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白细胞介素-2新型突变蛋白在炎症性肠病治疗中的价值

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中华炎性肠病杂志（中英文） 2022年第1期6卷 79-82页

作者：王二嫚刘占举同济大学附属第十人民医院消化内科上海200072

白细胞介素(IL)-2在免疫调节中具有双重作用,一方面可作用于效应细胞激活免疫反应,另一方面可作用于调节性T细胞发挥免疫抑制作用,因此成为炎症性肠病和自身免疫性疾病的治疗靶点之一。低剂量的IL-2已用于某些炎性和自身免疫性疾病的治... 详细信息

白细胞介素(IL)-2在免疫调节中具有双重作用,一方面可作用于效应细胞激活免疫反应,另一方面可作用于调节性T细胞发挥免疫抑制作用,因此成为炎症性肠病和自身免疫性疾病的治疗靶点之一。低剂量的IL-2已用于某些炎性和自身免疫性疾病的治疗,但因其不良反应限制了IL-2在临床上的应用。为了提高IL-2疗效减少不良反应,目前利用基因工程技术合成了多种IL-2突变蛋白,为IL-2在炎症性肠病和自身免疫性疾病中的应用提供了新的可能。

关键词：白细胞介素-2 突变蛋白炎性和自身免疫性疾病

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技术进步(贡献)率的本质

中国科技论坛 2014年第8期 138-141页

作者：曾尔曼厦门产业技术研究院厦门市生产力促进中心福建厦门361024

以《资本论》不变资本C与可变资本V替代柯布-道格拉斯生产函数的主要变量(K,L),构建了马克思生产力经济学的数理体系框架,以得到的马克思生产函数Q、剩余价值生产函数M、成本函数Cv以及利润率函数p,结合斯密-杨格的分工理论并运用新古... 详细信息

以《资本论》不变资本C与可变资本V替代柯布-道格拉斯生产函数的主要变量(K,L),构建了马克思生产力经济学的数理体系框架,以得到的马克思生产函数Q、剩余价值生产函数M、成本函数Cv以及利润率函数p,结合斯密-杨格的分工理论并运用新古典分析技术,将技术进步的本质——劳动分工以柯布-道格拉斯生产函数的劳动力产出弹性表征作为分工系数,从而对技术进步率——索洛余值的经济学内涵赋予了马克思主义观点的阐释。

关键词：索洛余值内生增长劳动分工

Drug dependence and its risk factors in emergency department patients:A retrospective cross-sectional study

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Journal of Acute Disease 2021年第5期10卷 202-207页

作者： Erdal Yavuz Kasim Turgut Umut Gulacti Ugur Lok erman Altunisik Department of Emergency Medicine Adiyaman University Medical FacultyAdiyamanTurkey Department of Neurology Adiyaman University Medical FacultyAdiyamanTurkey

Objective:To determine the characteristics and risk factors of drug dependence among patients who were administered drugs with addictive potential(DAP)in an emergency department(ED).Methods:This retrospective cross-sectional study included patients who were administered DAP 3 or more times in the emergency room between September 1,2019 and March 1,*** demographic and baseline information were *** the prescibed DAP,the reasons to use these drugs,secondary drug dependence,the department where DAP were first prescribed,types of doctors who preferred to prescribed DAP,and the risk factors for the development of drug dependence were ***:A total of 3000 patients were screened from medical records,and among them,80 patients developed drug *** dependence only developed for tramadol(n=57,71.3%),diazepam(n=11,13.8%),and biperiden(n=12,15.0%).Tramadol was the most frequently prescribed drug(n=57,71.3%).The most common reason for drug dependence was psychiatric disorders(n=29,36.3%).Drug dependence developed in renal colic patients due to the administration of tramadol(n=7,100%).On the contrary,dependence to biperiden were mainly developed in patients with psychiatric complaints(n=12,41.4%).The rate of secondary drug dependence was 15%(n=12).Of the Biperiden users,41.7%developed secondary drug dependence on *** DAP were first prescribed in the ED(n=52,65%),and the specialist preferred to prescribe DAP(n=43,53.8%).For the development of dependence,the presence of renal colic(OR:3.387,95%confidence interval(CI):1.473-7.788,P=0.004)and low back pain(OR:5.778,95%CI:2.779-12.014,P<0.001)were the risk ***:Most DAP were first prescribed in the ED compared to other departments,and specialist are preferred to use *** is the most commonly used drugs caused drug *** disorder patients are easier to develope drug ***,renal colic and low back pain patients needs more attention to

关键词： Drug with addictive portential Drug dependence Emergency room Risk

Characterization of the Natural and Organomodified Clay Soil of Moukosso (Republic of Congo) by Dimethylsulfoxide: Application to the Adsorption of Lead (II) in Aqueous Solution

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Materials Sciences and Applications 2023年第2期14卷 63-77页

作者： Ottard Arnaud M. R. Ossiby Mwa Ngo Ferland Ngoro-Elenga erman E. Nzaba Madila Zita F. Diamouangana Mpissi Exaucé R. Kinzonzi Ngongot Joseph Marie Moutou Laboratoire de Chimie Minérale et Appliquée Faculté des Sciences et Techniques Université Marien Ngouabi Brazzaville Congo Faculté des Sciences et Techniques Université Marien Ngouabi Brazzaville Congo Centre de Recherches Géologiques et Minières Brazzaville Congo Institut de Recherche sur l’Hydrogène Université du Québec à Trois-Rivières Québec Canada Ecole Normale Supérieure Université Marien Ngouabi Brazzaville Congo

In this study, the authors characterized the raw clayey soil of Moukosso and modified by dimethylsulfoxide (DMSO) by several analytical methods, namely: X-ray diffraction (XRD), Fourier transform infrared (FTIR) and gravimetric thermal analysis (TGA). The cation exchange capacity (CEC) was also determined. Mineralogical analysis by XRD revealed the presence of muscovite (29.7%), kaolinite (8.9%), anatase (2.4%) and quartz (58.9%). The characterization of the organo-clay by infrared and by thermogravimetric analysis confirmed the intercalation of DMSO by the presence of vibration bands at 1008 cm-1 and 1070 cm-1 and a strong increase in the loss of mass. The cation exchange capacity of the raw material is 7.4 meq/100g. Rapid adsorption of Pb2+ ions was observed between 5 and 15 minutes of stirring time in both cases (raw clay and organomodified clay). The modeling of the isotherms by the models of Langmuir and Freudlich showed that these are of type S with a maximum amount of adsorption of 22.471 mg/g for the fine fraction and 41.493 mg/g for the clay intercalated with DMSO. Langmuir’s model best reproduces the experimental data of this study.

关键词： Clay Dimethylsulfoxide Organoclay Characterization Adsorption Isotherm Moukosso

Labial Fusion Causing Coital and Voiding Difficulty in a Young Woman

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Advances in Sexual Medicine 2013年第1期3卷 11-13页

作者： Murat Ozekinci Selcuk Yucel Cem Sanhal Munire erman Akar Department of Obstetrics and Gynecology Akdeniz University School of Medicine Antalya Turkey Department of Urology Akdeniz University School of Medicine Antalya Turkey

Adhesions of the labia are extremely rare in the reproductive population with only a few cases described in the literature. We report a young female patient with coital and voiding difficulty. The patient was a 22-year-old woman presented with voiding difficulty and inability to achieve sexual intercourse. Clinical examination revealed normally developed labia majora, clitoris, and vaginal opening, but fused labia minora and pinhole external urethral orifice. Intraoperatively, labial fusion was dissected with sharp dissection. Urethral dilatation was performed with dittel dilators. Local estrogen ointment was administered postoperatively for four weeks resulting with complete resolution of coital and voiding symptoms.

关键词： Labial Fusion Labial Adhesion

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基于瓦斯燃烧余热利用的煤矸石快速风化成土

环境工程学报 2023年第10期17卷 3359-3366页

作者：胡寒谢迩嫚张清田森林胡学伟昆明理工大学环境科学与工程学院昆明650500 云南省煤炭产业集团有限公司昆明650231

基于瓦斯燃烧的余热利用,对煤矸石进行高频率的干湿/冷热交替处理,加速煤矸石结构风化粉化,提升风化产物的保墒-透气-蓄肥等土壤学性能。结果表明煤矸石在50℃下经30次干湿/冷热交替后粒径显著下降,粗砂(5~10 mm)比例下降43%,细砂(<1 mm... 详细信息

基于瓦斯燃烧的余热利用,对煤矸石进行高频率的干湿/冷热交替处理,加速煤矸石结构风化粉化,提升风化产物的保墒-透气-蓄肥等土壤学性能。结果表明煤矸石在50℃下经30次干湿/冷热交替后粒径显著下降,粗砂(5~10 mm)比例下降43%,细砂(<1 mm)含量上升35%,持水率可达12.78%,达到砂土持水标准,持水率、微粒含量、毛管孔隙度与循环次数呈正比;颗粒粉化主要受矿物溶出产生溶蚀裂隙、矿物重构并干燥产生盐结晶强化裂隙涨裂,以及黏土矿物的不均匀性膨胀/收缩的影响;风化产物种植紫花苜蓿,发芽率在80%以上,发芽时间、茎长等优于低扰动样品。本研究结果可为瓦斯与煤矸石的能源化、资源化协同利用提供参考。

关键词：瓦斯煤矸石余热利用风化粉化矿物溶解重构

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基于水量平衡下的灌区用水计划编制方法综述

排灌机械工程学报 2022年第3期40卷 294-301页

作者：丰尔蔓李援农胡战峰杨靖闵迪西北农林科技大学水利与建筑工程学院陕西杨凌712100 陕西省桃曲坡水库灌溉中心陕西铜川727031

为了精准指导农田灌溉,合理优化渠系输配水,提高水资源的利用率、灌区的管理水平和总效益,对灌区用水计划的编制方法展开了理论研究.将用水计划的编制过程概括为实时灌溉预报和渠系配水两部分,分别进行归纳整理和分析.在对国内灌区用水... 详细信息

为了精准指导农田灌溉,合理优化渠系输配水,提高水资源的利用率、灌区的管理水平和总效益,对灌区用水计划的编制方法展开了理论研究.将用水计划的编制过程概括为实时灌溉预报和渠系配水两部分,分别进行归纳整理和分析.在对国内灌区用水计划的编制方式进行了解的基础上,着重介绍了利用土壤水分平衡方程进行实时灌溉预报的方法,总结各参数预测值和计算修正值的获取方法,分析对比各方法的适用范围,提炼普遍灌区实时灌溉预报中适用的方法.为了优化田间渠系配水次序和配水量,以保证作物得到及时有效灌溉,归纳总结了国内灌区常用的渠系配水模型,论述了常见的目标函数及相关约束的选取原则,并指出其局限性和可能的发展趋势.研究结果可为各灌区进行实时灌溉预报和建立优化配水模型提供借鉴与参考.

关键词：灌区用水管理用水计划土壤水分平衡方程实时灌溉预报渠系配水模型

Serum arylesterase and paraoxonase activity in patients with chronic hepatitis

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World Journal of Gastroenterology 2005年第46期11卷 7351-7354页

作者： Suleyman Sirri Kilic Suleyman Aydin Nermin Kilic Fazilet erman Suna Aydin Ilhami Celik Department of Infection and Clinical MicrobiologyMedical School (Firat Medical Center) Firat UniversityElazig 23119Turkey Department of Biochemistry and Clinical BiochemistryMedical School (Firat Medical Center) Firat UniversityElazig 23119Turkey Department of Medical EducationMedical School (Firat Medical Center) Elazig 23119Turkey

AIM: To investigate the relationship between serum paraoxonase (PON1), AST, ALT, GGT, and arylesterase (AE) activity alterations and the degree of liver damage in patients with chronic ***: We studied 34 chronic hepatitis patients and 32 control subjects, aged between 35 and 65 years,in the Department of Infection and Clinical Microbiology at the Firat University School of Medicine. Blood samples were collected from subjects between 8:00 and 10:00 a.m. following a 12-h fast. Baseline and salt-stimulated PON1 activities were measured by the hydrolysis of paraoxon. Phenyl acetate was used as the substrate and formed phenol was measured spectrophotometrically at 270 nm after the addition of a 10-fold diluted serum sample in AE activity ***: The results of this investigation revealed that the levels of AE activity decreased from 132±52 to 94±36 (29%), baseline PON1 activity from 452±112 to 164±67 (64%), salt-stimulated PON1 activity from 746±394 to 294±220 (61%), HDL from 58.4±5.1 to 47.2±5.6(20%), triglyceride from 133±51.2 to 86±34.0 (35%),while a slight increase in the level of LDL (from 163±54.1 to 177.3±56.0; 9%) and significant increases in the levels of AST (from 29±9.3 to 98±44), ALP (from 57.2±13.1 to 91±38.1), ALT (from 27.9±3.32 to 89±19.1), GGT (from 24.3±2.10 to 94±48.2), total bilirubin (from 0.74±0.02 to 1.36±0.06; 84%) and direct bilirubin (from 0.18±0.01 to 0.42±0.04; 133%) were ***, the levels of albumin, total protein, cholesterol,and uric acid were almost the same in chronic hepatitis and the control ***: Low PON1 and AE activity may contribute to the increased liver dysfunction in chronic hepatitis patients by reducing the ability of HDL to retard LDL oxidation and might be clinically useful for monitoring the disease of chronic hepatitis.

关键词：芳基酯酶血清二乙基对硝基苯磷酸酯酶酶活性慢性肝炎

Management of colorectal neoplasia during pregnancy and in the postpartum period

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World Journal of Gastrointestinal Oncology 2016年第7期8卷 550-554页

作者： erman Aytac Gokhan Ozuner Ozgen Isik Emre Gorgun Luca Stocchi Department of Colorectal Surgery Digestive Disease Institute Cleveland Clinic

AIM: To report our experience on management of colorectal neoplasia during pregnancy and in the postpartum ***: Patients who were diagnosed with colorectal cancer during pregnancy or in the postpartum period(< 6 mo), between 8/1997 and 4/2013, in our department were reviewed. Patient characteristics, operations, fetal health and follow-up during pregnancy, type of delivery and oncologic outcomes were ***: Eight patients met our study criteria. Median age at the time of diagnosis of colorectal cancer was 31 years. Median follow-up after surgery was 36 mo. Median duration of symptoms before diagnosis was 16 wk. Three patients were diagnosed with colorectal cancer during pregnancy and underwent surgery prior to delivery. None of the patients received adjuvant treatment during pregnancy. Five patients were diagnosed with colorectal cancer within a median of 2.1 mo after delivery and underwent surgery. No adverse neonatal outcomes were noted. All deliveries were at term(2 cesarean sections) except for one preterm delivery following low anterior resection on the 34 th week of ***: There has been a significant delay in the diagnosis of colorectal cancer which is probably due to overlap of symptoms and signs between these tumors and a normal pregnancy. Surgery for colorectal cancer during pregnancy can be performed safely without compromisingmaternal and fetal outcomes.

关键词： Colorectal cancer Pregnancy Postpartum Neoplasia