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Alternatives to left lateral sector in paediatric liver transplantation-a systematic review on monosegmental and reduced grafts

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 567-576,I0005页

作者： Paschalis Gavriilidis ernest hidalgo Department of Hepatopanceaticobiliary Surgery.Imperial College Healthcare NHS Trust Hammersmith HospitalLondonUK Department of Hepato-Pancreatic-Biliary Surgery and Liver Transplantation Hospital Universitari Vall d’HebronBarcelonaSpain

Background: Paediatric liver transplantation (pLT) is the treatment of choice for many liver conditions. However, it still poses relevant challenges, mainly related to the size of the recipients. Unlike in adults, excessive graft volume might represent an issue when the estimated graft-recipient-weight-ratio (GRWR) is significantly disproportionate. In this situation, the traditional left lateral sector (LLS) grafts are too big and other alternatives are required, such as monosegmental or reduced (including hyper-reduced) grafts (RLLS/HRLLS). Results with conventional LLS-pLT are excellent and replicating them with monosegmental or RLLS is challenging given (I) the technical complexity and (II) the need to overcome the large-for-size scenario. This article is to review the existing experience with monosegmental, RLLS/HRLLS grafts and appraise its results. Methods: Systematic search of the electronic databases, conducted from their inception until May 2020. Results: After scrutiny of the available literature, 16 studies were included reporting 330 patients transplanted with monosegmental and RLLS/HRLLS grafts. There were 10 re-grafts (6 of them <90 days);90% of grafts were LDLT. Overall, median recipient’s age and weight were 7 months (range, 5 days-22 months) and 5.8 kg (range, 2.6-8 kg) respectively. Median graft weight was 209 grams (range, 124-264 grams) and median GRWR was 3.5% (range, 2.7-5.6%). Hepatic artery and portal vein thrombosis overall incidence were 1.5% and 4.2%;120 out of the 330 pLT were monosegmental (37%) producing a smaller graft (median of 164 grams) and accordingly a lower GRWR (median 3.2%) compared to reduced LLS. With a median follow-up of 39 months (range, 6-87 months), the overall graft and patient survival were 84% (285/340) and 89% (295/330). Discussion: Monosegmental and RLLS/HRLLS grafts provide access to liver transplantation for very small recipients with excellent results comparable to the standard LLS.

关键词： Monosegmental monosegment(MSG) reduced hyper-reduced left lateral sector graft liver transplantation

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Terlipressin versus placebo in living donor liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2022年第1期21卷 76-79页

作者： Paschalis Gavriilidis ernest hidalgo Robert P Sutcliffe Keith J Roberts Department of Hepato-Pancreato-Biliary and Liver Transplant surgery Queen Elizabeth University Hospitals Birmingham NHS Foundation TrustBirmingham B152THUK Department of Hepato-Pancreatico-Biliary Surgery and Transplantation Hospital Universitari Vall d’HebronBarcelona 08035Spain

To the Editor:Terlipressin is a long-acting synthetic analogue of vasopressin,demonstrating several potential benefits in the context of living donor liver transplantation(LDLT).During the recipient hepatec-tomy,terlipressin reduces the portal flow.Consequently,it may mitigate the extent of bowel congestion following portal vein clamping.By decreasing portal hyperperfusion and hypertension,it protects the graft from further injury and improves renal blood flow.

关键词： donor liver Terlipressin

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Navigated liver surgery:State of the art and future perspectives

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Hepatobiliary & Pancreatic Diseases International 2022年第3期21卷 226-233页

作者： Paschalis Gavriilidis Bjørn Edwin Egidijus Pelanis ernest hidalgo Nicola de’Angelis Riccardo Memeo Luca Aldrighetti Robert P Sutcliffe Department of Hepato-Pancreato-Biliary and Liver Transplant Surgery Queen Elizabeth University Hospitals Birmingham NHS Foundation TrustB152THUK The Intervention Centre and Department of HPB Surgery Oslo University Hospital and Faculty of MedicineUniversity of OsloOsloNorway Department of Hepato-Pancreatico-Biliary Surgery and Transplantation Hospital Universitari Vall d’HebronBarcelonaSpain Department of Digestive Surgery University Hospital Henri Mondor(AP-HP)94010 Creteil and University of Paris EstCreteilFrance Department of Hepatobiliary and Pancreatic Surgery Miulli HospitalAcquaviva delle FontiBari 70021Italy Division of Hepatobiliary Surgery San Raffaele HospitalVia Olgettina 60Milan 20132Italy

Background:In recent years,the development of digital imaging technology has had a significant influence in liver surgery.The ability to obtain a 3-dimensional(3D)visualization of the liver anatomy has provided surgery with virtual reality of simulation 3D computer models,3D printing models and more recently holograms and augmented reality(when virtual reality knowledge is superimposed onto reality).In addition,the utilization of real-time fluorescent imaging techniques based on indocyanine green(ICG)uptake allows clinicians to precisely delineate the liver anatomy and/or tumors within the parenchyma,applying the knowledge obtained preoperatively through digital imaging.The combination of both has transformed the abstract thinking until now based on 2D imaging into a 3D preoperative conception(virtual reality),enhanced with real-time visualization of the fluorescent liver structures,effectively facilitating intraoperative navigated liver surgery(augmented reality).Data sources:A literature search was performed from inception until January 2021 in MEDLINE(Pub Med),Embase,Cochrane library and database for systematic reviews(CDSR),Google Scholar,and National Institute for Health and Clinical Excellence(NICE)databases.Results:Fifty-one pertinent articles were retrieved and included.The different types of digital imaging technologies and the real-time navigated liver surgery were estimated and compared.Conclusions:ICG fluorescent imaging techniques can contribute essentially to the real-time definition of liver segments;as a result,precise hepatic resection can be guided by the presence of fluorescence.Furthermore,3D models can help essentially to further advancing of precision in hepatic surgery by permitting estimation of liver volume and functional liver remnant,delineation of resection lines along the liver segments and evaluation of tumor margins.In liver transplantation and especially in living donor liver transplantation(LDLT),3D printed models of the donor’s liver and models of the recipient’s hilar anatomy ca

关键词： Navigated Hepatic surgery 3D Computer assistance Image guidance Image guided surgery Indocyanine green 3D print Visual simulation Virtual reality Augmented reality Real-time navigated liver surgery

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Cardialysis 40年:领先欧洲的心血管研究机构

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中华心血管病杂志 2024年第1期52卷 107-110页

作者： Spitzer ernest Ren Claire Ben Cardialysis 鹿特丹3012KM 欧洲心血管研究所鹿特丹3012KM 荷兰鹿特丹伊拉斯谟大学医学中心胸部中心心内科鹿特丹3015GD

该文总结了Cardialysis的定位、过往成就及其未来发展的方向,其核心是在全球层面巩固和扩大临床试验研究者和临床研究专业人员之间的合作。Cardialysis的独特性在于其学术优势与独立性的结合以及高质量学术成果的产出。该文还总结了Card... 详细信息

该文总结了Cardialysis的定位、过往成就及其未来发展的方向,其核心是在全球层面巩固和扩大临床试验研究者和临床研究专业人员之间的合作。Cardialysis的独特性在于其学术优势与独立性的结合以及高质量学术成果的产出。该文还总结了Cardialysis心血管影像核心实验室和其过往完成的重要介入心脏病学临床试验;同时阐述了该组织提供的科技服务。此外,它还介绍了由Cardialysis(参与)创立的学术研究联盟(ARC)和欧洲心血管研究所(ECRI)两个非营利性学术组织。最后文章提到了Cardialysis成功的最重要贡献者,并分享了未来发展的方向。

关键词：心血管疾病核心实验室研究机构合作介入心脏病学心血管影像

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Metallaphotoredox-Catalyzed Three-Component Couplings for Practical Synthesis of Ureas and Carbamates

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Chinese Journal of Chemistry 2024年第3期42卷 264-270页

作者： ernest Koranteng Zhen-Cao Shu Yi-Yin Liu Qian Yang Bin Shi Qiang-Xian Wu Fen Tan Liang-Qiu Lu Wen-Jing Xiao Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction Ministry of EducationCollege of ChemistryCentral China Normal University152 Luoyu RoadWuhanHubei430079 China Wuhan Youji Industries Co. LtdNo.1 2nd Chemical Rd.WuhanHubei430082 China Hubei Key Laboratory of Purification and Application of Plant Anti-cancer Active Ingredients School of Chemistry and Life SciencesHubei University of EducationWuhanHubei430205 China State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhouGansu730000 China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiangHenan453007 China Wuhan Institute of Photochemistry and Technology WuhanHubei430082 China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai200032 China

Ureas are widely used in drugs,materials and catalysts because of their diamide structure,which can form strong hydrogen bonds.Therefore,it is of great scientific significance to develop efficient and green methods for the synthesis of urea compounds,especially unsymmetrical ureas.Here,we have disclosed novel and highly efficient three-component coupling reactions of organic halides,sodium cyanate and amines enabled by nickel/photoredox dual catalysis for the preparation of unsymmetrical ureas.The reaction features simple and safe operations,broad substrate scopes,and product diversities.It allows the facile synthesis of N-aryl/vinyl ureas from readily available,user-friendly feedstocks under mild conditions(27 examples,36%—98%yields).In addition,this method is further derived to alcohols as nucleophiles to synthesize a series of carbamates(15 examples,40%—95%yields).The mechanism experiment shows that the isocyanate produced by the coupling of halide and sodium cyanate may be the key intermediate in this reaction.

关键词： Cross-coupling Nickel Photoredox catalysis Three-component reaction Ureas Carbamates

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Efficient C-N coupling in electrocatalytic urea generation on copper carbonate hydroxide electrocatalysts

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Journal of Energy Chemistry 2024年第6期93卷 289-298,I0008页

作者： Yinuo Wang Yian Wang Qinglan Zhao Hongming Xu Shangqian Zhu Fei Yang ernest P.Delmo Xiaoyi Qiu Chi Song Juhee Jang Tiehuai Li Ping Gao MDanny Gu Minhua Shao Advanced Materials Thrust The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400GuangdongChina Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Department of Materials Science and Engineering Southern University of Science and Technology of Chin11088 Xueyuan BoulevardShenzhen 518055GuangdongChina Energy Institute and Chinese National Engineering Research Center for Control&Treatment of Heavy Metal PollutionThe Hong Kong University of Science and TechnologyKowloonHong KongChina Department of Chemistry City University of Hong KongTat Chee AvenueKowloonHong KongChina

Urea generation through electrochemical CO_(2) and NO_(3)~-co-reduction reaction(CO_(2)NO_(3)RR)is still limited by either the low selectivity or yield rate of urea.Herein,we report copper carbonate hydroxide(Cu_2(OH)_2CO_(3))as an efficient CO_(2)NO_(3)RR electrocatalyst with an impressive urea Faradaic efficiency of45.2%±2.1%and a high yield rate of 1564.5±145.2μg h~(-1)mg_(cat)~(-1).More importantly,H_(2) evolution is fully inhibited on this electrocatalyst over a wide potential range between-0.3 and-0.8 V versus reversible hydrogen electrode.Our thermodynamic simulation reveals that the first C-N coupling follows a unique pathway on Cu_2(OH)_2CO_(3) by combining the two intermediates,~*COOH and~*NHO.This work demonstrates that high selectivity and yield rate of urea can be simultaneously achieved on simple Cu-based electrocatalysts in CO_(2)NO_(3)RR,and provide guidance for rational design of more advanced catalysts.

关键词： Copper carbonate hydroxide Co-reduction Urea generation C-N coupling DFT calculation

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Evidence-based universal health coverage interventions delivery in infectious disease of poverty elimination and eradication

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Infectious Diseases of Poverty 2024年第1期13卷 90-90页

作者： ernest Tambo Chidiebere E.Ugwu Amberbir Alemayehu Anil Krishna Agnes Binagwaho Center for Leadership in Global Health Equity University of Global HealthEquityKigaliRwanda Africa Disease Intelligence Preparedness and Response(ADIPR)YaoundeCameroon Higher Institute of Health Sciences Faculty of MedicineBangangteCameroon Institute for Global Health Equity Research University of Global Health EquityKigaliRwanda Department of Human Biochemistry Nnamdi Azikiwe UniversityNnewiAnambraNigeria

The recent 78th United Nations General Assembly(UNGA)declaration relaunched a new health priority and political commitment in accelerating Universal Health Coverage(UHC),adopted by the United Nations(UN)in 2015 and are intended to be met by 2030.At mid-way point of UHC implementation,we advocate for the much needed program-matic implementation research,evidence-based interventions(EBls)policies and strategies leadership and manage-ment capacity building to enable robust,resilient and sustainable multi-sectoral partnerships,integrated coordination and governance mechanisms capabilities in accelerating UHC package mainly infectious diseases of poverty elimina-tion and eradication agenda.

关键词： elimination enable poverty

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Investigating environmental quality among G20 nations: The impacts of environmental goods and low-carbon technologies in mitigating environmental degradation

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Geoscience Frontiers 2024年第1期15卷 84-96页

作者： ernest Baba Ali Samira Shayanmehr Riza Radmehr Richard Bayitse Ebenezer Agbozo Department of Economics University for Development StudiesTamale P.O.Box TL1350Ghana Department of Agricultural Economics Ferdowsi University of MashhadIran Council for Scientific and Industrial Research Institute of Industrial ResearchAccra P.O.Box LG 576Ghana Department of Big Data Analytics and Methods of Video Analysis Ural Federal University19 Mira Str60002 EkaterinburgRussia

Environmental goods and low-carbon technologies have long been identified as having the potential to drive long-term economic progress without compromising environmental quality. However, their exact role in mitigating environmental degradation are yet to be unravelled. In addressing this shortfall, the extant literature relied on research funding and patent application as proxies for green technologies. Having established the weaknesses in the use of these variables as proxies for green technologies, this study explored the role of trade in environmental goods and low-carbon technologies in boosting environmental quality among G20 nation using a panel dataset from 1994 to 2018. The study employed the Method of Moment quantile regression for the model estimation and the Ridge regression, Discroll-Kraay standard error, and the Newey-West standard error estimators to test the robustness of our findings. Our findings indicate that whereas environmental goods promote environmental quality, low-carbon technologies decrease same. Also, the study found economic growth to exert an aggravating effect on environmental quality, while foreign direct investments, natural resource rents, human capital development, and renewable energy consumption exert positive influence on environmental quality. Based on the findings of the study, G20 nations are encouraged to improve green market structures to improve the trade in environmental goods and low-carbon technologies. Also the share of renewable energy sources in the overall energy basket must be improved to help improve environmental quality.

关键词： Environmental quality Environmental goods Low-carbon technology G20 nations

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可解释的视觉问答研究进展

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计算机应用研究 2024年第1期41卷 10-20页

作者：张一飞孟春运蒋洲栾力 ernest Domanaanmwi Ganaa 江苏科技大学经济管理学院江苏镇江212100 江苏大学计算机科学与通信工程学院江苏镇江212013 中国科学技术大学公共事务学院合肥230026 希拉·利曼技术大学应用科学与技术学院加纳瓦00233

在视觉问答(VQA)任务中,“可解释”是指在特定的任务中通过各种方法去解释模型为什么有效。现有的一些VQA模型因为缺乏可解释性导致模型无法保证在生活中能安全使用,特别是自动驾驶和医疗相关的领域,将会引起一些伦理道德问题,导致无法... 详细信息

在视觉问答(VQA)任务中,“可解释”是指在特定的任务中通过各种方法去解释模型为什么有效。现有的一些VQA模型因为缺乏可解释性导致模型无法保证在生活中能安全使用,特别是自动驾驶和医疗相关的领域,将会引起一些伦理道德问题,导致无法在工业界落地。主要介绍视觉问答任务中的各种可解释性实现方式,并分为了图像解释、文本解释、多模态解释、模块化解释和图解释五类,讨论了各种方法的特点并对其中的一些方法进行了细分。除此之外,还介绍了一些可以增强可解释性的视觉问答数据集,这些数据集主要通过结合外部知识库、标注图片信息等方法来增强可解释性。对现有常用的视觉问答可解释方法进行了总结,最后根据现有视觉问答任务中可解释性方法的不足提出了未来的研究方向。

关键词：视觉问答视觉推理可解释性人工智能自然语言处理计算机视觉

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《获而一无所获》(节选)

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中国翻译 2024年第3期45卷 171-173页

作者：海明威曹明伦(译) 不详

[1]我们送这家伙去冲流钓鱼都三个星期了。在过海之前他曾付我一百美元,用来打点领事,结清海关,购买鱼饵,给船加油,除此之外我还没见过他一分钱。他以每天三十五美元的价格租船,我负责提供所有的钓鱼用具。他晚上睡在旅馆里,每天早上登... 详细信息

[1]我们送这家伙去冲流钓鱼都三个星期了。在过海之前他曾付我一百美元,用来打点领事,结清海关,购买鱼饵,给船加油,除此之外我还没见过他一分钱。他以每天三十五美元的价格租船,我负责提供所有的钓鱼用具。他晚上睡在旅馆里,每天早上登船。是埃迪给我揽的这笔生意,所以我不得不带着他。每天付给他四美元。

关键词：三个星期租船埃迪

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