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探究早期帕金森病Thy 1-sNCA模型小鼠运动学习障碍的时间特征

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首都医科大学学报 2024年第5期45卷 881-890页

作者：付文欣王铁杨汝宁曲明芹高歌杨慧贾军首都医科大学基础医学院生理学与病理生理学学系北京100069 首都医科大学基础医学院神经生物学学系北京100069

目的本实验通过建立早期帕金森病(Parkinson s disease,PD)小鼠模型,以探究PD模型出现运动学习障碍的时间特征。方法选用6月龄Thy 1-sNC A转基因(transgenic,TG)小鼠作为早期PD模型,与同龄野生型(wild type,WT)小鼠进行对比分析。通过... 详细信息

目的本实验通过建立早期帕金森病(Parkinson s disease,PD)小鼠模型,以探究PD模型出现运动学习障碍的时间特征。方法选用6月龄Thy 1-sNC A转基因(transgenic,TG)小鼠作为早期PD模型,与同龄野生型(wild type,WT)小鼠进行对比分析。通过旷场实验、爬杆实验和Y迷宫等行为学手段来评估小鼠的运动功能和空间工作记忆能力,并以经典的匀加速转棒实验作为运动学习的行为学范式,来评估其运动学习能力。结果6月龄的Thy 1-sNC A TG小鼠在运动功能和空间记忆能力方面并未显示出异常,却呈现出明显的运动学习障碍。结论在早期PD模型小鼠上存在着特定的运动学习障碍,可作为早期PD的一个重要诊断指标;同时匀加速转棒测试可作为检测PD运动学习障碍的一种重要的行为学手段。

关键词：帕金森病早期帕金森病模型运动学习障碍运动症状

Chronic prostatitis in Korea:a nationwide postal survey of practicing urologists in 2004

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Asian Journal of Andrology 2005年第4期7卷 427-432,页

作者： ja-Hyeon Ku jae-seung Paick soo-Woong Kim Department of Urology Seoul National University College of MedicineSeoul 110-744Korea

Aim： To examine the diagnosis and treatment of chronic prostatitis by means of a nationwide postal survey of practicing urologists in 2004. Methods： A random sample of 850 Korean urologists from the Korean Urological Association Registry of Physicians were asked to complete a questionnaire that explored practicing characteristics, attitudes and diagnostic and treatment strategies in the management of chronic prostatitis. Results： Of the 850 questionnaires sent, 302 were returned （response rate 35.5 %） and 275 were induced in the final analysis. More than 50 % believed in a multifactorial etiology for chronic prostatitis and 52 % considered chronic abacterial prostatitis to be bacterial in nature. For routine diagnostic assessment, the most commonly used tests were reported to be urinalysis （95.3 %）, analysis of expressed prostatic secretions （89.5 %） and digital rectal examination （81.1%）. Only a few urologists use specific lower urinary tract cultures. symptom assessment according to the National Institute of Health-Chronic Prostatitis symptom Index was less frequently used （12.7 %）. First choices for therapy included antibiotics （96.4 %）, alpha-blockers （71.6 %） and sitz baths （70.5 %）. If unsuccessful, urologists frequently continued to prescribe a second course of either alpha-blockers （69.5 %） or antibiotics （57.8 %）. Conclusion： These data provide a picture of current practice regarding the management of chronic prostatitis in Korea. The diagnostic and treatment practices for prostatitis do not follow standard textbook algorithms. Further studies are needed to elucidate the etiology and pathogenesis of chronic prostatitis and to establish guidelines for its diagnosis and treatment.

关键词： prostatitis chronic pelvic pain syndrome questionnaire diagnosis treatment

Curing Kinetics of Tannin and Lignin Biobased Adhesives Determined by DsC and ABEs

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Journal of Renewable Materials 2022年第8期10卷 2117-2131页

作者： jaša saražin Ida Poljanšek Antonio Pizzi MilanŠernek University of Ljubljana Biotechnical FacultyLjubljana1000Slovenia Universitéde Lorraine LERMAB-ENsTIB Epinal88000France

The curing process of two biobased adhesives:pine tanninhexamine(TH)and organosolv lignin non-isocyanate polyurethane(NIPU),suitable for interior nonstructural use,were compared with commercial urea-formaldehyde(UF)*** in chemical structure before and after the curing process were observed with Fouriertransform infrared spectroscopy(FTIR).The process of adhesive curing was monitored with differential scanning calorimetry(DsC)and the automated bonding evaluation system(ABEs).Both DsC and ABEs measurements confirmed UF as the fastest and NIPU as the slowest curing adhesive *** into account the ABEs results,the optimal pressing parameters for the TH adhesive would be 4 min at 175℃,for the NIPU adhesive 7 min at 200℃and for the UF 1.5 min at 100℃.strong linear correlation was observed between mechanical and chemical curing for the UF and NIPU adhesives,whereas lower correlation was observed for the TH *** all observed adhesives,the DsC measurements were underestimating the curing process determined by ABEs in the first part and overestimating it at the *** underestimation was the most evident with the TH adhesive and the less with the UF *** comparing the uncured and cured FTIR spectra of all three types of adhesives,a drastic decrease in the characteristic band of-OH groups at 3330–3400 cm^(−1)and an increase in the signal intensity at 2920 cm^(−1)of aliphatic-CH2-groups were *** the UF adhesive,the C=O stretching frequency has shifted from 1632 cm^(−1)for uncured to three different bands at 1766,1701,and 1655 cm^(−1)for cured *** sharp band for phenolic alcohols at 1236 cm^(−1)of C–O stretch and hydroxyl O–H functional group at 1009 cm^(−1)and at 684 cm^(−1)of uncured TH adhesive diminished during curing,which indicates that a crosslinking reaction occurs via-OH *** peak of the C=O group of urethane bridges at 1697 cm^(−1)for uncured NIPU shifted to lower wavenumber at 1633 cm^(−1)for cured NIPU.

关键词： Biobased adhesives curing kinetics tannin lignin ABEs DsC FTIR

Coastal landscape evolution tracked from late Holocene wave-cut benches in the sinan Archipelago,southwest Korea

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Geoscience Frontiers 2020年第1期11卷 293-301页

作者： sung-ja Choi Bokchul Kim Yong sik Gihm sanghoon Kwon Geology Division Korea Institute of Geoscience and Mineral ResourcesDaejeon34132Republic of Korea Department of Earth system sciences Yonsei UniversitySeoul03722Republic of Korea school of Earth sciences The Ohio State UniversityColumbusOH43210USA

Glacio-isostatic adjustment(GIA)and tectonic activity are important factors in the formation of marine *** Holocene wave-cut benches in the eastern part of the West sea of Korea,also called the Yellow sea,can be divided into two steps:531 cm above sea level(AsL)for the upper bench(T2)and 464-481 cm AsL for the lower bench(T1).sediments on the benches a re classified into four units,and are interpreted to be beach deposits acco rding to gravel shape,textu re,and seaward *** ove rlying sediment indicates that T2 was formed at approximately 530 cm AsL before 2900 yr BP,and T1 at approximately 460-480 cm AsL before 1520 yr *** Holocene(4000-2000 yr BP)relative sea level(RsL)curves based on GIA models are inconsistent with the wave-cut bench *** T1 and T2 benches to the RsL curves of the West sea,the upper and the lower benches were uplifted by approximately 5-8 m and 4-7 m,*** the area is several hundred kilometers away from plate boundaries,the high frequency of earthquakes in the West sea may have induced the uplift of wave-cut benches during the last 2000 *** indicate that the west coast of the Korean Peninsula(KP)should no longer be considered an area of subsidence,but be assigned to a regime of uplift during the late Holocene.

关键词： West sea of Korea Yellow sea Late Holocene Wave-cut benches Beach sediment Uplift Tectonics

Measurement　of　Excursion　of　Finger　Flexor　Tendons　Produced　by　a　Continuous　Passive　Motion　Machine

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中华骨科杂志 1995年第2期15卷 76-83页

作者： Yoshida E Dent ja Rowley JI University of Dundee 苏格兰

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ＭｅａｓｕｒｅｍｅｎｔｏｆＥｘｃｕｒｓｉｏｎｏｆＦｉｎｇｅｒＦｌｅｘｏｒＴｅｎｄｏｎｓＰｒｏｄｕｃｅｄｂｙａＣｏｎｔｉｎｕｏｕｓＰａｓｓｉｖｅＭｏｔｉｏｎＭａｃｈｉｎｅＹｏｓｈｉｄａＥ；ＤｅｎｔＪＡ；ＲｏｗｌｅｙＪＩＲｅｃｅｉｖｅｄ９Ａｕｇｔｔｓｔ１...

关键词：掌指关节指尖手指指间关节指关节 Continuous Excursion Finger Flexor Machine Measurement Motion Passive Produced Tendons

Identity（Re） Construction and the sense of Belongingness among International students in China:A Case study of Zhejiang Normal University

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Identity（Re） Construction and the Sense of Belongingness a...

作者： ja ZIN 浙江师范大学

学位级别：硕士

Discussion about international students in China is a topic with a long history and different *** the development of the socio-economy of China,the number of international students in China grows faster than *** number of International students coming to China is adhesively increasing,though summative with a lot of challenges faced during their studies and majorly accruing from ***,their life experiences and identity issues deserve more attention that it already hadIdentity is now defined as a self-concept,self-perception,both individual and social-cultural,and that may develop over time regarding to a group which they belong to,such as a particular student in Chinese *** is an individual’s sense of belonging to a group;this belonging offers a feeling of security and *** identity（re）construction is mostly shaped by both historical and cultural *** the theoretical framework combining social identity theory（Tajfel,1974）and Maslow’s（1943）theory of human motivation,this thesis investigated the identity construction and sense of belongingness of international students in Zhejiang Normal University as a case *** study utilized combining semi-structured interviews and a thematic analysis to examine the intercultural experiences of ten international students through their own *** themes were uncovered and further discussed on findings as the participants shared stories about the difficulties,they have been challenged with such as cultural misunderstanding,academic achievement,social acceptance,identity confusion,and other societal pressures and *** students encountered various problems in both their academic and social life.

关键词：国际学生归属感师范大学

Decadal Changes in Climatological Intraseasonal Fluctuation of subseasonal Evolution of summer Precipitation over the Korean Peninsula in the mid-1990s

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Advances in Atmospheric sciences 2011年第3期28卷 591-600页

作者： WonMoo KIM Jong-Ghap JHUN Kyung-ja HA Masahide KIMOTO school of Earth and Environmental sciences/Research Institute of Oceanography Seoul National University151-742Korea Divison of Earth Environmental system Pusan National University609-735Korea Atmosphere and Ocean Research Institute University of Tokyo277-8564Japan

Decadal changes in the subseasonal evolution and the phase-locked climatological intraseasonal fluctuation of summertime rainfall over the Korean Peninsula before and after the mid-1990s are *** activity and the migration speed of the monsoon rain band over the East Asian region are altered in the recent decade,resulting in the drier conditions in late spring and the earlier onset of *** early August when a climatological monsoon break was clear in the earlier decade,the precipitation has increased dramatically with a meridional *** response to the enhanced convection over the south China sea and southeastern China provides a favorable condition for more precipitation in early August through the changes in moisture transport and tropical cyclone passage.

关键词： decadal change intraseasonal fluctuation East Asian summer monsoon

Organosolv Lignin for Non-Isocyanate Based Polyurethanes (NIPU) as Wood Adhesive

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Journal of Renewable Materials 2021年第5期9卷 881-907页

作者： jaša saražin Antonio Pizzi siham Amirou Detlef schmiedl MilanŠernek Biotechnical Faculty University of LjubljanaLjubljana1000Slovenia LERMAB-ENsTIB Universitéde LorraineEpinal88000France Fraunhofer Institute for Chemical Technology Pfinztal76327Germany

A non-isocyanate-based polyurethane(NIPU)wood adhesive was produced from organosolv lignin,which is a bio-sourced raw material,available in large quantities and produced as a by-product of the paper *** formulation of this new lignin-based NIPU adhesive,which is presented,was chemically characterised by Matrix-Assisted Laser Desorption Ionization Time of Flight(MALDI ToF)mass spectrometry and by Fourier Transform Infra-Red(FTIR)spectrometry *** oligomers formed were determined and showed that the three species involved in the NIPU adhesive preparation were formed by the co-reaction of the three reagents used:lignin,dimethyl carbonate,and hexamethylene *** and branched structures were both *** properties of the adhesive were determined using the Automated Bonding Evaluation system(ABEs)and internal bond(IB)strength test of the laboratory particleboard bonded with *** adhesive has shown satisfactory mechanical properties after hot pressing at 230℃.such a temperature is used industrially in the most modern particleboard factories,but since it is hardly feasible for more conventional wood bonding equipment,the reactivity of the NIPU adhesive was successfully increased with the addition of a small percentage of a silane coupling *** the addition of the silane,the proposed NIPU adhesive could also be used at a hot-pressing temperature lower than 200℃.

关键词： Organosolv lignin NIPU MALDI ToF FTIR ABEs

The study of the Behaviors of Zinc and strontium in Caries-Affected Teeth by Laser-Induced Breakdown spectroscopy(LIBs) Technique

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光谱学与光谱分析 2020年第3期40卷 980-984页

作者： R.Nouir s.Hamzaoui H.Ghalila N.ja dane Faculty of sciences of Tunis University of TunisEl ManarTunisTunisia Institute of Medical Technologies of Tunis University of Tunis El ManarTunisTunisia

We report on the application of Laser Induced Breakdown spectroscopy(LIBs)technique to the study of Ca,P,Zn and sr evolutions for adult caries-affected teeth using nanosecond laser *** aim of this work is to better understand the behaviors of Zn and sr as trace-elements in the caries eruption with respect to the behaviors of one of the main compounds of the hydroxyapatite crystal which is the *** study was focused on the investigation of these elements’evolutions from three parts of the enamel surfaces of twenty two adult caries-affected teeth;the healthy part,the dental plaque part and the caries-affected *** decrease rates of Zn,sr and P was,also,compared to the Ca *** concerned normalized emission line *** every species,normalization was done relatively to the emission line intensities of the healthy *** showed that abundances of these elements decrease similarly from the healthy parts to the affected-caries *** higher decrease rate was noticed for the *** evolutions of Zn and sr for the three parts of the teeth surfaces cannot inform about the substitution of the calcium by these trace-elements,however the comparison of their decrease rates to the calcium one can be considered as a valuable index of this substitution.

关键词： Teeth Caries Trace-elements substitution LIBs