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Relationship between T-lymphocyte cytokine levels and sero-response to hepatitis B vaccines

World Journal of Gastroenterology 2008年第22期14卷 3534-3540页

作者： Vijayakumar Velu Shanmugam Saravanan Subhadra Nandakumar esaki muthu shankar Appasamy Vengatesan Suresh Sakharam Jadhav Prasad Suryakant Kulkarni Sadras Panchatcharam Thyagarajan Department of Medical Microbiology Dr ALM PGIBMS University of Madras Chennai 600113 and National Referral Centre for Viral Hepatitis India Vaccine Research Centre Department of Microbiology and Immunology Emory University Atlanta Georgia 30329 United States Department of Medical Microbiology Dr ALM PGIBMS University of Madras Chennai 600113 and National Referral Centre for Viral Hepatitis India the YRG Centre for AIDS Research and Education VHS campus Taramani Chennai 600113 India Department of Medical Microbiology Dr ALM PGIBMS University of Madras Chennai 600113 and National Referral Centre for Viral Hepatitis India Clinical Epidemiology Unit Stanley Medical College Chennai 600001 Tamilnadu India Serum Institute of India Ltd. Pune India Department of Medical Microbiology Dr ALM PGIBMS University of Madras Chennai 600113 and National Referral Centre for Viral Hepatitis India Sri Ramachandra University Porur Chennai 600113 India the YRG Centre for AIDS Research and Education VHS campus Taramani Chennai 600113 India

AIM: To investigate the cellular defects by analyzing the (Th1/Th2) cytokine levels in vaccine responders and non-responders. METHODS: Peripheral blood mononuclear cell (PBMC) from responders and non-responders were stimulated with or with out recombinant HBsAg or PHA. Broad spectrum of cytokines viz (Th1) IFN-γ, IL-2, TNF-α, IL-12 and (Th2) IL-10, IL-4 were measured after in vitro stimulation with recombinant HBsAg and were compared with respective antibody titers. RESULTS: A significant decrease (P = 0.001) in Th1 and Th2 cytokines namely, IL-2, INF-γ, TNF-α and IL-10in non-responders was observed. The level of IL-4 was not significant between the three groups. Furthermore, despite a strong Th1 and Th2 cytokine response, the level of IL-12 was elevated in high-responders compared to other groups (P = 0.001) and demonstrated a positive correlation with anti-HBs titers and Th1 cytokine response. CONCLUSION: Our findings suggest that unrespon-siveness to recombinant hepatitis B vaccines (rHB) is multifactorial, including specific failure of antigen presentation or the lack of both T helper Th1 and Th2 response.

关键词： Hepatitis B vaccine Cytokines Humoral response T cell response Adult vaccines

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Mechanistic insights on immunosenescence and chronic immune activation in HIV-tuberculosis co-infection

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World Journal of Virology 2015年第1期4卷 17-24页

作者： esaki M shankar Vijayakumar Velu Adeeba Kamarulzaman Marie Larsson Tropical Infectious Disease Research and Education Center Department of Medical MicrobiologyFaculty of MedicineUniversity of Malaya Department of Microbiology and Immunology Emory Vaccine CenterYerkes National Primate Research Center Center of Excellence for Research in AIDS University of Malaya Division of Molecular Virology Department of Clinical and Experimental MedicineLink?ping University

Immunosenescence is marked by accelerated degradation of host immune responses leading to the onset of opportunistic infections, where senescent T cells show remarkably higher ontogenic defects as compared to healthy T cells. The mechanistic association between T-cell immunosenescence and human immunodeficiency virus(HIV) disease progression, and functional T-cell responses in HIV-tuberculosis(HIV-TB) co-infection remains to be elaborately discussed. Here, we discussed the association of immunosenescence and chronic immune activation in HIV-TB co-infection and reviewed the role played by mediators of immune deterioration in HIV-TB coinfection necessitating the importance of designing therapeutic strategies against HIV disease progression and pathogenesis.

关键词： Cluster of differentiation 38 Human immunodeficiency virus-tuberculosis co-infection Immunosenescence

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