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A Systems Biology Approach for Studying Heterotopic Ossification： Proteomic Analysis of Clinical Serum and Tissue Samples

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Genomics, Proteomics & Bioinformatics 2018年第3期16卷 212-220页

作者： erin L. Crowgey Jennifer T. Wyffels Patrick m. Osborn Thomas T. Wood Laura E. Edsberg Nemours Biomedical Research Nemours Alfred I. duPont Hospital for Children Wilmington DE 19803 USA Natural and Health Sciences Researeh Center Center for Wound Healing Research Daemen College Amherst NY 14226 USA Department of Computer and Information Sciences Center for Bioinformatics and Computational Biology University of Delaware Newark DE 19711 USA San Antonio military medical Center San Antonio TX 78219 USA

Heterotopic ossification （HO） refers to the abnormal formation of bone in soft tissue. Although some of the underlying processes of HO have been described, there are currently no clinical tests using validated biomarkers for predicting HO formation. As such, the diagnosis is made radiographically after HO has formed. To identify potential and novel biomarkers for HO, we used isobaric tags for relative and absolute quantitation （iTRAQ） and high-throughput antibody arrays to produce a semi-quantitative proteomics survey of serum and tissue from subjects with （HO ＋） and without （HO-） heterotopic ossification. The resulting data were then analyzed using a systems biology approach. We found that serum samples from subjects experiencing traumatic injuries with resulting HO have a different proteomic expression controls. Subsequent quantitative ELISA identified profile compared to those from the matched five blood serum proteins that were differentially regulated between the HO-- and HO- groups. Compared to HO- samples, the amount of insulin-like growth factor I （IGF1） was up-regulated in HO＋ samples, whereas a lower amount of osteopontin （OPN）, myeloperoxidase （mPO）, runt-related transcription factor 2 （RUNX2）,and growth differentiation factor 2 or bone morphogenetic protein 9 （BmP-9） was found in HO ＋ samples （Welch two sample t-test; P 〈 0.05）. These proteins, in combination with potential serum biomarkers previously reported, are key candidates for a serum diagnostic panel that may enable early detection of HO prior to radiographic and clinical manifestations.

关键词： Heterotopic ossification Proteomics Runt-related transcriptionfactor 2 Extracellular matrixorganization Keratinization

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Parents' participation in physical activity predicts maintenance of some,but not all, types of physical activity in offspring during early adolescence:A prospective longitudinal study

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Journal of Sport and Health Science 2019年第3期8卷 273-279页

作者： Jennifer Brunei Jeffrey Gaudet erin K.Wing mathieu Bélanger School of Human Kinetics University of Ottawa Institut du Savoir montfort (ISm) H?pital Montfort Cancer Therapeutic Program Ottawa Hospital Research Institute (OHRI) Centre de formation medicale du Nouveau-Brunswick Universite de Moncton Centre de formation médicale du Nouveau-Brunswick Université de Moncton

Purpose: We aimed to examine the longitudinal associations between parents' and youth's participation in physical activity(PA).methods-: One hundred and ninety youth cuompleted self-admitiistered questionnaires 3 times per year from 2011 to 2015, and their parents completed an interviewer-administered questionnaire during a telephone interview once in2011-2012. Data on youth's and parents' activities were classified as interdependent or coactive/***: Youth with one or both parents who participated in interdependent activities were more likely to maintain participation in interdependent activities(hazard ratio(HR) = 3.63: 95% confidence interval(CI) = 1.30-10.17). Youth's sustained participation in coactive/independent activities was not associated with parents' participation in coactive/independent activities(HR= 0.97; 95%CI=0.46-2.06).Conclusion: Longitudinal associations between parents' and youth's participation in PA differed across type of PA. Encouraging parents' participation in interdependent activities may promote sustained participation in interdependent activities in youth.

关键词： Longitudinal maintenance Parental behavior Physical activity Sports Youth

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作者： erin Hunter.

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Promises and pitfalls of immune-based strategies for Huntington's disease

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Neural Regeneration Research 2017年第9期12卷 1422-1425页

作者： Gabriela Delevati Colpo erin Furr Stimming Natalia Pessoa Rocha Antonio Lucio Teixeira Neuropsychiatry Program Department of Psychiatry and Behavioral Sciences Mc Govern Medical School The University of Texas Health Science Center at Houston Department of Neurology McGovern Medical School The University of Texas Health Science Center at Houston

Huntington＇s disease （HD） is an autosomal-dominant neurodegenerative disease characterized by the selec- tive loss of neurons in the striatum and cortex, leading to progressive motor dysfunction, cognitive decline and behavioral symptoms. HD is caused by a trinucleotide （CAG） repeat expansion in the gene encoding for huntingtin. Several studies have suggested that inflammation is an important feature of HD and it is already observed in the early stages of the disease. Recently, new molecules presenting anti-inflammatory and/or immunomodulatory have been investigated for HD. The objective of this review is to discuss the data obtained so far on the immune-based therapeutic strategies for HD.

关键词： Huntington's disease treatment disease modifying therapy inflammation

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Self-reported physical functioning,cardiometabolic health conditions, and healthcare utilization patterns in million Veteran Program enrollees with Traumatic Brain Injury Screening and Evaluation Program data

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military medical Research 2023年第5期10卷 587-598页

作者： Alexandra L.Clark makenna B.mcGill erin D.Ozturk David m.Schnyer Catherine Chanfreau‑Cofnier Victoria C.merritt Research Service VA San Diego Healthcare System(VASDHS)San DiegoCA92161USA Department of Psychology The University of Texas at AustinAustinTX 78712USA San Diego State University/University of CaliforniaSan Diego Joint Doctoral Program San DiegoCA 92120USA VA Informaticsand Computing Infrastructure(VINCI) VA Salt Lake City Health Care SystemSalt Lake CityUT 84148USA Department of Psychiatry School of MedicineUniversity of California San DiegoLa JollaCA 29093USA Center of Excel‑lence for Stress and mental Health VASDHSSan Diego 92161USA

Background Examining the health outcomes of veterans who have completed the United States Veterans Health Administration’s(VHA’s)Traumatic Brain Injury(TBI)Screening and Evaluation Program may aid in the refinement and improvement of clinical care initiatives within the *** study compared self-reported physical functioning,cardiometabolic health conditions,and health care utilization patterns in million Veteran Program enrollees with TBI Screening and Evaluation Program data(collected between 2007 and 2019),with the goal of enhancing understanding of potentially modifiable health conditions in this *** In this observational cohort study,veterans(n=16,452)were grouped based on the diagnostic outcome of the TBI Screening and Evaluation Program:1)negative TBI screen(Screen^(-));2)positive TBI screen but no confirmed TBI diagnosis[Screen^(+)/Comprehensive TBI Evaluation(CTBIE)^(-)];or 3)positive TBI screen and confirmed TBI diagnosis(Screen^(+)/CTBIE^(+)).Chi-square tests and analysis of covariance were used to explore group differences in physical functioning,cardiometabolic health conditions,and health care utilization patterns,and logistic regressions were used to examine predictors of Screen^(+/-)and CTBIE^(+/-)group *** The results showed that veterans in the Screen^(+)/CTBIE^(-)and Screen^(+)/CTBIE^(+)groups generally reported poorer levels of physical functioning(P’smetabolic health conditions(P’s0.5)compared with the Screen-group;however,health outcomes were generally comparable between the Screen^(+)/CTBIE^(-)and Screen^(+)/CTBIE^(+)***-up analyses confirmed that while physical functioning,hypertension,stroke,healthcare utilization,and prescription medication use reliably distinguished between the Screen-and Screen^(+)groups(P’s<0.02,OR’s 0.78 to 3.38),only physical functioning distinguished bet

关键词： Traumatic brain injury(TBI)screen Comprehensive TBI Evaluation(CTBIE) Health outcomes Cardiometabolichealth Veterans million Veteran Program(mVP)

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Perceptions of the effectiveness of Advanced Practice Nurses on a neurosurgery unit in a Canadian Tertiary Care Centre:A pre-and-post implementation design

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International Journal of Nursing Sciences 2018年第2期5卷 138-143页

作者： Alanna m.Keenan erin E.mutterback Kristi m.Velthuizen monika E.Pantalone Kira L.Gossack-Keenan The Ottawa Hospital OttawaOntarioCanada University of Ottawa OttawaOntarioCanada mcmaster University HamiltonOntarioCanada

Objectives:A framework for the advanced practice nurse(APN)role was developed in our Canadian Tertiary Care Centre,delineating five domains of advanced nursing practice:clinical practice,consultation,research,education and *** goal of this study was to evaluate perceptions of the effectiveness of the implementation of an innovative APN role on an in-patient Neurosurgery ***:A pre-and-post implementation design,incorporating both qualitative and quantitative data,was *** innovative APN role was implemented within the Neurosurgery program focusing on the clinical domain and required the successful candidates to be NP *** APN role was designed to improve patient flow,documentation,communication and patient and staff *** primary outcomes were measured:pre-implementation questionnaire(nurses),post-implementation questionnaire(nurses and residents)and number of pages to the on-call ***:Survey scores by nurses and residents indicated improvement across all aspects *** scores increased from 1.1 to 2.6,reflecting an overall statistically significant *** number of pages to the on-call resident also showed a ***:Perceptions of patient care delivery and professional collaboration improved following implementation of the APN *** indicated that APNs significantly impacted patient care and improved nurses and residents'job satisfaction.

关键词： Advanced practice nursing Delivery of health care Patient care team Pre-post tests Professional practice gaps

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Explaining farmers'reluctance to adopt green manure cover crops planting for sustainable agriculture in Northwest China

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Journal of Integrative Agriculture 2022年第11期21卷 3382-3394页

作者： Sheng-Han-erin CHANG YI Xiao-yan Johannes SAUER YIN Chang-bin LI Fu-duo Agricultural Production and Resource Economics Technical University of MunichFreising 85354Germany Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural SciencesBeijing 100081P.R.China

Green manure cover crops(GmCCs)planting has a potential for mitigating greenhouse gas emissions(GHG)in agroecosystems and provides important ecosystem services,thereby achieving the Sustainable Development Goals(SDGs)stipulated by the United ***,the advantages of cultivating GmCCs on arable land are not widely *** example,in the whole of China,the GmCCs planting area is less than 3.5%of total arable *** aim of this study is to explore reasons for the low adoption rate of GmCCs *** best–worst scaling(BWS)approach,farmers ranked their preferred conservation practices including three types of GmCC cropping *** Gansu Province in Northwest China as a case study,a survey with 276 farmers was *** findings indicated that three factors are related to the low adoption rate of GmCCs:1)farmers preferred improving farmland irrigation facilities and substituting chemical fertilizers with organic rather than planting GmCCs;2)lack of awareness and understanding of government policy on GmCCs and limited access to training courses;3)financial support and subsidies from the government are *** study provides insights and strategic implications for policymakers on how to further promote GmCCs in the future.

关键词： best–worst scaling farmers'preferences green manure cover crops sustainable agriculture Northwest China

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Hypermobility of SHORT-ROOT in the development of multiple cortex layers

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molecular Plant 2022年第2期15卷 211-211页

作者： m.Arif Ashraf erin Sparks Department of Biology University of Massachusetts AmherstAmherstMAUSA Department of Plant and Soil Sciences and the Delaware Biotechnology Institute University of DelawareNewarkDE 19711USA

Intricate and reproducible patterning of root tissues is critical for root function and plant *** particular,patterning of the ground tissue(endodermis and cortex)is vital to regulating mate-rial exchange and ***,ground tissue patterns are variable in different plant *** example,the model plant Arabidopsis thaliana,where the canonical genetic circuit for ground tissue patterning was defined,contains only one layer of endodermis and one layer of *** contrast,maize has eight layers of cortex(Figure 1),but the formation mechanism of multiple cortex layers is not well understood.

关键词： Figure multiple ground

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Site directed mutagenesis as a precision tool to enable synthetic biology with engineered modular polyketide synthases

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Synthetic and Systems Biotechnology 2020年第2期5卷 62-80页

作者： erin E.Drufva Elijah G.Hix Constance B.Bailey Department of Chemistry University of Tennessee-KnoxvilleKnoxvilleTN37996USA

modular polyketide synthases(PKSs)are a multidomain megasynthase class of biosynthetic enzymes that have great promise for the development of new compounds,from new pharmaceuticals to high value commodity and specialty *** colinear biosynthetic logic has been viewed as a promising platform for synthetic biology for *** to this colinearity,domain swapping has long been used as a strategy to introduce molecular ***,domain swapping often fails because it perturbs critical protein-protein interactions within the *** our increased level of structural elucidation of PKSs,using judicious targeted mutations of individual residues is a more precise way to introduce molecular diversity with less potential for global disruption of the protein *** we review examples of targeted point mutagenesis to one or a few residues harbored within the PKS that alter domain specificity or selectivity,affect protein stability and interdomain communication,and promote more complex catalytic reactivity.

关键词： Polyketide synthase Site directed mutagenesis Rational design Saturation mutagenesis Synthetic biology Protein engineering

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Soil resource availability and its effect on the ecophysiology and establishment of Stipa pulchra

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Journal of Plant Ecology 2019年第4期12卷 603-614页

作者： Robert L.Fitch erin J.Questad Edward G.Bobich Department of Biological Sciences California State Polytechnic UniversityPomona3801 West Temple Avenue PomonaCA 91768USA

Aims The objectives of this study were to(i)determine the importance of soil moisture and soil nitrogen availability as resource requirements for the establishment of Stipa pulchra,(ii)to examine how changes in slope within a local habitat can affect the accumulation of soil moisture and soil nitrogen and(iii)to measure the physiological re-sponses of *** among such slope *** The field experiment occurred in the San JoséHills of Southern California on the California State Polytechnic University,Pomona *** were established within three different slope loca-tions(shallow,moderate and steep)within four separate *** nitrogen treatments(ambient,addition and removal)were replicated within each slope location for all four canyons,and five *** plants were planted in each *** nitrogen accumula-tion and soil moisture,as well as other abiotic variables,were meas-ured across the varied slope locations and nitrogen *** measured the cover,stress,and reproduction of *** plants for 2 years and used a mesocosm experiment to determine how ***-chra responds to varying water and nitrogen *** Findings Stipa pulchra had a strong positive response to the wettest watering treatment and a weak response to nitrogen addition in the meso-cosm *** the field experiment,*** responded positively in moderate slope locations and did not respond to ni-trogen treatments,possibly due to *** patterns of soil moisture were driven by slope,soil compaction and solar *** nitrogen accumulation did not vary among slope *** restoration of ***,priority should be placed on managing soil moisture availability and determining suitable edaphic factors.

关键词： establishment ecophysiology slope soil moisture soil properties nitrogen deposition

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