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Health 2013年第8期5卷 6-13页

作者： Pauline Décima erwan stéphan-blanchard André Léké Loic Dégrugilliers stéphane Delanaud Jean-Pierre Libert Pierre Tourneux Laboratory PériTox EA 4285-UMI 01 INERIS Amiens France

Background: The thermal environment surrounding neonates in closed incubators can be regulated via two different modes: skin servocontrol mode (SSC) and air temperature control mode (ATC). These produce different patterns of incubator air and infant body temperatures. Objective: To assess the effects of incubator control mode on clinical outcomes of low-birth-weight-infants during the first days of life and at hospital discharge. Methods: 52 low-birth-weight neonates were nursed over ten days in closed incubators functioning either with SSC mode (n = 29), or with ATC mode (n = 23). Results: The anthropomorphic characteristics of the two groups of neonates were homogenous (gestational age = 29.4 ± 1.4 vs. 29.9 ± 1.2 weeks and birthweight = 1214 ± 347 vs. 1263 ±292 gin the SSC-group and the ATC-group, respectively) and the caregiving (energy and fluid intakes, ventilator assistance and drug administration) did not differ statistically. Daily means of incubator air temperature were similar in the SSC and the ATC-group, however, the SSC mode resulted in more variable incubator air temperature but more stable skin abdominal temperature whereas the reverse was found when using the ATC mode. Those differences had no impact on the body weight of the neonates or their clinical outcomes at hospital discharge which were not statistically different. Conclusion: The clinical outcomes do not differ depending on the incubator control mode after the first ten days of life and at hospital discharge.

关键词： Clinical Outcomes Preterm Neonates Closed Incubators Incubator Control Mode

Genome-resolved metagenomics of Venice Lagoon surface sediment bacteria reveals high biosynthetic potential and metabolic plasticity as successful strategies in an impacted environment

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Marine Life Science & Technology 2024年第1期6卷 126-142页

作者： Elisa Banchi erwan Corre Paola Del Negro Mauro Celussi Francesca Malfatti National Institute of Oceanography and Applied Geophysics OGS TriesteItaly FR2424 Station Biologique de RoscoffPlateforme ABiMS(Analysis and Bioinformatics for Marine Science)Sorbonne Universite CNRS29680 RoscoffFrance Department of Life Sciences University of TriesteTriesteItaly

Bacteria living in sediments play essential roles in marine ecosystems and deeper insights into the ecology and biogeochemistry of these largely unexplored organisms can be obtained from‘omics’***,we characterized metagenome-assembled-genomes(MAGs)from the surface sediment microbes of the Venice Lagoon(northern Adriatic Sea)in distinct sub-basins exposed to various natural and anthropogenic *** were explored for biodiversity,major marine metabolic processes,anthropogenic activity-related functions,adaptations at the microscale,and biosynthetic gene *** from 126 MAGs,a non-redundant dataset of 58 was compiled,the majority of which(35)belonged to(Alpha-and Gamma-)*** the broad microbial metabolic repertoire(including C,N,and S metabolisms)the potential to live without oxygen emerged as one of the most important *** was also found as a successful *** analysis showed that different MAGs encoded the same metabolic patterns(e.g.,C fixation,sulfate oxidation)thus suggesting metabolic *** and toxic compounds resistance genes were coupled,a condition that could promote the spreading of these genetic *** showed a high biosynthetic potential related to antimicrobial and biotechnological classes and to organism defense and interactions as well as adaptive strategies for micronutrient uptake and cellular *** results highlighted that bacteria living in an impacted environment,such as the surface sediments of the Venice Lagoon,may benefit from metabolic plasticity as well as from the synthesis of a wide array of secondary metabolites,promoting ecosystem resilience and stability toward environmental pressures.

关键词： Antibiotic resistance PAHs Biosynthetic gene clusters Microscale Mobilome Resistome

Specific alterations of regional myocardial work in strength-trained athletes using anabolic androgenic steroids compared to athletes with genetic hypertrophic cardiomyopathy

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Journal of Sport and Health Science 2023年第4期12卷 477-485页

作者： Antoine Grandperrin Frédéric Schnell erwan Donal Elena Galli Christophe Hedon Olivier Cazorla stéphane Nottin Avignon University LaPEC UPR 4278Avignon F-84000France Rennes University CHU RennesInsermLTSI-UMR 1099Rennes F-35000France Montpellier University PhyMedExpINSERMCNRSPhysiology and Experimental Heart and Muscle MedicineMontpellier 34295France

Background:strength-trained athletes using anabolic androgenic steroids(AAS)have left ventricular(LV)hypertrophy and myocardial fibrosis that can lead to sudden cardiac death.A similar feature was described in athletes with hypertrophic cardiomyopathy(HCM),which complicates the diagnosis for *** this context,we aimed to compare the LV function of the 2 populations by measuring global and regional strain and myocardial work using speckle-tracking ***:Twenty-four strength-trained asymptomatic athletes using AAS(AAS-Athletes),22 athletes diagnosed with HCM(HCM-Athletes),and 20 healthy control athletes(Ctrl-Athletes)underwent a resting echocardiography to assess LV *** evaluated LV global and regional strains and myocardial work,with an evaluation of the constructive work(CW),wasted work,and work efficiency(WE).Results:Compared to Ctrl-Athletes,both AAS-Athletes and HCM-Athletes had a thicker interventricular septum,with maj ored values in *** strain was reduced in AAS-Athletes and even more in ***,global WE was significantly diminished in both AAS and HCM-Athletes(93%±2%in Ctrl-Athletes,90%±4%in AAS-Athletes,and 90%±5%in HCM-Athletes(mean±SD);pstructive work and WE regional analysis showed specific alterations,with the basal septal segments preferentially affected in AAS-Athletes,and both septal and apical segments affected in ***:The regional evaluation of myocardial work reported specific alterations of the major LV hypertrophy induced by the regular use of AAS compared to the LV hypertrophy due to *** finding could help clinicians to differentiate between these 2 forms of pathological hypertrophy.

关键词： Anabolic androgenic steroids Hypertrophic cardiomyopathy Left ventricular function Myocardial work Speckle-tracking echocardiography

Coupled Electromagnetic-thermal Analysis of Segmented PM Consequent Pole Flux Switching Machine

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Chinese Journal of Electrical Engineering 2021年第2期7卷 50-60页

作者： Wasiq Ullah Faisal Khan Muhammad Umair erwan Sulaiman Department of Electrical and Computer Engineering COMSATS University IslamabadAbbottabad CampusAbbottabad 22060Pakistan Department of Electrical Power Engineering Universiti Tun Hussein Onn MalaysiaParit Raja 86400Malaysia

Compact stator structure of flux switching machines(FSMs)encompassing both permanent magnets(PMs)and armature winding slots(AWS)attract research interest whenever high power and density are the basic ***,it also results in temperature rises owing to heat generation by electromagnetic power losses degrading the electromagnetic performance and affecting machine *** this study,a segmented permanent magnet(SPM)consequent pole FSM(SPM-CPFSM)is developed,which provides a stator cooling channel(duct)for improved heat dissipation to avoid demagnetization of PM as well as ***,this study investigates detailed electromagnetic performance analysis and prediction of temperature variation in various machine parts owing to the heat generated by iron,copper,and magnet eddy current losses utilizing coupled electromagnetic-thermal analysis accounting for magnetic flux density *** comparison with the 2D analysis,the developed 3D coupled-field analysis more accurately predicts electromagnetic performance and temperature *** reveals that a cooling duct at the stator significantly assists in stator heat dissipation in the axial direction ensuring a safe operating condition of the PMs as well as machine parts to avoid overheating.

关键词： AC machines coupled field consequent pole permanent magnet loss analysis thermal analysis

Local transgene expression and whole-body transgenesis to model brain diseases in nonhuman primate

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Animal Models and Experimental Medicine 2019年第1期2卷 9-17页

作者： Lucie Chansel-Debordeaux erwan Bezard Institut des Maladies Neurodégénératives University of Bordeaux CNRS Institut des Maladies Neurodégénératives CHU Bordeaux Service de Biologie de la reproduction-CECOS

Animal model is an essential tool in the life sciences research, notably in understanding the pathogenesis of the diseases and for further therapeutic intervention success. Rodents have been the most frequently used animals to model human disease since the establishment of gene manipulation technique. However, they remain inadequate to fully mimic the pathophysiology of human brain disease, partially due to huge differences between rodents and humans in terms of anatomy, brain function, and social behaviors. Nonhuman primates are more suitable in translational perspective. Thus, genetically modified animals have been generated to investigate neurologic and psychiatric disorders. The classical transgenesis technique is not efficient in that model; so, viral vector-mediated transgene delivery and the new genome-editing technologies have been promoted. In this review, we summarize some of the technical progress in the generation of an ad hoc animal model of brain diseases by gene delivery and real transgenic nonhuman primate.

关键词： animal models neuroscience nonhuman primates

CONTROLLING THE 3D NANOSCALE ORGANIZATION OF BULK HETEROJUNCTION POLYMER SOLAR CELLS

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Chinese Journal of Polymer Science 2009年第1期27卷 85-92页

作者： Svetlana S.van Bavel erwan Sourty Gijsbertus de With Joachim Loos Laboratory of Materials and Interface Chemistry Soft Matter Cryo-TEM Research UnitEindhoven University of TechnologyP.O.Box 513NL-5600 MB EindhovenThe Netherlands Dutch Polymer Institute P.O.Box 902NL-5600 AX EindhovenThe Netherlands Laboratory of Materials and Interface Chemistrt Soft Matter Cryo-TEM Research UnitEindhoven University of TechnologyP.O.Box 513NL-5600 MB EindhovenThe Netherlands FEI Company Achtseweg Noord 5NL-565I GG EindhovenThe Netherlands

In this study,the three dimensional nanoscale organization in the photoactive layers of poly(3-hexylthiophene) (P3HT) and a methanofullerene derivative (PCBM) is revealed by transmission electron *** annealing treatment,either at elevated temperature or during slow solvent evaporation,nanoscale interpenetrating networks are formed with high crystalline order and favorable concentration gradients of both components through the thickness of the photoactive *** a tailored morphology account...

关键词： Polymer solar cells Morphology Electron tomography Device performance

Torque Characteristics of High Torque Density Partitioned PM Consequent Pole Flux Switching Machines With Flux Barriers

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CES Transactions on Electrical Machines and Systems 2020年第2期4卷 130-141页

作者： Wasiq Ullah Faisal Khan erwan Sulaiman Muhammad Umair Department of Electrical and Computer Engineering COMSATS University IslamabadAbbottabad Campus22060Pakistan.Erwan Suliman is with Department of Electrical Power EngineeringUniversiti Tun Hussein Onn Malaysia86400 Parit RajaJohorMalaysia

Unique double salient structure of Permanent Magnet Flux Switching Machines(PMFSM)with both Concentrated Armature inding(CAW)and Permanent Magnet(PM)on stator attract researcher's interest for high speed brushless application when high torque density(T den)and power density(P den)are the primal ***,despite of stator leakage flux,high rare-earth PM usage,PMFSM is subjected to slot effects due to presence of both PM and CAW in stator and partial saturation due to double salient structure which generates cogging torque(T cog),torque ripples(Trip)and lower average torque(T avg).To overcomne aforesaid demerits,this paper presents Partitioned PM(PPM)Consequent Pole Flux Switching Machine(PPM-CPFSM)with flux barriers to enhance flux mnodulation,curtail PM usage and diminish stator leakage flux which reduces slotting effects and partial saturation to ultimately reduces T cog and Trip In comparison with the existing state of the art,proposed PPM-CPFSM reduces 46.5390 of the total PM volumne and offer Tavg higher up to 88.8%,suppress Trip naximun up to 24.8%,diminish Tcog up to 22.74%and offer 2.45 times Tden and ***,torque characteristics of proposed PPM-CPFSM is investigated utilizing space harmonics injection *** cosine,inverse cosine with 3rd harmonics and rotor pole shaping techniques i.e.,ecce ntric circle,chanfering and *** electromagnetic perfornance analysis reveals that harmonics injection suppressed Tcog maximun up to 83.5%,Trip up to 40.72%at the cost of 4.71%***,rotor mnechanical stress analysis is utilized for rotor withstand capability and 3D-FEA based Coupled Elctromagnetic Thermal Analysis(CETA)for thermal behavior of the developed PPM *** reveals that open space along PPM act as cooling duct that inprove heat dissipation.

关键词： AC Machines Consequent Pole Cogging Torque Finite element analysis Permanent Magnet Machine Torque ripples Magnetic flux leakages Harmonics Injection

EXIstENCE OF EXPECTATION EQUILIBRIUM OF REAL ASSET ECONOMIES WITH TRANSACTION COstS

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Applied Mathematics(A Journal of Chinese Universities) 1999年第4期14卷 461-466页

作者： Mao erwan School of Economics & Management Tsinghua Univ. Beijing

To some two\|period economies with countable infinite state spaces, the existence of expectation equilibrium of real asset economies with transaction costs is given. This work extends the researches of Zame in 1993.

关键词： Expectation equilibrium ,realassets transaction costs

Micromorphological description of vernacular cob process and comparison with rammed earth

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Frontiers of Architectural Research 2020年第1期9卷 203-215页

作者： erwan Hamard Cécilia Cammas Blandine Lemercier Bogdan Cazacliu Jean-Claude Morel IFstTAR MASTGPEMF-44344BouguenaisFrance INRAP UMR 5140AgroParisTechF-78850Thiverval-GrignonFrance UMR SAS AGROCAMPUS OUESTINRAF-35042RennesFrance Faculty of Engineering Environment and ComputingCentre for the Built and Natural EnvironmentCoventry UniversityCoventryCV15FBUK

Past builders have developed very low-embodied energy construction techniques optimizing the use of local building *** techniques are a source of inspiration for modern sustainable ***,this know-how was orally transmitted and was lost as earth construction fell into disuse during the 20th century in European *** absence of written documents makes necessary to use an archaeological approach in order to rediscover these construction *** analysis of thin sections collacted in earth building walls was used for the first time to describe cob construction technique and highlighted several typical pedofeatures allowing to clearly identifying this ***,a first comparison of the cob and rammed earth micromorphological features permitted to identify two key factors to distinguish these two techniques,the manufacturing state(solid or plastic)and the organization of the material in the wall.

关键词： Cob Rammed earth Micromorphology Architectural heritage Pedology

Evolution of a Holocene banner bank controlled by morphodynamics and structural setting of a macrotidal coast: Saint-Brieuc Bay (NW-Europe)

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Geoscience Frontiers 2021年第5期12卷 166-181页

作者： Kalil Traoréa David Menier erwan Gensac Pascal Le Roy Clément Lambert Paul Bessin Kevin Pedoja Anne Duperret Romain Le Gall Laboratoire Géoscience Océan UMR 6538CNRSUniversitéBretagne SudCampus de Tohannic56000 VannesFrance Laboratoire Géoscience Océan UMR 6538CNRSIUEMUniversitéBretagne Occidentale29280 PlouzanéFrance Laboratoire de Planétologie et Géodynamique UMR 6112CNRSLe Mans UniversitéAvenue Olivier Messiaen72085 Le Mans CEDEX 9France Laboratoire Morphodynamique Continentale et Côtière UMR 6143CNRSUniversitéCaen Normandiecampus 12-4Rue des Tilleuls14000 Caen cedexFrance Laboratoire Ondes et Milieux Complexes UMR 6294CNRSUniversitéLe Havre Normandie53 rue de PronyCS8054076058 Le Havre cedexFrance

The morphology and internal structure of the Horaine Bank(Bay of Saint-Brieuc,NW France)are described based on multibeam echosounder and high-resolution seismic datasets coupled with vibro-core *** Horaine Bank shows large-scale bedforms in the lee of a submerged rocky shoal,which allowed defining it as a Banner *** internal structure of the sandbank reveals four seismic units(U1-U4)on a Cambrian basement(U0).The basal unit U1 is interpreted as reworked lowstand fluvial sediments those infilled micro incised valleys during a rise in sea *** unit is overlain by paleo-coastal barrier sand-spit(U2)whose development was controlled by swell in the context of a rapid rise in sea *** successive prograding unit(U3)is interpreted as flooding deposits in continuity with unit *** unit U4 is characterized by oblique reflectors oriented in two opposite *** last unit,dated post 3500 yr BP,corresponds to migrating dunes superimposed on the bank and observable in the high-resolution bathymetric *** strong correlation between tidal currents and the apparent clockwise migration of dune crests suggests the presence of a tidal gyre controlling the present-day dynamics of most of the Horaine bank *** study proposes a new model for the construction of banner banks characterized by the gradual transition of a sand spit to a banner bank during marine transgression and ensuing hydrodynamic variability.

关键词： Sand banks Banner bank Holocene climate Geomorphology Sea level rise Tidal gyre