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Use of bio-based products towards more sustainable road paving binders: A state-of-the-art review

Journal of Road Engineering 2024年第2期4卷 151-162页

作者： Alessio Musco Giulia Tarsi Piergiorgio Tataranni ernesto salzano Cesare Sangiorgi Department of Civil ChemicalEnvironmental and Materials Engineering(DICAM)Alma Mater Studiorum-University of BolognaBologna 40131Italy

Many industrial sectors exploit fossil sources to develop useful and necessary materials for our needs,such as bituminous paving ***,a key component of asphalt mixtures,is derived from oil refining and its properties are influenced by the crude oil source and refining process,resulting in a significant carbon *** growing awareness of resource depletion and environmental concerns,pavement researchers are exploring sustainable alternatives to reduce dependence on fossil *** includes a rising trend in using renewable materials like biomasses to produce bio-based binders as substitutes for bitumen,aiming for a more sustainable ***,including vegetal and animal wastes,and waste cooking oils,as substitutes for crude oil in the production of *** thermochemical conversion(TCC),such as pyrolysis,biomasses can be converted into bio-char and bio-oils,which can replace fossil-based components in *** have utilized these bio-products to reduce the dependency on fossil fuels in ***,there are no set minimum requirements for bio-components in bio-based *** the percentage of replaced bitumen increases,various types of binders are produced,including modified bitumen,extended bitumen,and alternative binders,where the fossil replacement is *** rheological tests on bio-binders,reveal that those containing biochar exhibit increased viscosity,stiffness,rutting resistance,and sometimes antioxidant ***,bio-binders with bio-oils as bitumen substitutes show poorer performance at high temperatures but improved behavior at low *** results suggest that bio-binders could provide versatile solutions for various climatic and loading conditions in road ***,the development of pavement mixtures based on bio-binders has not been studied in depth and requires further attention to unlock its full *** sustainability considerations,includin

关键词： Biomass Chemical process Bitumen replacement Bio-binder Paving material

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Quantification of Global Protein Disulfides and Thiol-Protein Mixed Disulfides to Study the Protein Dethiolation Mechanisms

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American Journal of Analytical Chemistry 2013年第10期4卷 9-19页

作者： Lucia Coppo Raffaella Priora Sonia salzano Pietro Ghezzi Paolo Di Simplicio Brighton and Sussex Medical School Trafford Centre Falmer Brighton UK Department of Neuroscience Pharmacology Unit University of Siena Siena Italy

The redox state of cellular thiols is widely studied because it was recently linked to many different diseases and pathologies. In this work we quantified the concentrations of protein disulfides (PSSP) and thiol-protein mixed disulfides (XSSP) in rat tissues (liver, kidney and heart) and cells (Raw 264.7) by an improved method of XSSP and PSSP determination after oxidative stress induced by diamide. Under native and denaturing conditions, a thiol block by N-ethymaleimide was introduced to avoid thiol exchange reaction activations by protein SH groups (PSH) (PSH + XSSP ←→ PSSP + XSH) and alterations of original XSSP/PSSP levels. Low molecular weight thiols (XSH) and PSH were respectively measured by HPLC on supernatants and on corresponding pellets by DTNB (Ellman’s reagent) after dithiothreitol reduction. PSSP concentrations of liver, heart and kidney were respectively 0.304, 0.605 and 0.785 μmoles/g and after diamide exposure they were significantly augmented of about 65%-70% in liver and heart, but not in the kidney. Normal XSSP, that were -20 times lower than normal PSSP were induced by diamide in liver and heart of about 40 times, but not in kidney. Thermodynamic criteria regarding the pKa values of thiols engaged as PSSP and GSSP were used to interpret dethiolation mechanisms via thiol exchange reactions.

关键词： Protein Disulfides S-Glutathionylation Thiol pKa Diamide Oxidative Stress

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Gelato:人人都爱意式冰淇淋

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农经 2017年第9期 86-91页

作者： Chiara Albanese Giovanni salzano 王倩

[√]健康趋势和文化潮流已经开始影响和改写越来越多的食品行业了。根据市场调研机构英敏特发布的最新报告,2016年全球冰淇淋的消费量为130亿升,而2015年这一数字为156亿升。在短短一年的时间里,冰淇淋消费量下降幅度竟达到了16.7%,而... 详细信息

[√]健康趋势和文化潮流已经开始影响和改写越来越多的食品行业了。根据市场调研机构英敏特发布的最新报告,2016年全球冰淇淋的消费量为130亿升,而2015年这一数字为156亿升。在短短一年的时间里,冰淇淋消费量下降幅度竟达到了16.7%,而下降的地区主要集中在北美和欧洲等成熟市场。这是因为消费者对于糖的摄入量越来越重视了。

关键词：冰淇淋消费量制作者 Gelato

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遗产的保护

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医学与哲学 2004年第10期25卷 22-23页

作者： Francisco Mauro salzano 赵明杰巴西Rio Grande联邦大学生命科学研究院

先辈传承的环境形态已经在许多方面发生的改变,这些改变可能是由自然和生物因素引起的,但最重要的动因是人类自身.几乎地球的每一个地方都有人类,虽然目前无法预知我们进化的前景,但有一点可以肯定,即我们是一种非常优势的生命物种.

关键词：遗产保护先辈传承环境形态生物多样性生命质量

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Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson’s disease and multiple system atrophy

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Translational Neurodegeneration 2019年第1期8卷 290-303页

作者： Chiara Maria Giulia De Luca Antonio Emanuele Elia Sara Maria Portaleone Federico Angelo Cazzaniga Martina Rossi Edoardo Bistaffa Elena De Cecco Joanna Narkiewicz Giulia salzano Olga Carletta Luigi Romito Grazia Devigili Paola Soliveri Pietro Tiraboschi Giuseppe Legname Fabrizio Tagliavini Roberto Eleopra Giorgio Giaccone Fabio Moda Fondazione IRCCS Istituto Neurologico Carlo Besta Unit of Neurology 5 and NeuropathologyMilanItaly Fondazione IRCCS Istituto Neurologico Carlo Besta Unit of Neurology I-Parkinson and Movement Disorders UnitMilanItaly Department of Health Sciences Universitàdegli Studi di MilanoOtolaryngology UnitSan Paolo HospitalMilanItaly Department of Neuroscience Scuola Internazionale Superiore di Studi Avanzati(SISSA)Laboratory of Prion BiologyTriesteItaly Fondazione IRCCS Istituto Neurologico Carlo Besta Scientific DirectorateMilanItaly

Background:Parkinson’s disease(PD)is a neurodegenerative disorder whose diagnosis is often challenging because symptoms may overlap with neurodegenerative *** is characterized by intraneuronal accumulation of abnormalα-synuclein in brainstem while neurodegenerative parkinsonisms might be associated with accumulation of eitherα-synuclein,as in the case of Multiple System Atrophy(MSA)or tau,as in the case of Corticobasal Degeneration(CBD)and Progressive Supranuclear Palsy(PSP),in other disease-specific brain *** diagnosis of all these diseases can be formulated only neuropathologically by detection and localization ofα-synuclein or tau aggregates in the *** evidence suggests that trace-amount of these proteins can appear in peripheral tissues,including receptor neurons of the olfactory mucosa(OM).Methods:We have set and standardized the experimental conditions to extend the ultrasensitive Real Time Quaking Induced Conversion(RT-QuIC)assay for OM *** particular,by using human recombinantα-synuclein as substrate of reaction,we have assessed the ability of OM collected from patients with clinical diagnoses of PD and MSA to induceα-synuclein aggregation,and compared their seeding ability to that of OM samples collected from patients with clinical diagnoses of CBD and ***:Our results showed that a significant percentage of MSA and PD samples inducedα-synuclein aggregation with high efficiency,but also few samples of patients with the clinical diagnosis of CBD and PSP caused the same ***,the final RT-QuIC aggregates obtained from MSA and PD samples owned peculiar biochemical and morphological features potentially enabling their ***:Our study provide the proof-of-concept that olfactory mucosa samples collected from patients with PD and MSA possess important seeding activities forα-*** studies are required for(i)estimating sensitivity and specificity of the technique and

关键词： RT-QuIC Olfactory mucosa Parkinson’s disease Neurodegenerative parkinsonisms α-Synuclein

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意大利的困境该归咎于欧元吗?

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商业周刊（中文版） 2019年第4期 32-33页

作者： Alessandro Speciale Chiara Albanese Giovanni salzano 永年(译) 不详

与20年前欧元诞生时一样,达里奥.卡洛杰罗(Dario Calogero)对欧元依然充满热情。2000年,在这个欧元区单一货币将满一周岁之际,他的金融服务创业公司从风投那里获得了100万欧元(约合人民币762.68万元)投资。但卡洛杰罗在意大利的银行无... 详细信息

与20年前欧元诞生时一样,达里奥.卡洛杰罗(Dario Calogero)对欧元依然充满热情。2000年,在这个欧元区单一货币将满一周岁之际,他的金融服务创业公司从风投那里获得了100万欧元(约合人民币762.68万元)投资。但卡洛杰罗在意大利的银行无法接受如此大额的金额转账到他开创性的欧元账户中。于是这位科技创业者不得不将28张支票放在公文包里,前往该银行的米兰分行亲自存入。

关键词：欧元区意大利科技创业者单一货币创业公司金融服务人民币开创性

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Transcriptome reprogramming,epigenetic modifications and alternative splicing orchestrate the tomato root response to the beneficial fungus Trichoderma harzianum

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Horticulture Research 2019年第1期6卷 1792-1806页

作者： Monica De Palma Maria salzano Clizia Villano Riccardo Aversano Matteo Lorito Michelina Ruocco Teresa Docimo Anna Lisa Piccinelli Nunzio D’Agostino Marina Tucci Institute of Biosciences and BioResources Research Division PorticiNational Research Council80055 PorticiItaly Department of Agricultural Sciences University of Naples Federico II80055 PorticiItaly Institute for Sustainable Plant Protection National Research Council80055 PorticiItaly Department of Pharmacy University of Salerno84084 FiscianoItaly CREA Research Centre for Vegetable and Ornamental Crops84098 Pontecagnano FaianoItaly

Beneficial interactions of rhizosphere microorganisms are widely exploited for plant biofertilization and mitigation of biotic and abiotic *** provide new insights into the onset of the roots–beneficial microorganisms interplay,we characterised the transcriptomes expressed in tomato roots at 24,48 and 72 h post inoculation with the beneficial fungus Trichoderma harzianum T22 and analysed the epigenetic and post-trascriptional regulation *** detected 1243 tomato transcripts that were differentially expressed between Trichoderma-interacting and control roots and 83 *** transcripts that were differentially expressed between the three experimental time *** with Trichoderma triggered a transcriptional response mainly ascribable to signal recognition and transduction,stress response,transcriptional regulation and *** tomato roots,salicylic acid,and not jasmonate,appears to have a prominent role in orchestrating the interplay with this beneficial *** regulation of many nutrient transporter genes indicated a strong effect on plant nutrition processes,which,together with the possible modifications in root architecture triggered by ethylene/indole-3-acetic acid signalling at 72 h post inoculation may concur to the well-described growth-promotion ability of this ***,***-induced defence priming and stress tolerance may be mediated by the induction of reactive oxygen species,detoxification and defence genes.A deeper insight into gene expression and regulation control provided first evidences for the involvement of cytosine methylation and alternative splicing mechanisms in the plant–Trichoderma interaction.A model is proposed that integrates the plant transcriptomic responses in the roots,where interaction between the plant and beneficial rhizosphere microorganisms occurs.

关键词： roots programming promotion

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急性心力衰竭患者肠道相关代谢产物与预后的关系

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中华高血压杂志 2021年第4期29卷 365-365页

作者：刘青(译) 练桂丽(审校) Israr MZ Bernieh D salzano A Cassambai S Yazaki Y Heaney LM Jones DJ Ng LL Suzuki T 不详

氧化三甲胺(trimethylamine N-oxide, TMAO)是一种肠道相关代谢物,与心力衰竭预后相关。然而,TMAO是一个复杂的代谢途径(即胆碱/肉碱)的最终产物,这个代谢途径在心力衰竭中的研究尚不深入。该研究调查了一组参与TMAO-胆碱/肉碱代谢途径... 详细信息

氧化三甲胺(trimethylamine N-oxide, TMAO)是一种肠道相关代谢物,与心力衰竭预后相关。然而,TMAO是一个复杂的代谢途径(即胆碱/肉碱)的最终产物,这个代谢途径在心力衰竭中的研究尚不深入。该研究调查了一组参与TMAO-胆碱/肉碱代谢途径的代谢物与急性心力衰竭患者预后的关系。方法:用改进的液相色谱-串联质谱法对来自急性心力衰竭患者的806份血浆样本中的TMAO、三甲基赖氨酸、左旋肉碱、乙酰左旋肉碱、γ丁甜菜碱.

关键词：急性心力衰竭氧化三甲胺左旋肉碱血浆样本代谢物代谢途径代谢产物胆碱

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开放性网膜疝修补术中，采用保留或分离髂腹股沟神经、髂腹下神经和生殖神经方案间的影响：一项对慢性疼痛的前瞻性、多中心研究

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医学信息（手术学分册） 2007年第8期20卷 745-745页

作者： Alfieri, Sergio Rotondi, Fabio Di Giorgio, Andrea Fumagalli, Uberto salzano, Antonio Di Miceli, Dario Ridolfni, Marco Pericoli Sgagari, Antonio Doglietto, Giovannibattista Groin Pain Trial Group

目的：旨在评价在开放性网膜疝修补术中，通过采用不同的保留生殖股神经的生殖支、髂腹股沟神经、髂腹下神经的手术方案，是否能有效缓解慢性术后疼痛。背景：近年来，出于对其治疗和法律意义的关注，疝修补术后出现的慢性腹股沟疼痛日... 详细信息

目的：旨在评价在开放性网膜疝修补术中，通过采用不同的保留生殖股神经的生殖支、髂腹股沟神经、髂腹下神经的手术方案，是否能有效缓解慢性术后疼痛。背景：近年来，出于对其治疗和法律意义的关注，疝修补术后出现的慢性腹股沟疼痛日益引起人们的兴趣。然而，应采取何种治疗方案以保留3支腹股沟感觉神经仍存在许多争议。方法：一项由11家意大利研究中心参与多中心、前瞻性研究、募集了973例疝修补病例。要求所有手术医生报告是否每一根神经都被识别，并予以保留或分离。本研究的主要终点为评价6个月和1年时中重度慢性疼痛的情况。结果：6个月和1年随访时，分别有9．7％和4．1％的患者出现腹股沟疼痛。在6个月时，7．9％的患者为轻度疼痛，2．1％为中重度疼痛，而在1年时，3．6％的患者为轻度疼痛，0．5％的患者为中重度疼痛。单变量和多变量分析显示，并未发现与慢性疼痛存在显著相关的神经，随着未检测到的神经数量的增加，腹股沟疼痛的发生危险也随之增加。同样的，神经分离与慢性疼痛的发生明显相关。结论：目前的研究结果显示，在开放性腹股沟疝修补术中，分辨并保留神经可减少慢性失能性腹股沟疼痛，并且对于大多数6个月时出现慢性疼痛的患者，只有采取保守或内科治疗方法才能缓解其1年时的疼痛症状。

关键词：腹股沟疝修补术髂腹股沟神经生殖股神经慢性疼痛髂腹下神经多中心研究分离腹股沟疼痛

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