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能源评论 2013年第12期 82-84页

作者： Gabriel ortiz-Barroeta (美)

Mixed-conducting ceramic–carbonate membranes exhibiting high CO2/O2 permeation flux and stability at high temperatures

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Journal of Advanced Ceramics 2020年第1期9卷 94-106页

作者： R.ORTEGA-LUGO J.A.FABIAN-ANGUIANO O.OVALLE-ENCINIA C.GOMEZ-YANEZ B.H.ZEIFERT J.ortiz-LANDEROS Instituto Politécnico Nacional Escuela Superior de Ingeniería Química e Industrias ExtractivasDepartamento de Ingeniería en Metalurgia y MaterialesUPALM-ZacatencoMexico City 07738Mexico Chemical Engineering School for Engineering of Matter Transport and EnergyArizona State UniversityTempeAZ 85287-6106USA

This investigation demonstrates the feasibility to fabricate high quality ceramic–carbonate membranes based on mixed-conducting ***,it is reported the simultaneous CO2/O2 permeation and stability properties of membranes constituted by a combination of ceramic and carbonate phases,wherein the microstructure of the ceramic part is composed,in turn,of a mixture of fluorite and perovskite *** ceramics showed ionic and electronic conduction,and at the operation temperature,the carbonate phase of the membranes is in liquid state,which allows the transport of CO32-and O2–species via different *** fabricate the membranes,the ceramic powders were uniaxially pressed in a disk ***,an incipient sintering treatment was carried out in such a way that a highly porous ceramic was ***,the piece is densified by the infiltration of molten *** of the membranes was accomplished by SEM,XRD,and gas permeation techniques among *** and chemical stability under an atmosphere rich in CO2 was ***2/O2 permeation and long-term stability measurements were conducted between 850 and 940℃.The best permeation–separation performance of membranes of about 1 mm thickness,showed a maximum permeance flux of about 4.46×10^–7 mol·m^–2·s^–1·Pa^–1 for CO2 and 2.18×10^–7 mol·m^–2·s^–1·Pa^–1 for O2 at 940℃.Membranes exhibited separation factor values of 150–991 and 49–511 for CO2/N2 and O2/N2 respectively in the studied temperature *** long-term stability test showed certain microstructural changes in the membranes,no significant detriment on the permeation properties was observed along 100 h of continuous operation.

关键词： CO2 separation O2 separation ceramic–carbonate membrane selectivity

Cancer stem cell impact on clinical oncology

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World Journal of Stem Cells 2018年第12期10卷 183-195页

作者： Mariel E Toledo-Guzmán Gabriele D Bigoni-Ordonez Miguel Ibanez Hernandez Elizabeth ortiz-Sánchez Subdirección de Investigación Básica Instituto Nacional de CancerologíaMexico City 14080Mexico Departamento de Bioquímica Laboratorio de Terapia GénicaEscuela Nacional de Ciencias BiológicasPosgrado de Biomedicina y Biotecnología MolecularInstituto Politécnico NacionalMexico City 11340Mexico

Cancer is a widespread worldwide chronic disease. In most cases, the high mortality rate from cancer correlates with a lack of clear symptoms, which results in late diagnosis for patients, and consequently, advanced tumor disease with poor probabilities for cure, since many patients will show chemo-and radio-resistance. Several mechanisms have been studied to explain chemo-and radio-resistance to anti-tumor therapies, including cell signaling pathways, anti-apoptotic mechanisms, stemness, metabolism, and cellular phenotypes. Interestingly, the presence of cancer stem cells(CSCs), which are a subset of cells within the tumors, has been related to therapy resistance. In this review, we focus on evaluating the presence of CSCs in different tumors such as breast cancer, gastric cancer, lung cancer, and hematological neoplasias, highlighting studies where CSCs were identified in patient samples. It is evident that there has been a great drive to identify the cell surface phenotypes of CSCs so that they can be used as a tool for anti-tumor therapy treatment design. We also review the potential effect of nanoparticles, drugs, natural compounds, aldehyde dehydrogenase inhibitors, cell signaling inhibitors, and antibodies to treat CSCs from specific tumors. Taken together, we present an overview of the role of CSCs in tumorigenesis and how research is advancing to target these highly tumorigenic cells to improve oncology patient outcomes.

关键词： Cancer Targeted therapy Clinical outcome Drug resistance Cancer stem cells

White House Original Series：＇Game of Thrones＇

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能源评论 2013年第8期 93-95页

作者： Gabriel ortiz-Barroeta[美]

A Bigger Slice of the Apple Pie

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能源评论 2013年第10期 93-95页

作者： Gabriel ortiz-Barroeta [美]

Surgical and nutritional interventions for endometrial receptivity:A case report and review of literature

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World Journal of Clinical Cases 2022年第33期10卷 12295-12304页

作者： Dinorah Hernández-Melchor Cecilia Palafox-Gómez Ivan Madrazo Ginna ortiz America Padilla-Viveros Esther López-Bayghen Science Technology and Society ProgramCentro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMéxico City 07360CDMXMéxico Clinical Research Instituto Regenera SCMéxico City 05320CDMXMéxico Departamento de Toxicología Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMéxico City 07360CDMXMéxico Investigación Clínica Instituto de Infertilidad y Genética México SCINGENESMéxico City 05320CDMXMéxico Departamento de Toxicología Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMexico City 07360CDMXMéxico

BACKGROUND Polycystic ovary syndrome(PCOS)is an endocrine disease that combines metabolic,reproductive,and psychological *** disorders and impaired endometrial receptivity in PCOS can cause *** resistance(IR)is a pathological state of inadequate response to insulin that affects reproduction in PCOS,as damage caused by IR at the endometrial level becomes an obstacle for embryo *** IR resulted in spontaneous pregnancies in PCOS patients,indicating that metabolic corrections improve endometrial *** stem-cell treatment has also corrected endometrial quality and lead to pregnancies in patients with Asherman’s *** propose a combination of nutritional intervention with the surgical placement of stem cells to improve endometrial quality to achieve pregnancy in a PCOS patient undergoing in vitro fertilization(IVF)*** SUMMARY After two failed IVF cycles,a metabolic intervention,consisting of a ketogenic diet with daily consumption of 50 g of carbohydrates(CH),was indicated until *** Syndrome was assessed using the Harmonizing Definition(3 of 5 pathologies:Central obesity,hypertension,hyperglycemia,hypertriglyceridemia,and dyslipidemia),and the Homeostatic Model Assessment of IR(HOMA-IR)was used to measure the level of *** IR improved,endometrial quality ***,two day 5-thawed embryos(euploid,donated oocyte–partner's sperm)failed to implant,suggesting endometrial quality improvement was ***,transmyometrial implantation of mesenchymal stem cells from the stromal vascular fraction of adipose tissue was performed to enrich the endometrial stem cell *** endometrial mean thickness for embryo transfer(6.9 mm)was achieved three months after stem cell treatment and continuous dietary control of *** euploid-day 5-thawed embryos(donated oocyte–partner's sperm)were transferred,and embryo implantation was confirmed on day 14 byβ-hCG s

关键词： Polycystic ovarian syndrome Insulin resistance Nutritional intervention Endometrial quality Stem cell treatment Case report

Transgenic Vegetable Breeding for Nutritional Quality and Health Benefits

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Food and Nutrition Sciences 2012年第9期3卷 1209-1219页

作者： Joao Silva Dias Rodomiro ortiz Technical University of Lisbon Instituto Superior de AgronomiaTapada da AjudaLisboaPortugal Swedish University of Agri-cultural Sciences AlnarpSweden

Vegetables are essential for well-balanced diets. About 3 billion people in the world are malnourished due to imbalanced diets. Vegetables can contribute to the prevention of malnutrition disorders. Genetic engineering enables vegetable breeders to incorporate desired transgenes into elite cultivars, thereby improving their value considerably. It further offers unique opportunities for improving nutritional quality and bringing other health benefits. Many vegetable crops have been genetically modified to improve traits such as higher nutritional status or better flavour, and to reduce bitterness or anti-nutritional factors. Transgenic vegetables can be also used for vaccine delivery. Consumers could benefit further from eating more nutritious transgenic vegetables, e.g. an increase of crop carotenoids by metabolic sink manipulation through genetic engineering appears feasible in some vegetables. Genetically engineering carrots containing increase Ca levels may boost Ca uptake, thereby reducing the incidence of Ca deficiencies such as osteoporosis. Fortified transgenic lettuce with zinc will overcome the deficiency of this micronutrient that severely impairs organ function. Folates deficiency, which is regarded as a global health problem, can also be overcomed with transgenic tomatoes with folate levels that provide a complete adult daily requirement. Transgenic lettuce with improved tocopherol and resveratrol composition may prevent coronary disease and arteriosclerosis and can contribute to cancer chemopreventative activity. Food safety and health benefits can also be enhanced through transgenic approaches, e.g. rural African resource-poor consumers will benefit eating cyanide-free cultivars of cassava. Biotechnology-derived vegetable crops will succed if clear advantages and safety are demonstrated to both growers and consumers.

关键词： Antioxidants GMOs Horticulture Phytochemicals Phytonutriceuticals Transgenic Vegetables

Liver histological changes and lipid peroxidation in the amphibian Ambystoma mexicanum induced by sediment elutriates from the Lake Xochimilco

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Journal of Environmental Sciences 2016年第8期28卷 156-164页

作者： Esperanza ortiz-Ordonez Eugenia López-López Jacinto Elías Sedeno-Díaz Esther Uría Ignacio Andrés Morales María Estela Pérez Mineko Shibayama Instituto Politécnico Nacional Depto.de Formación Básica e InterdisciplinariaCICS-USTAv.de los Maestros s/n.Col.Sto Instituto Politécnico Nacional Laboratorio de Evaluación de la Salud de Ecosistemas AcuáticosENCBProl.de Carpio y Plan de Ayala s/n.Col.Sto Instituto Politécnico Nacional Coordinación Politécnica para la SustentabilidadEdificio de la Biblioteca Nacional3er PisoAv.Instituto Politécnico Nacional s/nesq.Wilfrido MassieuCol Instituto Politécnico Nacional Laboratorio de HistologíaENCBProl.de Carpio y Plan de Ayala s/n.Col.Sto Unidad de Servicio Académico Acuario BiologíaFacultad de CienciasUniversidad Autónoma de MéxicoCiudad Universitaria Laboratorio de Infectómica Centro de Investigación y de Estudios Avanzados del IPNAv.Instituto Politécnico Nacional

Lacustrine sediments accumulate pollutants that input from the lake watershed and can be released to the water column by sediment resuspension; thus, pollutants can change their bioavailability and exert adverse effects to aquatic biota. Shallow-urban lakes are particularly susceptible to receive pollutants from urban discharges and sediment resuspension. Lake Xochimilco, in Mexico City, an urban-shallow lake, faces multiple problems： urban sprawl, overexploitation of aquifers, drying of springs, discharge of wastewater from treatment plants, and sediment resuspension. The aquatic biota living in this ecosystem is continuously exposed to the release of pollutants from the sediments. We assessed the risk that pollutants released from sediments from Lake Xochimilco, Touristic（TZ） and Agriculture zone（AZ）, can exert on a native amphibian species of the lake（Ambystoma mexicanum） through exposure bioassays to sediment elutriates. We evaluate alterations in the amphibian by three approaches： biochemical（level of lipid peroxidation,LPO）, cellular（ultrastructure） and the liver histology of A. mexicanum and we compare them with a batch control. Additionally, we assessed heavy metals（Pb, Cd and Hg） in *** from TZ showed the highest concentrations of the metals assessed. Organisms exposed to sediment elutriates from either study sites showed higher LPO values than control organisms（p 〈 0.05）. Organisms exposed to elutriates from the TZ showed the most conspicuous damages： hepatic vasodilation of sinusoids, capillaries with erythrocytes,leukocyte infiltration and cytoplasmic vacuolation in hepatocytes. The biological responses assessed reflected the risk that faces A. mexicanum when is exposed for prolonged periods to sediment resuspension in Lake Xochimilco.

关键词： Elutriates Amphibian Liver Histological alterations Ultrastructure Oxidative stress Metals Urban lake

Survivin activity in normal human osteoblasts and osteosarcoma cells

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中国口腔颌面外科杂志 2010年第3期8卷 241-249页

作者： Jan ortiz Maria Gabriela Marquez Henry M. Goldman School of Dental Medicine Boston University

PURPOSE: This study was designed to investigate and compare in vitro survivin activity in normal human osteoblast and MG-63 osteosarcoma cell cultures with and without vitamin D3. METHODS: Normal human alveolar bone explants were recovered from extraction sites of non-carious teeth of 9 healthy donors and cultured to the 2nd passage. MG-63 osteosarcoma cells were obtained from ATCC. To compare the survivin activities in these two types of cells and to determine the effect of vitamin D3 on survivin expression and associated activities of cell proliferation and differentiation, levels of survivin, osteocalcin and alkaline phosphatase were measured at 7-20 day cultures with and without vitamin D3 in both cultures of normal osteoblasts and osteosarcoma cells. Matched pair t-test and two sample independent t-test were applied for statistical analysis of the data. P values of 0.05 or less were considered statistically significant. RESULTS: A significantly higher level of survivin was detected in normal osteoblasts compared to osteosarcoma cells at 7 days without vitamin D3 treatment (P<0.01). Survivin expression in normal osteoblasts significantly decreased after vitamin D3 treatment at 7 days (P<0.05), but not at 20 days of culture (P=NS), compared to that in normal osteoblast culture without vitamin D3 treatment. Vitamin D3 had no effect on survivin expression in osteosarcoma cells at 7 or 20 days (P=NS). CONCLUSIONS: Expression of survivin in cultured normal human osteoblasts and osteosarcoma cells was positively identified. There is a positive correlation between higher expression of survivin and less differentiated osteoblasts that still retain their proliferative ability. Vitamin D3 has significant negative effect on expression of survivin in normal human osteoblasts but not on that in osteosarcoma cells.

关键词： Survivin Osteoblasts Osteosarcoma Apoptosis

Advances in Transgenic Vegetable and Fruit Breeding

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Agricultural Sciences 2014年第14期5卷 1448-1467页

作者： Joao Silva Dias Rodomiro ortiz University of Lisbon Instituto Superior de AgronomiaLisboaPortugal Swedish University of Agricultural Sciences AlnarpSweden

Vegetables and fruits are grown worldwide and play an important role in human diets because they provide vitamins, minerals, dietary fiber, and phytochemicals. Vegetables and fruits are also associated with improvement of gastrointestinal health, good vision, and reduced risk of heart disease, stroke, chronic diseases such as diabetes, and some forms of cancer. Vegetable and fruit production suffers from many biotic stresses caused by pathogens, pests, and weeds and requires high amounts of plant protection products per hectare. United States vegetables farmers are benefiting from growing transgenic squash cultivars resistant to Zucchini yellow mosaic virus, Watermelon mosaic virus, and Cucumber mosaic virus, which were deregulated and commercialized since 1996. Bt-sweet corn has also proven effective for control of some lepidopteran species and continues to be accepted in the fresh market in the USA, and Bt-fresh-market sweet corn hybrids are released almost every year. Likewise, transgenic Bt-eggplant bred to reduce pesticide use is now grown by farmers in Bangladesh. Transgenic papaya cultivars carrying the coat-protein gene provide effective protection against Papaya ring spot virus elsewhere. The transgenic “Honey Sweet” plum cultivar provides an interesting germplasm source for Plum pox virus control. Enhanced host plant resistance to Xanthomonas campestris pv. musacearum, which causes the devastating banana Xanthomonas wilt in the Great Lakes Region of Africa, was achieved by plant genetic engineering. There are other vegetable and fruit crops in the pipeline that have been genetically modified to enhance their host plant resistance to insects and plant pathogens, to show herbicide tolerance, and to improve features such as slow ripening that extends the shelf-life of the produce. Consumers could benefit further from eating more nutritious transgenic vegetables and fruits. Transgenic plant breeding therefore provides genetically enhanced seed embedded technol

关键词： Biosafety Fruits GM-Crops GMO Health Benefits IPM Market Nutrition Plant Breeding Sustainability Vegetables