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Dynamic magnetic behavior of the mixed spin (2, 5/2) Ising system with antiferromagnetic/antiferromagnetic interactions on a bilayer square lattice

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Chinese Physics B 2013年第12期22卷 160-167页

作者： Mehmet ertas Mustafa Keskin Department of Physics Erciyes University

Using the mean-field theory and Glauber-type stochastic dynamics, we study the dynamic magnetic properties of the mixed spin （2, 5/2） Ising system for the antiferromagnetic/antiferromagnetic （AFM/AFM） interactions on the bilayer square lattice under a time varying （sinusoidal） magnetic field. The time dependence of average magnetizations and the thermal variation of the dynamic magnetizations are examined to calculate the dynamic phase diagrams. The dynamic phase diagrams are presented in the reduced temperature and magnetic field amplitude plane and the effects of interlayer coupling interaction on the critical behavior of the system are investigated. We also investigate the influence of the frequency and find that the system displays richer dynamic critical behavior for higher values of frequency than that of the lower values of it. We perform a comparison with the ferromagnetic/ferromagnetic （FM/FM） and AFM/FM interactions in order to see the effects of AFM/AFM interaction and observe that the system displays richer and more interesting dynamic critical behaviors for the AFM/AFM interaction than those for the FM/FM and AFM/FM interactions.

关键词： dynamic magnetic behavior of a bilayer Ising system mixed spins glauber-type stochastic dynamics antiferromagnetic/antiferromagnetic interactions

Effect of water on behaviour of Na_2B_4O_7·5H_2O and Na_2B_4O_7 in HCl-CH_3OH medium

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Transactions of Nonferrous Metals Society of China 2010年第8期20卷 1541-1544页

作者： A.E.ertas .GIRGIN Mining Engineering Department Hacettepe University

The reactivity of Na2B4O7·5H2O and Na2B4O7 in non-aqueous HCl-CH3OH solvent system was *** effects of H2O,CH3OH/B mole ratio and reaction time on the reaction at room temperature were *** results show that when Na2B4O7·5H2O and Na2B4O7 are the reactants,the dissolved B2O3 contents are observed to be 98.2%and 99%,respectively,in 5 min at the CH3OH/B mole ratio of *** decrease of water in the reaction medium was observed to increase the crystallization of NaCl in the order of Na2B4O7>Na2B4O7·*** was also observed that the boron solution obtained after the reaction could be hydrolyzed by the addition of *** results show that HCl-CH3OH system is a more effective solvent compared to H2SO4-CH3OH both in the reactivity and the shortened reaction time.

关键词：反应介质 CH3OH 硼砂盐酸非水反应时间甲醇系统作者

Hexagonal Type Ising Nanowire with Spin-1 Core and Spin-2 Shell Structure

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Communications in Theoretical Physics 2015年第10期64卷 401-408页

作者： Mehmet ertas Ersin Kantar Department of Physics Erciyes University

Thermodynamic properties and phase diagrams of a mixed spin-(1,2) Ising ferrimagnetic system with single ion anisotropy on hexagonal nanowire are studied by using effective-field theory with correlations. The susceptibility,internal energy and specific heat of the system are numerically examined and some interesting phenomena in these quantities are found. The effect of the Hamiltonian parameters on phase diagrams are examined in detail. Besides second-order phase transition, lines of first-order transition and tricritical points are found. In particular, we found that for some negative values of single-ion anisotropies, there exist first-order phase transitions.

关键词： hexagonal Ising nanowire mixed spin-(1 2) effectiv

Global existence and decay of solutions for the generalized bad Boussinesq equation

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Applied Mathematics(A Journal of Chinese Universities) 2013年第3期28卷 253-268页

作者： Hatice Taskesen Necat Polat Abdulkadir ertas Department of Statistics Yuzuncu Yil UniversityVan 65080 Turkey Department of Mathematics Dicle UniversityDiyarbakir 21280 Turkey

In this paper, we consider the global existence of solutions for the Cauchy problem of the generalized sixth order bad Boussinesq equation. Moreover, we show that the supremum norm of the solution decays algebraically to zero as （1 ＋ t）-（1/7） when t approaches to infinity, provided the initial data are sufficiently small and regular.

关键词： bad Boussinesq equation global existence asymptotic behavior oscillatory integral.

Shattering the castle walls: Anti-stromal therapy for pancreatic cancer

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World Journal of Gastrointestinal Oncology 2018年第8期10卷 202-210页

作者： Ozkan Kanat Hulya ertas Department of Medical Oncology Faculty of Medicine Uludag University

Despite the availability of potent chemotherapy regimens, such as 5-fluorouracil, folinic acid, irinotecan, and oxaliplatin(FOLFIRINOX) and nab-paclitaxel plus gemcitabine, treatment outcomes in metastatic pancreatic cancer(PC) remain unsatisfactory. The presence of an abundant fibrous stroma in PC is considered a crucial factor for its unfavorable condition. Apparently, stroma acts as a physical barrier to restrict intratumoral cytotoxic drug penetration and creates a hypoxic environment that reduces the efficacy of radiotherapy. In addition, stroma plays a vital supportive role in the development and progression of PC, which has prompted researchers to assess the potential benefits of agents targeting several cellular(e.g., stellate cells) and acellular(e.g., hyaluronan) elements of the stroma. This study aims to briefly review the primary structural properties of PC stroma and its interaction with cancer cells and summarize the current status of antistromal therapies in the management of metastatic PC.

关键词： Pancreatic cancer Stroma Stellate cells Hyaluronan Secreted protein acidic and rich in cysteine

Contemporary treatment approaches for metastatic colorectal cancer driven by BRAF V600 mutations

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World Journal of Gastrointestinal Oncology 2020年第10期12卷 1080-1090页

作者： Ozkan Kanat Hulya ertas Burcu Caner Department of Medical Oncology Acıbadem Bursa HospitalBursa 16059Turkey Department of Medical Oncology Bursa City HospitalBursa 16059Turkey Department of Medical Oncoloy Balıkesir Ataturk City HospitalBursa 16059Turkey

The treatment of metastatic colorectal cancer(mCRC)harboring BRAF V600 mutations is *** tumors are often refractory to standard ***,the patients may exhibit rapid clinical deterioration,depriving them of the chance to receive salvage *** newly diagnosed patients with good performance status,the administration of an intensive chemotherapy regimen like FOLFOXIRI(5-fluorouracil,leucovorin,oxaliplatin,and irinotecan)along with the antiangiogenic agent bevacizumab can modify this aggressive behavior of the disease and improve patient clinical *** recently published results of the BEACON(Binimetinib,Encorafenib,and Cetuximab Combined to Treat BRAF-Mutant Colorectal Cancer)study demonstrated that a combination therapy consisting of BRAF,epidermal growth factor receptor,and mitogen-activated protein kinase kinase inhibitors could be a useful second-or third-line *** review summarizes the current treatment strategies for BRAF-mutant mCRC.

关键词： BRAF mutation V600 mutations Metastatic colorectal cancer Targeted therapies

Dual HER2 inhibition strategies in the management of treatment-refractory metastatic colorectal cancer:History and status

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World Journal of Clinical Cases 2018年第11期6卷 418-425页

作者： Ozkan Kanat Hulya ertas Burcu Caner Department of Medical Oncology Faculty of MedicineUludag University

Human epidermal growth factor receptor 2(HER2) signaling pathway activation has been identified as a contributor to de novo or acquired resistance to epidermal growth factor receptor(EGFR) inhibitors in a small subset of patients with metastatic colorectal cancer(mCRC). Dual anti-HER2-targeted treatment exhibits strong antitumor activity in preclinical models of HER2-positive mCRC, supporting its testing in clinical trials. The HERACLES trial at four Italian academic cancer centers has confirmed the effectiveness of dual blockage of HER2 with trastuzumab plus lapatinib in patients with heavily pretreated HER2-positive mCRC, refractory to the anti-EGFR antibodies cetuximab or panitumumab. Here, we reviewed the preclinical studies exploring the role of HER2 signaling in the development of anti-EGFR therapy resistance and discussed the status of clinical trials assessing the activity of HER2 inhibitors in this setting.

关键词： Epidermal growth factor receptor Cetuximab Panitumumab Human epidermal growth factor receptor 2 Anti-epidermal growth factor receptor resistance Trastuzumab Dual inhibition

Platinum-induced neurotoxicity: A review of possible mechanisms

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World Journal of Clinical Oncology 2017年第4期8卷 329-335页

作者： Ozkan Kanat Hulya ertas Burcu Caner Department of Medical Oncology Uludag University Faculty of Medicine

Patients treated with platinum-based chemotherapy frequently experience neurotoxic symptoms, which may lead to premature discontinuation of therapy. Despitediscontinuation of platinum drugs, these symptoms can persist over a long period of time. Cisplatin and oxaliplatin, among all platinum drugs, have significant neurotoxic potential. A distal dose-dependent symmetrical sensory neuropathy is the most common presentation of platinum neurotoxicity. DNA damage-induced apoptosis of dorsal root ganglion(DRG) neurons seems to be the principal cause of neurological symptoms. However, DRG injury alone cannot explain some unique symptoms such as cold-aggravated burning pain affecting distal extremities that is observed with oxaliplatin administration. In this article, we briefly reviewed potential mechanisms for the development of platinum drugs-associated neurological manifestations.

关键词： Cisplatin Dorsal root ganglion Mechanism Oxaliplatin Neurotoxicity Neuropathic pain Sodium channel

COMPLEXITY OF SYSTEM MAINTAINABILITY ANALYSIS BASED ON THE INTERPRETIVE STRUCTURAL MODELING METHODOLOGY： TRANSDISCIPLINARY APPROACH

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Journal of Systems Science and Systems Engineering 2016年第2期25卷 254-268页

作者： A. ertas M.W. Smith D. Tate W.D. Lawson T.B. Baturalp Department of Mechanical Engineering Texas Tech University Lubbock TX USA 79410 Department of Industrial Design Xi 'an Jiaotong-Liverpool University Suzhou 215123 Jiangsu China Department of Civil Engineering Texas Tech University Lubbock TX USA 79410

This paper outlines a diagnostic approach to quantify the maintainability of a Commercial off-the-Shelf （COTS）-based system by analyzing the complexity of the deployment of the system components. Interpretive Structural Modeling （ISM） is used to demonstrate how ISM supports in identifying and understanding interdependencies among COTS components and how they affect the complexity of the maintenance of the COTS Based System （CBS）. Through ISM analysis we have determined which components in the CBS contribute most significantly to the complexity of the system. With the ISM, architects, system integrators, and system maintainers can isolate the COTS products that cause the most complexity, and therefore cause the most effort to maintain, and take precautions to only change those products when necessary or during major maintenance efforts. The analysis also clearly shows the components that can be easily replaced or upgraded with very little impact on the rest of the system.

关键词： COTS Based System maintainability complexity Interpretive Structural Modeling