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Building an e-Portfolio with a learning plan centric approach

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第1期13卷 37-47页

作者： Lam-for KWOK ka-shing CHAN Department of Computer Science City University of Hong Kong

A portfolio records achievements in the personal growth process. A personal development e-Portfolio assists an individual in planning his/her development path and reflecting upon his/her own learning. In this article, we propose an approach to constructing a personal development portfolio. An abstract information model is presented to support such a portfolio. The information model is proposed based upon and according to IMS standards. The use of this approach is illustrated by way of a prototype e-Portfolio system. The usage scenario and limitations of such a portfolio are also discussed.

关键词： E-Portfolio Educational technology system Lifelong learning

Gastrointestinal bleeding in patients on novel oral anticoagulants:Risk,prevention and management

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World Journal of Gastroenterology 2017年第11期23卷 1954-1963页

作者： ka-shing Cheung Wai K Leung Department of Medicine The University of Hong KongQueen Mary HospitalHong KongChina

Novel oral anticoagulants(NOACs), which include direct thrombin inhibitor(dabigatran) and direct factor Xa inhibitors(rivaroxaban, apixaban and edoxaban), are gaining popularity in the prevention of embolic stroke in non-valvular atrial fibrillation as well as in the prevention and treatment of venous thromboembolism. However, similar to traditional anticoagulants, NOACs have the side effects of bleeding, including gastrointestinal bleeding(GIB). Results from both randomized clinical trials and observations studies suggest that high-dose dabigatran(150 mg b.i.d), rivaroxaban and high-dose edoxaban(60 mg daily) are associated with a higher risk of GIB compared with warfarin. Other risk factors of NOAC-related GIB include concomitant use of ulcerogenic agents, older age, renal impairment, Helicobacter pylori infection and a past history of GIB. Prevention of NOAC-related GIB includes proper patient selection, using a lower dose of certain NOACs and in patients with renal impairment, correction of modifiable risk factors, and prescription of gastroprotective agents. Overt GIB can be managed by withholding NOACs followed by delayed endoscopic treatment. In severe bleeding, additional measures include administration of activated charcoal, use of specific reversal agents such as idarucizumab for dabigatran and andexanent alfa for factor Xa inhibitors, and urgent endoscopic management.

关键词： Warfarin Endoscopy Apixaban Edoxaban Gastrointestinal bleeding Dabigatran Rivaroxaban Novel anticoagulants

Multiomics approaches to uncover endometrial receptivity in embryo implantation:a mini-review

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Reproductive and Developmental Medicine 2024年第3期8卷 178-185页

作者： Sudini R.Fernando Yang Yan Manish Kumar Hoi-Lam Lai Yin-Lau lee ernest H.Y.Ng William S.B.Yeung kai-Fai lee Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong SAR 999077China Department of Animal Science Faculty of Animal Science and Export AgricultureUva Wellassa UniversityBadullaSri Lanka Shenzhen Key Laboratory of Fertility Regulation The University of Hong Kong-Shenzhen HospitalFutian DistrictShenzhen 518053China

Successful implantation requires concerted interactions during the apposition,adhesion,and invasion of the embryo into a receptive ***,the embryo implantation rate for assisted reproduction remains low despite the transfer of good quality *** in endometrial transcriptomics,proteomics,lipidomics,and even microbiota all play important roles in embryo ***,the expression of steroid hormone-regulated adhesive and anti-adhesive molecules during the embryo implantation window is becoming an area of increasingly intense *** review(a)summarizes the different molecules expressed in the receptive endometrium and(b)proposes the use of surface protein markers to predict pregnancy outcomes from assisted reproduction.

关键词： Cell surface proteins Steroid regulation Endometrial receptivity Receptivity marker Infertility

Risk of gastric cancer development after eradication of Helicobacter pylori

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World Journal of Gastrointestinal Oncology 2018年第5期10卷 115-123页

作者： ka-shing cheung Wai K Leung Department of Medicine The University of Hong Kong Queen Mary Hospital

Helicobacter pylori(H. pylori) infection is the most important risk factor for gastric cancer(gc) development through the correa's gastric carcinogenesis cascade. However, H. pylori eradication alone does not eliminate gc, as pre-neoplastic lesions(atrophic gastritis, intestinal metaplasia and dysplasia) may have already developed in some patients. It is therefore necessary to identify patients at high-risk for gastric cancer after H. pylori eradication to streamline the management plan. If the patients have not undergone endoscopy with histologic assessment, the identification of certain clinical risk factors and non-invasive testing(serum pepsinogen) can predict the risk of atrophic gastritis. For those with suspected atrophic gastritis, further risk stratification by endoscopy with histologic assessment according to validated histologic staging systems would be advisable. Patients with higher stages may require long-term endoscopic surveillance. Apart from secondary prevention to reduce deaths by diagnosing gc at an early stage, identifying medications that could potentially modify the gc risk would be desirable. The potential roles of a number of medications have been suggested by various studies, including proton pump inhibitors(PPIs), aspirin, statins and metformin. However, there are currently no randomized clinical trials to address the impact of these medications on gc risk after H. pylori eradication. In addition, most of these studies failed to adjust for the effect of concurrent medications on gc risk. Recently, large population-based retrospective cohort studies have shown that PPIs were associated with an increased gc risk after H. pylori eradication, while aspirin was associated with a lower risk. The roles of other agents in reducing gc risk after H. pylori eradication remain to be determined.

关键词： Gastric adenocarcinoma Stomach cancer Helicobacter pylori Chemoprevention Intestinal metaplasia

Application of Big Data analysis in gastrointestinal research

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World Journal of Gastroenterology 2019年第24期25卷 2990-3008页

作者： ka-shing Cheung Wai K Leung Wai-kay Seto Department of Medicine The University of Hong KongQueen Mary HospitalHong KongChina Department of Medicine The University of Hong Kong- Shenzhen HospitalShenzhen 518053Guangdong ProvinceChina

Big Data,which are characterized by certain unique traits like volume,velocity and value,have revolutionized the research of multiple fields including *** Data in health care are defined as large datasets that are collected routinely or automatically,and stored *** the rapidly expanding volume of health data collection,it is envisioned that the Big Data approach can improve not only individual health,but also the performance of health care *** application of Big Data analysis in the field of gastroenterology and hepatology research has also opened new research *** it retains most of the advantages and avoids some of the disadvantages of traditional observational studies(case-control and prospective cohort studies),it allows for phenomapping of disease heterogeneity,enhancement of drug safety,as well as development of precision medicine,prediction models and personalized *** randomized controlled trials,it reflects the real-world situation and studies patients who are often under-represented in randomized controlled ***,residual and/or unmeasured confounding remains a major concern,which requires meticulous study design and various statistical adjustment *** potential drawbacks include data validity,missing data,incomplete data capture due to the unavailability of diagnosis codes for certain clinical situations,and individual *** continuous technological advances,some of the current limitations with Big Data may be further *** review will illustrate the use of Big Data research on gastrointestinal and liver diseases using recently published examples.

关键词： Healthcare dataset Epidemiology Gastric cancer Inflammatory bowel disease Colorectal cancer Hepatocellular carcinoma Gastrointestinal bleeding

Housing price dispersion in the presale market

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Economic and Political Studies 2020年第1期8卷 65-81页

作者： Siu Kei Wong ka shing Cheung Department of Real Estate and Construction University of Hong Kongthe Hong Kong SARChina The Ronald Coase Centre for Property Rights Research University of Hong Kongthe Hong Kong SARChina Department of Property The University of Auckland Business SchoolAucklandNew Zealand

Sale before completion(***)is a common practice that real estate developers use to sell residential *** presale buyers are unable to inspect uncompleted units,developers may take advantage of asymmetric information and release information about quality to the market *** search theory also suggests that incomplete pricing information,especially for new products,will induce a less competitive market that is characterised by dispersed presale *** price dispersion be reduced if developers were required to provide more quality and pricing information?In this study,we argue that this is not necessarily the *** conduct a natural experiment using a new information disclosure ordinance governing first-hand residential sales in the Hong Kong SAR,*** find that the ordinance reduced the price dispersion of presale units with asymmetric information about property quality,but increased their price dispersion when limited pricing information(*** trading volume)was available in the *** a critical test,we further show that the ordinance increased price dispersion even more after the units were *** suggests that the ordinance has indeed made presale pricing more difficult because developers are no longer allowed to use different strategies to test market demand.

关键词： Price dispersion presale housing market pricing information quality information natural experiment

Molecular Evidence for the Hybrid Origin of Bauhinia blakeana(Caesalpinioideae)

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Journal of Integrative Plant Biology 2008年第1期50卷 111-118页

作者： Chun Yin Mak ka shing Cheung Pui Ying Yip Hoi Shan Kwan Department of Biology The Chinese University of Hong KongShatinHong KongChina

Bauhinia blakeana Dunn is the Hong Kong Special Administrative Region emblem and a popular horticultural species in many Asian countries. It was first described as a new species from Hong Kong almost a century ago. This plant is sterile and has long been considered a hybrid, possibly from two related species, B. purpurea and B. variegata. However, not much evidence based on molecular methods was available to support this hypothesis. In this study, sequences of internal transcribed spacer I （ITS1）, rbcL and atpB-rbcL intergenic spacer for five Bauhinia species and two varieties of one of the species were determined and compared. There were two types of ITS1 sequences in B. blakeana, one indistinguishable from that of B. purpurea and the other one identical to that of B. variegata. This confirmed that B. blakeana was a hybrid of these two species. Chloroplast atpB-rbcL intergenic spacer sequence of B. blakeana was identical to that of B. purpurea, indicating that B. purpurea was the female parent. The hybridization event seemed to occur only recently and was a rare incident. Its occurrence was likely facilitated by interspecific pollen competition. It appeared that human efforts played a crucial role in the preservation and ubiquity of B. blakeana.

关键词： atpB-rbcL intergenic spacer Bauhinia internal transcribed spacer 1 interspecific hybrid interspecific pollen competition.

Inferior vena cava reconstruction in extended right hepatectomy

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 533-534页

作者： karin KY Ho Sui Ling Sin Kin Pan Au Henry HY lee Daniel TL Chan Albert Chan Department of Surgery The University of Hong Kong102 Pok Fu Lam RoadHong KongChina Department of Surgery Yan Chai Hospital7 Yan Chai StreetHong KongChina State Key Laboratory of Liver Research(Li ka shing Faculty of Medicine The University of Hong Kong)102 Pok Fu Lam RoadHong KongChina

To the Editor : Barcelona Clinic Liver Cancer(BCLC) Stage C hepatocellular carcinoma(HCC) with vascular invasion has been considered unresectable. However, the curative rate from systemic treatment is rather dismal. Even with the use of immunotherapy, complete remission is less than 10% [ 1 ]. On the contrary, recent advances in transplant oncology, especially in the application of liver transplant-related surgical techniques in complex liver resections, make the operation possible for patients with locally advanced HCC who were previously considered to be unresectable [ 2 ]. We hereby present the surgical management of a patient with giant HCC in right liver lobe with inferior vena cava(IVC) invasion.

关键词： invasion vena Liver

Carvedilol Versus Other Nonselective Beta Blockers for Variceal Bleeding Prophylaxis and Death: A Network Meta-analysis

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Journal of Clinical and Translational Hepatology 2023年第5期11卷 1143-1149页

作者： ka-shing Cheung Chiu-Hang Mok Lok-ka Lam Xian-Hua Mao Lung-Yi Mak Wai-kay Seto Man-Fung Yuen Department of Medicine School of Clinical MedicineThe University of Hong KongQueen Mary HospitalHong KongChina Department of Medicine The University of Hong Kong-Shenzhen HospitalShenzhenGuangdongChina School of Clinical Medicine The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

Background and Aims:We aimed to perform a network meta-analysis(NWM)to examine comparative effectiveness of non-selective beta blockers(NSBBs)on prophylaxis of gastroesophageal variceal bleeding(GVB)and mortality ***:MEDLINE(OVID)and EMBASE databases were searched for eligible randomized clinical trials(RCTs)from inception to July 3,*** of interest included primary/secondary prophylaxis of GVB,failure to achieve hepatic venous pressure gradient(HVPG)decremental response,liver-related and all-cause mortality.A Bayesian NWM was performed to derive relative risk(RR)with 95%credible intervals(CrIs).The ranking probability of each NSBB was assessed by surface under cumulative ranking curve(SUCRA).Results:Thirty-three RCTs including 3,188 cirrhosis patients with gastroesophageal varices were *** with placebo,nadolol ranked first for reducing variceal bleeding[RR:0.25,(95%CrI:0.11–0.51);SUCRA:0.898],followed by carvedilol[RR:0.33,(95%CrI:0.11–0.88);SUCRA:0.692]and propranolol[RR:0.52,(95%CrI:0.37–0.75);SUCRA:0.405].Carvedilol was more effective than propranolol in achieving HVPG decremental response[RR:0.43,(95%CrI:0.26–0.69)].Carvedilol ranked first for reducing all-cause mortality[RR:0.32,(95%CrI:0.17–0.57);SUCRA:0.963],followed by nadolol[RR:0.48,(95%CI:0.29–0.77);SUCRA:0.688],and propranolol[RR:0.77,(95%CI:0.58–1.02);SUCRA:0.337].Similar findings were observed for liver-related *** ranked the *** RR of adverse events was 4.38,(95%CrI:0.33–161.4);SUCRA:0.530,followed by propranolol[RR:7.54,(95%CrI:1.90–47.89);SUCRA:0.360],and nadolol[RR:18.24,(95%CrI:91.51–390.90);SUCRA:0.158].Conclusions:Carvedilol is the preferred NSBB with better survival benefit and lower occurrence of adverse events among patients with gastroesophageal varices.

关键词： NSBB Carvedilol Nadolol Propranolol Varices Cirrhosis CPSH