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Magnetic resonance imaging findings of redundant nerve roots of the cauda equina

World Journal of Radiology 2021年第1期13卷 29-39页

作者： erkan gökçe Murat Beyhan Department of Radiology Tokat Gaziosmanpasa UniversityFaculty of MedicineTokat 60100Turkey

BACkgROUND Redundant nerve roots(RNRs)of the cauda equina are often a natural evolutionary part of lumbar spinal canal stenosis secondary to degenerative processes characterized by elongated,enlarged,and tortuous nerve roots in the superior and/or inferior of the stenotic *** magnetic resonance imaging(MRI)findings have been defined more frequently in recent years,this condition has been relatively under-recognized in radiological *** this study,lumbar MRI findings of RNRs of the cauda equina were evaluated in spinal stenosis *** To evaluate RNRs of the cauda equina in spinal stenosis *** One-hundred and thirty-one patients who underwent lumbar MRI and were found to have spinal stenosis between March 2010 and February 2019 were included in the *** axial T2-weighted images(T2WI),the cross-sectional area(CSA)of the dural sac was measured at L2-3,L3-4,L4-5,and L5-S1 levels in the axial *** levels below 100 mm^2 were considered ***,expansion,and tortuosity in cauda equina fibers in the superior and/or inferior of the stenotic segment were evaluated as *** patients were divided into two groups:Those with RNRs and those without *** CSA cut-off value resulting in RNRs of cauda equina was *** length(RL)of RNRs was calculated by dividing the length of RNRs at mid-sagittal T2WI by the height of the vertebral body superior to the stenosis *** associations of CSA leading to RNRs with RL,disc herniation type,and spondylolisthesis were *** Fifty-five patients(42%)with spinal stenosis had RNRs of the cauda *** average CSA was 40.99±12.76 mm^2 in patients with RNRs of the cauda equina and 66.83±19.32 mm^2 in patients without RNRs.A significant difference was found between the two groups for CSA values(Pg a cut-off value of 55.22 mm^2 for RNRs of the cauda equina,sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV

关键词： Cauda equina Dural sac Lumbar spine Magnetic resonance imaging Redundant nerve roots Spinal stenosis

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Diagnostic efficacy of diffusion-weighted imaging and semiquantitative and quantitative dynamic contrast-enhanced magnetic resonance imaging in salivary gland tumors

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World Journal of Radiology 2023年第1期15卷 20-31页

作者： erkan gökçe Murat Beyhan Department of Radiology Tokat Gaziosmanpasa UniversityFaculty of MedicineTokat 60100Turkey

BACkgROUND Increased use of functional magnetic resonance imaging(MRI)methods such as diffusion-weighted imaging(DWI)and dynamic contrast-enhanced(DCe)MRI consisting of sequential contrast series,allows us to obtain more information on the microstructure,cellularity,interstitial distance,and vascularity of tumors,which has increased the discrimination power for benign and malignant salivary gland tumors(SgTs).In the last few years,quantitative DCe MRI data containing T1 perfusion parameters(k_(trans),k_(ep)and V_(e)),were reported to contribute to the differentiation of benign or malignant subtypes in *** To evaluate the diagnostic efficacy of DWI and semiquantitative and quantitative perfusion MRI parameters in *** Diffusion MRI[apparent diffusion coefficient(ADC)value]with a 1.5 T MR machine,semiquantitative perfusion MRI[time intensity curve(TIC)pattern],and quantitative perfusion MRI examinations(k_(trans),k_(ep)and V_(e))of 73 tumors in 67 patients with histopathological diagnosis performed from 2017 to 2021 were retrospectively *** the ADC value and semiquantitative perfusion MRI measurements,cystic components of the tumors were not considered,and the region of interest(ROI)was manually placed through the widest axial section of the *** patterns were divided into four groups:Type A=T_(peak)>120 s;type B=T_(peak)≤120 s,washout ratio(WR)≥30%;type C=T_(peak)≤120 s,WRe D=flat *** the quantitative perfusion MRI analysis,a 3D ROI was placed in the largest solid component of the tumor,and the k_(trans),k_(ep)and V_(e)values were automatically *** The majority of SgTs were located in the parotid glands(86.3%).Of all the SgTs,68.5%were benign and 31.5%were *** differences were found for ADC values among pleomorphic adenomas(PMAs),Warthin's tumors(WTs),and malignant tumors(MTs)(Pe A and WTs had type B TIC pattern while the vast majority of MTs and other benign tumors(OBTs)(5

关键词： salivary diffusion dynamic

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Advanced magnetic resonance imaging findings in salivary gland tumors

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World Journal of Radiology 2022年第8期14卷 256-271页

作者： erkan gökçe Murat Beyhan Department of Radiology Faculty of MedicineTokat Gaziosmanpasa UniversityTokat 60100Turkey

Salivary gland tumors(SgTs)make up a small portion(approximately 5%)of all head and neck *** of them are located in the parotid glands,while they are less frequently located in the submandibular glands,minor salivary glands or sublingual *** incidence of malignant or benign tumors(BTs)in the salivary glands varies according to the salivary gland from which they *** most of those detected in the parotid gland tend to be benign,the incidence of malignancy increases in other *** use of magnetic resonance imaging(MRI)in the diagnosis of SgTs is increasing every *** conventional sequences provide sufficient data on the presence,localization,extent and number of the tumor,they are insufficient for tumor *** the widespread use of advanced techniques such as diffusion-weighted imaging,semiquantitative and quantitative perfusion MRI,studies and data have been published on the differentiation of malignant or BTs and the specificity of their *** diffusion MRI,differentiation can be made by utilizing the cellularity and microstructural properties of *** example,SgTs such as high cellular Warthin’s tumor(WT)or lymphoma on diffusion MRI have been reported to have significantly lower apparent diffusion values than other *** agent uptake and wash-out levels of tumors can be detected with semiquantitative perfusion *** example,it is reported that almost all of the pleomorphic adenomas show an increasing enhancement time intensity curve and do not *** quantitative perfusion MRI studies using perfusion parameters such as ktrans,kep,and Ve,it is reported that WTs can show higher kep and lower Ve values than other *** this study,the contribution of advanced MRI to the diagnosis and differential diagnosis of SgTs will be reviewed.

关键词： Salivary gland tumors Magnetic resonance imaging Diffusion-weighted imaging Dynamic contrast-enhanced imaging Perfusion-weighted magnetic resonance imaging

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NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael k.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal g-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

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Advancement in utilization of magnetic resonance imaging and biomarkers in the understanding of schizophrenia

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World Journal of Clinical Cases 2025年第1期13卷 11-15页

作者： Aidan k Tirpack Danyaal g Buttar Mandeep kaur Department of Psychiatry Campbell University School of Osteopathic MedicineBuies CreekNC 27506United States Department of Psychiatry and Behavioral Health Mercyhealth Hospital and Trauma CenterJanesvilleWI 53548United States

Historically,psychiatric diagnoses have been made based on patient’s reported symptoms applying the criteria from diagnostic and statistical manual of mental *** utilization of neuroimaging or biomarkers to make the diagnosis and manage psychiatric disorders remains a distant *** have been several studies that examine brain imaging in psychiatric disorders,but more work is needed to elucidate the complexities of the human *** this editorial,we examine two articles by Xu et al and Stoyanov et al,that show developments in the direction of using neuroimaging to examine the brains of people with schizo-phrenia and *** et al used magnetic resonance imaging to examine the brain structure of patients with schizophrenia,in addition to examining neurotransmitter levels as *** et al used functional magnetic resonance imaging to look at modulation of different neural circuits by diagnostic-specific scales in patients with schizophrenia and *** two studies provide crucial evidence in advancing our understanding of the brain in prevalent psychiatric disorders.

关键词： Schizophrenia Magnetic resonance imaging Biomarkers Neurotransmitters Psychiatric disorders

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enhancing the efficiency of cabin heaters in emergency shelters after earthquakes through an optimized fuzzy controller

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Building Simulation 2023年第9期16卷 1759-1776页

作者： erkan Duman Dila Seckin Computer engineering Department Engineering FacultyFirat UniversityElazig 23119Turkey

In just one and half minutes,more than fifty thousand died due to the 7.7 and 7.6 magnitude earthquakes that struck Turkey’s southeast on February 6,2023;thousands of families who barely escaped struggled to survive in the freezing weather.A warm shelter was the most basic requirement of these *** buildings are a rapid and easy solution to this ***,there is a need for a more effective and safe heating option than a wood fire for these *** this study,cabin heaters,which allow truck drivers to warm up when they park their vehicles to sleep,are specially optimized for emergency shelters after an *** optimized fuzzy controller was developed to use in such buildings,which allows an air–fuel ratio in the combustion chamber of the cabin heater to be controlled adaptively based on system dynamics to get lower carbon emissions and fuel *** TRNSYS software was used to establish the transient simulation model of a cabin heater with a capacity of 4 kW for a typical 21 m^(2) shelter building in Turkey’s cold *** developed fuzzy controller carried out the heating process of this shelter from the 15th of November to the 15th of *** of using expert knowledge,the gray Wolf Optimization(gWO)method was applied to optimize the fuzzy controller parameters developed for the cabin *** the optimized fuzzy controller,the fuel consumption at the end of the heating season was reduced by an average of 0.2 L/h,and the cabin heater’s efficiency increased by more than 13%.Our simulation results show that the intelligent controller we developed could improve diesel fuel combustion efficiency by up to 85%.

关键词： parking heater cabin heater emergency shelters fuzzy controller gray wolf optimization TRNSYS simulation

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An SPH Framework for earthquake-Induced Liquefaction Hazard Assessment of geotechnical Structures

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Computer Modeling in engineering & Sciences 2025年第1期142卷 251-277页

作者： Sourabh Mhaski g.V.Ramana Department of Civil engineering Indian Institute of Technology DelhiNew Delhi110016India

earthquake-induced soil liquefaction poses significant risks to the stability of geotechnical structures *** understanding of the liquefaction triggering,and the post-failure large deformation behaviour is essential for designing resilient *** present study develops a Smoothed Particle Hydrodynamics(SPH)framework for earthquake-induced liquefaction hazard assessment of geotechnical *** coupled flowdeformation behaviour of soils subjected to cyclic loading is described using the PM4Sand model implemented in a three-phase,single-layer SPH framework.A staggered discretisation scheme based on the stress particle SPH approach is adopted to minimise numerical inaccuracies caused by zero-energy modes and tensile ***,non-reflecting boundary conditions for seismic analysis of semi-infinite soil domains using the SPH method are *** numerical framework is employed for the analysis of cyclic direct simple shear test,seismic analysis of a level ground site,and liquefaction-induced failure of the Lower San Fernando *** agreement for liquefaction triggering and post-failure behaviour demonstrates that the SPH framework can be utilised to assess the effect of seismic loading on field-scale geotechnical *** present study also serves as the basis for future advancements of the SPH method for applications related to earthquake geotechnical engineering.

关键词： earthquake seismic liquefaction stress particle PM4Sand smoothed particle hydrodynamics(SPH)

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Annual Change of the Testosterone Hormone in Male White goats

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Agricultural Sciences in China 2011年第2期10卷 312-316页

作者： Hüseyin Polat güsel Dellal Ilkay Baritci erkan Pehlivan Department of Biology Faculty of Art and ScienceAksaray University Department of Animal Faculty of AgricultureAnkara University Department of Animal Faculty of AgricultureGazi Osman Pasha University

In this research,changes of testosterone hormone in the blood serum of 9 male（3 of age 2 and 6 of age 4） White goats have been studied for a duration of one *** performed show that the general monthly averages of the testosterone hormone of the male White goats in the period of 12 months starting in January were（2.11±.73）,（2.22±.52）,（2.44±.59）,（2.10±.41）,（2.35±.00）,（3.42±.48）,（4.77±.32）,（5.61±.40）,（7.91±.24）,（10.84±.59）,（7.82±.60）,and（2.63±.61） ng mL-1,respectively（P0.05）.The effect of the age factor on the testosterone production in White goats（age 2 and 4） was generally significant（P 0.05） for differences among months in each age group,but not significant for differences between age groups in each *** testosterone hormone levels of male White goats encountered significant changes（P0.05） with respect to the season.

关键词： White goat age testosterone

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Palliation of malignant esophageal obstruction and fistulas with self expandable metallic stents

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World Journal of gastroenterology 2010年第45期16卷 5739-5745页

作者： Ahmet Dobrucali erkan Caglar Division of gastroenterology Department of Internal MedicineCerrahpasa Medical FacultyIstanbul UniversityIstanbul 34300Turkey

AIM: To evaluate the efficacy of self expandable metallic stents (SeMS) in patients with malignant esophageal obstruction and fistulas. MeTHODS: SeMS were implanted in the presence of fluoroscopic guidance in patients suffering from advanced and non-resectable esophageal, cardiac and invasive lung cancer between 2002 and 2009. All procedures were performed under conscious sedation. All patients had esophagus obstruction and/or fistula. In all patients who required reintervention, recurrence of dysphagia, hemorrhage, and fistula formation were indications for further endoscopy. Patients' files were scanned retrospectively and the obtained data were analyzed using SPSS 13.0 for Windows. The χ 2 test was used for categorical data and was analysis of variance for noncategorical data. Patients' long-term survival was assessed using the kaplan-Meier method. ReSULTS: Stents were successfully implanted in 90 patients using fluoroscopic guidance. Reasons for stent implantation in these patients were esophageal stricture (77/90, 85.5%), external pressure (8/90, 8.8%) and tracheo-esophageal fistula (5/90, 5.5%). Dysphagia scores (mean ± SD) were 3.37 ± 0.52 before and 0.90 ± 0.43 after stent implantation (P = 0.002). Intermittent, nonmassive hemorrhage due to the erosion caused by the distal end of the stent in the stomach occurred in only one patient who received implementation at cardioesophageal junction. Mean survival following stenting was 134.14 d (95% confidence interval: 94.06-174.21).CONCLUSION: SeMS placement is safe and effective in the palliation of dysphagia in selected patients with malignant esophageal strictures.

关键词： esophagus cancer Stenosis Stents Complication Dysphagia

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Biliary endoscopic sphincterotomy: Techniques and complications

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World Journal of Clinical Cases 2018年第16期6卷 1073-1086页

作者： Ayd?n Seref kksal Ahmet Tarik eminler erkan Parlak Department of gastroenterology Sakarya University School of Medicine Department of gastroenterology Hacettepe University School of Medicine

Biliary endoscopic sphincterotomy(eST) refers to the cutting of the biliary sphincter and intraduodenal segment of the common bile duct following selective cannulation, using a high frequency current applied with a special knife, sphincterotome, inserted into the papilla. eST is either used solely for the treatment of diseases of the papilla of Vater, such as sphincter of Oddi dysfunction or to facilitate subsequent therapeutic biliary interventions, such as stone extraction, stenting, etc. It is a prerequisite for biliary interventions, thus every practitioner who performs endoscopic retrograde cholangiopancreatography needs to know different techniques and the clinical and anatomic parameters related to the efficacy and safety of the procedure. In this manuscript, we will review the indications, contraindications and techniques of biliary eST and the management of its complications.

关键词： Complication Indication Biliary endoscopic sphincterotomy endoscopic retrograde cholangiopancreatography

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