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Role of the combination of biologics and/or small molecules in the treatment of patients with inflammatory bowel disease

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World Journal of Gastroenterology 2022年第47期28卷 6743-6751页

作者： domingo Balderramo Department of Gastroenterology Hospital Privado Universitario de CórdobaInstituto Universitario de Ciencias Biomédicas de CórdobaCórdoba 5016Argentina

Inflammatory bowel disease(IBD)is a group of chronic diseases that includes ulcerative colitis,Crohn’s disease,and indeterminate *** with IBD require prolonged treatment and high utilization of healthcare resources for proper *** treatment of patients with IBD is focused on achieving therapeutic goals including clinical,biochemical,and endoscopic variables that result in improvement of the quality of life and prevention of *** IBD treatment includes tumor necrosis factor inhibitors,integrin antagonist,antagonist of the p40 subunit of interleukin 12/23,and small molecule ***,despite the multiple treatments available,about 40%of patients are refractory to therapy and present with persistent symptoms that have a great impact on their quality of life,with hospitalization and surgery being necessary in many *** therapy,a strategy sometimes applicable to refractory IBD patients,includes the combination of two biologics or a biologic in combination with a small molecule *** are two distinct scenarios in IBD patients in which this approach can be used:(1)Refractory active luminal disease without extraintestinal manifestations;and(2)patients with IBD in remission,but with active extraintestinal manifestations or immune-mediated inflammatory *** review provides a summary of the results(clinical response and remission)of different combinations of advanced drugs in patients with IBD,both in adults and in the pediatric *** addition,the safety profile of different combinations of dual therapy is *** use of newer combinations,including recently approved treatments,the application of new biomarkers and artificial intelligence,and clinical trials to establish effectiveness during long-term followup,are needed to establish new strategies for the use of advanced treatments in patients with refractory IBD.

关键词： Inflammatory bowel disease Ulcerative colitis Crohn’s disease Dual-therapy biologic therapy Small molecule drugs Clinical remission

Convergence of optimal control problems governed by second kind parabolic variational inequalities

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控制理论与应用（英文版） 2013年第3期11卷 422-427页

作者： Mahdi BOUKROUCHE domingo A.TARZIA Lyon University UJM F-42023 CNRS UMR 5208 Institut Camille Jordan 23 Paul Michelon 42023 Saint-Etienne Cedex 2 France Departamento de Matemtica-CONICET FCE Austral UniversityParaguay 1950 S2000FZF Rosario Argentina

We consider a family of optimal control problems where the control variable is given by a boundary condition of Neumann type. This family is governed by parabolic variational inequalities of the second kind. We prove the strong convergence of the optimal control and state systems associated to this family to a similar optimal control problem. This work solves the open problem left by the authors in IFIP TC7 CSMO2011.

关键词： Parabolic variational inequalities of the second kind Aubin compactness arguments Boundary control Convergence of optimal control problems Tresca boundary conditions, free boundary problems

A graph-based approach for the structural analysis of road and building layouts

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Geo-Spatial Information Science 2019年第1期22卷 59-72页

作者： Mathieu domingo Rémy Thibaud Christophe Claramunt Department of Computer Science University of Pau and Pays de l’AdourPauFrance Naval Academy Research Institute Brest CedexFrance

A better understanding of the relationship between the structure and functions of urban and suburban spaces is one of the avenues of research still open for geographical information *** research presented in this paper develops several graph-based metrics whose objective is to characterize some local and global structural properties that reflect the way the overall building layout can be cross-related to the one of the road *** structural properties are modeled as an aggregation of parcels,buildings,and road *** introduce several computational measures(Ratio Minimum Distance,Minimum Ratio Minimum Distance,and Metric Compactness)that respectively evaluate the capability for a given road to be connected with the whole road *** measures reveal emerging sub-network structures and point out differences between less-connective and moreconnective parts of the *** on these local and global properties derived from the topological and graph-based representation,and on building density metrics,this paper proposes an analysis of road and building layouts at different levels of *** metrics developed are applied to a case study in which the derived properties reveal coherent as well as incoherent neighborhoods that illustrate the potential of the approach and the way buildings and roads can be relatively connected in a given urban ***,and by integrating the parcels and buildings layouts,this approach complements other previous and related works that mainly retain the configurational structure of the urban network as well as morphological studies whose focus is generally limited to the analysis of the building layout.

关键词： Urban and suburban spaces graph-based modeling structural analysis GIS

On a Classical Theorem on the Diameter and Minimum Degree of a Graph

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Acta Mathematica Sinica,English Series 2017年第11期33卷 1477-1503页

作者： Veronica HERNANDEZ domingo PESTANA Jose M. RODRIGUEZ Universidad CarlosⅢde Madrid Avenida de la Universidad3028911 LeganesSpain

In this work, we obtain good upper bounds for the diameter of any graph in terms of its minimum degree and its order, improving a classical theorem due to Erdos, Pach, Pollack and Tuza. We use these bounds in order to study hyperbolic graphs （in the Gromov sense）. To compute the hyperbolicity constant is an almost intractable problem, thus it is natural to try to bound it in terms of some parameters of the graph. Let H（n, δ0） be the set of graphs G with n vertices and minimum degree 50, and J（n, Δ） be the set of graphs G with n vertices and maximum degree A. We study the four following extremal problems on graphs： a（n,δ0） = min{δ（G）｜ G ∈H（n, δ0）}, b（n, δ0） =- max{δ（G）｜ e ∈H（n, δ0）}, α（n, Δ） = min{δ（G） [ G ∈ J（n, Δ）} and β（n,Δ） = max{δ（G） ] G∈Π（n,Δ）}. In particular, we obtain bounds for b（n, δ0） and we compute the precise value of a（n, δ0）, α（n, Δ） and w（n, Δ） for all values of n, r0 and A, respectively.

关键词： Extremal problems on graphs diameter minimum degree maximum degree Gromov hyperbolicity hyperbolicity constant finite graphs

Earth observations for sustainable development goals monitoring based on essential variables and driver-pressure-state-impactresponse indicators

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International Journal of Digital Earth 2020年第2期13卷 217-235页

作者： Joan Masó Ivette Serral Cristina domingo-Marimon Alaitz Zabala CREAF Grumets Research Group CREAFEdifici C.Universitat Autònoma de BarcelonaBellaterraCataloniaSpain Dept.Geografia Grumets Research GroupEdifici B.Universitat Autònoma de BarcelonaBellaterraCataloniaSpain

In recent years,researchers of different communities have increased their efforts in formalizing a set of measurements regularly collected for analysing changes in Drivers,States,Impacts and Responses of a given *** some cases,different actors have converged in a minimum set of Essential Variables(EVs),such as for Climate,Biodiversity or *** definition of such EVs is an ongoing evolution and in extension(*** for water)although some communities have not even started(*** and energy).This paper characterizes the Earth Observation(EO)networks and creates a graph representation of their ***,this graph is enriched with the EVs produced by each network creating a knowledge ***,an effort has been done to identify links between EVs and Sustainable Development Goals(SDG)indicators in a way that they indirectly connect the *** analysis to detect gaps in EO variables due to a lack of observational networks is *** suggestions for improving SDG indicators framework by considering EVs are exposed,as well as proposing new necessary EVs and suggesting new EO based *** complete graph is available in the ENEON website(http://***/graphev-sdg/).

关键词： Gap analysis policy monitoring essential variables earth observation

Lilly Reich:The architecture and critique of an invisibilized woman

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Frontiers of Architectural Research 2023年第1期12卷 15-27页

作者： Laura Lizondo-Sevilla Debora domingo-Calabuig Department of Architectural Projects Universitat Politecnica de ValenciaValencia 46022Spain

The architectural modernity that prevailed in Germany during the first half of the twentieth century cannot be understood without an appreciation of the work of Lilly Reich,a brilliant designer of interiors,furniture,and ephemeral architecture who exerted significant influence from her active position as a member of the Deutscher *** the critical recognition she acquired in the media of the time during her solo career,her association with the architect Mies van der Rohe,far from positioning her in the field of contributions,relegated her to the role of a mere *** this reason,this article aims to shed light on the extensive legacy of Lilly Reich,a woman whose figure is being acknowledged as a result of recent research but who was nevertheless omitted from the leading books on the history of *** methodology employed in the research analyses comparatively“what she did”and“what was said about her”,highlighting the convergences and divergences between“work”and“criticism”.The study and its results yield interesting conclusions regarding both the recognition that Lilly Reich received during her lifetime and the criticism she received after her death and up to the present day.

关键词： Lilly Reich Architecture Design Critique Invisibilization Woman

Effect of Implementing Ecosystem Functional Type Data in a Mesoscale Climate Model

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Advances in Atmospheric Sciences 2013年第5期30卷 1373-1386页

作者： Seung-Jae LEE E. Hugo BERBERY domingo ALCARAZ-SEGURA Complex Systems Science Laboratory Department of Landscape Architecture and Rural Systems Engineering Seoul National University Department of Atmospheric and Oceanic Science University of Maryland College Park Department of Botany University of Granada

In this paper, we introduce a new concept of land-surface state representation for southern South America, which is based on ＂functional＂ attributes of vegetation, and implement a new land-cover （Ecosystem Functional Type, hereafter EFT） dataset in the Weather and Research Forecasting （WRF） model. We found that the EFT data enabled us to deal with functional attributes of vegetation and time-variant features more easily than the default land-cover data in the WRF. In order to explore the usefulness of the EFT data in simulations of surface and atmospheric variables, numerical simulations of the WRF model, using both the US Geological Survey （USGS） and the EFT data, were conducted over the La Plata Basin in South America for the austral spring of 1998 and compared with observations. Results showed that the model simulations were sensitive to the lower boundary conditions and that the use of the EFT data improved the climate simulation of 2-m temperature and precipitation, implying the need for this type of information to be included in numerical climate models.

关键词： Ecosystem Functional Type WRF land cover climate simulation

The Impact of Ecosystem Functional Type Changes on the La Plata Basin Climate

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Advances in Atmospheric Sciences 2013年第5期30卷 1387-1405页

作者： Seung-Jae LEE E. Hugo BERBERY domingo ALCARAZ-SEGURA Department of Atmospheric and Oceanic Science University of Maryland College Park Department of Botany University of Granada

In this paper, the effects of land cover changes on the climate of the La Plata Basin in southern South America are investigated using the Weather and Research Forecasting （WRF） Model configured on a 30/10- km two-way interactive nested grid. To assess the regional climate changes resulting from land surface changes, the standard land cover types are replaced by time-varying Ecosystem Functional Types （EFTs）, which is a newly devised land-cover classification that characterizes the spatial and interannual variability of surface vegetation dynamics. These variations indicate that natural and anthropogenic activities have caused changes in the surface physical parameters of the basin, such as albedo and roughness length, that contributed to regional climate changes. EFTs are obtained from functional attributes of vegetation computed from properties of the Normalized Difference Vegetation Index （NDVI） to represent patches of the land surface with homogeneous energy and gas exchanges with the atmosphere. Four simulations are conducted, each experimental period ranging from September to November in two contrasting years, 1988 and 1998. The influence of an identical EFT change on the surface heat fluxes, 2-m temperature and humidity, 10-m winds, convective instabilities and large-scale moisture fluxes and precipitation are explored for 1988 （a dry year） and 1998 （a wet year）. Results show that the surface and atmospheric climate has a larger response to the same EFT changes in a dry year for 2-m temperature and 10-m wind; the response is larger in a wet year for 2-m water vapor mixing ratio, convective available potential energy, vertically integrated moisture fluxes and surface precipitation. For EFTs with high productivity and a weak seasonal cycle, the near- surface temperature during the spring of 1988 and 1998 increased by as much as I^C in the central and western portions of La Plata Basin. Additionally, for higher productivity EFTs, precipitation differences were g

关键词： EFT ecosystem function land cover La Plata Basin model simulation

Phages and Nanotechnology:New Insights against Multidrug-Resistant Bacteria

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BioDesign Research 2023年第1期5卷 12-24页

作者： Marco Pardo-Freire Pilar domingo-Calap Institute for Integrative Systems Biology I2SysBioUniversitat de València-CSIC46980 PaternaSpain.

Bacterial infections are a major threat to the human healthcare system worldwide,as antibiotics are becoming less effective due to the emergence of multidrug-resistant ***,there is a need to explore nontraditional antimicrobial alternatives to support rapid interventions and combat the spread of pathogenic *** nonantibiotic approaches are being developed,many of them at the interface of physics,nanotechnology,and *** physical factors(e.g.,pressure,temperature,and ultraviolet light)are typically used in the sterilization process,nanoparticles and phages(bacterial viruses)are also applied to combat pathogenic ***,phage-based therapies are rising due to the unparalleled specificity and high bactericidal activity of *** the success of phages mostly as compassionate use in clinical cases,some drawbacks need to be addressed,mainly related to their stability,bioavailability,and systemic *** phages with nanoparticles can improve their performance in ***,the combination of nanotechnology and phages might provide tools for the rapid and accurate detection of bacteria in biological samples(diagnosis and typing),and the development of antimicrobials that combine the selectivity of phages with the efficacy of targeted therapy,such as photothermal ablation or photodynamic *** this review,we aim to provide an overview of how phage-based nanotechnology represents a step forward in the fight against multidrug-resistant bacteria.

关键词： diagnosis mostly ultraviolet