offer great potential for improving the toxicity profile of radiation delivery by focused and precise targeting of well-defined tumors under stereotactic immobilization and image ***,we provide

关键词： Radiosurgery Stereotactic irradiation Stereotactic radiosurgery Pediatric glioma Gamma knife Linear accelerator

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Adaptive radiation therapy of breast cancer by repeated imaging during irradiation

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World Journal of Radiology 2020年第5期12卷 68-75页

作者： Omer Sager Ferrat Dincoglan Selcuk Demiral Bora Uysal Hakan Gamsiz Fatih Ozcan Onurhan Colak Yelda Elcim esin gundem Bahar Dirican Murat Beyzadeoglu Department of Radiation Oncology Gulhane Medical FacultyUniversity of Health SciencesEtlikAnkara 06018Turkey

Breast cancer is the most frequent cancer among females and also a leading cause of cancer related mortality worldwide.A multimodality treatment approach may be utilized for optimal management of patients with combinations of surgery,radiation therapy(RT)and systemic *** composes an integral part of breast conserving treatment,and is typically used after breast conserving surgery to improve local *** years have witnessed significant improvements in the discipline of radiation oncology which allow for more focused and precise treatment *** radiation therapy(ART)is among the most important RT techniques which may be utilized for redesigning of treatment plans to account for dynamic changes in tumor size and anatomy during the course of *** the context of breast cancer,ART may serve as an excellent tool for patients receiving breast irradiation followed by a sequential boost to the tumor *** benefits of ART include more precise boost localization and potential for improved normal tissue sparing with adapted boost target volumes particularly in the setting of seroma reduction during the course of ***,we provide a concise review of ART for breast cancer in light of the literature.

关键词： Breast cancer Adaptive radiation therapy Tumor bed boost Computed tomography Imaging Replanning

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Optimal timing of thoracic irradiation for limited stage small cell lung cancer:Current evidence and future prospects

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World Journal of Clinical Oncology 2022年第2期13卷 116-124页

作者： Omer Sager Ferrat Dincoglan Selcuk Demiral Hakan Gamsiz Bora Uysal Fatih Ozcan Onurhan Colak Esra Gumustepe Yelda Elcim esin gundem Bahar Dirican Murat Beyzadeoglu Gulhane Medical Faculty Department of Radiation Oncology University of Health SciencesAnkara 0090Turkey

Lung cancer is a global health concern as the leading cause of cancer related mortality *** cell lung cancer(SCLC)poses a formidable challenge to the treating physicians with the worst prognosis among all lung ***,limited stage SCLC(LS-SCLC)has a relatively better outcome with multimodality *** have been focused on optimal integration of treatment modalities to achieve an improved therapeutic ratio for patients with *** chemotherapy and thoracic radiation therapy(TRT)are primary components of initial management for LS-SCLC,there is no consensus on optimal timing of *** this context,we herein provide a concise overview of current evidence and future prospects regarding the optimal timing of thoracic irradiation for LS-SCLC in light of the literature.

关键词： Small cell lung cancer Thoracic irradiation Limited stage small cell lung cancer Timing of thoracic radiation therapy Thoracic radiation therapy

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