检索结果-南通市图书馆

Anatomical and chemical characteristics associated with lodging resistance in wheat

在线全文

学校读者我要写书评

暂无评论

The Crop Journal 2013年第1期1卷 43-49页

作者： eryan kong Dongcheng Liu Xiaoli Guo Wenlong Yang Jiazhu Sun Xin Li Kehui Zhan Dangqun Cui Jinxing Lin Aimin Zhang The State Key laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyChinese Academy of Sciences (CAS) College of Biology China Agricultural University The Collaborative Innovation Center for Grain Crops in Henan College of Agronomy Henan Agricultural University Key Laboratory of Plant Photosynthesis and Environmental Molecular Physiology Institute of Botany CAS

Anatomical and chemical characteristics of stems affect lodging in wheat(Triticum aestivum L.) cultivars. Traits associated with lodging resistance, such as plant height, stem strength, culm wall thickness, pith diameter, and stem diameter, were extensively investigated in earlier studies. However, the solid stem trait was rarely considered. In this study, we measured a range of anatomical and chemical characteristics on solid and hollow stemmed wheat cultivars. Significant correlations were detected between resistance to lodging and several anatomical features, including width of mechanical tissue, weight of low internodes, and width of stem walls. Morphological features that gave the best indication of improved lodging resistance were increased stem width, width of mechanical tissue layer, and stem density. Multiple linear regression analysis showed that 99% of the variation in lodging resistance could be explained by the width of the mechanical tissue layer, suggesting that solid stemmed wheat has several anatomical features for increasing resistance to lodging. In addition, microsatellite markers GWM247 and GWM340 were linked to a single solid stem QTL on chromosome 3BL in a population derived from the cross Xinongshixin(solid stem)/Line 3159(hollow stem). These markers should be valuable in breeding wheat for solid stem.

关键词： Molecular marker Solid stemmed wheat Lodging resistance Anatomical feature

Distinct palmitoylation of Foxp3 regulates the function of regulatory T cells via palmitoyltransferases

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2024年第7期21卷 787-789页

作者： Binhui Zhou Mengjie Zhang Haoyuan Ma Ying Wang Juanjuan Qiu Yang Liu Liaoxun Lu Tianhan Li Lichen Zhang Rong Huang Yanrong Gu eryan kong Yinming Liang Second Affiliated Hospital of Xinxiang Medical University Xinxiang453003China Laboratory of Mouse Genetics Institute of Psychiatry and NeuroscienceXinxiang Medical UniversityXinxiang453003China Laboratory of Genetic Regulators in the Immune System Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory MedicineXinxiang Medical UniversityXinxiang453003China Basic Medical College Xinxiang Medical UniversityXinxiang453003China Center of Disease Model and Immunology Hunan Academy of Chinese MedicineChangshaChina

Regulatory T cells(Tregs)play pivotal roles in maintaining immune homeostasis and preventing excessive immune responses in *** key players in suppressing immune reactions,they help to preserve immune tolerance and are thus crucial for preventing autoimmune *** the tumor microenvironment(TME),Tregs facilitate tumor immune evasion by impairing the activity of effector cells via multiple mechanisms,thus contributing to the initiation and progression of tumors[1].To perform this regulatory function,Tregs depend on the master transcription factor forkhead box protein p3(Foxp3)[2].The expression of Foxp3 has emerged as indispensable for the development and optimal function of Tregs[3].Interestingly,different posttranslational modifications,including phosphorylation,ubiquitination,glycosylation,and acetylation,exert significant regulatory effects on the biological function of Foxp3[4-8].

关键词： Foxp3 homeostasis function

Palmitoylation regulates myelination by modulating the ZDHHC3-Cadm4 axis in the central nervous system

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第10期9卷 4683-4699页

作者： Yanli Chang Jiangli Zhu Xiaopeng Li Yi Deng Birou Lai Yidan Ma Jia Tong Huicong Liu Juanjuan Li Chenyu Yang Qiao Chen Chengbiao Lu Yinming Liang Shiqian Qi Xiaoning Wang eryan kong The Third Affiliated Hospital of Xinxiang Medical University XinxiangChina Institute of Psychiatry and Neuroscience Xinxiang Key Laboratory of Protein Palmitoylation and Major Human DiseasesXinxiang Medical UniversityXinxiangChina Department of Urology State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan University and National Collaborative Innovation CenterChengduChina Center of Cryo-Electron Microscopy Zhejiang UniversityHangzhouChina Department of Nutrition Third Medical Center of PLA General HospitalBeijingChina School of Life Sciences Fudan UniversityShanghaiChina

The downregulation of Cadm4 (Cell adhesion molecular 4) is a prominent feature in demyelination diseases, yet, the underlying molecular mechanism remains elusive. Here, we reveal that Cadm4 undergoes specific palmitoylation at cysteine-347 (C347), which is crucial for its stable localization on the plasma membrane (PM). Mutation of C347 to alanine (C347A), blocking palmitoylation, causes Cadm4 internalization from the PM and subsequent degradation. In vivo experiments introducing the C347A mutation (Cadm4-KI) lead to severe myelin abnormalities in the central nervous system (CNS), characterized by loss, demyelination, and hypermyelination. We further identify ZDHHC3 (Zinc finger DHHC-type palmitoyltransferase 3) as the enzyme responsible for catalyzing Cadm4 palmitoylation. Depletion of ZDHHC3 reduces Cadm4 palmitoylation and diminishes its PM localization. Remarkably, genetic deletion of ZDHHC3 results in decreased Cadm4 palmitoylation and defects in CNS myelination, phenocopying the Cadm4-KI mouse model. Consequently, altered Cadm4 palmitoylation impairs neuronal transmission and cognitive behaviors in both Cadm4-KI and ZDHHC3 knockout mice. Importantly, attenuated ZDHHC3-Cadm4 signaling significantly influences neuroinflammation in diverse demyelination diseases. Mechanistically, we demonstrate the predominant expression of Cadm4 in the oligodendrocyte lineage and its potential role in modulating cell differentiation via the WNT-β-Catenin pathway. Together, our findings propose that dysregulated ZDHHC3-Cadm4 signaling contributes to myelin abnormalities, suggesting a common pathological mechanism underlying demyelination diseases associated with neuroinflammation.

关键词： myelin system Together

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

突触后致密蛋白95棕榈酰化修饰的研究进展

中华老年医学杂志 2018年第12期37卷 1423-1427页

作者：张莹晗张红红孔二艳张中健王小宁新乡医学院神经精神医学研究院 453003 解放军总医院老年医学研究所衰老与相关疾病研究北京市重点实验室国家老年疾病临床医学研究中心 100853

突触后致密蛋白95(PSD-95)是兴奋性突触中含量最丰富、最主要的一种突触脚手架蛋白,是突触功能的标志性蛋白.蛋白质的棕榈酰化是重要的蛋白翻译后修饰方式之一,在神经系统的发生率高于其他脏器组织,PSD-95依赖蛋白质棕榈酰化修饰并且其... 详细信息

突触后致密蛋白95(PSD-95)是兴奋性突触中含量最丰富、最主要的一种突触脚手架蛋白,是突触功能的标志性蛋白.蛋白质的棕榈酰化是重要的蛋白翻译后修饰方式之一,在神经系统的发生率高于其他脏器组织,PSD-95依赖蛋白质棕榈酰化修饰并且其棕榈酰化已成为神经可塑性及神经精神疾病的研究热点.

关键词：突触后蛋白质类 N-甲基天冬氨酸异恶唑类

脑苷肌肽对APP/PS1阿尔茨海默病模型小鼠脑内胶质纤维酸性蛋白和神经元核抗原表达的影响

在线全文

学校读者我要写书评

暂无评论

中华老年医学杂志 2020年第9期39卷 1067-1071页

作者：张莹晗胡亚卓韩志涛高雅李瑞生孔二艳王小宁张中健张红红新乡医学院精神神经医学研究院 453003 解放军总医院第二医学中心老年医学研究所衰老与相关疾病研究北京市重点实验室国家老年疾病临床医学研究中心 100853 河北医科大学第二医院老年病科 050000 解放军总医院第五医学中心临床转化医学研究中心 100039

目的研究脑苷肌肽对APP/PS1阿尔茨海默病模型小鼠脑内胶质纤维酸性蛋白(GFAP)和神经元核抗原(NeuN)表达的影响。方法5月龄APP/PS1双转基因模型小鼠36只,数字抽签随机分为模型组(氯化钠6.6 ml·kg-1·d-1腹腔注射)、脑苷肌肽组(脑腺苷肌... 详细信息

目的研究脑苷肌肽对APP/PS1阿尔茨海默病模型小鼠脑内胶质纤维酸性蛋白(GFAP)和神经元核抗原(NeuN)表达的影响。方法5月龄APP/PS1双转基因模型小鼠36只,数字抽签随机分为模型组(氯化钠6.6 ml·kg-1·d-1腹腔注射)、脑苷肌肽组(脑腺苷肌肽6.6 ml·kg-1·d-1腹腔注射)、多奈哌齐组(多奈呱齐2 mg·kg-1·d-1灌胃),每组12只,同月龄C57BL/6J小鼠12只为正常对照组,连续给药6周,取脑组织进行免疫组化染色检测β淀粉样蛋白(Aβ)、GFAP及NeuN的表达并定量分析。结果免疫组化染色结果显示,模型组小鼠的Aβ、GFAP表达均高于正常对照组,(0.147±0.068)%比0%、(61.750±22.020)个比(26.000±4.598)个(均P0.05)。结论脑苷肌肽具有多靶点的神经保护作用,该作用可能是通过降低AD小鼠的Aβ、GFAP表达水平并上调NeuN的表达实现。

关键词：脑苷肌酶阿尔茨海默病神经胶质原纤维酸性蛋白质神经元