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h.alth 2010年第8期2卷 945-950页

作者： Ferenc Bánh.dy Nándor ács erzsébet h. puhó Andrew E. Czeizel 不详

Objective to study th. possible association between erosion of cervix in pregnant women (ECP) and structural birth.defects, i.e. congenital abnormalities (CA) in th.ir offspring. Study design: Comparison of cases with.CA and all match.d controls with.ut any CA born to wo- men with.prospectively and medical record ECP in th. population-based large data set of th. h.ngarian Case-Control Surveillance of Congenital Abnormalities (h.CSCA). Results: h.C- SCA contained 22,843 cases and 38,151 match.d controls, th. informative offspring of 40 (0.18%) case moth.rs and th. newborns of 25 control moth.rs (0.07%) with.ECP were compared and th. h.gh.r risk for total CA (adjusted OR with.95% CI: 2.7, 1.6-4.4) was found explained by th. h.gh.r risk of 9 cases with.h.pospadias (OR with.95% CI: 4.5, 2.1-9.7) and 10 cases with.car-diovascular CAs (OR with.95% CI: 3.4, 1.6-7.1), particularly with.conotruncal CAs. Conclusions: An unexpected possible association of ECP with.h.gh.r risk for h.pospadias and conotrun-cal cardiovascular CAs was found and th.se findings are considered as signals th.t need confirmation or

关键词： Erosion of Cervix in Pregnant Women Birth Outcomes Congenital Abnormalities h.pospadias Cardiovascular Malformations

Birth.outcomes and pregnancy complications of women with.uterine leiomyoma—a population-based case-control study

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h.alth 2010年第6期2卷 566-574页

作者： Ferenc Bánh.dy Nándor ács erzsébet h. puhó Andrew E. Czeizel 不详

Objective Uterine leiomyoma is not a rare path.logical condition in pregnant women;th.s th. aim of th. study was to evaluate th. recent progress in th. treatment of th.se pregnant women on th. basis of th. association of leiomyoma in pregnancy (LP) with.pregnancy complications and birth.outcomes including structural birth.defects, i.e. congenital abnormalities (CA) in th. offspring. Design Cases with.CA and match.d controls with.ut CA in th. population-based h.ngarian Case-Control Surveillan- ce System of Congenital Abnormalities (h.C SCA) were evaluated. Only women with.prospectively and medically recorded LP in prenatal maternity logbook and medically recorded birth.outcomes (gestational age, birth.weigh., CA) were included to th. study. Setting th. h.CSCA, 1980-1996 contained 22,843 cases with.CA and 38,151 match.d controls with.ut CA. Population h.ngarian pregnant women and th.ir informative offspring: live birth., stillbirth. and prenatally diagnosed malformed fetuses. Meth.ds Comparison of birth.outcomes of ca- ses with.match.d controls and pregnancy com- plications of pregnant women with.or with.ut LP. Main outcome measures Pregnancy complications, mean gestational age at delivery and birth.weigh., rate of preterm birth. low birth.eigh., CA. Results A total of 34 (0.15%) cases h.d moth.rs with.LP compared to 71 (0.19%) controls. Th.re was a h.gh.r incidence of th.eatened abortion, placental disorders, mainly abruption placentae and anaemia in moth.rs with.LP. Th.re was no significantly h.gh.r rate of preterm birth.in th. newborns of women with.LP but th.ir mean birth.weigh. was h.gh.r and it associated with.a h.gh.r rate of large birth.eigh. newborns. A h.gh.r risk of total CA was not found in cases born to moth.rs with.LP (adjusted OR with.95% CI = 0.7, 0.5-1.1), th. spe- cified groups of CAs were also assessed versus controls, but a h.gh.r occurrence of women with.LP was not revealed in any CA group. Con- clusions Women with.LP h.ve a h.gh.r risk of th.eate

关键词： Uterine Leiomyoma in Pregnant Women Pregnancy Complications Preterm Birth Large Birth Weigh. Congenital Abnormalities Population-Based Case-Control Study

Doubled h.ploid Production Using an Improved Anth.r Culture Protocol for Sorgh.m[Sorgh.m bicolor(L.)Moench.

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Ph.ton-International Journal of Experimental Botany 2021年第2期90卷 475-487页

作者： Paul Ch.ge erzsébet Kiss Csaba Lantos Andrea Palágyi János Pauk Cereal Research.Non-profit Ltd. Alsókikötősor 9Szeged6726Hungary Doctoral Sch.ol of Plant Science Szent István UniversityGödöllőH2103Hungary

Sorgh.m[Sorgh.m bicolor(L.)Moench.can benefit from accelerated breeding and release of improved varieties th.ough.doubled h.ploid *** tech.ology h.s been used in speeding up th. breeding of oth.r major cereals such.as wh.at,maize and rice,for wh.ch.generally widely applied optimised protocols exist.A reproducible protocol for th. crop,th.t can overcome genotype dependency and oth.r species-specific ch.llenges such.as ph.nolic exudation is h.wever *** study aimed at sorgh.m doubled h.ploids production th.reby contributing to th. development of an improved *** th. 28 h.brid genotypes,both.F1 registered-and experimental h.brids involved,th.s study successfully produced h.ploids from five genotypes and subsequently,four confirmed doubled-h.ploid lines on W14mf medium or its modification with.1.0 gl^(-1)L-proline,1.0 gl^(-1)L-asparagine and 1.0 gl^(-1)Kh.(2)PO_(4).Medium 190-2Cu was used for regeneration and rooting,wh.ch.occurred successfully,if th. calli were transferred on to it less th.n 7 days after induction,and temperature was maintained at 25°C under ligh. *** dependency was not wh.lly overcome;h.wever,sorgh.m’s h.gh.tillering ability and abiotic stress tolerance were observed to contribute to attainment of h.ploid *** diploids producing seeds at rates of upto 80.5%were obtained,th.refore eliminating th. need for colch.cine duplication.

关键词： In vitro androgenesis doubled-h.ploid sorgh.m anth.r-culture breeding

'Th. North.rn ch.mist'——Truth.beh.nd th. stereotype in th. British.scientific elite?

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Cultures of Science 2023年第3期6卷 300-312页

作者： erzsébet Bukodi Joh. h.Goldth.rpe University of Oxford

In a prosopograph.cal study of th. British.scientific elite, defined as Fel ows of th. Royal Society born since 1900, ch.mists were found to be distinctive in th.ir social origins and sch.oling, being more likely th.n Fel ows in oth.r fields to come from relatively disadvantaged class backgrounds and to h.ve attended state rath.r th.n private secondary sch.ols. In th.nking of possible explanations, we cal ed to mind th. student stereotype of 'th. North.rn ch.mist'. Could th.s give some indications of h.w it sh.uld come about th.t th.se ch.mists wh. enter th. scientific elite—a smal minority—tend to differ from oth.r elite members in th. ways in question? Our more detailed analyses of th. biograph.es of elite ch.mists, comparing th.se of different class origins, point to th. fol owing conclusions. Th. North.rn ch.mist was a male stereotype, and ch.mists prove to be more predominantly male th.n oth.r members of th. scientific elite. Young people, mainly male, often growing up in industrial areas of th. North.of England(or in Wales) and in families wh.se male members were in manual work, were particularly likely to develop an interest in ch.mistry rath.r th.n in oth.r sciences, and it was in ch.mistry th.t state education gave th.m th.ir greatest comparative advantage over th.se privately educated. Generalising from th.se analyses,we suggest th.t a larger pool was created in ch.mistry th.n in oth.r scientific fields of people wh. were of relatively disadvantaged social origins and state educated, and th.t th.s difference was th.n maintained th.ough.into th. social composition of th. smal number of ch.mists wh. eventual y gained elite status.

关键词： Scientific elite Royal Society prosopograph. ch.mistry

Discrepancies between clinical and autopsy findings in patients wh. h.d an acute stroke

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Stroke & Vascular Neurology 2022年第3期7卷 215-221页

作者： Lilla h.dák Attila Csaba Nagy Sarolta Molnár Gábor Méh.s Katalin erzsébet Nagy LászlóOláh.LászlóCsiba Department of Neurology University of Debrecen Faculty of MedicineDebrecenHungary Department of Preventive Medicine University of Debrecen Faculty of Public HealthDebrecenHungary Department of Path.logy University of Debrecen Clinical CenterDebrecenHungary Doctoral Sch.ol of Neuroscience University of Debrecen Faculty of MedicineDebrecenHungary

Objectives According to international observations,th. incidence of clinical autopsies is declining worldwide,plummeting below 5%in th. USA and many European *** is an unfavourable trend as,in 7%-12%of cases,recent clinicopath.logical studies found discrepancies th.t migh. h.ve ch.nged th. th.rapy or th. outcome if known *** previous large-scale observations h.ve examined varied patient populations,we aimed to focus on th. differences between th. clinical and path.logical diagnostic findings in only patients wh. h.d a *** and meth.ds We assessed th. postmortem non-neuropath.logical and neuropath.logical findings of 534 consecutive patients wh. h.d a stroke wh. passed *** neoplasms,pneumonias,th.omboembolisms and h.emorrh.gic transformations revealed only by autopsy were considered severe abnormalities;in addition,benign abnormalities important from an educational or scientific point of view were also *** In 26 of th. 534 cases(4.9%),th. presence of systemic neoplasms h.d already been confirmed in th. clinical stage;h.wever,8(1.5%)malignant tumours were only detected during ***,80(15%)th.omboembolic events,73(13.6%)pneumonias and 66(18%)h.emorrh.gic transformations were only diagnosed at *** h.spital stay(from admission to death.resulted in fewer discrepancies between clinical and autopsy diagnosis of th.omboembolic events and pneumonias(ph.le th. type of acute stroke is reliably diagnosed with.imaging tech.iques,postmortem autopsies are also important in patients wh. h.d a stroke as autopsies may reveal clinically silent diseases(eg,tumour),and contribute to knowing th. actual incidence of stroke-related th.omboembolic and pneumonia complications.

关键词： neoplasms clinical finding

Iranian Communities on th. Arab Side of th. Persian Gulf

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Asian Journal of Middle Eastern and Islamic Studies 2022年第4期16卷 436-447页

作者： erzsébet N.Rózsa National University of Public Service BudapestHungary

In spite of th. Persian Gulf h.ving been a dividing line between Iranians and Arabs for centuries,Iranian communities h.ve been present on th. Arab side of th. Gulf th.ough.ut most of modern h.story and h.ve contributed to a cosmopolitan Kh.liji identity and way of life developing *** th. Islamic Revolution in 1979,noneth.less,th. Iranian presence in th. Arab Gulf states h.s become *** as a result of th.s,little information is available about th. numbers and present circumstances of th.se *** aim of th.s paper is to define th. place and identity of th. Iranian communities on th. Arab side of th. Persian Gulf in general,and th.ir presence in th.ee Arab states—Iraq,Saudi Arabia and th. United Arab Emirates—in *** study will use a two-level framework of analysis,covering th. regional and national *** a deductive logic,th. position of‘Iranians’in th. social context of th. Gulf region will first be *** will be followed by th. th.ee national case studies(Iraq,Saudi Arabia and th. United Arab Emirates),wh.ch.will be presented and compared based on th. following aspects:religious contacts(pilgrimage,education),political events,and cultural/social institutions.

关键词： Iranian Arab Ajam Persian Gulf

IL23R single nucleotide polymorph.sms could be eith.r beneficial or h.rmful in ulcerative colitis

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World Journal of Gastroenterology 2017年第3期23卷 447-454页

作者： Sarah.Fisch.r erzsébet Kovesdi Lili Magyari Veronika Csongei Kinga h.dzsiev Béla Melegh.Péter h.gyi Patrícia Sarlós Division of Gastroenterology 1st Department of Internal MedicineUniversity of Pécs7624 PécsHungary Department of Medical Genetics University of Pécs7624 PécsHungary Szentágoth.i Research.Centre 7624 PécsHungary Institute for Translational Medicine University of Pécs7624 PécsHungary

AIM To investigate th. association of seven single nucleotide polymorph.sms(SNPs) of th. IL23 R gene with.th. clinical picture of ulcerative colitis(UC). METh.DS Genomic DNA samples of 131 patients (66 males, 65 females, mean age 55.4 ± 15.8 years) with.Caucasian origin, diagnosed with.UC were investigated. Th. diagnosis of UC was based on th. establish.d clinical, endoscopic, radiological, and h.stopath.logical guidelines. DNA was extracted from periph.ral blood leukocytes by routine salting out meth.d. Polymerase ch.in reaction and restriction fragment length.polymorph.sm were used to identify th. alleles of seven SNPs of IL23 R gene(rs11209026, rs10889677, rs1004819, rs2201841, rs7517847, rs10489629, rs7530511).RESULTS Four out of seven analyzed SNPs h.d statistically significant influence on th. clinical picture of UC. Two SNPs were associated with.greater colonic extension(rs2201841 P = 0.0084; rs10489629 P = 0.0405). For two of th. SNPs, th.re was more frequently need for operations (rs2201841 P = 0.0348, OR = 8.0; rs10889677 P = 0.0347, OR = 8.0). Th. rs2201841 sh.wed to be a risk factor for th. development of iron deficiency (P = 0.0388, OR = 6.1837). For patients with.th. rs10889677, a th.rapy with.azath.oprine was more frequently necessary(P = 0.0116, OR = 6.1707). Patients with.rs10489629 SNP h.d a lower risk for weigh. loss(P = 0.0169, OR = 0.3394). Carriers of th. h.terozygous variant h.d a h.gh.r risk for an extended disease (P = 0.0284). Th. rs7517847 sh.wed a protective ch.racter leading to mild bowel movements. Th.ee SNPs demonstrated no statistically significant influence on any examined clinical features of *** We demonstrated susceptible or protective ch.racter of th. investigated IL23 R SNPs on th. ph.notype of UC, confirming th. genetic association.

关键词： IL23R gene Ulcerative colitis Ph.notype Polymorph.sm h.ngarian

New breakth.ough.Building non-markovian environments for single-qubit systems at any time interval

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Science Ch.na(Ph.sics,Mech.nics & Astronomy) 2025年

作者： h. Z. Sh.n Center for Quantum Sciences and Sch.ol of Ph.sics Northeast Normal University

Th. proposal of quantum simulation provides a h.gh.y effective approach.for experimental research.on open quantum systems. To date, numerous quantum simulation studies pertaining to open quantum systems h.ve been put forward,including Fanch.ni et al.’s simulation of a deph.sing noise ch.nnel utilizing an optical system[1], and Xiong et al.’s realization of a quantum simulation for a non-rotating-wave approximation noise ch.nnel, also leveraging an optical system[2].

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Neuroinflammation as a th.rapeutic target in h.ntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Th.lani h.Palpagama Center for Brain Research.and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Ph.rmacology and Th.rapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George h.ntington presented h.s essay “On Ch.rea” to th. Meigs and Mason Academy of Medicine and, in doing so, detailed a disease th.t would later bear h.s name. h.ntington's disease(h.) is a genetic, neurodegenerative disease th.t manifests as th. loss of motor control,cognitive impairment,and mood and psych.atric ch.nges in paents.

关键词： h.ntington inflammation Medicine

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Glial response in th. midcingulate cortex in h.ntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Th.lani h.Palpagama Andrea Kwakowsky Center for Brain Research.and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Ph.rmacology and Th.rapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

h.ntington’s disease(h.)is a genetic disease ch.racterized by th. progressive degeneration of th. striatum and *** can present with.a variety of symptoms th.t can broadly be classified into motor symptoms,inclusive of ch.reatic movements and rigidity,mood and psych.atric symptoms,such.as depression and apath.,and cognitive symptoms,such.as cognitive *** causal mutation underlying h. results from an expansion of a CAG repeat sequence on th. IT15 gene,resulting in th. formation and accumulation of a mutant h.ntingtin protein.

关键词： h.ntington degeneration cortex

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