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Improved Osteointegration of Ti-6Al-4V-implants of Different surface Texture by the Use of Bone Morphogenetic Protein-3 (BMP-3)

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Journal of Wuhan University of Technology(Materials science) 2005年第B12期20卷 301-303页

作者： esenwein s a esenwein s Herr G Hauser J Muhr G Hartwig C-H Department of surgery BG Trauma Center Bergmannsheil University Hospital Buerkle-de-la-Camp-Platz 1 D-44789 Bochum Germany Dental Practice Am Obstmarkt 5 D-71522 Backnang Germany Advanced Tissue Regeneration GmbH Turmstr. 16 D-35578 Wetzlar Germany Department of Orthopaedics Michaelis-Hospital Eichenstrasse 34 D-20244 Hamburg Germany

Half of altogether 60 cylindrical implant devices made of titanium-aluminum-vanadium alloy （ Ti-6Al-4V） were plusna-sprayed with a hydroxyapatite-couting and the other half had a corundum blasted porous surface. 15 implants of each group of the titanium test buplants were coated with 230 μg porcine, high-purified BMP- 3-precipitute per implant. In each case a BMP- 3-couted and an uncoated control-device were implanted into the femoral part of the putellofemoral joint of the right and left leg of 30 adult giant rabbits. Histomorphological and histomorphometrical we found in both groups with BMP- 3-coated test devices an improved osteointegrution. stutistical evaluation using the t-test for matched samples showed 5 weeks after surgery a significant higher volume of tony formed bone of the BMP- 3-coated corundum- blasted or hydroxyapathe- coated Ti- 6Al- 4 V test devices compared to the non-couted controls of the same t）pe （p 〈 0.01, t-test for matched samples）. In both implant groups with BMP-couting a synergetic effect was verifiable although the bone ongrowth in the hydroxyaputite coated implants was more extensive than in the corundum blasted implants. Light microscopy demonstrated osteointegrution without connective tissue membrane around the surface of the implants. Our results indicate that composite metal implants,as used in endoprosthetics and implantology , are suitable carriers for BMP- 3 and im proved fixation of the implants can be achieved. The hydroxyapatite surface is superior to the corundum-blasted surface with regards to the observed parameters because of its pronounced bioactivity and its osteoconductive characteristics.

关键词： bone morphogenetic protein-3 BMP- 3 hydroxyapatite osteointegration surface coating bone ingrowth implantology

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