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Alternatives to left lateral sector in paediatric liver transplantation-a systematic review on monosegmental and reduced grafts

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 567-576,I0005页

作者： Paschalis Gavriilidis ernest Hidalgo Department of Hepatopanceaticobiliary Surgery.Imperial College Healthcare NHS Trust Hammersmith HospitalLondonUK Department of Hepato-Pancreatic-Biliary Surgery and Liver Transplantation Hospital Universitari Vall d’HebronBarcelonaSpain

Background: Paediatric liver transplantation (pLT) is the treatment of choice for many liver conditions. However, it still poses relevant challenges, mainly related to the size of the recipients. Unlike in adults, excessive graft volume might represent an issue when the estimated graft-recipient-weight-ratio (GRWR) is significantly disproportionate. In this situation, the traditional left lateral sector (LLS) grafts are too big and other alternatives are required, such as monosegmental or reduced (including hyper-reduced) grafts (RLLS/HRLLS). Results with conventional LLS-pLT are excellent and replicating them with monosegmental or RLLS is challenging given (I) the technical complexity and (II) the need to overcome the large-for-size scenario. This article is to review the existing experience with monosegmental, RLLS/HRLLS grafts and appraise its results. Methods: Systematic search of the electronic databases, conducted from their inception until May 2020. Results: After scrutiny of the available literature, 16 studies were included reporting 330 patients transplanted with monosegmental and RLLS/HRLLS grafts. There were 10 re-grafts (6 of them <90 days);90% of grafts were LDLT. Overall, median recipient’s age and weight were 7 months (range, 5 days-22 months) and 5.8 kg (range, 2.6-8 kg) respectively. Median graft weight was 209 grams (range, 124-264 grams) and median GRWR was 3.5% (range, 2.7-5.6%). Hepatic artery and portal vein thrombosis overall incidence were 1.5% and 4.2%;120 out of the 330 pLT were monosegmental (37%) producing a smaller graft (median of 164 grams) and accordingly a lower GRWR (median 3.2%) compared to reduced LLS. With a median follow-up of 39 months (range, 6-87 months), the overall graft and patient survival were 84% (285/340) and 89% (295/330). Discussion: Monosegmental and RLLS/HRLLS grafts provide access to liver transplantation for very small recipients with excellent results comparable to the standard LLS.

关键词： Monosegmental monosegment(MSG) reduced hyper-reduced left lateral sector graft liver transplantation

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Socioeconomic performance of in-between open spaces in a post-socialist city of Tirana,Albania

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Frontiers of Architectural Research 2024年第4期13卷 858-875页

作者： Anna Yunitsyna ernest Shtepani Kevin Hasa Department of Architecture University Metropolitan TiranaTiranaAlbania Department of Architecture Epoka UniversityTiranaAlbania

The urban development of Tirana during the last few years is characterized by significant expansion,population growth and intensive residential *** post-socialist city became much denser,more diverse in terms of building types,taller,and relatively lacking in public *** study is focused on the evaluation of in-between open public spaces,which are specific for different urban *** spatial configuration of in-between spaces is analyzed in relation to the level of social interaction and the presence of economic *** neighborhoods,which belong to socialist and post-socialist tower,slab,and courtyard building typologies,are selected as case *** methodology includes Space Syntax analysis,site surveys,and observations aiming to comprehend the socioeconomic performance and spatial organization of the *** overlap of the activity pattern,human behavior mapping,syntactic measurements,and site survey allows understanding the performance of different types of open spaces and to find the in-between space that facilitates the development of social and economic activities.

关键词： In-between space Building typology Space syntax Social activity Socioeconomic performance

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Command and Control Cities in Global Space-economy Before and after 2008 Geo-economic Transition

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Chinese Geographical Science 2012年第3期22卷 334-342页

作者： ernest Ka Shing LEE Simon Xiaobin ZHAO Yang XIE International Center for China Development Studies & Department of Geography Faculty of Social Sciences the University of Hong Kong Hong Kong China Department for Rural Economic Development Research Center of the State Council Beijing 100010 China

The global economic downturn caused primarily by the US sub-prime mortgage crisis in 2007 engendered revenue loss of the multinational corporations. Existing studies have yet to depict the detrimental impacts on city＇s command and control functions induced by the sub-prime mortgage crisis together with its residual wave of global economic recession on the global spatial economy. Recent and previous studies have produced an ＇instant history＇ of the global spatial economy before the global economic downturn undermines the global economy in late 2008. How- ever, the waxes and wanes of major cities＇ command and control functions on the global economic arena before and after the outbreak of financial crisis and its associated geo-economic transitions are still poorly understood. This paper attempts to contribute a new set of customized data to update and fill in the gap in the literature with the investigation of the command and control functions of cities arotmd the world from 2005 to 2009. Particular attentions are paid to the time-space relationship of the geo-economic transition that can capture the recent historical images of the com- mand and control situation of different cities in the world.

关键词： global space-economy command and control cities geo-economic transition China

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Multimodality image fusion for diagnosing coronary artery disease

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The Journal of Biomedical Research 2013年第6期27卷 439-451页

作者： Marina Piccinelli ernest Garcia Department of Radiology and Imaging Sciences Emory University

Coronary artery disease （CAD） is one of the leading causes of death in the US and a substantial health-care burden in all industrialized societies. In recent years we have witnessed a constant strive towards the development and the clinical application of novel or improved detection methods as well as therapies. Particularly, noninvasive imaging is a decisive component in the cardiovascular field. Image fusion is the ability of combining into a sin- gle integrated display the anatomical as well as the physiological data retrieved by separated modalities. Clinical evidence suggests that it represents a promising strategy in CAD assessment and risk stratification by significantly improving the diagnostic power of each modality independently considered and of the traditional side-by-side in- terpretation. Numerous techniques and approaches taken from the image registration field have been implemented and validated in the context of CAD assessment and management. Although its diagnostic power is widely ac- cepted, additional technical developments are still needed to become a routinely used clinical tool.

关键词： image fusion CAD diagnosis computed tomography angiography nuclear imaging

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老人与海

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作者： ernest Hemingway []

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Investigating environmental quality among G20 nations: The impacts of environmental goods and low-carbon technologies in mitigating environmental degradation

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Geoscience Frontiers 2024年第1期15卷 84-96页

作者： ernest Baba Ali Samira Shayanmehr Riza Radmehr Richard Bayitse Ebenezer Agbozo Department of Economics University for Development StudiesTamale P.O.Box TL1350Ghana Department of Agricultural Economics Ferdowsi University of MashhadIran Council for Scientific and Industrial Research Institute of Industrial ResearchAccra P.O.Box LG 576Ghana Department of Big Data Analytics and Methods of Video Analysis Ural Federal University19 Mira Str60002 EkaterinburgRussia

Environmental goods and low-carbon technologies have long been identified as having the potential to drive long-term economic progress without compromising environmental quality. However, their exact role in mitigating environmental degradation are yet to be unravelled. In addressing this shortfall, the extant literature relied on research funding and patent application as proxies for green technologies. Having established the weaknesses in the use of these variables as proxies for green technologies, this study explored the role of trade in environmental goods and low-carbon technologies in boosting environmental quality among G20 nation using a panel dataset from 1994 to 2018. The study employed the Method of Moment quantile regression for the model estimation and the Ridge regression, Discroll-Kraay standard error, and the Newey-West standard error estimators to test the robustness of our findings. Our findings indicate that whereas environmental goods promote environmental quality, low-carbon technologies decrease same. Also, the study found economic growth to exert an aggravating effect on environmental quality, while foreign direct investments, natural resource rents, human capital development, and renewable energy consumption exert positive influence on environmental quality. Based on the findings of the study, G20 nations are encouraged to improve green market structures to improve the trade in environmental goods and low-carbon technologies. Also the share of renewable energy sources in the overall energy basket must be improved to help improve environmental quality.

关键词： Environmental quality Environmental goods Low-carbon technology G20 nations

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Aberrant cytokine milieu and signaling affect immune cell phenotypes and functions in tuberculosis pathology:What can we learn from this phenomenon for application to inflammatory syndromes?

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Cellular & Molecular Immunology 2021年第8期18卷 2062-2064页

作者： ernest Adankwah Julia Seyfarth Richard Phillips Marc Jacobsen Department of General Pediatrics Medical FacultyUniversity Hospital DüsseldorfHeinrich-Heine-UniversityDüsseldorfGermany Department of Medical Diagnostics College of Health SciencesKwame Nkrumah University of Science and Technology(KNUST)KumasiGhana Department of Medicine School of Medicine and DentistryCollege of Health SciencesKwame Nkrumah University of Science and Technology(KNUST)KumasiGhana Kumasi Centre for Collaborative Research in Tropical Medicine(KCCR) KumasiGhana

Our previous study published in Cellular&Molecular Immunology(Harling et al.1)described aberrant immunological features in the pathogenesis of ***,we provided evidence supporting an impact chain regarding aberrant high interleukin(IL)-6 and IL-10 cytokine expression and respective receptor signaling affecting T-cell functions in acute *** STAT3 phosphorylation,high expression of its key regulator suppressor of cytokine signaling(SOCS)3 and spontaneous IL-6/IL-10 secretion characterized CD4^(+)T cells from tuberculosis patients.

关键词： tuberculosis cytokine STAT3

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Nexus between selected macroeconomic variables and carbon emission in Kenya

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Regional Sustainability 2022年第3期3卷 233-243页

作者： James NJUMWA ernest SAINA Alfred SEREM Agricultural Economics and Resource Management Moi UniversityEldoret30100Kenya

Agriculture is not only influenced by climate change,but it is also one of the significant contributors of CO_(2) *** CO_(2) emission and macroeconomic variables is critical to solving the challenges and threats faced by Kenya’s agriculture and *** study used the Environmental Kuznets Curve(EKC)hypothesis and the autoregressive distribution lag model(ADLM)to analyze the relationships of CO_(2) emission with agricultural output,government direct investment,trade openness,and inflation rate in Kenya from 1983 to *** study found that there exists a positive(direct)relationship between CO_(2) emission and foreign direct investment in the long run in ***,CO_(2) emission and trade openness have a negative(indirect)and statistically significant relationship after the error correction term adjustment in the long ***,the relationship between CO_(2) emission and agricultural output is positive(direct)and statistically significant in the long *** is a positive(direct)and statistically insignificant relationship between CO_(2) emission and inflation rate in the short ***,the EKC hypothesis indicated that the Kenya’s economy is still on the environmental degradation trade-off through the gradual increase of both CO_(2) emission and agricultural *** results are important to Kenya’s economy because the derived insights will assist in relevant departments to formulate sustainable strategies to minimize environmental degradation.

关键词： CO_(2)emission Agricultural output Foreign direct investment Trade openness Inflation rate Environmental Kuznets Curve(EKC) Autoregressive distribution lag model (ADLM)

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What is a nation?

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作者： ernest Renan.

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Need of surveillance response systems to combat Ebola outbreaks and other emerging infectious diseases in African countries

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Infectious Diseases of Poverty 2014年第1期3卷 278-284,277页

作者： ernest Tambo Emmanuel Chidiebere Ugwu Jeane Yonkeu Ngogang Sydney Brenner Institute for Molecular Bioscience Wits 21st Century InstituteFaculty of Health SciencesUniversity of the WitwatersrandJohannesburgSouth Africa Center for Sustainable Malaria Control Department of BiochemistryFaculty of Natural and Agricultural SciencesUniversity of PretoriaPretoriaSouth Africa Faculty of Basic Medical Sciences Department of Human BiochemistryNnamdi Azikiwe University AwkaNnewi CampusNigeria Facultédes Sciences Biomédicales Département de BiochimieUniversitéde YaoundéYaoundéRépublique du Cameroun National Institute of Parasitic Diseases Chinese Center for Disease Control and Preventionand the WHO Collaborating Centre on MalariaSchisostomiasis and FilariasisShanghai 200025PR China

There is growing concern in Sub-Saharan Africa about the spread of the Ebola virus disease(EVD),formerly known as Ebola haemorrhagic fever,and the public health burden that it *** 1976,there have been 885,343 suspected and laboratory confirmed cases of EVD and the disease has claimed 2,512 cases and 932 fatality in West *** are certain requirements that must be met when responding to EVD outbreaks and this process could incur certain *** the purposes of this paper,five have been identified:(i)the deficiency in the development and implementation of surveillance response systems against Ebola and others infectious disease outbreaks in Africa;(ii)the lack of education and knowledge resulting in an EVD outbreak triggering panic,anxiety,psychosocial trauma,isolation and dignity impounding,stigmatisation,community ostracism and resistance to associated socio-ecological and public health consequences;(iii)limited financial resources,human technical capacity and weak community and national health system operational plans for prevention and control responses,practices and management;(iv)inadequate leadership and coordination;and(v)the lack of development of new strategies,tools and approaches,such as improved diagnostics and novel therapies including vaccines which can assist in preventing,controlling and containing Ebola outbreaks as well as the spread of the ***,there is an urgent need to develop and implement an active early warning alert and surveillance response system for outbreak response and control of emerging infectious *** the unending risks of transmission dynamics and resurgence is essential in implementing rapid effective response interventions tailored to specific local settings and ***,the following actions are recommended:(i)national and regional inter-sectorial and trans-disciplinary surveillance response systems that include early warnings,as well as critical human resources developme

关键词： Surveillance response system Ebola Outbreak Emerging infectious diseases Africa

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