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Human adipose derived stem cells are superior to human osteoblasts (HOB) in bone tissue engineering on a collagen-fibroin-ELR blend

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Bioactive Materials 2017年第2期2卷 71-81页

作者： esen sayin Rosti Hama Rashid JoséCarlos Rodríguez-Cabello Ahmed Elsheikh Erkan Türker Baran Vasif Hasirci METU Department of BiotechnologyAnkaraTurkey BIOMATEN METU Center of Excellence in Biomaterials and Tissue EngineeringDumlupinar Blvd No:106800 AnkaraTurkey University of Liverpool School of EngineeringL693GH LiverpoolUK BIOFORGE CIBER-BBNCampus“Miguel Delibes”Edificio LUCIAUniversidad de ValladolidPaseo Belen 1947011 ValladolidSpain METU Department of Biological SciencesAnkara06800Turkey

The ultrastructure of the bone provides a unique mechanical strength against compressive, torsional andtensional stresses. An elastin-like recombinamer (ELR) with a nucleation sequence for hydroxyapatitewas incorporated into films prepared from a collagen-silk fibroin blend carrying microchannel patternsto stimulate anisotropic osteogenesis. SEM and fluorescence microscopy showed the alignment ofadipose-derived stem cells (ADSCs) and the human osteoblasts (HOBs) on the ridges and in the groovesof microchannel patterned collagen-fibroin-ELR blend films. The Young's modulus and the ultimatetensile strength (UTS) of untreated films were 0.58 ± 0.13 MPa and 0.18 ± 0.05 MPa, respectively. After 28days of cell culture, ADSC seeded film had a Young's modulus of 1.21 ± 0.42 MPa and UTS of0.32 ± 0.15 MPa which were about 3 fold higher than HOB seeded films. The difference in Young'smodulus was statistically significant (p: 0.02). ADSCs attached, proliferated and mineralized better thanthe HOBs. In the light of these results, ADSCs served as a better cell source than HOBs for bone tissueengineering of collagen-fibroin-ELR based constructs used in this study. We have thus shown theenhancement in the tensile mechanical properties of the bone tissue engineered scaffolds by usingADSCs.

关键词： Adipose-derived stem cells Human osteoblasts Tissue engineering Bone Mechanical properties

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Physical and mechanical properties of some hybrid corn varieties

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International Journal of Agricultural and Biological Engineering 2013年第1期6卷 111-116页

作者： TurgutÖztürk Bilge esen Department of Agricultural Structure and Irrigation Faculty of AgricultureUniversity of Ondokuz Mayıs55139 SamsunTurkey

The aim of this study was to determine the structural designing parameters of silo and bins used for storage of some hybrid corn varieties(Zea mays L.).In the research,three corn varieties-dentcorn(Zea mays indentata Sturt.),popcorn(Zea mays everta Sturt.),sweetcorn(Zea mays sacharata Sturt.)-widespread cultivated in Turkey were ***-mechanical parameters(bulk density,true density,angle of internal friction,static coefficient of friction)were considered as the dependent variables,and moisture content(8%,10%,12%,and 14%)as the independent *** bulk density,true density and angle of internal friction varied from 608.46 to 856.46 kg/m^(3),950.88 to 1110.89 kg/m^(3),and 25.2°to 34.2°,respectively,with the increase in moisture content from 8% to 14%.According to results of the research,the highest average value for bulk density,true density,angle of internal friction were found in popcorn variety(839.17 kg/m^(3)),popcorn variety(1074.40 kg/m^(3)),sweetcorn variety(30.50°),*** highest average value for static coefficient of friction at concrete surface(C30)was recorded in dentcorn variety(0.662).

关键词： corn varieties physical properties angle of internal friction coefficient of friction

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Mobility of large clusters on a semiconductor surface:Kinetic Monte Carlo simulation results

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Chinese Physics B 2016年第1期25卷 580-584页

作者： M esen A T Ttizemen M Ozdemir Vocational School of Adana Cukurova UniversityAdana O1160Turkey Department of Science and Mathematics Education Faculty of EducationCumhuriyet UniversitySivas 58140Turkey Department of Physics Cukurova UniversityAdana 01330Turkey

The mobility of clusters on a semiconductor surface for various values of cluster size is studied as a function of temperature by kinetic Monte Carlo method. The cluster resides on the surface of a square grid. Kinetic processes such as the diffusion of single particles on the surface, their attachment and detachment to/from clusters, diffusion of particles along cluster edges are considered. The clusters considered in this study consist of 150-6000 atoms per cluster on average. A statistical probability of motion to each direction is assigned to each particle where a particle with four nearest neighbors is assumed to be immobile. The mobility of a cluster is found from the root mean square displacement of the center of mass of the cluster as a function of time. It is found that the diffusion coefficient of clusters goes as D = A（T）Na where N is the average number of particles in the cluster, A（T） is a temperature-dependent constant and a is a parameter with a value of about -0.64 〈 a 〈 -0.75. The value of a is found to be independent of cluster sizes and temperature values （170-220 K） considered in this study. As the diffusion along the perimeter of the cluster becomes prohibitive, the exponent approaches a value of -0.5. The diffusion coefficient is found to change by one order of magnitude as a function of cluster size.

关键词： diffusion constant cluster mobility Monte Carlo method

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Structural and Optical Properties of Zinc Nitride Films Prepared by Pulsed Filtered Cathodic Vacuum Arc Deposition

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Chinese Physics Letters 2007年第12期24卷 3477-3480页

作者： SENADIM TUZEMEN Ebru KAVAK Hamide esen Ramazan Department of Physics Cumhuriyet University 58140 Sivas Turkey Department of Physics Qukurova University 01330 Adana Turkey

Polycrystalline zinc nitride films are deposited on Coming 7059 glass substrates by pulsed filtered cathodic vacuum arc deposition （PFCVAD）. The crystallographic structure is studied by means of x-ray diffraction. These measurements show that all the films are crystallized in the cubic structure, in a preferred orientation along the （332） and （631） directions. Weak XRD signal shows small crystallites distributed in an amorphous tissue. A small improvement of crystallinity is observed with annealing. Optical parameters such as absorption, energy band gap, Urbach tail, extinction coefficients have been determined. The Urbach tail energy is decreased with annealing at 500℃ for one hour. Energy band gap values are found to be increased by annealing.

关键词： thermoelectric half-Heusler compounds thermal conductivity

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Double Exp-Function Method for Multisoliton Solutions of The Tzitzeica-Dodd-Bullough Equation

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Acta Mathematicae Applicatae Sinica 2016年第2期32卷 461-468页

作者： Alaattin esen N.Murat YAGMURLU Orkun TASBOZAN Department of Mathematics Faculty of Science and Art Inn University

In this work, it is aimed to find one- and two-soliton solutions to nonlinear Tzitzeica-Dodd-Bullough （TDB） equation. Since the double exp-function method has been widely used to solve several nonlinear evolution equations in mathematical physics, we have also used it with the help of symbolic computation for solving the present equation. The method seems to be easier and more accurate thanks to the recent developments in the field of symbolic computation.

关键词： double exp-function method one-soliton two-soliton Tzitzeica-Dodd-Bullough equation solitary waves

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Traveling wave structures of some fourth-order nonlinear partial differential equations

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Journal of Ocean Engineering and Science 2023年第2期8卷 124-132页

作者： Handenur esen Neslihan Ozdemir Aydin Secer Mustafa Bayram Department of Mathematical Engineering Yildiz Technical UniversityIstanbul34220Turkey Department of Software Engineering Istanbul Gelisim UniversityIstanbulTurkey Department of Computer Engineering Biruni UniversityIstanbulTurkey

This study presents a large family of the traveling wave solutions to the two fourth-order nonlinear partial differential equations utilizing the Riccati-Bernoulli sub-ODE *** this method,utilizing a traveling wave transformation with the aid of the Riccati-Bernoulli equation,the fourth-order equation can be transformed into a set of algebraic *** the set of algebraic equations,we acquire the novel exact solutions of the integrable fourth-order equations presented in this research *** physical interpretation of the nonlinear models are also detailed through the exact solutions,which demonstrate the effectiveness of the presented *** Bäcklund transformation can produce an infinite sequence of solutions of the given two fourth-order nonlinear partial differential ***,3D graphs of some derived solutions in this paper are depicted through suitable parameter values.

关键词： Fourth-order equations Riccati-Bernoulli sub-ODE method Traveling wave solution Bäcklund transformation

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Optical screw-wrench for microassembly

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Microsystems & Nanoengineering 2017年第1期3卷 389-395页

作者： Jannis Köhler Sarah Isabelle Ksouri Cemal esen Andreas Ostendorf Applied Laser Technologies Ruhr-Universität BochumUniversitätsstraße 150Bochum 44801Germany

For future micro-and nanotechnologies,the manufacturing of miniaturized,functionalized,and integrated devices is *** this paper,an assembly technique based on a bottom-up strategy that enables the manufacturing of complex microsystems using only optical methods is presented.A screw connection is transferred to the micrometer range and used to assemble screwand nut-shaped ***-stereolithography is performed by means of two-photon polymerization,and microstructures are fabricated and subsequently trapped,moved,and screwed together using optical forces in a holographic optical tweezer *** design and construction of interlocking microcomponents and the verification of a stable and releasable joint form the main focus of this *** assembly technique is also applied to a microfluidic system to enable the pumping or intermixing of fluids on a microfluidic *** strategy not only enables the assembly of microcomponents but also the combination of different materials and features to form complex hybrid microsystems.

关键词： holographic optical tweezer microassembly microfabrication microfluidics optical assembly screw connection screw-wrench two-photon polymerization

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Sutureless amniotic membrane transplantation following excision of ocular surface neoplasia

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International Journal of Ophthalmology(English edition) 2015年第3期8卷 637-640页

作者： Altan Ozcan Ebru esen Emine Ciloglu Department of Ophthalmology School of MedicineCukurova University Department of Ophthalmology Adana Numune Training and Research Hospital

Dear Sir,S uccess of surgical management of conjunctival neoplasias primarily depends on the complete excision of the mass and eradication of tumor cells from the ocular surface[1-3].Especially in cases that extensive resections are required,primary closure may not be feasible;so ocular surface reconstruction can be a challenging problem for the *** conjunctival tissue defects different surgical

关键词： Sutureless amniotic membrane transplantation following excision of ocular surface neoplasia AMT

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Comment on bilateral same-session intravitreal injections

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International Journal of Ophthalmology(English edition) 2015年第4期8卷 852-853页

作者： Levent Karabas Fehim esen Ozlem Sahin Department of Ophthalmology Kocaeli University School of Medicine Department of Ophthalmology Marmara University School of Medicine

Dear Editor,We have read the article by Abu-Yahgi et al[1]with great *** authors share their experience with bilateral same-session intravitreal injection of anti-vascular endothelial growth factors(anti-VEGF).They report a single case of endophthalmitis in a series of 342 injections of 74patients and compare their results with their 3634 cases of unilateral injections with 2 cases of endophthalmitis[1].There are some issues related with the article that may benefit from

关键词： Comment on bilateral same-session intravitreal injections

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Identification, synthesis and characterization of process related desfluoro impurity of ezetimibe and HPLC method validations

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Journal of Pharmaceutical Analysis 2015年第6期5卷 356-370页

作者： esen Bellur Atici Bekir Karl??a Deva Holding A.?.?erkezk?y-2 Production Plant

Ezetimibe, which selectively inhibits cholesterol absorption across the intestinal wall and is used as an antihyperlipidemic agent, is synthesized for commercial use as a drug substance in highly pure form. During the synthetic process development studies of ezetimibe, an impurity was detected in the final product at levels ranging from 0.05% to 0.15% in reverse phase gradient high performance liquid chro- matography （HPLC） method and its molecular weight was determined by LC-MS analysis. The impurity was identified as （3R,4S）-3-（（S）-3-（4-fluorophenyl）-3-hydroxypropyl）-4-（4-hydroxyphenyl）-1-phenyla- zetidin-2-one which is called desfluoro ezetimibe （lactam-related） impurity, synthesized and char- acterized, the mechanism of its formation was discussed in detail, After all standardization procedures, it was used as a reference standard during validation of HPLC method and routine analyses. In addition, content of Eze-I desfluoro impurity in Eze-1 intermediates was specified as 0.10% to keep the formation of desfluoro ezetimibe impurity under control and the related substances HPLC method was validated accordingly.

关键词： EzetimibeDesfluoro ezetimibeSynthesisCharacterizationNMRHPLC

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