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From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

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Neural Regeneration Research 2025年第3期20卷 660-670页

作者： ernesto Doncel-pérez Gabriel Guízar-Sahagún Israel Grijalva-Otero Hospital Nacional de parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medical Research Unit for Neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. Most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. Despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

Skew-symmetric Elements in Nonlinear Involutions in Group Rings

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Algebra Colloquium 2015年第2期22卷 321-332页

作者： A.p. raposo Escuela Universitaria de Arquitectura Tecnica Universidad politecnica de Madrid Madrid Spain

Given an involution in a group G, it can be extended in various ways to an involution in the group ring RG, where R is a ring, not necessarily commutative. In this paper nonlinear extensions are considered and necessary and sufficient conditions are given on the group G, its involution, the ring R and the extension for the set of skew-symmetric elements to be commutative and for it to be anticommutative.

关键词： group ring involution skew-symmetric element

Maximum mass of magnetic white dwarfs

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Research in Astronomy and Astrophysics 2015年第10期15卷 1735-1741页

作者： Daryel Manreza paret Jorge ernesto Horvath Aurora pérez Martínez Departamento de Fisica General Facultad de FísicaUniversidad de la Habana Instituto de Astronomia Geofisica e Ciencias Atmosfericas USP Instituto de Cibernética Matemática y Física(ICIMAF)

We revisit the problem of the maximum masses of magnetized white dwarfs （WDs）. The impact of a strong magnetic field on the structure equations is addressed. The pressures become anisotropic due to the presence of the magnetic field and split into parallel and perpendicular components. We first construct stable solutions of the Tolman-Oppenheimer-Volkoff equations for parallel pressures and find that physical solutions vanish for the perpendicular pressure whenB ≥ 10^13 G. This fact estab- lishes an upper bound for a magnetic field and the stability of the configurations in the （quasi） spherical approximation. Our findings also indicate that it is not possible to obtain stable magnetized WDs with super-Chandrasekhar masses because the val- ues of the magnetic field needed for them are higher than this bound. To proceed into the anisotropic regime, we can apply results for structure equations appropriate for a cylindrical metric with anisotropic pressures that were derived in our previous work. From the solutions of the structure equations in cylindrical symmetry we have con- firmed the same bound for B- 10^13 G, since beyond this value no physical solutions are possible. Our tentative conclusion is that massive WDs with masses well beyond the Chandrasekhar limit do not constitute stable solutions and should not exist.

关键词： magnetic fields -- white dwarfs -- equation of state

Anisotropic stellar structure equations for magnetized strange stars

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Research in Astronomy and Astrophysics 2015年第7期15卷 975-985页

作者： Daryel Manreza paret Jorge ernesto Horvath Aurora pérez Mart'nez Departamento de F'sica General Facultad de F'sica Universidad de la Habana Instituto de Astronomia Geofisica e Ciencias Atmosfericas USP Instituto de Cibernética Matemática y Física (ICIMAF)

The fact that a fermion system in an external magnetic field breaks the spherical symmetry suggests that its intrinsic geometry is axisymmetric rather than spherical. In this work we analyze the impact of anisotropic pressures, due to the presence of a magnetic field, in the structure equations of a magnetized quark *** assume a cylindrical metric and an anisotropic energy momentum tensor for the source. We found that there is a maximum magnetic field that a strange star can sustain, closely related to the violation of the virial relations.

关键词： magnetic fields -- stars: neutron -- equation of state

Bresse Beam with Damping and Logarithmic Source

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Chinese Annals of Mathematics,Series B 2024年第5期45卷 685-702页

作者： Sebastiao CORDEIRO Carlos BALDEZ Carlos raposo Ducival pEREIRA Octavio VERA Department of Mathematics Federal University of ParaAbaetetubaParaBrazil Department of Mathematics Federal University of ParaBragancaParaBrazil Department of Mathematics Federal University of ParaSalinopolisParaBrazil Department of Mathematics State University of ParaBelemParaBrazil Department of Mathematics University of TarapacaAricaChile

This paper investigates the stabilization of a Bresse system with internal damping and logarithmic *** authors use the potential well *** initial data in the stability set created by the Nehari surface,the existence of a global solution is proved by using Faedo-Galerkin's *** Nakao theorem gives the exponential decay.A numerical approach is presented to illustrate the results obtained.

关键词： Bresse beam Logarithmic source Global solution Exponential decay Numerical approach

Assessing the Environmental Impact of Extensive Beef production in Grazing Lands of Argentina

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phyton-International Journal of Experimental Botany 2024年第8期93卷 1943-1962页

作者： ernesto Viglizzo Florencia Ricard Instituto de Ciencias de la Tierra y Ambientales de La pampa Consejo Nacional de Investigaciones Científicas y TécnicasSanta Rosa6300La PampaArgentina Universidad Austral Rosario2000Santa FeArgentina Secretaría de Ambiente y Cambio Climático del Gobierno de La pampa Santa Rosa6300La PampaArgentina Facultad de Ciencias Exactas y Naturales Universidad Nacional de La PampaSanta Rosa6300La PampaArgentina

Because of environmental constraints,beef cattle was for more than a century the only viable farming option in the extensive semiarid and subhumid lands of Argentina and the main source of nutrients for humans as ***,a growing concern and criticism have risen today about its possible negative impact on the climate and the *** worries tend to affect current public opinions,national policies,and international *** on 40 beef cattle farms scattered across different semiarid and subhumid regions of Argentina,here we evaluated the impact of extensive cattle production on carbon,water,and nutrient ***-Cycle Assessment(LCA)and Land-Based Assessment(LBA)were the two approaches we used here to compare the environmental impact of beef *** the environmental footprint(EF)resulting from LCA expresses the impact per unit of food,the environmental balance(EB),derived from LBA,aims at quantifying the impact per unit of *** such,the EB considers both negative and positive impacts on the farm as an integrated *** standardized procedures,we evaluated EF and EB up to the farm gate,leaving aside delocalized post-farm impacts such as those of processing,packaging,and transportation that occur beyond the farm *** agreement with previous evidence,our results show that the EF tends to decrease as per-head production *** coefficients and statistical significance were the following for carbon(R=−0.574;pppphosphorus(p)pollution(R=−0.802;pper-hectare beef production *** were the following for carbon emissions(CE:R=0.955;pption(WC:R=0.822;ppphosphorus excretion(pE:R=0.945;ppact in intensive beef

关键词： Beef production extensive cattle raising grazing conditions environmental impact assessment

Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： Siva S.V.p.Sakamuri Anil Sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

Relationship between vegetation structure and microenvironment in Fagus grandifolia *** forest relicts in Mexico

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Journal of plant Ecology 2018年第2期11卷 237-247页

作者： ernesto ChRodríguez-Ramírez Arturo Sánchez-González GregorioÁngeles-pérez Laboratorio de Biogeografía y Sistemática Facultad de CienciasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico Laboratorio de Ecología de poblaciones Centro de Investigaciones BiológicasUniversidad Autónoma del Estado de HidalgoCiudad UniversitariaCarretera Pachuca-Tulancingo Km.4.5Mineral de la Reforma 42184Hidalgo postgrado en Ciencias Forestales Colegio de PostgraduadosMontecillo 56230TexcocoEstado de MéxicoMéxico

Aims Changes in the structure and composition of forests,whether caused by natural or anthropic events,alter the microenviron-ment,sometimes *** the local environment has a direct impact on basic ecological processes,this has become a key component of *** beech forests(Fagus grandi-folia ***)in the Sierra Madre Oriental are restricted to sites with specific climate,soils and topography,making them an ideal natural system for ecological *** objectives of this study were to identify the relationship between the microen-vironment and the tree and shrub structure and composition of Mexican beech forests in the state of Hidalgo,and to compare the floristic similarity of these forests on the country scale using data from seven *** Specimens were collected for a period of one year at all locali-ties in the state of Hidalgo where beech forests are *** each locality,five 400 m2 plots were established,and structural attributes(basal area,coverage,density and species richness)and six environmental variables were measured in the *** relationship between structure and microenvironment was estimated by simple correlation and canonic correspondence analysis(CCA).in addition,floristic similarity between different beech forest localities in the Sierra Madre Oriental was esti-mated by correspondence analysis(CA).Important Findings Twenty tree species and eight shrub species were identified;at all localities studied *** *** dominated the *** multivariate analysis indicated that(i)in the four localities in the state of Hidalgo,all microenvironmental variables except pH are related to the variation observed in species composition and structure;(ii)the El Gosco locality had both tree and shrub species and microenvironmental factors different from those observed in the Fagus forests at the other localities in the study and(iii)the localities studied in order to draw country-scale compa

关键词： Canonical correspondence analysis fagus forest floristic composition Mexico montane cloud forest richness

Navigating the complexities of perianal Crohn’s disease:Diagnostic strategies,treatment approaches,and future perspectives

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World Journal of Gastroenterology 2024年第44期30卷 4745-4753页

作者： Jai p Singh Maryam Aleissa ernesto R Drelichman Vijay K Mittal Jasneet S Bhullar Department of Surgery-Colon and Rectal Surgery Ascension Providence HospitalSouthfieldMI 48075United States Department of Surgery-Colon and Rectal Surgery Ascension Providence HospitalMichigan State University College of Human MedicineSouthfieldMI 48075United States Department of Surgery Ascension Providence HospitalMichigan State University College of Human MedicineSouthfieldMI 48075United States

This article discusses the literature review article by pacheco et al published in July 2024;the authors provided good reviews of perianal Crohn’s disease(CD),and challenges faced by clinicians in the ***,characterized by its chronic and relapsing nature,is an idiopathic condition that can involve any segment of the gastrointestinal *** disease impacts up to 40%of patients with CD,with perianal fistulas constituting up to 80%of perianal *** CD can be highly incapacitating and profoundly diminish the overall well-being of *** management focuses on controlling the perianal sepsis and treating luminal *** are crucial to the treatment approach,and results have been *** surgery focuses on controlling the sepsis,with more definitive treatments being fistula surgery,fecal diversion,and proctectomy as the last *** manuscript briefly describes the burden of CD,the challenges posed by perianal CD,and the role of different treatment modalities from colorectal surgeon’s perspective.

关键词： Crohn’s disease perianal Fistula Fistulotomy Biologics Stem cell therapy