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Advanced HP/IP Blading Technologies for the Design of Highly Efficient Steam Turbines

热力透平 2004年第300期3卷 209-215页

作者： Mathias Deckers ernst wilhelm pfitzinger Wilfried Ulm Siemens AG Power Generation (PG) Muelheim an der Ruhr Germany Siemens AG Power Generation (PG) Muelheim an der Ruhr Germany Siemens Westinghouse Power Corporation Orlando-Florida USA

This paper presents Siemens’ latest improvements in steam turbine blading and blading design tools. The technology offers improved performance and highest efficiencies for a wide range of steam turbine applications.

关键词：蒸汽轮机西门子公司叶片装置 HP/IP

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Involvement of CYP347W1 in neurotoxin 3-nitropropionic acid-based chemical defense in mustard leaf beetle Phaedon cochleariae

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Insect Science 2022年第2期29卷 453-466页

作者： Nanxia Fu Tobias Becker Wolfgang Brandt Maritta Kunert Antje Burse wilhelm Boland Department of Bioorganic Chemistry Max Planck Institute for Chemical EcologyJenaGermany Key Laboratory of Tea Biology and Resource Utilization Tea Research InstituteChinese Academy of Agricultural SciencesHangzhouChina Department of Bioorganic Chemistry Leibniz Institute of Plant BiochemistryHalle(Saale)Germany Department of Natural Product Biosynthesis Max Planck Institute for Chemical EcologyJenaGermany Department of Medical Technology and Biotechnology Ernst Abbe Hochschule JenaJenaGermany

Chrysomelina beetlesstore 3-nitropropionic acid in form of a pretoxin,isoxazolin-5-one glucoside-conjugated ester,to protect themselves against *** we identified a cytochrome P450 monooxygenase,CYP347W1,to be involved in the production of the 3-nitropropionic acid moiety of the isoxazolin-5-one glucoside *** down CYP347W1 led to a significant depletion in the concentration of the isoxazolin-5-one glucoside ester and an increase in the concentration of the isoxazolin-5-one glucoside in the larval *** assays with the heterologously expressed CYP347W1 showed freeβ-alanine was not the direct *** modeling indicated thatβ-alanine-CoA ester can fit into CYP347W1’s active ***,we proved that Phaedon cochleariae eggs are not able to de novo synthesize 3-NPA,although both isoxazolin-5-one glucoside and its 3-NPA-conjugated ester are present in the *** results provide direct evidence for the involvement of CYP347W1 in the biosynthesis of a *** chemical defense compound.

关键词： chemical defense isoxazolin-5-one glucoside isoxazolin-5-one glucoside ester leaf beetles P450 3-nitropropionic acid(3-NPA)

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Patient-centered developments in colon-and rectal cancer with a multidisciplinary international team:From translational research to national guidelines

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World Journal of Gastrointestinal Surgery 2021年第12期13卷 1597-1614页

作者： Karl-Heinrich Link Marko Kornmann Ludger Staib ernst-Dietrich Kreuser wilhelm Gaus Erwin Röttinger Peter Suhr Catharina Maulbecker-Armstrong Peter Danenberg Kathleen Danenberg Miriam Schatz Silvia Sander Zhen-Ling Ji Jiang-Tao Li Shu-You Peng Reinhard Bittner Hans Günther Beger Benno Traub Asklepios Tumor Center(ATC)and Surgical Center Asklepios Paulinen KlinikWiesbaden 65197Germany FOGT(Multidisciplinary Study Group on Oncology of Gastrointestinal Tumors) University of UlmUlm 89081Germany Department of General and Visceral Surgery University of UlmUlm 89081Germany Department of Biometry and Medical Documentation University of UlmUlm 89081Germany Department of Radiotherapy University of UlmUlm 89081Germany Fachbereich Gesundheit Medizinisches ManagementSozialversicherungssystemeInternationales Versorgungsmanagemente-HealthTechnische Hochschule MittelhessenGiessen 35390Germany Department of Biochemistry and Molecular Medicine Keck-USC School of MedicineLos AngelesCA 90033United States Norris Comprehensive Cancer Center Keck-USC School of MedicineLos AngelesCA 90033United States Private Practice for Psychology Adelsdorf 91325Germany Department of General Surgery Southeast UniversityNanjing 210009Jiangsu ProvinceChina Department of Surgery The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009Zhejiang ProvinceChina Surgical Clinic MarienhospitalStuttgart 70177Germany

Rarely,scientific developments centered around the patient as a whole *** multidisciplinary group,headed by gastrointestinal surgeons,applied this research philosophy considering the most important aspects of thediseases“colon-and rectal cancer”in the long-term *** expertcooperation/knowledge at the Comprehensive Cancer Center Ulm(CCCU)wereapplied in several phase III trials for multimodal treatments of primary tumors(MMT)and metastatic diseases(involving nearly 2000 patients and 64 centers),fortreatment individualization of MMT and of metastatic disease,for psychooncology/quality of life involving the patients’wishes,and for disease *** of the targets initially were heavily rejected/discussed in thescientific communities,but now have become standards in treatments andnational guidelines or are topics in modern translational research protocolsinvolving molecular biology for e.g.,“patient centered individualized treatment”.In this context we also describe the paths we had to tread in order to realize ournew goals,which at the end were highly beneficial for the patients from manypoints of *** description is also important for students and youngresearchers who,with an actual view on our recent developments,might want toknow how medical progress was achieved.

关键词： Colon-and rectal cancer Translational research Interdisciplinary treatment Personalized treatment National guidelines

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角膜接触镜用于眼球穿通伤术后视力的恢复

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世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 40-41页

作者： Grunauer-Kloevekorn C. Habermann A. wilhelm F. 肖颖 Universitatsaugenklin. mit Poliklin. Martin-Luther-Univ. Halle-Witte n berg Ernst-Grube-Strasse 40 06097 Halle Germany Dr.

Introduction: Visual rehabilitation after open globe injury may be a challengi ng process because of ametropia following aphakia, corneal scarring with high or irregular corneal astigmatism or loss of contrast sensitivity due to traumatic aniridia. We report on contact lens fitting for visual rehabilitation in patient s after open globe injury. Patients: From 2000 to 2003, contact lenses were fitt ed unilaterally for the visual rehabilitation in 13 patients after open globe in jury. In three patients we found unilateral aphakia, in 8 patients a high or irr egular astigmatism after penetrating or autorotation keratoplasty and in two pat ients a traumatic aniridia, in one case combined with aphakia. Results: 11 rigid contact lenses were fitted with different designs of the front and back surface as well as two iris-print lenses. In 11 patients (86%) a good visual rehabili tation was achieved with an increase of visual acuity up to 9 lines while obtain ing a good contact lens tolerance. One patient wearing an iris-print contact le ns was unable to tolerate the contact lens due to its thickness and its weight. In another patient fitting of a contact lens was not possible because of the com plicated corneal condition. We did not observed severe contact lens complication s at any time. Conclusions: In addition to operative procedures for visual rehab ilitation after open globe injuries, the use of contact lenses is another possib le procedure for refractive correction. Different problems such as ametropia fol lowing aphakia, irregular or high astigmatism or aniridia can be solved with goo d visual results, good tolerance and less complications.

关键词：眼球穿通伤术后视力外伤性无虹膜角膜接触镜角膜散光屈光不正角膜瘢痕角膜成形术对比敏感度表面设计

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