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Efficacy of nonsolvent flower pollen extracts in healthy women with urinary incontinence:A randomized,double-blind,placebo-controlled,parallel study

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Current Urology 2024年第3期18卷 203-211页

作者： Marc Moulin erin d.lewis david C.Crowley Colleen E.May Malkanthi Evans KGK Science Inc. LondonOntarioCanada Graminex L.L.C.SaginawMIUSA

Background Urinary incontinence(UI)is a debilitating and common condition that adversely affects quality of *** and surgical approaches for managing UI symptoms may result in undesirable risks and *** randomized,double-blind,placebo-controlled,parallel study investigated the efficacy of 2 nonsolvent flower pollen extracts on UI in healthy *** and methods One-hundred and fourteen women aged 40–75 years who scored≥5 on the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form(ICIQ-SF)were randomized to receive either Graminex®RCT Fem™UI,Graminex®PollenBerry®,or placebo for 24 *** primary outcome was the change in the ICIQ-SF score between the trial and placebo groups after 24 weeks of *** secondary outcomes included changes in the frequency of nocturia(recorded in 3-day void diaries)and 24-hour leakage volume(assessed via pad weight)after 6,12,18,and 24 weeks of supplementation and changes in stress-induced urinary leakage volume(after completion of a provocative maneuver challenge)after 24 weeks of *** All the groups demonstrated improvement in ICIQ-SF scores at week 24(pd the greatest improvement in ICIQ-SF scores(−4.07±3.4),followed by the PollenBerry®group(−3.34±2.87)and placebo group(−2.61±3.52).The RCT Fem™UI group had corresponding improvements in 24-hour leakage volume(−17.68±39.84 g)and frequency of nocturia(−0.52±1.26)(p≤0.05).PollenBerry®supplementation significantly improved stress-induced urinary leakage volume(−7.12±15.64 g)at week *** study products demonstrated safe hematological and chemical *** RCT Fem™UI supplementation resulted in significant and clinically meaningful reductions in UI severity,with corresponding improvements in daily urinary leakage volume and frequency of ***®significantly improved stress-induced urinary leakage volume,suggesting that it may be eff

关键词： Urinary incontinence Pollen extract Healthy women dietary supplement ICIQ-SF Urinary leakage

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Inhaled volatile anesthetics in the intensive care unit

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World Journal of Critical Care Medicine 2024年第1期13卷 28-39页

作者： erin d Wieruszewski Mariam ElSaban Patrick M Wieruszewski Nathan J Smischney department of Pharmacy Mayo ClinicRochesterMN 55905United States Anesthesiology and Perioperative Medicine Mayo ClinicRochesterMN 55905United States department of Anesthesiology&Perioperative Medicine Mayo ClinicRochesterMN 55905United States

The discovery and utilization of volatile anesthetics has significantly transformed surgical practices since their inception in the mid-19th ***,a paradigm shift is observed as volatile anesthetics extend beyond traditional confines of the operating theatres,finding diverse applications in intensive care *** the dynamic landscape of intensive care,volatile anesthetics emerge as a promising avenue for addressing complex sedation requirements,managing refractory lung pathologies including acute respiratory distress syndrome and status asthmaticus,conditions of high sedative requirements including burns,high opioid or alcohol use and neurological conditions such as status *** anesthetics can be administered through either inhaled route via anesthetic machines/devices or through extracorporeal membrane oxygenation circuitry,providing intensivists with multiple options to tailor ***,their unique pharmacokinetic profiles render them titratable and empower clinicians to individualize management with heightened accuracy,mitigating risks associated with conventional sedation *** the amounting enthusiasm for the use of these therapies,barriers to widespread utilization include expanding equipment availability,staff familiarity and training of safe *** article delves into the realm of applying inhaled volatile anesthetics in the intensive care unit through discussing their pharmacology,administration considerations in intensive care settings,complication considerations,and listing indications and evidence of the use of volatile anesthetics in the critically ill patient population.

关键词： Anesthesia Critical care Mechanical ventilation Sedation Volatile anesthetics Sedative

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distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis

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Frontiers of Medicine 2024年第1期18卷 147-168页

作者： Weiwei Xian Mohammad Asad Shuai Wu Zhixin Bai Fengjiao Li Junfeng Lu Gaoyu Zu erin Brintnell Hong Chen Ying Mao Guomin Zhou Bo Liao Jinsong Wu Edwin Wang Linya You department of Human Anatomy&Histoembryology School of Basic Medical SciencesFudan UniversityShanghai200032China Cumming School of Medicine University of CalgaryCalgaryAlbertaT2N 4N1Canada Glioma Surgery division Department of NeurosurgeryHuashan HospitalFudan UniversityShanghai200040China department of Pathology Huashan HospitalFudan UniversityShanghai200040China department of Neurosurgery Huashan HospitalFudan UniversityShanghai200040China Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention Fudan UniversityShanghai200040China School of Mathematics and Statistics Hainan Normal UniversityHaikou570100China

The association of neurogenesis and gliogenesis with glioma remains *** conducting single-cell RNA-seq analyses on 26 gliomas,we reported their classification into primitive oligodendrocyte precursor cell(pri-OPC)-like and radial glia(RG)-like tumors and validated it in a public cohort and TCGA *** RG-like tumors exhibited wild-type isocitrate dehydrogenase and tended to carry EGFR mutations,and the pri-OPC-like ones were prone to carrying TP53 *** subclones only in pri-OPC-like tumors showed substantially down-regulated MHC-I genes,suggesting their distinct immune evasion ***,the two subgroups appeared to extensively modulate glioma-infiltrating lymphocytes in distinct *** specific genes not expressed in normal immune cells were found in glioma-infiltrating *** example,glial/glioma stem cell markers OLIG1/PTPRZ1 and B cell-specific receptors IGLC2/IGKC were expressed in pri-OPC-like and RG-like glioma-infiltrating lymphocytes,*** expression was positively correlated with those of immune checkpoint genes(e.g.,LGALS33)and poor survivals as validated by the increased expression of LGALS3 upon IGKC overexpression in Jurkat *** finding indicated a potential inhibitory role in tumor-infiltrating lymphocytes and could provide a new way of cancer immune evasion.

关键词： single-cell RNA-seq glioma radial glia primitive oligodendrocyte precursor cell immune escape

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Cognitive function among military veterans with STEM occupations

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Military Medical Research 2024年第2期11卷 308-310页

作者： Justin T.Mcdaniel Kevin N.Hascup erin R.Hascup Ugochukwu G.Ezigbo Amanda M.Weidhuner Harvey Henson david L.Albright dale and deborah Smith Center for Alzheimer's Research and trEatment(CARE) Southern Illinois University School of MedicineSpringfieldIL 62794USA STEM Education Research Center Southern Illinois UniversityCarbondaleIL 62901USA department of Political Science The University of AlabamaTuscaloosaAL 35487USA

dear Editor,There is limited research on the relationship between science,technology,engineering,and mathematics(STEM)occupational history and cognitive function in later life,especially among military veterans,who may be at greater risk for later-life cognitive *** study examines a nationally representative sample of military veterans to address this gap in knowledge.

关键词： Alzheimer's disease Veterans Science technology engineering and mathematics(STEM) Animal fluency test dementia

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保费上涨成为年轻一代新烦恼

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商业周刊（中文版） 2024年第2期 23-24页

作者： erin Lowry 逸思(译) 不详

成年人常常觉得自己面临着没完没了的待办事项,还不得不在知之甚少或毫无经验的情况下做出重大决策——很有可能导致可怕后果。这听上去或许有些夸张,但从买房到选择医疗保险,再到正确填写W-4税表,如果出现失误,都会带来严重经济后果。... 详细信息

成年人常常觉得自己面临着没完没了的待办事项,还不得不在知之甚少或毫无经验的情况下做出重大决策——很有可能导致可怕后果。这听上去或许有些夸张,但从买房到选择医疗保险,再到正确填写W-4税表,如果出现失误,都会带来严重经济后果。也许,决策方面的疲劳感正是许多人。

关键词：疲劳感医疗保险年轻一代成年人

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蓝莓不是蓝色的

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中学生英语 2024年第27期 36-37页

作者： erin Garcia de Jesús 陈佳武汉市光谷五小

Roses are red and blueberries look *** the berry's color is not really *** fruit's waxy1coat just masquerades2as blue.玫瑰是红色的,蓝莓看起来是蓝色的。但蓝莓的颜色并不是真的。这种水果的蜡质外皮只是伪装成蓝色。A waxy covering coats some blue-colored fruits—such as blueberries,dark grapes and certain *** wax contains a host of tiny structures,each less th an a th ousandth the thickness of a piece of paper.

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Elite,transformable haploid inducers in maize

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The Crop Journal 2024年第1期12卷 314-319页

作者： Brent delzer dawei Liang david Szwerdszarf Isadora Rodriguez Gonzalo Mardones Sivamani Elumalai Francine Johnson Samson Nalapalli Rachel Egger erin Burch Kerry Meier Juan Wei Xiujuan Zhang Huaping Gui Huaibing Jin Huan Guo Kun Yu Yubo Liu Becky Breitinger Ana Poets Jason Nichols Wan Shi david Skibbe Qiudeng Que Timothy Kelliher Seeds development Syngenta SeedsJanesvilleWI 53546USA Seeds Research Syngenta Biotechnology China Co.Ltd.Beijing 102206China Centro de Investigación de Cultivos Arica Syngenta R&DArica 1000000Chile Syngenta S.A. Proyecto la SoledadGraneros 2880000Chile Seeds Research Syngenta Crop Protection LLCRTPNC 27709USA Seeds development Syngenta SeedsSlaterIA 50244USA

The introduction of alleles into commercial crop breeding pipelines is both time consuming and *** technologies that are disrupting traditional breeding processes are doubled haploid(dH)breeding and genome editing(GE).Recently,these techniques were combined into a GE trait delivery system called HI-Edit(Haploid Inducer-Edit).In HI-Edit,the pollen of a haploid inducer line is reprogrammed to deliver GE traits to any variety,obviating recurrent *** HI-Edit to operate at scale,an efficient transformable HI line is needed,but most maize varieties are recalcitrant to transformation,and haploid inducers are especially difficult to transform given their aberrant reproductive *** marker assisted selection and a three-tiered testing scheme,we report the development of new Iodent and Stiff Stalk maize germplasm that are transformable,have high haploid induction rates,and exhibit a robust,genetically-dominant anthocyanin native trait that may be used for rapid haploid *** show that transformation of these elite‘‘HI-Edit”lines is enhanced using the BABYBOOM and WUSCHEL morphogenetic ***,we evaluate the HI-Edit performance of one of the lines against both Stiff Stalk and non-Stiff Stalk *** strategy and results of this study should facilitate the development of commercially scalable HI-Edit systems in diverse crops.

关键词： Zea mays L doubled haploids Transformation Genome editing QTL

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Large animal ischemic stroke models: replicating human stroke pathophysiology

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Neural Regeneration Research 2020年第8期15卷 1377-1387页

作者： erin E.Kaiser Franklin d.West Regenerative Bioscience Center University of GeorgiaAthensGAUSA Neuroscience Program Biomedical and Health Sciences InstituteUniversity of GeorgiaAthensGAUSA department of Animal and dairy Science College of Agricultural and Environmental SciencesUniversity of GeorgiaAthensGAUSA

The high morbidity and mortality rate of ischemic stroke in humans has led to the development of numerous animal models that replicate human stroke to further understand the underlying pathophysiology and to explore potential therapeutic *** promising therapeutics have been identified using these animal models,with most undergoing significant testing in rodent models,the vast majority of these interventions have failed in human clinical *** failure of preclinical translation highlights the critical need for better therapeutic assessment in more clinically relevant ischemic stroke animal *** animal models such as non-human primates,sheep,pigs,and dogs are likely more predictive of human responses and outcomes due to brain anatomy and physiology that are more similar to humans-potentially making large animal testing a key step in the stroke therapy translational *** objective of this review is to highlight key characteristics that potentially make these gyrencephalic,large animal ischemic stroke models more predictive by comparing pathophysiological responses,tissue-level changes,and model limitations.

关键词： brain ischemia clinical translation gyrencephalic large animal model magnetic resonance imaging stroke

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Prediction of esophageal and gastric histology by macroscopic diagnosis during upper endoscopy in pediatric celiac disease

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World Journal of Gastroenterology 2017年第4期23卷 646-652页

作者： erin d Boschee Jason YK Yap Justine M Turner department of Pediatrics University of Alberta Edmonton Clinic Health Academy University of Alberta Hospital division of Pediatric Gastroenterology Department of PediatricsUniversity of Alberta

AIMTo determine the sensitivity of macroscopic appearance for predicting histological diagnosis at sites other than duodenum in pediatric celiac disease (Cd).METHOdSEndoscopic and histologic findings in pediatric patients undergoing upper endoscopy for first-time diagnosis of Cd at Stollery Children’s Hospital from 2010-2012 were retrospectively *** charts from 140 patients were reviewed. Esophageal and gastric biopsies were taken in 54.3% and 77.9% of patients, respectively. Endoscopic appearance was normal in the esophagus and stomach in 75% and 86.2%. Endoscopic esophageal diagnoses were eosinophilic esophagitis (EE) (11.8%), esophagitis (7.9%), glycogenic acanthosis (1.3%) and non-specific abnormalities (3.9%). Endoscopic gastric diagnoses were gastritis (8.3%), pancreatic rest (0.9%), and non-specific abnormalities (4.6%). Histology was normal in 76.3% of esophageal and 87.2% of gastric specimens. Abnormal esophageal histology was EE (10.5%), esophagitis (10.5%), glycogenic acanthosis (1.3%) and non-specific (1.3%). Gastritis was reported in 12.8% of specimens. Sensitivity and specificity of normal endoscopy for predicting normal esophageal histology was 86.2% and 61.1%, and for normal gastric histology was 87.4% and 21.4%.CONCLUSIONIn the absence of macroscopic abnormalities, routine esophageal and gastric biopsy during endoscopy for pediatric Cd does not identify major pathologies. These findings have cost and time saving implications for clinical practice.

关键词： Endoscopy Histology Esophagus Gastric biopsy Celiac disease

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Predicting the dynamics of local adaptation in invasive species

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Journal of Arid Land 2013年第3期5卷 268-274页

作者： erin K ESPELANd USdA-ARS Pest Management Research Unit Sidney MT 59270USA

An invasive plant species may restrict its spread to only one type of habitat, or, after some time, may continue to spread into a different, often stressful, secondary, habitat. The question of whether evolution is required for an invasive species to spread from one habitat to another is currently hotly debated. In order for local adaptation to occur, genetic variation must be present within invasive populations. In this paper, I focus on the effect of habitat on the maintenance of genetic variation during the lag phase, the phase of population stability prior to expansion. Genetic diversity in invasive plant populations accumulates through multiple introductions, gene flow, mutation, and hybridization, but diversity is maintained by population level processes influencing effective population size （Ne）. I show that when the plastic response to the environment results in little variation in reproductive output among indi- viduals, Ne is maximized and genetic variation is maintained. Established models of plant competition show that below-ground competition reduces the variation in reproductive output, whereas competition for light increases variation in reproductive output. The same environments that maintain high Ne also reduce the opportunity for se- lection and minimize the response to selection, and thus the effects of the environment are synchronized to prevent genetic purges. When the primary invasion habitat supports high Ne, conditions are ripe for local adaptation to a secondary habitat, particularly if the secondary habitat has high opportunity for selection. When the primary invasion habitat supports low Ne, genetic diversity is less likely to be sufficient for local adaptation to secondary habitat to occur.

关键词： canalization phenotypic plasticity population expansion secondary invasion

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