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Correlation between severity of endoscopic findings and apnea-hypopnea index in patients with gastroesophageal reflux disease and obstructive sleep apnea

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World Journal of Gastroenterology 2005年第6期11卷 839-841页

作者： Pál Demeter Katalin Várdi Visy Pál Magyar Department of Gastroenterology Department of Pulmonology

AIM: To assess the relationship between severity of gastroesophageal reflux disease and apnea-hypopnea index (AHI) as an indicator of the severity of obstructive sleep apnea. METHODS: Data of 57 patients with proven obstructive sleep apnea and gastroesophageal reflux disease were analyzed. Patients were divided into two groups according to severity of the sleep apnea: 'mild-moderate' (A)-AHI 5≥5-30, n=27, 'severe' (B)-AHI >30, n=30. All patients underwent apnea monitoring during the night, upper panendoscopy and were asked about typical reflux symptoms. RESULTS: All examined patients in both groups showed a significant overweight and there was a positive correlation between body mass index and the degree of sleep apnea (P = 0.0002). The occurence of erosive reflux disease was significantly higher in 'severe' group (P = 0.0001). Using a logistic regression analysis a positive correlation was found between the endoscopic severity of reflux disease and the AHI (P = 0.016). Forty-nine point five percent of the patients experienced the typical symptoms of reflux disease at least three times a week and there was no significant difference between the two groups. CONCLUSION: A positive correlation can be found between the severity of gastroesophageal reflux disease and obstructive sleep apnea.

关键词： Obstructive sleep apnea Gastroesophageal reflux disease Severity Correlation

Improvement of transfection with reprogramming factors in urine-derived cells

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BIOCELL 2020年第3期44卷 401-409页

作者： OLIVIA A.ROBLES-RODRÍGUEZ MARÍA J.LOERA-ARIAS JOSÉJ.PÉREZ-TRUJILLO ARNULFO VILLANUEVA-OLIVO ernesto picÓN-GALINDO LAURA VILLARREAL-MARTÍNEZ ADOLFO SOTO-DOMÍNGUEZ HUMBERTO RODRÍGUEZROCHA ARACELY GARCÍA-GARCÍA ODILA SAUCEDO-CÁRDENAS ROBERTO MONTES DE OCA-LUNA Facultad de Medicina Departamento de HistologíaUniversidad Autónoma de Nuevo LeónMonterreyC.P.64460México Hospital Universitario“Dr.JoséEleuterio González González” Servicio de HematologíaUniversidad Autónoma de Nuevo LeónMonterreyC.P.64460México Centro de Investigación Biomédica del Noreste Departamento de Genética MolecularInstituto Mexicano del Seguro SocialMonterreyC.P.64720México

Human-induced pluripotent stem cells(iPSCs)are an accessible source of adult-derived,patient-specific pluripotent stem cells for use in basic research,drug discovery,disease modeling,and stem cell *** the accessibility of methods to obtain iPSCs regardless of the cell source can enhance their clinical ***,our purpose is to report a simple protocol to obtain iPS-like cells from urine-derived renal epithelial cells(RECs)using different extracellular matrices and transfection *** this study,we began by culturing urine-derived cells from healthy donors to establish a primary culture of renal epithelial cells,followed by their ***,we generated iPS-like cells by transfecting renal epithelial cells(RECs)with vectors expressing Oct4,Sox2,L-Myc,Lin-28,and Klf4,and we compared the efficacy of different extracellular matrices and transfection *** resultant iPS-like cells showed a human embryonic stem cell-like morphology and expressed the specific pluripotency markers Oct3/4,Nanog,Lin28,and *** concluded that Lipofectamine Stem Cell transfection reagent is more effective than FuGENE in obtaining iPS-like cells under the conditions ***,the three matrices are similar in their efficiency of obtaining iPS-like *** report provides an experimental protocol for obtaining and generating iPS-like cells from urine samples for further cell therapy research on different human diseases.

关键词： Reprogramming factors iPSCs Renal epithelial cells Extracellular matrix Transfection reagent

Under the Same Sky——Educating Migrant Woukers's Children

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Women of China 2007年第3期 24-31页

作者：同欣 Sun-pic CFP

Since the 1980's,there has been a massive migration of rural residents to some of China's large,economically developed cities—such as Beijing,Shanghai and Guangzhou—as they search for higher incomes and better *** recent years,the problems that migrant workers face have become fodder for some intense discussions in *** example,the education of migrant workers' children has evoked great concern among many *** rural children have moved to large cities or towns with their parents,who have f...

关键词：农民工子女教育农民工子弟学校 US

“H_(2)-free” demethoxylation of guaiacol in subcritical water using Pt supported on N-doped carbon catalysts:A cost-effective strategy for biomass upgrading

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Journal of Energy Chemistry 2021年第7期30卷 377-385页

作者： Laura Pastor-Pérez Wei Jin Juan J.Villora-picó Qiang Wang M.Mercedes Pastor-Blas Antonio Sepúlveda-Escribano Tomas R.Reina Department of Chemical and Process Engineering University of SurreyGuildford GU27XHUnited Kingdom Laboratorio de Materiales Avanzados Departamento de Química Inorgánica-Instituto Universitario de Materiales de AlicanteUniversidad de AlicanteApartado 99E-03080 AlicanteSpain College of Environmental Science and Engineering Beijing Forestry UniversityBeijing 100083China

"H_(2)-free" HDO is a revolutionary route to circumvent the limitations of H_(2)-fed HDO reactors for biomass *** work demonstrates the viability of this economically appealing route when an adequate catalyst is ***,we have developed a new family of Pt catalysts supported on N-doped activated carbons for the H_(2)-free HDO process of *** N-donors have been used to tune the catalyst’s structural and electronic *** a general trend,the N-promoted samples are more selective towards oxygen-depleted *** best performing material,namely Pt/PANI-AC reached outstanding guaiacol conversion values-ca.75% at 300℃ while displaying reasonable stability for multiple recycling *** advanced performance is ascribed to the modified electronic and acid-base properties which favor guaiacol activation and C-O cleavage,as well as the excellent dispersion of the Pt nano particles.

关键词： Biomass upgrading N-doped carbon Pt HDO Guaiacol H_(2)-free

Organising a juvenile ratio monitoring programme for 10 key waterbird species in the Yangtze River floodplain:analysis and proposals

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Avian Research 2021年第4期12卷 645-657页

作者： Yuxi Wang Iderbat Damba Qingshan Zhao Yanbo Xie Xueqing Deng rdi Ga Guanhua Liu Zhiwen Xu Yue Li Dali Gao Wenbin Xu Guoxun Chen Lei Cao School of Life Science University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Urban and Regional Ecology Research Center for Eco Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Institute of Biology Mongolian Academy of SciencesUlaanbaatar 13330Mongolia Department of Modern Physics University of Science and Technology of ChinaHefei 230026China College of Life Sci-ence and Technology Inner Mongolia Normal UniversityHuhehaote 010000China Jiangxi Poyang Lake National Reserve Authority Nan Chang 330038China Authority of Jiangxi Duchang Provincial Natural Reserve Duchang 332600China Authority of East Dongting Lake National Nature Reserve Yueyang 414000China Anhui Shengjin Lake National Reserve Author-ity Dongzhi 247000China Authority of Longgang Lake National Nature Reserve Huanggang 435500China

Background:In the face of continued degradation and loss of wetlands in the Yangtze River floodplain(YRF),there is an urgent need to monitor the abundance and distribution of wintering *** understand fully observed annual changes,we need to monitor demographic rates to understand factors affecting global population *** reproduction success contributes to dynamic changes in population size and age structure,so an assessment of the juvenile ratio(*** winter birds as a proportion of total number aged)of overwintering waterbirds can be an important indicator of the reproductive success in the preceding breeding ***:During 2016-2019,we sampled juvenile ratios among 10 key waterbird species from the wetlands in the *** on these data,we here attempt to establish a simple,efficient,focused and reliable juvenile ratio monitoring scheme,to assess consistently and accurately relative annual breeding success and its contribution to the age structure among these waterbird ***:We compared juvenile ratio data collected throughout the winter and found that the optimal time for undertaking these samples was in the early stages of arrival for migratory waterbirds reaching their wintering area(early to mid-December).We recommend counting consistently at key points(*** where>1%biogeographical flyway population were counted)at sites of major flyway importance(Poyang Lake,East Dongting Lake,Shengjin Lake,Caizi Lake,Longgan Lake and Chen Lake).Based on this,the error rate of the programme(155 planned points,the count of 10 waterbird species is 826-8955)is less than 5%.Conclusions:We established a juvenile ratio monitoring programme for 10 key waterbird species in the wetlands of the YRF,and discuss the feasibility and necessity of implementing such a future programme,and how to use these data in our monitoring and understanding of the population dynamics of these waterbird populations.

关键词： Juvenile ratio Monitoring scheme The Yangtze River floodplain Statistical independence

ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer’s disease with a bispecific,brain-penetrating fusion protein

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Translational Neurodegeneration 2022年第1期11卷 70-83页

作者： Gillian Bonvicini Stina Syvänen Ken G.Andersson Merja Haaparanta-Solin Francisco López-picón Dag Sehlin Department of Public Health and Caring Sciences Uppsala University75185 UppsalaSweden BioArctic AB 11251 StockholmSweden Preclinical Imaging Laboratory Turku PET CentreUniversity of Turku20520 TurkuFin-land MediCity Research Laboratory University of Turku20520 TurkuFinland.

Background:Hijacking the transferrin receptor(TfR)is an effective strategy to transport amyloid-beta(Aβ)immuno-positron emission tomography(immunoPET)ligands across the blood-brain barrier(BBB).Such ligands are more sensitive and specific than small-molecule ligands at detecting Aβpathology in mouse models of Alzheimer’s disease(AD).This study aimed to determine if this strategy would be as sensitive in rats and to assess how TfR affinity affects BBB transport of bispecific immunoPET ***:Two affinity variants of the rat TfR antibody,OX26,were chemically conjugated to a F(ab′)2 fragment of the anti-Aβantibody,bapineuzumab(Bapi),to generate two bispecific fusion proteins:OX265-F(ab′)2-Bapi and OX2676-F(ab′)*** analyses were performed 4 h and 70 h post-injection of radioiodinated fusion proteins in wild-type(WT)rats.[124I]I-OX265-F(ab′)2-Bapi was administered to TgF344-AD and WT rats for in vivo PET *** vivo distribution of injected[124I]I-OX265-F(ab′)2-Bapi and Aβpathology were ***:More[125I]I-OX265-F(ab′)2-Bapi was taken up into the brain 4 h post-administration than[124I]I-OX2676-F(ab′)2-Bapi.[124I]I-OX265-F(ab′)2-Bapi PET visualized Aβpathology with significantly higher signals in the TgF344-AD rats than in the WT littermates without Aβ*** PET signals significantly correlated with Aβlevels in AD ***:Affinity to TfR affects how efficiently a TfR-targeting bispecific fusion protein will cross the BBB,such that the higher-affinity bispecific fusion protein crossed the BBB more ***,bispecific immunoPET imaging of brain Aβpathology using TfR-mediated transport provides good imaging contrast between TgF344-AD and WT rats,suggesting that this immunoPET strategy has the potential to be translated to higher species.

关键词： ImmunoPET Transferrin receptor Alzheimer’s disease Amyloid-beta

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生活在地壳边缘的人

中国社会导刊 2004年第11期 36-39页

作者：吴芳 SUN-pic

四川达县的老赵叫赵世富,其实他只有43岁,由于长期在外风吹日晒,显得有些苍老.几年前,他是和妻子以及村里的十几个民工一起到合肥,专门为建筑工地的基础工程打井,这个工作他已经干了有好几年了.

关键词：打井工作建筑工地基础工程农民工

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惊心探访“炸药包”

中国社会导刊 2003年第12期 50-53页

作者：安星袁星红 sun-pic

11月3日、22日、27日安徽省境内先后发生了三次烟花爆竹引发的爆炸事故,造成9人死亡,8人受伤.春节将近,烟花爆竹"产销两旺",会不会引发新的惨剧?

关键词：居民楼炸药包

DURIAN/LA MIGRA/THE BRICKS/ZIM BROADWAY 9 Club 9th April 2015

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城市漫步（全国英文版） 2015年第7期 20-25页

作者： William Gray 刘小青(pic) 不详

Seeking to delve deeper into Hangzhou's burgeoning music scene,indie troubadour about town Wiltiam Gray trots off to g-Club to find out what's *** a lot it would appear... 详细信息

Seeking to delve deeper into Hangzhou's burgeoning music scene,indie troubadour about town Wiltiam Gray trots off to g-Club to find out what's *** a lot it would appear...

关键词： OAD indie happen